Dr Lynley Lewis

2026

Journal - Research Article

Lau, H. J., Pilbrow, A. P., Thompson, J., Sulit, A., Pearson, J., Frampton, C. M. A., Lewis, L., Pearson, A., Fa'atoese, A., Pitama, S., Troughton, R., & Cameron, V. A. (2026). The Family Heart Study: Rationale, design and methodology. New Zealand Medical Journal/Te ara tika o te hauora hapori, 139(1639), 35-45. doi: 10.26635/6965.7409

Journal - Research Other

Pearson, A., Cunningham, E., Kane, J., Troughton, R. W., Pearson, J. F., Lewis, L. K., Woodcock, E., Pemberton, C., McKerchar, C., & Patu, M. (2026). Hauora Manawa mō ngā Kaumātua me ngā Whānau: A co-designed community-based cohort study of cardiovascular health among older Māori in Canterbury, New Zealand: A study protocol. BMJ Open, 16(8), e120784. doi: 10.1136/bmjopen-2026-120784

2025

Journal - Research Article

Pearson, A. G., Pearson, J. F., Lewis, L. K., Fa'atoese, A., Poppe, K. K., Pemberton, C., … Richards, A. M., Troughton, R., & Doughty, R. N. (2025). Lower NT-proBNP plasma concentrations in Pacific peoples with heart failure. ESC Heart Failure, 12(4), 2976-2984. doi: 10.1002/ehf2.15314

Prickett, T. C. R., Lewis, L. K., Pearson, J. F., & Espiner, E. A. (2025). Metabolism of natriuretic peptides and impact on insulin resistance and fat mass in healthy subjects. Clinical Biochemistry, 136, 110893. doi: 10.1016/j.clinbiochem.2025.110893

2024

Conference Contribution - Published proceedings: Abstract

Pearson, A., Lewis, L., Pemberton, C., Troughton, R., Richards, M., Devlin, G., … Fa'atoese, A. (2024). Lower levels of NT-proBNP in Pacific peoples with heart failure. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S80). doi: 10.1016/j.hlc.2024.04.269

2023

Journal - Research Article

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082

2022

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126

Wu, Z., Pilbrow, A. P., Liew, O. W., Chong, J. P. C., Sluyter, J., Lewis, L. K., Lasse, M., Frampton, C. M., … Cameron, V. A., … Richards, A. M. (2022). Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations. EBioMedicine, 82, 104170. doi: 10.1016/j.ebiom.2022.104170

Conference Contribution - Published proceedings: Abstract

Lewis, L., Raudsepp, S., Whitlow, J., Appleby, S., Pemberton, C., & Richards, A. M. (2022). Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays? European Heart Journal, 43(Suppl. 1), (pp. i76). doi: 10.1093/eurheartj/ehab849.060

Conference Contribution - Poster Presentation (not in published proceedings)

Lewis, L. (2022, August). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Poster session presented at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Conference Contribution - Published proceedings: Abstract

Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044

2020

Journal - Research Article

Harris, S. L., Troughton, R., Lewis, L., Austin, N., & Pemberton, C. (2020). Circulating forms of B-type natriuretic peptide in very preterm infants. Journal of Applied Laboratory Medicine, 5(3), 506-515. doi: 10.1093/jalm/jfaa003

Journal - Research Other

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Pemberton, C. J., & Richards, A. M. (2020). ProBNP processing is decreased by obesity in patients with heart failure. Annals of Translational Medicine, 8(4), 135. doi: 10.21037/atm.2019.12.81

Conference Contribution - Published proceedings: Abstract

Lewis, L., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Richards, A. M., Prickett, T. C. R., … Pemberton, C. J. (2020). ProBNP glycosylation of threonine 71 is increased with obesity in patients with heart failure. European Heart Journal, 41(Suppl. 1), ehz872.007. doi: 10.1093/ehjci/ehz872.007

2019

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry, 65(9), 1115-1124. doi: 10.1373/clinchem.2019.302547

2017

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

2016

Conference Contribution - Poster Presentation (not in published proceedings)

