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Contact Details

Phone
+64 3 364 1559
Email
christoph.goebl@otago.ac.nz

University Links

Position
Senior Research Fellow
Department
Department of Pathology and Biomedical Science (Christchurch)
Qualifications
PhD (Graz)

Research

Dr Christoph Goebl obtained his Bachelor and Master's degrees in Chemistry from the Karl-Franzens-University of Graz in Austria, and then his PhD in molecular biology from the same institute with Prof Klaus Zangger. During his PhD, he was a recipient of a DOC-fellowship of the Austrian Academy of Sciences and performed a one-year research stay with Dr Nico Tjandra at the NIH in Bethesda, USA, focusing on NMR spectroscopy of proteins. After his PhD, Dr Goebl joined Prof Tobias Madl as a PFP Helmholtz Fellow at the Technical University of Munich and the Helmholtz Center Munich, Germany where he became interested in the molecular basis of reactive oxygen species in biology. He then carried out a cell-biology focused post-doctoral position with Prof Tak W. Mak and Dr Chiara Gorrini at the Princess Margaret Cancer Centre in Toronto, Canada, working on cancer-pathways and redox signalling.

Dr Goebl combines expertise in structural biology (using NMR spectroscopy, small-angle X-ray scattering (SAXS) and X-ray crystallography) with experience in biochemical methods in oxidative stress signalling. He is exploring oxidative stress pathways of the Aryl hydrcarbon receptor (AhR) with focus on its metabolomic signalling in cancers. He also discovered redox-mediated amyloid formation of the tumour suppressor protein p16, and is currently investigating its role in melanoma.

Dr Goebl’s work is currently supported by a Sir Charles Hercus Fellowship from the Health Research Council and a Marsden project grant.

Publications

Pulido, S., Rückert, H., Falsone, S. F., Göbl, C., Meyer, N. H., & Zangger, K. (2023). The membrane-binding bacterial toxin long direct repeat D inhibits protein translation. Biophysical Chemistry, 298, 107040. doi: 10.1016/j.bpc.2023.107040 Journal - Research Article

Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792 Journal - Research Article

Nechanitzky, R., Nechanitzky, D., Ramachandran, P., Duncan, G. S., Zheng, C., Göbl, C., … Mak, T. W. (2023). Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis. Cell Death & Differentiation, 30, 407-416. doi: 10.1038/s41418-022-01092-y Journal - Research Article

Morris, V. K., Heath, S. G., O'Connor, K. M., Bozonnet, S., Gray, S. G., Naughton, J. D., Magon, N. J., Smith, B. R., Botha, A. D., … Göbl, C. (2022, August). The tumour suppressor protein p16 forms amyloid structures. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Goebl, C. (2021, August). The Southern BioNMR Centre: Establishing a new resource for measuring metabolites. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation]. Other Research Output

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