Contact Details
- Phone
- +64 3 378 6238
- bhatia.madhav@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Pathology and Molecular Medicine (Christchurch)
- Qualifications
- BSc(Hons), MSc, PhD
- Research summary
- Inflammation
Research
Professor Madhav Bhatia's research focuses on inflammation, and he is the head of the Inflammation Research Group at the University of Otago, Christchurch.
Professor Bhatia leads an active research programme on the molecular pharmacology and molecular pathology of inflammatory conditions, such as acute pancreatitis, polymicrobial sepsis, burns, and arthritis.
His research has shown hydrogen sulfide and substance P as mediators of inflammation and potential therapeutic targets for inflammatory diseases. Professor Bhatia is interested in defining the mechanism by which hydrogen sulfide and substance P contribute to inflammation.
The Group's research has shown a key role of chemokines in inflammatory diseases, and of pancreatic acinar cell apoptosis in acute pancreatitis. The Group has also been working on novel markers for diagnosis and prognosis of inflammatory and infectious diseases.
The long-term goal of this research is to translate this knowledge to the clinic, and early results in this direction have been promising.
Funding
The Inflammation Research Group is supported by:
- Lottery Health
- Canterbury Medical Research Foundation
- Arthritis New Zealand
- University of Otago Research Grant
- Maurice & Phyllis Paykel Trust
- Health Reseach Council of New Zealand Singapore Networking Grant
- Royal Scoiety of New Zealand's Catalyst: Leaders New Zealand-China Scientist Exchange Programme
Prior to moving to Christchurch, Professor Bhatia's research was supported by research grants from Biomedical Research Council, Singapore, National Medical Research Council, Singapore, Academic Research Fund, National University of Singapore, Singapore, and Defence Science and Technology Agency-National University of Singapore Joint Applied R&D Co-operation Programme, Singapore.
Publications
Shahid, A., Chambers, S., Scott-Thomas, A., Zawari, M., & Bhatia, M. (2026). Anti-inflammatory effects of alpha-lipoic acid modulate cystathionine-γ-lyase expression in RAW 264.7 macrophages. International Journal of Molecular Sciences, 27(2), 949. doi: 10.3390/ijms27020949 Journal - Research Article
Kumar, R., Yadav, S., Kumar, S., Bhatia, M., & Pandey, A. K. (2025). Antioxidant activity and in-silico evaluation of natural compounds of Carissa carandas as potential inhibitors of Gamma-Glutamyl Transpeptidase to enhance the efficacy of chemotherapy drugs against prostate cancer. Bioorganic Chemistry, 164, 108848. doi: 10.1016/j.bioorg.2025.108848 Journal - Research Article
Shahid, A., Nasir, K., & Bhatia, M. (2025). Therapeutic potential of alpha-lipoic acid: Unraveling its role in oxidative stress and inflammatory conditions. Current Issues in Molecular Biology, 47, 322. doi: 10.3390/cimb47050322 Journal - Research Other
Bhatia, M. (2025). Molecular biology: Challenges and opportunities. Current Issues in Molecular Biology, 47(2), 109. doi: 10.3390/cimb47020109 Journal - Research Other
Pan, X., Ren, Z., Liang, W., Dong, X., Li, J., Wang, L., Bhatia, M., … Sun, J. (2025). Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages. British Journal of Pharmacology, 182, 1897-1911. doi: 10.1111/bph.17435 Journal - Research Article
2026
Journal - Research Article
Shahid, A., Chambers, S., Scott-Thomas, A., Zawari, M., & Bhatia, M. (2026). Anti-inflammatory effects of alpha-lipoic acid modulate cystathionine-γ-lyase expression in RAW 264.7 macrophages. International Journal of Molecular Sciences, 27(2), 949. doi: 10.3390/ijms27020949
2025
Journal - Research Article
Kumar, R., Yadav, S., Kumar, S., Bhatia, M., & Pandey, A. K. (2025). Antioxidant activity and in-silico evaluation of natural compounds of Carissa carandas as potential inhibitors of Gamma-Glutamyl Transpeptidase to enhance the efficacy of chemotherapy drugs against prostate cancer. Bioorganic Chemistry, 164, 108848. doi: 10.1016/j.bioorg.2025.108848