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., & Richards, A. M. (2016, August). Development of a specific immunoassay to measure BNP1-32 in plasma without the confounding influences of precursor peptides and peptide metabolites: Could this improve heart failure diagnosis? Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

2015

Journal - Research Article

Justice, T. D., Hammer, G. L., Davey, R. J., Paramalingam, N., Guelfi, K. J., Lewis, L., … Fournier, P. A. (2015). Effect of antecedent moderate-intensity exercise on the glycemia-increasing effect of a 30-sec maximal sprint: A sex comparison. Physiological Reports, 3(5), 12386. doi: 10.14814/phy2.12386

2014

Journal - Research Article

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). Endogenous ouabain is not ouabain. Hypertension, 64, 680-683. doi: 10.1161/hypertensionaha.114.03919

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Journal - Research Other

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). [Response to letter re Endogenous ouabain is not ouabain]. Hypertension, 64. Retrieved from http://hyper.ahajournals.org/content/64/4/680/reply#hypertensionaha_el_351

2013

Journal - Research Article

Adem, A., Al Haj, A., Benedict, S., Yasin, J., Nagelkerke, N., Nyberg, F., Yandle, T. G., Frampton, C. M., Lewis, L. K., Nicholls, M. G., & Kazzam, E. (2013). ANP and BNP responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 8(3), e57806. doi: 10.1371/journal.pone.0057806

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Palmer, S. C., Troughton, R. W., & Richards, A. M. (2013). Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA. Clinical Biochemistry, 46(4-5), 388-390. doi: 10.1016/j.clinbiochem.2012.11.022

Conference Contribution - Poster Presentation (not in published proceedings)

Byers, M. S., Bailey, M., Siriwardena, M., Lewis, L. K., Oliver, J., Troughton, R., Richards, A. M., & Pemberton, C. J. (2013, August). Plasma ghrelin signal peptide can exclude co-existent pneumonia in acute decompensated heart failure. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Journal - Research Article

Ali, M. A., Adem, A., Chandranath, I. S., Benedict, S., Pathan, J. Y., Nagelkerke, N., … Lewis, L. K., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Kazzam, E. (2012). Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 7(5), e37299. doi: 10.1371/journal.pone.0037299

Scott, N. J. A., Cameron, V. A., Raudsepp, S., Lewis, L. K., Simpson, E. R., Richards, A. M., & Ellmers, L. J. (2012). Generation and characterization of a mouse model of the metabolic syndrome: Apolipoprotein E and aromatase double knockout mice. American Journal of Physiology: Endocrinology & Metabolism, 302, E576-E584. doi: 10.1152/ajpendo.00222.2011

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Braithwaite, J. E., Yandle, T. G., Nicholls, M. G., & Lewis, L. K. (2012). Interference by o-phenanthroline in the radioimmunoassay of angiotensin II in small volume blood samples. Clinical Biochemistry, 45(1-2), 168-170. doi: 10.1016/j.clinbiochem.2011.10.008

2011

Journal - Research Article

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2011). B-type natriuretic peptides: Looking to the future. Annals of Medicine, 43(3), 188-197. doi: 10.3109/07853890.2010.526630

2009

Journal - Research Article

Nicholls, M. G., Lewis, L. K., Yandle, T. G., Lord, G., Mckinnon, W., & Hilton, P. J. (2009). Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? Journal of Hypertension, 27(1), 3-8. doi: 10.1097/HJH.0b013e32831101d1

2003

Journal - Research Article

Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.

2002

Journal - Research Article

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2002). Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. Journal of Endocrinology, 175, 225-232.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

2001

Journal - Research Article

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a man. Peptides, 22, 1745-1752.

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in man. Peptides, 22(11), 1745-1752.

Troughton, R. W., Frampton, C. M., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2001). Differing thresholds for modulatory effects of adrenomedullin infusion on hemodynamic and hormone responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers. Clinical Science, 101, 103-109.

