Professor Parry Guilford

2026

Journal - Research Article

Decourtye-Espiard, L., Schulpen, E., McElroy, K., Charlton, A., van der Post, R. S., Godwin, T., Bougen-Zhukov, N., … Chen, A., Zou, D., Vaessen, C., Black, M., … Guilford, P. (2026). E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model. Gut. Advance online publication. doi: 10.1136/gutjnl-2025-336182

Journal - Research Other

Vaessen, C., Redpath, K., Schulpen, E., & Guilford, P. (2026). The changing landscape of hereditary diffuse gastric cancer. Journal of Gastric Cancer, 26(1), 31-51. doi: 10.5230/jgc.2026.26.e5

2025

Journal - Research Article

Moloney-Geany, K., Black, M. A., Day, R. C., Guilford, P., & Dunnet, M. J. (2025). A set cover algorithm identifies minimal circulating tumour DNA sequencing targets for colorectal cancer detection. Scientific Reports, 15, 40949. doi: 10.1038/s41598-025-24719-9

Journal - Research Other

Decourtye-Espiard, L., Godwin, T., & Guilford, P. (2025). Hereditary diffuse gastric cancer: the evolution of a cancer syndrome*. Journal of the Royal Society of New Zealand. Advance online publication. doi: 10.1080/03036758.2025.2511007

Conference Contribution - Published proceedings: Abstract

Werry, R., Dunnet, M., & Guilford, P. (2025). A hot new biomarker has entered the villa: Modelling the effect of DNA amount in CRC detection assays on downstream sequencing metrics. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2025, March). Community driven early detection of colorectal cancer using ctDNA [Panel discussion: Investing in the future: Transforming cancer screening through innovation]. Verbal presentation at the Cancer Society of New Zealand Inaugural In Pursuit of Cancer Research and Innovation Conference, Ōtautahi Christchurch, New Zealand.

2024

Journal - Research Article

Garcia-Pelaez, J., Dias, A., Guilford, P., & Oliveira, C. (2024). High frequency of lobular breast cancer in CDH1 germline carriers supports update of clinical guidelines for CDH1 testing and pathological characterization. European Journal of Human Genetics, 32(Suppl. 2), P18.059.B. doi: 10.1038/s41431-024-01734-4

Harvey, J. C., Cambridge, L. M., Ellen, C. W., Colonval, M., Hazlett, J. A., Newell, J., … Guilford, P. J. (2024). Analytical validation of Cxbladder detect, triage, and monitor: Assays for detection and management of urothelial carcinoma. Diagnostics, 14, 2061. doi: 10.3390/diagnostics14182061

Sreeram, A., Stroobant, E. E., Laszkowska, M., Guilford, P., Shimada, S., Nishimura, M., … Strong, V. E. (2024). Disappearing signet ring cell adenocarcinoma in gastric cancer patients. Annals of Surgical Oncology, 31, 9030-9038. doi: 10.1245/s10434-024-16117-8

Journal - Research Other

Robb, T. J., Liu, Y., Woodhouse, B., Windahl, C., Hurley, D., McArthur, G., … Guilford, P., … Jackson, C., … Lawrence, B. (2024). Blending space and time to talk about cancer in extended reality. npj Digital Medicine, 7, 261. doi: 10.1038/s41746-024-01262-x

Conference Contribution - Published proceedings: Abstract

Camilli, J. C., Fairhall, J. M., Brind, T. K., Guilford, P., Hook, S., & Gamble, A. B. (2024). Novel prodrugs for targeted colorectal cancer drug delivery. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. (pp. 198). Retrieved from https://nzic.org.nz/conferences

Fairhall, J., Yap, P. J., Godwin, T., Krittaphol Bailey, P., Walker, G., Gamble, A., & Guilford, P. (2024). Acid-cleavable polymer-drug conjugates for targeted delivery to the stomach. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. (pp. 10). Retrieved from https://nzic.org.nz/conferences

Redpath, K. J., Bougen-Zhukov, N., Vaessen, C., Decourtye-Espiard, L., Schulpen, E., Godwin, T., McElroy, K., Black, M. A., & Guilford, P. (2024). Single-cell RNA-seq reveals candidate synergistic treatments for the chemoprevention of hereditary diffuse gastric cancer. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Liu, L., Tongoi, T., Yap, A., Guilford, P., Winship, I., Southey, M., & Rosenbluh, S. (2024). Systematic functional characterisation of CDH1 variants. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Conference Contribution - Verbal presentation and other Conference outputs

Camilli, J. C., Fairhall, J. M., Brind, T. K., Guilford, P., Hook, S., & Gamble, A. B. (2024, November). Novel combretastatin A-4 prodrugs for targeted colorectal cancer drug delivery. Verbal presentation at the School of Pharmacy Research Symposium, Dunedin, New Zealand.

Guilford, P. (2024, June). Twenty-six years of HDGC. Verbal presentation at the 5th International Gastric Cancer Linkage Consortium (IGCLC) Meeting, Porto, Portugal.

Working Paper; Discussion Paper; Technical Report

Mann, J., Ni Mhurchu, C., Sporle, A., Guilford, P., Cockram, J., & Stayner, C. (2024). Healthier lives for all New Zealanders: Evidence for equitable health outcomes in Aotearoa New Zealand, He Oranga Hauora Ake mō ngā Tāngata Katoa o Aotearoa: He taunakitanga mō ngā putanga hauora tōkeke i Aotearoa. Healthier Lives-He Oranga Hauora National Science Challenge. Retrieved from https://healthierlives.co.nz

2023

Chapter in Book - Research

Decourtye-Espiard, L., & Guilford, P. (2023). The chemoprevention of hereditary diffuse gastric cancer. In G. Corso, P. Veronesi & F. Roviello (Eds.), Hereditary gastric and breast cancer syndrome: CDH1: One genotype with multiple phenotypes. (pp. 321-341). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-21317-5_21

Journal - Research Article

Fitzgerald, S., Blenkiron, C., Stephens, R., Mathy, J. A., Somers-Edgar, T., Rolfe, G., … Jackson, C., Eccles, M., … Rodger, E., … Guilford, P., … Print, C. G. (2023). Dynamic ctDNA mutational complexity in patients with melanoma receiving immunotherapy. Molecular Diagnosis & Therapy, 27, 537-550. doi: 10.1007/s40291-023-00651-4

