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Contact Details

Email
jim.smith@otago.ac.nz
Position
Honorary Research Fellow
Department
Department of Pathology (Dunedin)
Qualifications
MBChB BMedSc(Hons)
Research summary
I am involved in molecular profiling of human cancers with the aim of clinical biomarker development

Research

Jim is a dual MBChB and BMedSc(Hons) graduate with several years’ experience in the field of cancer epigenomics. He completed his BMedSc(Hons) with the Chatterjee Laboratory in 2018, which involved establishing targeted DNA methylation editing of cell line models in New Zealand using CRISPR-based systems.

Alongside his clinical work as a junior doctor, Jim remains an active member of the Chatterjee Laboratory. His current research involves genomic and epigenomic profiling of clinical prostate cancer samples, with the aim of identifying molecular biomarkers to improve prostate cancer screening, diagnosis, and disease monitoring in New Zealand populations.

Publications

Banerjee, R., Ajithkumar, P., Keestra, N., Smith, J., Gimenez, G., Rodger, E. J., Eccles, M. R., Antony, J., Weeks, R. J., & Chatterjee, A. (2024). Targeted DNA methylation editing using an all-in-one system establishes paradoxical activation of EBF3. Cancers, 16, 898. doi: 10.3390/cancers16050898 Journal - Research Article

Zhang, X., Barnett, E., Smith, J., Wilkinson, E., Subramaniam, R. M., Zarrabi, A., Rodger, E. J., & Chatterjee, A. (2024). Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications. In S. Spada & L. Galluzzi (Eds.), International review of cell and molecular biology (Vol. 383): Epigenetic regulation of cancer (Part B). (pp. 41-66). London, UK: Elsevier. doi: 10.1016/bs.ircmb.2023.06.002 Chapter in Book - Research

Smith, J., Barnett, E., Rodger, E. J., Chatterjee, A., & Subramaniam, R. M. (2023). Neuroendocrine neoplasms: Genetics and epigenetics. PET Clinics, 18, 169-187. doi: 10.1016/j.cpet.2022.11.003 Journal - Research Article

Smith, J., Banerjee, R., Waly, R., Keestra, N., Gimenez, G., Day, R., Weeks, R. J., & Chatterjee, A. (2022, August). Editing DNA methylation in cancer cells. Verbal presentation at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., Antony, J., & Chatterjee, A. (2022, August). Investigating DNA methylation as a mechanism for paradoxical gene activation using targeted epigenetic editing. Verbal presentation at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

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