Pan, X., Ren, Z., Liang, W., Dong, X., Li, J., Wang, L., Bhatia, M., … Sun, J. (2025). Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages. British Journal of Pharmacology, 182, 1897-1911. doi: 10.1111/bph.17435
Journal - Research Other
Shahid, A., Nasir, K., & Bhatia, M. (2025). Therapeutic potential of alpha-lipoic acid: Unraveling its role in oxidative stress and inflammatory conditions. Current Issues in Molecular Biology, 47, 322. doi: 10.3390/cimb47050322
Bhatia, M. (2025). Molecular biology: Challenges and opportunities. Current Issues in Molecular Biology, 47(2), 109. doi: 10.3390/cimb47020109
2024
Journal - Research Article
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2024). Novel monoclonal antibodies 1D2 and 4E4 against aspergillus glycoprotein antigens detect early invasive aspergillosis in mice. Journal of Fungi, 10(12), 832. doi: 10.3390/jof10120832
Zhu, Z., Chambers, S., & Bhatia, M. (2024). Substance P promotes leukocyte infiltration in the liver and lungs of mice with sepsis: A key role for adhesion molecules on vascular endothelial cells. International Journal of Molecular Sciences, 25(12), 6500. doi: 10.3390/ijms25126500
Zhu, Z., Chambers, S., & Bhatia, M. (2024). Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs. Antioxidants, 13, 300. doi: 10.3390/antiox13030300
Manandhar, S., Gaddam, R. R., Chambers, S., & Bhatia, M. (2024). Kupffer cell inactivation alters endothelial cell adhesion molecules in cecal ligation and puncture-induced sepsis. Biomolecules, 14, 84. doi: 10.3390/biom14010084
Journal - Research Other
Bhatia, M. (2024). The 25th anniversary of Current issues in molecular biology: Marking this significant milestone. Current Issues in Molecular Biology, 46, 14321-14323. [Editorial].
Shahid, A., Chambers, S., Scott-Thomas, A. J., & Bhatia, M. (2024). Gut microbiota and liver dysfunction in sepsis: The role of inflammatory mediators and therapeutic approaches. International Journal of Molecular Sciences, 25(24), 13415. doi: 10.3390/ijms252413415
Shahid, A., & Bhatia, M. (2024). Hydrogen sulfide: A versatile molecule and therapeutic target in health and diseases. Biomolecules, 14, 1145. doi: 10.3390/biom14091145
Relja, B., Ghezzi, P., Coldewey, S. M., Pavlov, V. A., Bhatia, M., Jungwirth, B., & Thiemermann, C. (2024). Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma: Volume III. Frontiers in Immunology, 15, 1447892. doi: 10.3389/fimmu.2024.1447892
2023
Journal - Research Article
Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650
Pan, L.-L., Ren, Z.-N., Yang, J., Li, B.-B., Huang, Y.-W., Song, D.-X., … Bhatia, M., … Sun, J. (2023). Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria. Acta Pharmaceutica Sinica B, 13(10), 4202-4216. doi: 10.1016/j.apsb.2023.08.002
Tian, H., Li, J., Chen, X., Ren, Z., Pan, X., Huang, W., Bhatia, M., … Sun, J. (2023). Oral delivery of mouse β-defensin 14 (mBD14)-producing Lactococcus lactis NZ9000 attenuates experimental colitis in mice. Journal of Agricultural & Food Chemistry, 71, 5185-5194. doi: 10.1021/acs.jafc.2c07098
Journal - Research Other
Zhu, Z., & Bhatia, M. (2023). Inflammation and organ injury the role of substance P and its receptors. International Journal of Molecular Sciences, 24, 6140. doi: 10.3390/ijms24076140
Ishii, I., & Bhatia, M. (2023). Amino acids in health and disease: The good, the bad, and the ugly. International Journal of Molecular Sciences, 24, 4931. doi: 10.3390/ijms24054931
Journal - Professional & Other Non-Research Articles
Bhatia, M. (2023). Current Issues in Molecular Biology keep evolving and getting better. Current Issues in Molecular Biology, 45, 7842. doi: 10.3390/cimb45100494
2022
Journal - Research Article
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2022). A novel monoclonal antibody 1D2 that broadly inhibits clinically important Aspergillus species. Journal of Fungi, 8, 960. doi: 10.3390/jof8090960
Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639