Journal - Research Other

Buckley, K. H., Tondon, R., Guilford, P., & Katona, B. W. (2023). Non-targeted biopsies in hereditary diffuse gastric cancer: Necessary, but not enough. Translational Cancer Research, 12(7), 1883-1886. doi: 10.21037/tcr-23-541

Decourtye-Espiard, L., & Guilford, P. (2023). Hereditary diffuse gastric cancer. Gastroenterology, 164, 719-735. doi: 10.1053/j.gastro.2023.01.038

Conference Contribution - Published proceedings: Abstract

Hughes, M., Brew, T., Godwin, T., Black, M., & Guilford, P. (2023). Single-cell RNA sequencing reveals synthetic lethal targets for chemoprevention of hereditary diffuse gastric cancer. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go

Redpath, K., Vaessen, C., Decourtye-Espiard, L., Schulpen, E., Godwin, T., Bougen-Zhukov, N., McElroy, K., Black, M., & Guilford, P. (2023). Single-cell RNA-Seq reveals candidate synergistic treatments for the chemoprevention of hereditary diffuse gastric cancer. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go

2022

Journal - Research Article

Bougen-Zhukov, N., Decourtye-Espiard, L., Mitchell, W., Redpath, K., Perkinson, J., Godwin, T., Black, M. A., & Guilford, P. (2022). E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers, 14, 1609. doi: 10.3390/cancers14071609

Conference Contribution - Published proceedings: Abstract

Hughes, M., Brew, T., Black, M., & Guilford, P. (2022). Single-cell RNA sequencing reveals potential synthetic lethal targets for chemoprevention of hereditary diffuse gastric cancer. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Redpath, K. J., Bougen-Zhukov, N., Black, M. A., & Guilford, P. J. (2022). Identification and development of novel drug combinations for diffuse gastric cancer. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Conference Contribution - Verbal presentation and other Conference outputs

Fitzgerald, S., Blenkiron, C., Somers-Edgar, T., Rolfe, G., Rykers, A., Stephens, R., … Jackson, C., Cocadiz, J. A., Zou, D., Eccles, M., Day, R., Guilford, P., … Print, C. (2022, August). Evolving genomic complexity unveiled in ctDNA analysis of melanoma patients. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Moloney-Geany, K., Slatter, T., Black, M., & Guilford, P. (2022, August). Characterisation of single cell transcriptomics in urinary cells for the detection of bladder cancer. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Chapter in Book - Research

Gullo, I., Oliveira, C., van der Post, R. S., van Dieren, J. M., Davis, J. L., Bougen-Zhukov, N., Guilford, P., & Carneiro, F. (2021). Updated perspective and directions on hereditary diffuse gastric cancer. In B. Jenkins (Ed.), Research and clinical applications of targeting gastric neoplasms. (pp. 217-258). London, UK: Elsevier. doi: 10.1016/B978-0-323-85563-1.00011-3

Journal - Research Article

Brew, T., Bougen-Zhukov, N., Mitchell, W., Decourtye, L., Schulpen, E., Nouri, Y., Godwin, T., & Guilford, P. (2021). Loss of E-cadherin leads to druggable vulnerabilities in sphingolipid metabolism and vesicle trafficking. Cancers, 14(1), 102. doi: 10.3390/ cancers14010102

Decourtye-Espiard, L., Bougen-Zhukov, N., Godwin, T., Brew, T., Schulpen, E., Black, M. A., & Guilford, P. (2021). E-cadherin-deficient epithelial cells are sensitive to HDAC inhibitors. Cancers, 14(1), 175. doi: 10.3390/ cancers14010102

Luxenburger, A., Bougen-Zhukov, N., Fraser, M. G., Beetham, H., Harris, L. D., Schmidt, D., … Guilford, P. J., & Evans, G. B. (2021). Discovery of AL-GDa62 as a potential synthetic lethal lead for the treatment of gastric cancer. Journal of Medicinal Chemistry, 64, 18114-18142. doi: 10.1021/acs.jmedchem.1c01609

Dixon, K., Brew, T., Farnell, D., Godwin, T. D., Cheung, S., Chow, C., … Guilford, P., & Huntsman, D. G. (2021). Modelling hereditary diffuse gastric cancer initiation using transgenic mouse-derived gastric organoids and single-cell sequencing. Journal of Pathology, 254, 254-264. doi: 10.1002/path.5675

Conference Contribution - Published proceedings: Abstract

Sika-Paotonu, D., Walton, M., Faavae, S., Tagi, S., & Guilford, P. (2021). Diagnostic approaches for early cancer detection in Pacific youth using ctDNA technology. Journal of Immunology, 206(Suppl. 1), 26.21. [Abstract]

Sika-Paotonu, D., Walton, M., Finau, E., Faavae, S., Vaimoli, J., & Guilford, P. (2021). The clinical considerations for early cancer detection using ctDNA within the Pacific setting. Journal of Immunology, 206(Suppl. 1), 12.08. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

McAtamney, A., Black, M., & Guilford, P. (2021, September). Early detection of colorectal cancer through analysis of ctDNA fragment sizes. Poster session presented at the Achieving Health Equity from Research Conference [Otago Spotlight Series], Wellington, New Zealand.

2020

Journal - Research Article

Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405

Zou, D., Day, R., Cocadiz, J. A., Parackal, S., Mitchell, W., Black, M. A., … Jackson, C., & Guilford, P. (2020). Circulating tumor DNA is a sensitive marker for routine monitoring of treatment response in advanced colorectal cancer. Carcinogenesis, 41(11), 1507-1517. doi: 10.1093/carcin/bgaa102

Brewer, N., Atkinson, J., Guilford, P., Print, C., Blakely, T., & Teng, A. (2020). An estimate of limited duration cancer prevalence in New Zealand using 'big' data. New Zealand Medical Journal, 133(1514), 49-62. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Blair, V. R., McLeod, M., Carneiro, F., Coit, D. G., D'Addario, J. L., van Dieren, J. M., … Paringatai, K., Bougen-Zhukov, N., Brew, T., … Godwin, T. D., … Nouri, Y., … Reeve, A. E., & Guilford, P. (2020). Hereditary diffuse gastric cancer: Updated clinical practice guidelines. Lancet Oncology, 21(8), e386-e397. doi: 10.1016/S1470-2045(20)30219-9