Conference Contribution - Published proceedings: Abstract

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2001). Individual human vascular endothelial cells contain and secrete both adrenomedullin and endothelin. Proceedings of the New Zealand Society of Endocrinology Scientific Meeting. (pp. 4). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

2000

Journal - Research Article

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Haemodynamic, hormonal and renal effects of short-term adrenomedullin infusion in healthy volunteers. Journal of Clinical Endocrinology & Metabolism, 85, 1016-1020.

Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Hemodynamic, hormone, and urinary effects of adrenomedullin infusion in essential hypertension. Hypertension, 36, 588-593.

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.

Troughton, R. W., McGregor, D. O., Charles, C. J., Lewis, L. K., Yandle, T., Richards, A. M., & Nicholls, M. G. (2000). Biological effects of adrenomedullin infusion in healthy volunteers, essential hypertension and chronic renal failure. Verbal presentation at the 2nd International Symposium on Adrenomedullin and PAMP, Japan.

1999

Journal - Research Article

Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173.

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Yandle, T. G., Lewis, L. K., & Richards, A. M. (1999). Bioactivity and interactions of adrenomedullin and brain natriuretic peptide in patients with heart failure. Hypertension, 34(1), 70-75.

Conference Contribution - Published proceedings: Abstract

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Low and high dose adrenomedullin infusion in normal volunteers. 72nd Scientific Sessions, American Heart Foundation. 100(18), (pp. I-350). Circulation. [Abstract]

1998

Journal - Research Article

Lai, K. N., Leung, J. C., Yeung, V. T. F., Lewis, L. K., & Nicholls, M. G. (1998). Gene transcription and synthesis of adrenomedullin by cultured human renal cells. Biochemical & Biophysical Research Communications, 244(2), 567-572.

Lewis, L. K., Smith, M. W., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin (1-52) measured in human plasma by radioimmunoassay: plasma concentration, adsorption and storage. Clinical Chemistry, 44(3), 571-577.

Conference Contribution - Verbal presentation and other Conference outputs

Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin in heart failure. Verbal presentation at the Centre of Excellence International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

1997

Journal - Research Article

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. L. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Clinical & Experimental Pharmacology & Physiology, 24(11), 807-813.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.

Lewis, L. K., Smith, M., Brennan, S. O., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Degradation of human adrenomedullin (1-52) by plasma membrane enzymes and identification of metabolites. Peptides, 18(5), 733-739.

Lainchbury, J. G., Cooper, G. J. S., Coy, D. H., Jiang, N. Y., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin: A hypotensive hormone in man. Clinical Science, 92(5), 467-472.

Conference Contribution - Published proceedings: Abstract

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. The Journal of Heart Failure. 4(1), (pp. 74). [Abstract]

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Proceedings of the 32nd Annual Meeting of Australian and New Zealand Society of Nephrology. 51, (pp. 1308). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin in heart failure. Verbal presentation at the 1st International Symposium on Adrenomedullin and PAMP, Osaka.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997, June). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Verbal presentation at the 8th European Society of Hypertension, Milan.

1996

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

Journal - Research Article

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Charles, C. J., Rademaker, M. T., Lynn, K. L., … Lewis, L. K., & Yandle, T. G. (1996). Chronic ouabain infusion does not cause hypertension in sheep. American Journal of Physiology: Endocrinology & Metabolism, 270(3), E386-E392.

Pidgeon, G. B., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1996). Endogenous ouabain, sodium balance and blood pressure. Journal of Hypertension, 14, 169-171.

Lewis, L. K., Yandle, T. G., Lewis, J. G., Richards, A. M., Pidgeon, G. B., Kaaja, R. J., & Nicholls, M. G. (1996). Diabetes mellitus in older patients. Drugs & Aging, 6, 401-407.

Journal - Research Other

Richards, A. M., Nicholls, M. G., Lewis, L., & Lainchbury, J. G. (1996). Adrenomedullin [Editorial review]. Clinical Science, 91(1), 3-16. doi: 10.1042/cs0910003

1995

Journal - Research Article

Nicholls, M. G., Richards, A. M., Lewis, L. K., & Yandle, T. G. (1995). Ouabain: a new steroid hormone? Lancet, 346, 1381-1382.