Dr Safina Gadeock

2025

Journal - Research Other

King, M. R., Kemp, R. A., & Gadeock, S. (2025). Type I interferons in inflammatory bowel diseases: Balancing barrier integrity, repair and inflammation in the intestinal epithelium [Mini review]. Frontiers in Medicine, 12, 1713424. doi: 10.3389/fmed.2025.1713424

2024

Conference Contribution - Verbal presentation and other Conference outputs

King, M., Highton, A., Fan, L., Schultz, M., Kemp, R., & Gadeock, S. (2024, August). The role of type I interferons in regulating epithelial barrier integrity in human 3D stem cell derived organoids. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

2023

Other Research Output

Gadeock, S. (2023, May). Organoids: A novel 3D platform for modelling inflammatory bowel disease. Department of Microbiology & Immunology Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].

2022

Journal - Research Article

Angus, H. C. K., Urbano, P. C. M., Laws, G. A., Fan, S., Gadeock, S., Schultz, M., … Highton, A. J., & Kemp, R. A. (2022). An autologous colonic organoid-derived monolayer model to study immune: bacterial interactions in Crohn's disease patients. Clinical & Translational Immunology, 11, e1407. doi: 10.1002/cti2.1407

Urbano, P. C. M., Angus, H. C. K., Gadeock, S., Schultz, M., & Kemp, R. A. (2022). Assessment of source material for human intestinal organoid culture for research and clinical use. BMC Research Notes, 15, 35. doi: 10.1186/s13104-022-05925-4

2021

Journal - Research Article

Girish, N., Liu, C. Y., Gadeock, S., Gomez, M. L., Huang, Y., Sharifkhodaei, Z., … Polk, D. B. (2021). Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease. American Journal of Physiology: Gastrointestinal & Liver Physiology, 321, G308-G324. doi: 10.1152/ajpgi.00248.2020

Schumacher, M. A., Hsieh, J. J., Liu, C. Y., Appel, K. L., Waddell, A., Almohazey, D., … Gadeock, S., … Frey, M. R. (2021). Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. Nature Communications, 12, 836. doi: 10.1038/s41467-021-21113-7

Conference Contribution - Published proceedings: Abstract

Gadeock, S., Liu, C. Y., & Polk, D. B. (2021). Mesenchymal TNFR1 expression preserves the colonic epitelial stem cell niche. Gastroenterology, 160(3, Suppl. 1), (pp. S10-S11). doi: 10.1053/j.gastro.2021.01.056

Gadeock, S., Liu, C. Y., & Polk, D. B. (2021). Mesenchymal TNFR1 expression preserves the colonic epitelial stem cell niche. Gastroenterology, 160(6, Suppl. 1), (pp. S-165). doi: 10.1016/S0016-5085(21)01145-8

2020

Conference Contribution - Published proceedings: Abstract

Gadeock, S., Liu, C. Y., & Polk, D. B. (2020). Stromal TNF receptor 1 (TNFR1) preserves the colonic epithelial stem cell niche. Gastroenterology, 158(6, Suppl. 1), (pp. S-187). doi: 10.1016/S0016-5085(21)01145-8

Schumacher, M. A., Appel, K., Gadeock, S., & Frey, M. R. (2020). Colonic Sprouty2 expression is dysregulated in inflammatory bowel disease. Gastroenterology, 158(6, Suppl. 1), (pp. S-137). doi: 10.1016/S0016-5085(20)31024-6

2017

Conference Contribution - Published proceedings: Abstract

Gadeock, S., Schultz, M., & Butt, G. (2017). An inherent defect in tight junction structure and permeability is apparent in colonoids from Crohn's disease patients. FASEB Journal, 31(Suppl. 1), 1043.3. doi: 10.1096/fasebj.31.1_supplement.1043.3

Gadeock, S. (2017). Increased permeability is an inherent defect in the colonic epithelium of Crohn's disease patients. Proceedings of the New Zealand Society of Gastroenterology and the NZNO Gastroenterology Nurses' College Annual Scientific Meeting. 19. Retrieved from http://gastro2017.co.nz

Angus, H., Norton, S., Dunn, E., Aluzaite, K., Gadeock, S., Butt, G., & Kemp, R. (2017). Development of in vitro models for human Crohn's disease. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 4). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Samuel, G., Gadeock, S., Schultz, M., & Butt, G. (2017). The differential response of human epithelial derived colonic organoids to TLR agonists. FASEB Journal, 31(Suppl. 1), 1049.6. doi: 10.1096/fasebj.31.1_supplement.1049.6

Gadeock, S., Schultz, M., & Butt, A. (2017). Increased permeability is an inherent defect in the colonic epithelium of Crohn’s disease patients. New Zealand Medical Journal, 130(1460), (pp. 95-96). Retrieved from http://www.nzma.org.nz/journal

Awarded Doctoral Degree

Gadeock, S. (2017). Human colonic organoids: An epithelial barrier model of Crohn's disease (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/7409

2016

Conference Contribution - Published proceedings: Abstract

Gadeock, S., Schultz, M., & Butt, G. (2016). TNF-α and IFN-γ induce a biphasic change in the distribution and expression of tight junction proteins in human colonic enteroids. FASEB Journal, 30(1, Suppl.), 1250.2. Retrieved from http://www.fasebj.org/content/30/1_Supplement/1250.2.abstract

2015

Conference Contribution - Poster Presentation (not in published proceedings)

Rodrigues, E., Slobbe, L., Samuel, G., Gadeock, S., Schultz, M., & Butt, A. G. (2015, August-September). Chronic exposure to LPS modified lineage development via the TLR4 dependent pathway in human colonic enteroids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Gadeock, S., Schultz, M., & Butt, A. G. (2015, August-September). TNF-α induces a biphasic change in the expression and distribution of tight junction proteins in human colonic enteroids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Gadeock, S. (2015, November). TNF-α induces a biphasic change in the expression and distribution of tight junction proteins in human colonic enteroids. Verbal presentation at the New Zealand Society of Gastroenterology & NZNO Gastroenterology Section Annual Scientific Meeting, Rotorua, New Zealand.

2014

Conference Contribution - Poster Presentation (not in published proceedings)

Gadeock, S., Schultz, M., & Butt, G. (2014, November). Colonoids: A model of the colonic epithelium in IBD. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Gadeock, S., Schultz, M., & Butt, G. (2014, November). Colonoids: A model of the colonic epithelium in IBD? Verbal presentation at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

2012

Journal - Research Other

Gadeock, S., Pupovac, A., Sluyter, V., Spildrejorde, M., & Sluyter, R. (2012). P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells. Purinergic Signalling, 8, 699, 676. doi: 10.1007/s11302-012-9320-9

2010

Journal - Research Article

Farrell, A. W., Gadeock, S., Pupovac, A., Wang, B., Jalilian, I., Ranson, M., & Sluyter, R. (2010). P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells. Biochimica et Biophysica Acta: General Subjects, 1800(11), 1173-1182. doi: 10.1016/j.bbagen.2010.07.001

Gadeock, S., Tran, J. N. S. N., Georgiou, J. G., Jalilian, I., Taylor, R. M., Wiley, J. S., & Sluyter, R. (2010). TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochimica et Biophysica Acta: Biomembranes, 1798(11), 2058-2066. doi: 10.1016/j.bbamem.2010.07.022