Conference Contribution - Published proceedings: Abstract

Ajithkumar, P., McCall, J., Guilford, P., Pattison, S., Rodger, E., & Chatterjee, A. (2020). Epigenetic profiling of colorectal cancer to predict patients at high risk of metastasis. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Chatterjee, A., McCall, J., Guilford, P., Pattison, S., Rodger, E., & Ajithkumar, P. (2020). Epigenomic profiling of colorectal cancer to predict patients at high risk of metastasis. Cancer Research, 80(16, Suppl.), 2434. doi: 10.1158/1538-7445.Am2020-2434

Sika-Paotonu, D., Anitelea, T., Cockburn, A., & Guilford, P. (2020). Early cancer detection using ctDNA technology: What is the relevance for Pacific communities? Journal of Immunology, 204(1, Suppl.), 159.54. [Abstract]

Sika-Paotonu, D., Anitelea, T., Faatoese, A., Laing, B., Puni, R., Vaipuna, T., & Guilford, P. (2020). ctDNA for early cancer diagnosis in Pacific communities. Journal of Immunology, 204(1, Suppl.), 86.51. [Abstract]

2019

Journal - Research Article

Norero, E., Alarcon, M. A., Hakkaart, C., de Mayo, T., Mellado, T., Garrido, M., … Guilford, P., & Corvalan, A. H. (2019). Identification of c.1531C>T pathogenic variant in the CDH1 gene as a novel germline mutation of hereditary diffuse gastric cancer. International Journal of Molecular Sciences, 20, 4980. doi: 10.3390/ijms20204980

Bougen-Zhukov, N., Nouri, Y., Godwin, T., Taylor, M., Hakkaart, C., Single, A., Brew, T., Permina, E., Chen, A., Black, M. A., & Guilford, P. (2019). Allosteric AKT inhibitors target synthetic lethal vulnerabilities in E-cadherin-deficient cells. Cancers, 11(9), 1359. doi: 10.3390/cancers11091359

Beetham, H., Chen, A., Telford, B. J., Single, A., Jarman, K. E., Lackovic, K., … Guilford, P. (2019). A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells. Scientific Reports, 9, 12511. doi: 10.1038/s41598-019-48929-0

Parackal, S., Zou, D., Day, R., Black, M., & Guilford, P. (2019). Comparison of Roche Cell-Free DNA collection Tubes^® to Streck Cell-Free DNA BCT^®s for sample stability using healthy volunteers. Practical Laboratory Medicine, 16, e00125. doi: 10.1016/j.plabm.2019.e00125

Godwin, T. D., Kelly, S. T., Brew, T. P., Bougen-Zhukov, N. M., Single, A. B., Chen, A., Stylianou, C. E., … Currie, S. K., Telford, B. J., Beetham, H. G., … Black, M. A., & Guilford, P. J. (2019). E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function. Gastric Cancer, 22(2), 273-286. doi: 10.1007/s10120-018-0859-1

Hakkaart, C., Ellison-Loschmann, L., Day, R., Sporle, A., Koea, J., Harawira, P., … Guilford, P. (2019). Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori. Familial Cancer, 18(1), 83-90. doi: 10.1007/s10689-018-0080-8

Journal - Research Other

van der Post, R. S., Oliveira, C., Guilford, P., & Carneiro, F. (2019). Hereditary gastric cancer: What's new? Update 2013-2018. Familial Cancer, 18, 363-367. doi: 10.1007/s10689-019-00127-7

Figueiredo, J., Melo, S., Carneiro, P., Moreira, A. M., Fernandes, M. S., Ribeiro, A. S., Guilford, P., … Seruca, R. (2019). Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of Medical Genetics, 56, 199-208. doi: 10.1136/jmedgenet-2018-105807

Conference Contribution - Published proceedings: Abstract

Sika-Paotonu, D., Liligeto, U., & Guilford, P. (2019). Early cancer detection in the Pacific. Journal of Immunology, 202(1, Suppl.), 229.2. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2019). Cancer in Pacific populations in New Zealand and ctDNA technology for early cancer detection. Journal of Immunology, 202(1, Suppl.), 229.3. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2019, January-February). Policy enablers for translational cancer research. Verbal presentation at the Cancer Care at a Crossroads Conference, Wellington, New Zealand.

2018

Journal - Research Other

Figueiredo, J., Melo, S., Gamet, K., Godwin, T., Seixas, S., Sanches, J. M., Guilford, P., & Seruca, R. (2018). E-cadherin signal sequence disruption: A novel mechanism underlying hereditary cancer. Molecular Cancer, 17, 112. doi: 10.1186/s12943-018-0859-0

Conference Contribution - Published proceedings: Abstract

Guilford, P., Kavalieris, L., O'Sullivan, P., Frampton, C., Darling, D., Jacobson, E., … Lotan, Y. (2018). Cxbladder: A high sensitivity urine test the surveillance of urothelial carcinoma. International Journal of Urology, 25(Suppl. 1), (pp. 149). doi: 10.1111/iju.13745

Nouri, Y., Brew, T., Godwin, T., & Guilford, P. (2018). The establishment and characterisation of gastric organoids as a model for hereditary diffuse gastric cancer. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Fitzgerald, S., Lasham, A., Blenkiron, C., Shields, P., Rolfe, G., Stephens, R., … Jackson, C., Rodger, E., Eccles, M., Day, R., Guilford, P., … Print, C. (2018). Development of plasma genomic biomarkers for mutation detection and monitoring in New Zealand cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Sika-Paotonu, D., Vaea, K., 'Ulufonua, L. K., Akau'ola, S., Aho, G., Tuipulotu, A. A., … Guilford, P. (2018). The utilization of ctDNA technology as an early diagnostic tool for Cancer detection in Tonga. Journal of Immunology, 200(1, Suppl.), 120.38. [Abstract]

