Dr Annika Seddon

2025

Journal - Research Other

Damiano, O. M., Stevens, A. J., Kenwright, D. N., & Seddon, A. R. (2025). Chronic inflammation to cancer: The impact of oxidative stress on DNA methylation. Frontiers in Bioscience - Landmark, 30(3), 26142. doi: 10.31083/fbl26142

2024

Journal - Research Article

Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385

Journal - Research Other

Seddon, A. R., MacArthur, C. P., Hampton, M. B., & Stevens, A. J. (2024). Inflammation and DNA methylation in Alzheimer’s disease: Mechanisms of epigenetic remodelling by immune cell oxidants in the ageing brain. Redox Report, 29(1), 2428152. doi: 10.1080/13510002.2024.2428152

Conference Contribution - Published proceedings: Abstract

Damiano, O. M., Stevens, A. J., Seddon, A. R., & Chatterjee, A. (2024). Altered DNA methylation patterns in colorectal cancer associated with immune cell oxidants. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Stevens, A., Seddon, A., Hampton, M., & Andrew, D. (2024). Oxidative stress induced changes in DNA methylation. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Seddon, A., Das, A., Hampton, M., & Stevens, A. (2024). Understanding how immune oxidants can drive epigenetic change. European Journal of Human Genetics, 32(Suppl. 1), (pp. 720). doi: 10.1038/s41431-023-01482-x

Conference Contribution - Poster Presentation (not in published proceedings)

Seddon, A. (2024, August-September). Investigating mechanisms of epigenetic change in colorectal cancer: The role of immune cell oxidants and gut bacteria. Poster session presented at the Queenstown Research Week (QRW) Cancer Meeting, Queenstown, New Zealand.

2023

Journal - Research Article

Seddon, A. R., Das, A. B., Hampton, M. B., & Stevens, A. J. (2023). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Human Molecular Genetics, 32(4), 632-648. doi: 10.1093/hmg/ddac232

Conference Contribution - Published proceedings: Abstract

Helem, S., Pace, P., Seddon, A., Selwood, A., & Hampton, M. (2023). The anti-proliferative properties of the marine derived bioactive compound portimine. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

2022

Conference Contribution - Poster Presentation (not in published proceedings)

Seddon, A. (2022, August). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Poster session presented at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Seddon, A. (2022, December). Epigenetic regulation of gene expression following exposure to neutrophil oxidants. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

2021

Journal - Research Article

Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6

Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453

2020

Conference Contribution - Published proceedings: Abstract

Das, A. B., O'Connor, K. M., Stevens, A. J., Seddon, A. R., & Winterbourn, C. C. (2020). Immune cell oxidants inhibit DNA methylation in proliferating cells [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Awarded Doctoral Degree

Seddon, A. R. (2020). Neutrophils and cancer: Regulation of cell death and epigenetic pathways (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10504

2017

Conference Contribution - Verbal presentation and other Conference outputs

Currie, M., Hock, B., McKenzie, J., Miller, A., Simcock, J., Mackenzie, K., Seddon, A., & Kennedy, B. (2017, July). Functional and prognostic significance of neutrophil subpopulations in cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

2015

Conference Contribution - Published proceedings: Abstract

Seddon, A. R., Hock, B. D., Miller, A. P., Frei, L. P., Pearson, J. F., McKenzie, J. L., Simcock, J. W., & Currie, M. J. (2015). Neutrophils in cutaneous squamous cell carcinoma: Potential prognostic markers? New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Other Research Output

Seddon, A. (2015, May). Circulating and tumor-localized neutrophils are associated with markers of poor prognosis in cutaneous squamous cell carcinoma, Canterbury District Health Board Canterbury Hospitals Friday Clinical Meeting. Christchurch, New Zealand. [Research Presentation].