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Contact Details

Phone
+64 3 479 7708
Email
roslyn.kemp@otago.ac.nz
Position
Professor
Department
Department of Microbiology and Immunology
Qualifications
BSc(Hons) PhD
Research summary
Applied and molecular immunology, cancer immunobiology, vaccines – immunology and technology

Research

My research focuses on T cells as mediators of anti-tumour immunity and inflammation. Specifically, we study the role of inflammation and the unique features of different subsets of T cells and myeloid cells, focussing on cancer and gut-specific immune responses; and how these cell subsets are involved in patient outcome.

We are currently looking at T cell and myeloid cell subsets in colorectal cancer and inflammatory bowel disease to improve diagnosis, prognosis and treatment. We are generating site-specific T cell memory using novel slow release vaccines and analysing the molecular signalling pathways required to maintain these populations.

Research projects

My current areas of research are mucosal and tumour immune responses, inflammation and T cell memory.

Mucosal Immune Responses in Cancer and Inflammatory Diseases

  • Using immune responses in the tumour to predict patient outcome in colorectal cancer
  • Investigating T cell responses in inflammatory bowel disease patients
  • Using human intestinal organoids to model the gut immune response
  • Heterogeneity and plasticity of T cell subsets in the gut mucosa and their influence on anti-tumour immune responses
  • Generating gut-specific memory T cells through vaccination
  • Development of new analytical tools to study high dimensional immune data

CD8+ T Cell Memory

  • Interactions between na?ve and memory T cell populations
  • Vaccination strategies to generate effective T cell memory populations

Molecular Pathways controlling T cells

  • Molecular signals controlling memory T cell development and maintenance
  • Signalling pathways in tumour immune responses

Publications

Tirados, J. F., Fenton, S., McGuire, H. M., Roberts, J. M., Ward-Hartstonge, K. A., & Kemp, R. A. (2026). Comparison of tissue preparations to identify and phenotype T cells in human colorectal tumor tissue. Cytometry Part A. Advance online publication. doi: 10.1002/cyto.a.70043 Journal - Research Article

Longoni, A., Major, G. S., Arnold, S., Tomkins, S., Spessot, E., Loeffler, S., … Harte, J., Kemp, R., … Hooper, G. J., Woodfield, T. B. F., Kieser, D. C., & Lim, K. S. (2026). Characterization of an injectable poly(vinyl alcohol)-gelatin hydrogel for growth factor delivery in an orthopedic application. Advanced Healthcare Materials, 15(20), e04224. doi: 10.1002/adhm.202504224 Journal - Research Article

King, M. R., Kemp, R. A., & Gadeock, S. (2025). Type I interferons in inflammatory bowel diseases: Balancing barrier integrity, repair and inflammation in the intestinal epithelium [Mini review]. Frontiers in Medicine, 12, 1713424. doi: 10.3389/fmed.2025.1713424 Journal - Research Other

Highton, A., Kemp, R., & Dummer, J. (2025). Mini-lungs as an airway disease model platform. Proceedings of the Infectious Diseases & Pandemic Preparedness Summit. (pp. 45-46). Retrieved from https://www.teniwha.com Conference Contribution - Published proceedings: Abstract

Gaskarth, D. A., Fan, S., Highton, A. J., & Kemp, R. A. (2025). The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity. Frontiers in Medicine, 12, 1577906. doi: 10.3389/fmed.2025.1577906 Journal - Research Article

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