Sika-Paotonu, D., Viali, S., Naseri, L. T. T. K., So'o, F. L. T. I. A., Lameko, T. V., Punivalu, M., … Guilford, P. (2018). The application of ctDNA technology for early Cancer diagnostics in Samoa. Journal of Immunology, 200(1, Suppl.), 120.40. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2018). The potential application of ctDNA technology as a cancer diagnostic tool within the Socialist Republic of Vietnam. Journal of Immunology, 200(1, Suppl.), 120.21. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2018). Exploring the applicability of ctDNA technology as a diagnostic tool for improved Cancer care and management within the Pacific. Journal of Immunology, 200(1, Suppl.), 120.20. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Fitzgerald, S., Lasham, A., Blenkiron, C., Shields, P., Rolfe, G., Stephens, R., … Jackson, C., Rodger, E., Eccles, M., Day, R., Guilford, P., … Print, C. (2018, August). Development of plasma genomic biomarkers for mutation detection and monitoring in New Zealand cancer patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Hoeksema, K., Wee, R., Macdonald, A., Guilford, P., Wall, J., & Cornwall, J. (2017). Where to from here? Posthumous healthcare data, digital e(lectronic)-mortality and New Zealand’s healthcare future. New Zealand Medical Journal, 130(1459), 64-70. Retrieved from http://www.nzma.org.nz/journal

Ellison-Loschmann, L., Sporle, A., Corbin, M., Cheng, S., Harawira, P., Gray, M., … Guilford, P., … Pearce, N. (2017). Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study. PLoS ONE, 12(7), e0181581. doi: 10.1371/journal.pone.0181581

McInnes, T., Zou, D., Rao, D. S., Munro, F. M., Phillips, V. L., McCall, J. L., Black, M. A., Reeve, A. E., & Guilford, P. J. (2017). Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer, 17, 228. doi: 10.1186/s12885-017-3226-4

Lotan, Y., OʼSullivan, P., Raman, J. D., Shariat, S. F., Kavalieris, L., Frampton, C., Guilford, P., … Darling, D. (2017). Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urologic Oncology, 35(8), 513.e15-513.e22. doi: 10.1016/j.urolonc.2017.03.008

Kavalieris, L., O'Sullivan, P., Frampton, C., Guilford, P., Darling, D., Jacobson, E., … Lotan, Y. (2017). Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study. Journal of Urology, 197(6), 1419-1426. doi: 10.1016/j.juro.2016.12.010

Conference Contribution - Published proceedings: Abstract

Sika-Paotonu, D., Viali, S. U., Lameko, V., Bunch, S., Best, K., Fiu, F., … Guilford, P. (2017). Exploring the potential application of ctDNA technology within a resource constrained environment. Journal of Immunology, 198(1, Suppl.), 157.18. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2017). The potential application of ctDNA for improved cancer management, treatment and diagnosis within the Pacific. Journal of Immunology, 198(1, Suppl.), 157.4. [Abstract]

Parackal, S., Zou, D., Day, R., & Guilford, P. (2017). Blood will tell: Circulating tumor DNA as a clinical diagnostic and surveillance tool for cancer patients in New Zealand. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 68-69). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Single, A., Chen, A., Telford, B., Beetham, H., & Guilford, P. (2017). Statins show synthetic lethality in E-cadherin-deficient cells and are synergistic with SRC and HDAC inhibitors. Clinical Cancer Research, 23(1, Suppl. ), B41. doi: 10.1158/1557-3265.PMCCAVULN16-B41

Guilford, P. J., Chen, A., Telford, B., Single, A., Beetham, H., & Godwin, T. (2017). Synthetic lethal targeting of E-cadherin-deficient cancers. Clinical Cancer Research, 23(1, Suppl.), B04. doi: 10.1158/1557-3265.PMCCAVULN16-B04

Parackal, S., Zou, D., Day, R., & Guilford, P. (2017). Evaluation of plasma cell-free DNA stability and preservation in Roche Cell- Free DNA Collection Tubes and Streck Cell- Free DNA BCT over a 14-day period. New Zealand Medical Journal, 130(1452), (pp. 79-80). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Sika-Paotonu, D., Viali, S. U., Lameko, V., Burich, S., Best, K., Fiu, F., … Guilford, P. (2017, March). Exploring the potential application of ctDNA technology within a resource constrained environment. Poster session presented at the 10th Health Disparities Conference, New Orleans, LA.

Sika-Paotonu, D., Ulufonua, L., Falevasiva, P., Vaka, E., & Guilford, P. (2017, March). The potential application of ctDNA for improved cancer management, treatment and diagnosis within the Pacific. Poster session presented at the 10th Health Disparities Conference, New Orleans, LA.

Leichter, A. L., Day, R. C., Stockwell, P. A., Wilson, M., Guilford, P., Eccles, M. R., & Chatterjee, A. (2017, September). Development of single-cell methodologies to interrogate DNA methylation patterns at a whole genome scale. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2017, September). E-cadherin’s synthetic lethal interactions. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kelly, S. T., Stylianou, C., Chen, A., Guilford, P. J., & Black, M. A. (2017, September). In silico detection of candidate synthetic lethal gene pairs using cancer genomics data. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Conference Contribution - Published proceedings: Abstract

Chen, A., Telford, B. J., Single, A., Beetham, H., Simpson, K. J., & Guilford, P. J. (2016). Synthetic lethal approaches targeting E-cadherin-deficient cancers. Cancer Research, 76(14, Suppl.), 3814. doi: 10.1158/1538-7445.AM2016-3814

McQuillan, H. J., Guilford, P. J., Day, R. C., Snow, B. J., & Reynolds, J. N. J. (2016). Probing synaptic plasticity: A single cell RNA sequencing approach. Proceedings of the Society for Neuroscience 46th Annual Meeting. 751.15. SfN. Retrieved from https://www.sfn.org/

Guilford, P. (2016). Cancer diagnostics: New strategies and old tricks. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P., Chen, A., Single, A., Beetham, H., Telford, B., Hakkaart, C., & Godwin, T. (2016, August-September). Hereditary diffuse gastric cancer: Battling the curse. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Single, A., Beetham, H., Telford, B. J., Guilford, P., & Chen, A. (2015). A comparison of real-time and endpoint cell viability assays for improved synthetic lethal drug validation. Journal of Biomolecular Screening, 20(10), 1286-1293. doi: 10.1177/1087057115605765

van der Post, R. S., Vogelaar, I. P., Carneiro, F., Guilford, P., Huntsman, D., Hoogerbrugge, N., … Fitzgerald, R. C. (2015). Hereditary diffuse gastric cancer: Updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. Journal of Medical Genetics, 52, 361-374. doi: 10.1136/jmedgenet-2015-103094

