Dr Sarah Appleby

2026

Journal - Research Article

Sulit, A. K., Miller, A. L., Danielson, K. M., Pemberton, C. J., Purcell, R. V., & Appleby, S. (2026). Comparison of Oxford Nanopore and sequencing-by-synthesis technologies for sequencing cell-free bacterial DNA. Scientific Reports. Advance online publication. doi: 10.1038/s41598-026-69111-3

2025

Journal - Research Other

Appleby, S., & Purcell, R. (2025). Circulating bacterial DNA in cardiovascular disease. Frontiers in Cardiovascular Medicine, 12, 1476165. doi: 10.3389/fcvm.2025.1476165

Ocariza, M. G. C., Paton, L. N., Templeton, E. M., Pemberton, C. J., Pilbrow, A. P., & Appleby, S. (2025). CNDP2: An enzyme linking metabolism and cardiovascular diseases? Journal of Cardiovascular Translational Research, 18, 48-57. doi: 10.1007/s12265-024-10560-4

2024

Journal - Research Article

Chew-Harris, J., Frampton, C., Greer, C., Appleby, S., Pickering, J. W., Kuan, W. S., … Adamson, P. D., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2024). Prognostic performance of soluble urokinase plasminogen activator receptor for heart failure or mortality in Western and Asian patients with acute breathlessness. International Journal of Cardiology, 406, 132071. doi: 10.1016/j.ijcard.2024.132071

Appleby, S., Aitken-Buck, H. M., Holdaway, M. S., Byers, M. S., Frampton, C. M., Paton, L. N., Richards, A. M., Lamberts, R. R., & Pemberton, C. J. (2024). Cardiac effects of myoregulin in ischemia-reperfusion. Peptides, 174, 171156. doi: 10.1016/j.peptides.2024.171156

Conference Contribution - Published proceedings: Abstract

Sulit, A., Appleby, S., Pearson, J., & Purcell, R. (2024). Using oxford nanopore technologies to study microbial cell-free DNA (mcfDNA). Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Ocariza, M. G. C., Paton, L. N., Tang, W. H. W., Templeton, E. M., Pilbrow, A. P., Pemberton, C. J., & Appleby, S. (2024). CNDP2 is a potential modulator of heart failure outcomes. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Ocariza, M., Paton, L., Tang, W., Templeton, E., Pilbrow, A., Pemberton, C., & Appleby, S. (2024). Investigating the role of carnosine dipeptidase II (CNDP2) in heart disease. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S62). doi: 10.1016/j.hlc.2024.04.228

Conference Contribution - Verbal presentation and other Conference outputs

Gooch, T., Kennedy, E., Lamberts, R., & Appleby, S. (2024, August). Saliva swabs: A game-changer for concussion diagnosis and management. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

Gooch, T., Kennedy, E., Lamberts, R., & Appleby, S. (2024, August-September). Saliva swabs: A game-changer for concussion diagnosis and management. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2023

Journal - Research Article

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082

Conference Contribution - Verbal presentation and other Conference outputs

Appleby, S., Sulit, A. K., Pemberton, C. J., Pearson, J. F., & Purcell, R. V. (2023, August). Circulating bacterial DNA as a prognostic marker for myocardial infarction. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Appleby, S., Frampton, C., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2022). Comparative performances of soluble urokinase plasminogen activator receptor and Mid-regional proADM to predict composite death and new heart failure rehospitalisation in acutely breathless patients. European Heart Journal, 43(Suppl. 2), (pp. 1087). doi: 10.1093/eurheartj/ehac544.1087

Lewis, L., Raudsepp, S., Whitlow, J., Appleby, S., Pemberton, C., & Richards, A. M. (2022). Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays? European Heart Journal, 43(Suppl. 1), (pp. i76). doi: 10.1093/eurheartj/ehab849.060

Conference Contribution - Poster Presentation (not in published proceedings)

Appleby, S. (2022, August). Circulating erythroferrone in the diagnosis of acute decompensated heart failure in patients with comorbidities. Poster session presented at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Conference Contribution - Published proceedings: Abstract

Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S85-S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Prognostic performance of soluble urokinase plasminogen activator receptor (suPAR) in predicting mortality in Asian and Western patients with acute breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in patients with acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.069

2020

Journal - Research Article

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1695). doi: 10.1093/ehjci/ehaa946.1695

Chew-Harris, J., Appleby, S., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., … Frampton, C., Troughton, R. W., … Richards, A. M., & Pemberton, C. J. (2020). Prognostic performance of soluble urokinase plasminogen activator receptor for 1-year mortality in Asian and Western patients with acute breathlessness. European Heart Journal, 41(Suppl. 2), (pp. 1202). doi: 10.1093/ehjci/ehaa946.1202

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1696). doi: 10.1093/ehjci/ehaa946.1696

2019

Journal - Research Article

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Lee, J. A., Aldous, S., Appleby, S., Chew-Harris, J., Than, M., Troughton, R. W., & Richards, A. M. (2019). The signal peptide of CNP is a novel predictor of MI, MACE and bleeding risk in chest pain patients. European Heart Journal, 40(Suppl. 1), (pp. 2029). doi: 10.1093/eurheartj/ehz745.0283

Chew-Harris, J. S., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Soluble urokinase plasminogen activator receptor (suPAR) predicts 1 year mortality in patients with acute breathlessness. European Heart Journal, 40(Suppl. 1), (pp. 1573). doi: 10.1093/eurheartj/ehz748.0939

2018

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Circulation, 138(Suppl. 1), A11125. [Abstract]

Appleby, S., Chew-Harris, J., Troughton, R., Richards, M., & Pemberton, C. (2018). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Circulation, 138(Suppl. 1), A11094. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018, August). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Appleby, S., Pearson, J. F., Aitchison, A., Spittlehouse, J. K., Joyce, P. R., & Kennedy, M. A. (2017). Mean telomere length is not associated with current health status in a 50-year-old population sample. American Journal of Human Biology, 29(1), e22906. doi: 10.1002/ajhb.22906

Conference Contribution - Poster Presentation (not in published proceedings)

Aitken-Buck, H. M., Appleby, S., Pemberton, C. J., & Lamberts, R. R. (2017, September). Myoregulin has no effect on contraction or relaxation of isolated rat hearts. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2016

Journal - Research Other

Stevens, A. J., Appleby, S., & Kennedy, M. A. (2016). Many commercial hot-start polymerases demonstrate activity prior to thermal activation. Biotechniques, 61(6), 293-296. doi: 10.2144/000114481

Conference Contribution - Poster Presentation (not in published proceedings)

Stevens, A., Appleby, S., & Kennedy, M. (2016, August-September). Many commercial hot-start polymerases demonstrate activity prior to thermal activation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Awarded Doctoral Degree

Appleby, S. (2016). Telomere length as a putative biomarker of health and disease (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/6188

2015

Journal - Research Article

Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208

Conference Contribution - Poster Presentation (not in published proceedings)

Jodczyk, S., Cree, S., & Kennedy, M. A. (2015, August-September). Trialling the MinION™ nanopore DNA sequencer for direct measurement of human telomere length. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014). No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS ONE, 9(5), e97102. doi: 10.1371/journal.pone.0097102

Conference Contribution - Published proceedings: Abstract

Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). No association between telomere length and exposure to life course stress or adversity in two longitudinal New Zealand cohorts. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 1325M. Retrieved from http://www.ashg.org/

Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). Association between telomere length and life stress in two New Zealand cohorts. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Jodczyk, S., Pearson, J., Fergusson, D., Horwood, J., Spittlehouse, J., Joyce, P., Hampton, M., & Kennedy, M. (2014, September). No association between telomere length and exposure to life course stress in two longitudinal New Zealand cohorts. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

2012

Conference Contribution - Poster Presentation (not in published proceedings)

Jodczyk, S., Miller, A., Fergusson, D., Horwood, J., & Kennedy, M. (2012, March). Association between nicotine and alcohol dependence and short mean telomere length in a longitudinal birth cohort study. Poster session presented at the Human Genome Meeting (HUGO): Genetics and Genomics in Personalised Medicine, Sydney, Australia.