Telford, B. J., Chen, A., Beetham, H., Frick, J., Brew, T. P., Gould, C. M., Single, A., Godwin, T., … Guilford, P. (2015). Synthetic lethal screens identify vulnerabilities in GPCR signalling and cytoskeletal organization in E-cadherin-deficient cells. Molecular Cancer Therapeutics, 14(5), 1213-1223. doi: 10.1158/1535-7163.mct-14-1092

Hansford, S., Kaurah, P., Li-Chang, H., Woo, M., Senz, J., Pinheiro, H., … Guilford, P., … Huntsman, D. G. (2015). Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond. JAMA Oncology, 1(1), 23-32. doi: 10.1001/jamaoncol.2014.168

Conference Contribution - Published proceedings: Abstract

Beetham, H., Chen, A., Jarman, K. E., Falk, H., & Guilford, P. J. (2015). The discovery of novel synthetic lethal compounds for the treatment of E-cadherin deficient tumours. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Conference Contribution - Poster Presentation (not in published proceedings)

McInnes, T., Zou, D., Black, M. A., Reeve, A. E., & Guilford, P. J. (2015, August-September). Genome-wide methylation analysis identifies a core set of hypermethylated CpG islands in CIMP-H colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Beetham, H., Chen, A., Single, A., Telford, B. J., & Guilford, P. J. (2015, August-September). The discovery of novel synthetic lethal compounds for the treatment of E-cadherin deficient tumours. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Single, A., Chen, A., & Guilford, P. (2015, October). A synergistic synthetic lethal drug combination for the treatment of E-cadherin-deficient tumours. Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Hakkaart, C., & Guilford, P. (2015, October). Screening for predisposition for gastric cancer in Māori. Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Beetham, H., Chen, A., Single, A., Telford, B., & Guilford, P. (2015, October). The discovery of novel synthetic lethal compounds for the treatment of E-cadherin deficient tumours. Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2015, August-September). Hereditary diffuse gastric cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Hakkaart, C., Day, R., Ellison-Loschmann, E., & Guilford, P. (2015, August-September). Screening for predisposition for gastric cancer in Māori. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Guilford, P. (2015, October). i) Finding cancer's vulnerabilities and ii) the Healthier Lives National Science Challenge: The rapid response to cancer progression. Verbal presentation at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Guilford, P. (2015, October). Overview. Verbal presentation at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

2014

Journal - Research Article

Chen, A., Beetham, H., Black, M. A., Priya, R., Telford, B. J., Guest, J., Wiggins, G. A. R., Godwin, T. D., … Guilford, P. J. (2014). E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer, 14, 552. doi: 10.1186/1471-2407-14-552

Journal - Research Other

Cornwall, J., Slatter, T., Guilford, P., Print, C. G., Henaghan, M., & Wee, R. (2014). Culture, law, ethics, and social implications: Is society ready for advanced genomic medicine? Australasian Medical Journal, 7(4), 200-202. doi: 10.4066/amj.2014.2069

Conference Contribution - Published proceedings: Abstract

Harris, C., Day, R., Godwin, T., Zou, D., & Guilford, P. (2014). Detection of a single prostate cancer derived cell transcriptome in a background population. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Kelly, S. T., Guilford, P. J., & Black, M. A. (2014, August). Bioinformatic prioritisation of synthetic lethal drug targets against E-cadherin deficient cancers. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Beetham, H., Chen, A., Telford, B. J., & Guilford, P. J. (2014, August). A cell based high throughput screen to find novel synthetic lethal lead-like compounds for the treatment of E-cadherin deficient tumours. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2014, October). The chemoprevention and treatment of hereditary diffuse gastric cancer. Invited presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

Guilford, P., Telford, B., Chen, A., Beetham, H., Single, A., Frick, J., Brew, T., & Godwin, T. (2014, November). Synthetic lethal targeting of E-cadherin-deficient cancers. Verbal presentation at the Frontiers of Biology Satellite Meeting: From Protein Structure and Function to Drugs, Wellington, New Zealand.

Other Research Output

Guilford, P. (2014, July). Cancer: Divide and conquer. University of Otago Winter Lecture Series. Auckland, New Zealand. [Public Seminar].

Guilford, P. (2014, July). Cancer: Divide and conquer. University of Otago Winter Lecture Series. Wellington, New Zealand. [Public Seminar].

2013

Journal - Research Article

Willson, J. S. B., Godwin, T. D., Wiggins, G. A. R., Guilford, P. J., & McCall, J. L. (2013). Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation. Journal of Hepatology, 59(4), 904-907. doi: 10.1016/j.jhep.2013.05.024

Conference Contribution - Published proceedings: Abstract

Chen, A., Telford, B., Beetham, H., Single, A., Godwin, T., & Guilford, P. (2013). Synthetic lethal interactions with the tumour suppressor protein E-cadherin. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/conference_2013

Single, A., Chen, A., Telford, B., & Guilford, P. (2013). Synthetic lethal interactions for the treatment of E-cadherin negative tumours. New Zealand Medical Journal, 126(1374). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2013, September). Cancer: The problem and the promise. Verbal presentation at the Inaugural Genetics Week, Dunedin, New Zealand.

Guilford, P. (2013, July). Targeting the vulnerabilities: Increased drug sensitivity of E-cadherin-negative tumours. Verbal presentation at the Cancer Trials New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

Other Research Output

Guilford, P. (2013, October). Cancer: The problem and the promise. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

2012

Journal - Research Article

Huang, R. Y.-J., Guilford, P., & Thiery, J. P. (2012). Early events in cell adhesion and polarity during epithelial-mesenchymal transition. Journal of Cell Science, 125(19), 4417-4422. doi: 10.1242/jcs.099697

O'Sullivan, P., Sharples, K., Dalphin, M., Davidson, P., Gilling, P., Cambridge, L., … Luxmanan, C., … Yoon, H.-S., … Guilford, P. J. (2012). A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. Journal of Urology, 188(3), 741-747. doi: 10.1016/j.juro.2012.05.003

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Conference Contribution - Published proceedings: Abstract

Lagishetty, C., Putt, T., Guilford, P., Walker, R., & Duffull, S. (2012). Evaluation of biological age indices to predict drug clearance. Proceedings of the Medical Sciences Congress (MedSci). (pp. 23-24). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Mehta, S., Lasham, A., Wright, D., Black, M. A., Reeve, A., Guilford, P., McCall, J., … Print, C. (2012, August). Towards improving clinical decisions for colon cancer patients: A step closer to personalised medicine. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Guilford, P., Telford, B., Black, M., & Chen, A. (2012, August). Synthetic lethal targeting of the tumour suppressor gene CDH1 in common cancers. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Conference Contribution - Published proceedings: Abstract

Yoon, H.-S., Zou, D.-H., Perez, D., Guilford, P., & Humar, B. (2011). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for the chemoprevention of lobular neoplasia. Virchows Archiv, 459(Suppl. 1), (pp. S7). doi: 10.1007/s00428-011-1113-y

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2011, December). Cancer Genetics Laboratory collaborations: Diagnosis, prognosis and drug development. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.

Intellectual Property

Guilford, P. J., Kerr, N. J., & Pollock, R. C. (2011). Urine markers for detection of bladder cancer. (553297).

Guilford, P. J., & Holyoake, A. J. (2011). Markers for detection of gastric cancer. (EP 1 649 064).

2010

Journal - Research Article

Mai, P. L., Friedlander, M., Tucker, K., Phillips, K.-A., Hogg, D., Jewett, M. A. S., … Guilford, P., … Greene, M. H. (2010). The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urologic Oncology, 28(5), 492-499. doi: 10.1016/j.urolonc.2008.10.004

Fitzgerald, R. C., Hardwick, R., Huntsman, D., Carneiro, F., Guilford, P., Blair, V., … on behalf of the International Gastric Cancer Linkage Consortium. (2010). Hereditary diffuse gastric cancer: Updated consensus guidelines for clinical management and directions for future research. Journal of Medical Genetics, 47(7), 436-444. doi: 10.1136/jmg.2009.074237

Guilford, P., Humar, B., & Blair, V. (2010). Hereditary diffuse gastric cancer: Translation of CDH1 germline mutations into clinical practice. Gastric Cancer, 13(1), 1-10. doi: 10.1007/s10120-009-0531-x

Nasri, S., Anjomshoaa, A., Song, S., Guilford, P., McNoe, L., Black, M., Phillips, V., Reeve, A., & Humar, B. (2010). Oligonucleotide array outperforms SNP array on formalin-fixed paraffin-embedded clinical samples. Cancer Genetics & Cytogenetics, 198(1), 1-6. doi: 10.1016/j.cancergencyto.2009.12.002

Guise, C. P., Abbattista, M. R., Singleton, R. S., Holford, S. D., Connolly, J., Dachs, G. U., Fox, S. B., Pollock, R., Harvey, J., Guilford, P., … Patterson, A. V. (2010). The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Research, 70(4), 1573-1584. doi: 10.1158/0008-5472.CAN-09-3237

Conference Contribution - Published proceedings: Abstract

O'Sullivan, P., Davidson, P., Gilling, P., Sharples, K., Guilford, P., & CxBladder Detection Study Group. (2010). A prospective study of a novel urine diagnostic test (CxBladder) for the detection of urinary tract transitional cell carcinoma. BJU International. 105(Suppl. 1), (pp. 6). doi: 10.1111/j.1464-410X.2010.09122.x

Conference Contribution - Verbal presentation and other Conference outputs

Guilford, P. (2010, August-September). A molecular diagnostic test for bladder cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Guilford, P. (2010, November). Hereditary diffuse gastric cancer: Cause and consequence. Invited presentation at the Genetics Otago Symposium, Dunedin, New Zealand.

2009

Journal - Research Article

Zou, D., Yoon, H.-S., Anjomshoaa, A., Perez, D., Fukuzawa, R., Guilford, P., & Humar, B. (2009). Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Research, 11(4), R45. doi: 10.1186/bcr2332

Humar, B., Blair, V., Charlton, A., More, H., Martin, I., & Guilford, P. (2009). E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Research, 69(5), 2050-2056.

Zou, D., Yoon, H.-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Journal - Research Other

Humar, B., & Guilford, P. (2009). Hereditary diffuse gastric cancer: A manifestation of lost cell polarity. Cancer Science, 100(7), 1151-1157. doi: 10.1111/j.1349-7006.2009.01163.x

2008

Journal - Research Article

John, T., Black, M. A., Toro, T. T., Leader, D., Gedye, C. A., Davis, I. D., Guilford, P. J., & Cebon, J. S. (2008). Predicting clinical outcome through molecular profiling in stage III melanoma. Clinical Cancer Research, 14(16), 5173-5180.

Kawanishi, H., Matsui, Y., Ito, M., Watanabe, J., Takahashi, T., Nishizawa, K., … Guilford, P., Reeve, A., … Ogawa, O. (2008). Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clinical Cancer Research, 14(9), 2579-2587. doi: 10.1158/1078-0432.CCR-07-1922

Nasri, S., More, H., Graziano, F., Ruzzo, A., Wilson, E., Dunbier, A., McKinney, C., Merriman, T., Guilford, P., … Humar, B. (2008). A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer, 8, 138. doi: 10.1186/1471-2407-8-138

Holyoake, A., O'Sullivan, P., Pollock, R., Best, T., Watanabe, J., Kajita, Y., … da Silva Tatley, F., Cambridge, L., Toro, T., … Guilford, P. (2008). Development of a multiplex RNA urine test for the detection and stratification of transitional cell carcinoma of the bladder. Clinical Cancer Research, 14(3), 742-749. doi: 10.1158/1078-0432.CCR-07-1672

Kwak, M. K., Lee, H.-J., Hur, K., Park, D. J., Lee, H. S., Kim, W. H., … Guilford, P., & Yang, H.-K. (2008). Expression of Krüppel-like factor 5 in human gastric carcinomas. Journal of Cancer Research & Clinical Oncology, 134(2), 163-167. doi: 10.1007/s00432-007-0265-2

Linger, R., Dudakia, D., Huddart, R., Tucker, K., Friedlander, M., Phillips, K.-A., … Guilford, P., … Rapley, E. A. (2008). Analysis of the DND I gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes & Cancer, 47(3), 247-252. doi: 10.1002/gcc.20526

Humar, B., & Guilford, P. (2008). Hereditary diffuse gastric cancer and lost cell polarity: A short path to cancer. Future Oncology, 4(2), 229-239.

Intellectual Property

Reeve, A. E., Futschik, M. E., Sullivan, M. J., Kasabov, N. K., & Guilford, P. J. (2008). Medical applications of adaptive learning systems using gene expression data. (US 7,370,021).

2007

Journal - Research Article

More, H., Humar, B., Weber, W., Ward, R., Christian, A., Lintott, C., … Guilford, P. (2007). Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Human Mutation, 28(2). doi: 10.1002/humu.9473

Matsui, S., Ito, M., Nishiyama, H., Uno, H., Kotani, H., Watanabe, J., Guilford, P., Reeve, A., … Ogawa, O. (2007). Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models. Bioinformatics, 23(6), 732-738.

Guilford, P., Blair, V., More, H., & Humar, B. (2007). A short guide to hereditary diffuse gastric cancer. Hereditary Cancer in Clinical Practice, 5(4), 183-194.

Ito, M., Nishiyama, H., Kawanishi, H., Matsui, S., Guilford, P., Reeve, A., & Ogawa, O. (2007). P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. Journal of Urology, 178, 1073-1079.

Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., … Reeve, A. E., … Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Research, 67(6), 2480-2489. doi: 10.1158/0008-5472.CAN-06-3021

Lin, Y.-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, V., Thompson-Fawcett, M., … van Rij, A., Yoon, H.-S., McCall, J. L., … Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clinical Cancer Research, 13(2), 498-507. doi: 10.1158/1078-0432.CCR-05-2734

Conference Contribution - Verbal presentation and other Conference outputs

Sykes, P., Evans, J., Nagasaki, J., Fisher, M., McGraine, Y., & Guilford, P. (2007, May). Understanding angiogenesis in endometrial cancer: A path to new therapies. Verbal presentation at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

2006

Journal - Research Article

Ramos-de la Medina, A., More, H., Medina-Franco, H., Humar, B., Gamboa, A., Ortiz, L. J., … Guilford, P. (2006). Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. Revista Española de Enfermedades Digestivas, 98(1), 36-41.

Crockford, G. P., Linger, R., Hockley, S., Dudakia, D., Johnson, L., Huddart, R., … Guilford, P., … Rapley, E. A. (2006). Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Human Molecular Genetics, 15(3), 443-451. doi: 10.1093/hmg/ddi459

Blair, V., Martin, I., Shaw, D., Winship, I., Kerr, D., Arnold, J., … Cox, B., Humar, B., More, H., & Guilford, P. (2006). Hereditary diffuse gastric cancer: Diagnosis and management. Clinical Gastroenterology & Hepatology, 4, 262-275. doi: 10.1016/j.cgh.2005.12.003

Conference Contribution - Published proceedings: Abstract

Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., Reeve, A., … Guilford, P. (2006). The early development of diffuse gastric cancer. Differentiation. 74(8), (pp. 455). [Abstract]

2005

Journal - Research Article

Shaw, D., Blair, V., Framp, A., Harawira, P., McLeod, M., & Guilford, P. (2005). Chromoendoscopic surveillance in hereditary diffuse gastric cancer: An alternative to prophylactic gastrectomy? Gut, 54, 461-468.

Nathanson, K. L., Kanetsky, P. A., . . ., Guilford, P., & et al (2005). The Y deletion gr/gr and susceptibility to testicular germ cell tumor. American Journal of Human Genetics, 77, 1034-1043.

Conference Contribution - Published proceedings: Full paper

Guilford, P. (2005). The initiation of hereditary diffuse gastric cancer and its clinical management. Proceedings of the New Zealand Society for Oncology Conference. (pp. 29). [Full Paper]

Conference Contribution - Published proceedings: Abstract

Dunbier, A. K., & Guilford, P. J. (2005). E-cadherin loss has a permissive but not active role in gastric cancer. Proceedings of the American Association for Cancer Research (AACR) 96th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2004

Journal - Research Article

Rapley, E. A., Hockley, S., Warren, W., Johnson, L., Huddart, R., Crockford, G., … Guilford, P., … Stratton, M. R. (2004). Somatic mutations of KIT in familial testicular germ cell tumours. British Journal of Cancer, 90, 2397-2401. doi: 10.1038/sj.bjc.6601880

Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., More, H., … Guilford, P., … Cascinu, S. (2004). Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clinical Cancer Research, 10, 2784-2789.

Charlton, A., Blair, V., Shaw, D., Parry, S., Guilford, P., & Martin, I. G. (2004). Hereditary diffuse gastric cancer: Predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut, 53, 814-820.

Conference Contribution - Published proceedings: Full paper

Guilford, P. (2004). Gene: Environment interactions in gastric cancer. Proceedings of the 13th CRI Cancer Symposium. (pp. 12). Seoul, Korea: Seoul National University College of Medicine. [Full Paper]

Guilford, P., Humar, B., More, H., Fukuzawa, R., Blair, V., Martin, I., … Charlton, A. (2004). The initiation and progression of hereditary diffuse gastric cancer. Proceedings of the 17th International Symposium of Foundation for Promotion of Cancer Research. (pp. 11-12). Tokyo, Japan. [Full Paper]

Guilford, P. (2004). The natural history and clinical management of hereditary diffuse gastric cancer. Proceedings of the Global Trends in Cancer Research. (pp. 4-5). Tokyo, Japan. [Full Paper]

Conference Contribution - Poster Presentation (not in published proceedings)

Blair, V., Charlton, C., Guilford, P., & Martin, I. (2004, May). Gastric neoplasia in CDH-1 knockout mice using N-methyl-N-nitrosourea carcinogenesis: A murine model of Hereditary Diffuse Gastric Cancer. Poster session presented at the Digestive Disease Week, New Orleans, USA.

Humar, B., Fukuzawa, R., Blair, V., More, H., Reeve, A., Charlton, A., … Guilford, P. (2004, June). A model for the development and progression of hereditary diffuse gastric cancer. Poster session presented at the World Congress on Gastrointestinal Cancer, Barcelona, Spain.

2003

Journal - Research Article

da Silva Tatley, F. M., Aldwell, F., Dunbier, A. K., & Guilford, P. J. (2003). N-terminal E-cadherin peptides act as decoy receptors for Listeria monocytogenes. Infection & Immunity, 71(3), 1580-1583.

Journal - Research Other

Graziano, F., Humar, B., & Guilford, P. J. (2003). The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice. Annals of Oncology, 14, 1705-1713.

2002

Chapter in Book - Research

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. In S. R. Hamilton & L. A. Aaltonen (Eds.), Encyclopedia of Cancer, Volume 2. (2nd ed.) (pp. 253-258). USA: Elsevier Science.

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. In J. R. Bertino (Ed.), Encyclopedia of cancer. (2nd ed.) (pp. 253-258). Academic Press. [Encyclopaedia/Dictionary Entry].

Journal - Research Article

Humar, B., Toro, T. T., Graziano, F., Muller, H., Dobbie, Z., Kwang-Yang, H., … Merriman, T. R., & Guilford, P. J. (2002). Novel Germline CDH1 mutations in hereditary diffuse gastric cancer families. Human Mutation, 19, 518-525.

Humar, B., Graziano, F., Cascinu, S., Catalano, V., Ruzzo, A. M., Magnani, M., Toro, T. T., Burchill, T., Futschik, M., Merriman, T. R., & Guilford, P. J. (2002). Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene, 21, 8192-8195.

2001

Journal - Research Article

Pharoah, P. D., Guilford, P. J., & Caldas, C. (2001). Incidence of gastric cancer and breast cancer in CDH1 (E-Cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology, 121, 1348-1353.

Dunbier, A. K., & Guilford, P. J. (2001). Hereditary diffuse gastric cancer. Advances in Cancer Research, 83, 55-65.

Chun, Y. S., Lindor, N. M., Smyrk, T. C., Petersen, B. T., Burgart, L. J., Guilford, P. J., & Donohue, J. H. (2001). Germline E-cadherin gene mutations - Is prophylactic total gastrectomy indicated? Cancer, 92(1), 181-187.

Conference Contribution - Published proceedings: Full paper

Guilford, P. J. (2001). Inherited susceptibility to gastric cancer: Mechanism and management. Proceedings of the International Conference. [Full Paper]

Guilford, P. (2001). The inherited susceptibility to gastric cancer. In M. F. Brennan & M. S. Karpeh (Eds.), Proceedings of the 4th International Gastric Cancer Congress. (pp. 45-51). New York: Monduzzi Editore. [Full Paper]

Guilford, P. (2001). Lessons from gene discovery in humans. Proceedings of the 14th Conference of the AABG: Animal Genetics and Breeding Unit. Armidale, Australia: AGBU, University of New England. Retrieved from http://agbu.une.edu.au/~aaabg/

2000

Chapter in Book - Research

Fenoglio-Preiser, C., Carneiro, F., Correa, P., Guilford, P., & et al (2000). Gastric carcinoma. In S. R. Hamilton & L. A. Aaltonen (Eds.), World Health Organization classification of tumours: Pathology and genetics of tumours of the digestive system. (pp. 39-52). Lyon, France: IARC Press.

Journal - Research Article

Grady, W. M., Willis, J., Guilford, P. J., Dunbier, A. K., Toro, T. T., Lynch, H., … Markowitz, S. D. (2000). Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics, 26, 16-17.

Guilford, P. J. (2000). The inherited susceptibility to cancer. Cellular & Molecular Life Sciences, 57, 589-603.

Journal - Research Other

Park, J.-G., Yang, H.-K., Kim, W. H., Caldas, C., Yokota, J., & Guilford, P. J. (2000). Report on the First Meeting of the International Collaborative Group on Hereditary Gastric Cancer. Journal of the National Cancer Institute, 92(21), 1781-1782.

Conference Contribution - Published proceedings: Full paper

Guilford, P. J. (2000). E-cadherin germline mutations in familial gastric cancer. Proceedings of the Aichi Cancer Center Research Institute. [Full Paper]

1999

Journal - Research Article

Gardner, R. J. M., Gaff, C. L., Macrae, F. A., St John, D. J. B., Hopkins, J., Guilford, P. J., & Reeve, A. E. (1999). E-cadherin unlikely to be a common "low penetrance" gene for colorectal cancer. American Journal of Medical Genetics, 84(2), 169-171.

Guilford, P. J., Hopkins, J. B. W., Grady, W. M., Markowitz, S. D., Willis, J., Lynch, H., … Toro, T. T., … Shaw, D. P., Findlay, M. P. N., & Reeve, A. E. (1999). E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Human Mutation, 14(3), 249-255. doi: 10.1002/(SICI)1098-1004

Shinmura, K., Kohno, T., Takahashi, M., Sasaki, A., Ochiai, A., Guilford, P., Hunter, A. K., Reeve, A. E., … Yokota, J. (1999). Familial gastric cancer: Clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. Carcinogenesis, 20(6), 1127-1131. doi: 10.1093/carcin/20.6.1127

1998

Journal - Research Article

Choi, K.-L., McNoe, L. A., French, M. C., Guilford, P. J., & Eccles, M. R. (1998). Absence of PAX2 gene mutations in patients with primary familial vesicoureteric reflux. Journal of Medical Genetics, 35(4), 338-339. doi: 10.1136/jmg.35.4.338

Guilford, P., Hopkins, J. B. W., Harraway, J., McLeod, M., McLeod, N., Harawira, P., … Miller, A., & Reeve, A. E. (1998). E-cadherin germline mutations in familial gastric cancer. Nature, 392(6674), 402-405. doi: 10.1038/32918

Journal - Professional & Other Non-Research Articles

Dodé, C., Weil, D., Levilliers, J., Crozet, F., Chaïb, H., Levi-Acobas, F., Guilford, P., & Petit, C. (1998). Sequence characterization of a newly identified human a-tubulin gene (TUBA2). Genomics, 47(1), 125-130. doi: 10.1006/geno.1997.5081

1997

Journal - Research Article

Guilford, P., Prakash, S., Zhu, J. M., Rikkerink, E., Gardiner, S., Bassett, H., & Forster, R. (1997). Microsatellites in Malus X domestica (apple): Abundance, polymorphism and cultivar identification. Theoretical & Applied Genetics, 94(2), 249-254. doi: 10.1007/s001220050407

Intellectual Property

Reeve, A. E., & Guilford, P. J. (1997). Method of Testing. number 328994. Cancer Genetics Laboratory Biochemistry Department.

1995

Journal - Research Article

Guilford, P., Dode, C., Crozet, F., Blanchard, S., Chaib, H., Levilliers, J., … Petit, C. (1995). A YAC contig and an EST map in the pericentromeric region of chromosome 13q surrounding the loci for neurosensory non-syndromic deafness (DFNB1 and DFNA3) and the limb-girdle muscular dystrophy type 2C (LGMD2C). Genomics, 29(1), 163-169. doi: 10.1006/geno.1995.1227