Lian, X., Chambers, S., Lewis, J. G., Scott-Thomas, A., & Bhatia, M. (2022). Two monoclonal antibodies that specifically recognize aspergillus cell wall antigens and can detect circulating antigens in infected mice. International Journal of Molecular Sciences, 23, 252. doi: 10.3390/ijms23010252
Journal - Research Other
Zhu, Z., Lian, X., & Bhatia, M. (2022). Hydrogen sulfide: A gaseous mediator and its key role in programmed cell death, oxidative stress, inflammation and pulmonary disease. Antioxidants, 11, 2162. doi: 10.3390/antiox11112162
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., MacPherson, S. A., Zeng, Y., & Chambers, S. T. (2022). Monoclonal antibodies and invasive aspergillosis: Diagnostic and therapeutic perspectives. International Journal of Molecular Sciences, 23, 5563. doi: 10.3390/ijms23105563
Kumar, R., Bhatia, M., & Pai, K. (2022). Role of chemokines in the pathogenesis of visceral leishmaniasis. Current Medicinal Chemistry, 29(33), 5441-5461. doi: 10.2174/0929867329666220509171244
Zhu, Z., Chambers, S., Zeng, Y., & Bhatia, M. (2022). Gases in sepsis: Novel mediators and therapeutic targets. International Journal of Molecular Sciences, 23, 3669. doi: 10.3390/ijms23073669
2021
Chapter in Book - Research
Manandhar, S., Sinha, P., Ejiwale, G., & Bhatia, M. (2021). Hydrogen sulfide and its interaction with other players in inflammation. In Y.-C. Zhu (Ed.), Advances in hydrogen sulfide biology: Advances in experimental medicine and biology (Vol. 1315). (pp. 129-159). Singapore: Springer. doi: 10.1007/978-981-16-0991-6_6
Journal - Research Other
Kumar, A., & Bhatia, M. (2021). Role of hydrogen sulfide, substance P and adhesion molecules in acute pancreatitis. International Journal of Molecular Sciences, 22(22), 12136. doi: 10.3390/ijms222212136
Patel, B. K., Patel, K. H., Bhatia, M., Iyer, S. G., Madhavan, K., & Moochhala, S. M. (2021). Gut microbiome in acute pancreatitis: A review based on current literature. World Journal of Gastroenterology, 27(30), 5019-5036. doi: 10.3748/wjg.v27.i30.5019
Bhatia, M., & Gaddam, R. R. (2021). Hydrogen sulfide in inflammation: A novel mediator and therapeutic target. Antioxidants & Redox Signaling, 34(17), 1368-1377. doi: 10.1089/ars.2020.8211
Mustansir Dawoodbhoy, F., Patel, B. K., Patel, K., Bhatia, M., Lee, C. N., & Moochhala, S. M. (2021). Gut microbiota dysbiosis as a target for improved post-surgical outcomes and improved patient care: A review of current literature. Shock, 55(4), 441-454. doi: 10.1097/shk.0000000000001654
2020
Journal - Research Article
Ellmers, L. J., Templeton, E. M., Pilbrow, A. P., Frampton, C., Ishii, I., Moore, P. K., Bhatia, M., Richards, A. M., & Cameron, V. A. (2020). Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. International Journal of Molecular Sciences, 21(12), 4284. doi: 10.3390/ijms21124284
Conference Contribution - Poster Presentation (not in published proceedings)
Lian, X., Scott-Thomas, A., Chambers, S., Lewis, J., Aamir, R., & Bhatia, M. (2020, December). The application of MARS spectral CT in diagnosing invasive aspergillosis. Poster session presented at the 6th One Health Aotearoa (OHA) Symposium, [Online].
2019
Journal - Research Article
Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191
Pan, L.-L., Niu, W., Fang, X., Liang, W., Li, H., Chen, W., … Bhatia, M., & Sun, J. (2019). Clostridium butyricum strains suppress experimental acute pancreatitis by maintaining intestinal homeostasis. Molecular Nutrition & Food Research, 63, 1801419. doi: 10.1002/mnfr.201801419
2018
Journal - Research Article
Pan, L.-L., Deng, Y.-Y., Wang, R., Wu, C., Li, J., Niu, W., … Bhatia, M., … Sun, J. (2018). Lactose induces phenotypic and functional changes of neutrophils and macrophages to alleviate acute pancreatitis in mice. Frontiers in Immunology, 9, 751. doi: 10.3389/fimmu.2018.00751
Journal - Research Other
Yan, F., Gao, H., Zhao, H., Bhatia, M., & Zeng, Y. (2018). Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease. Journal of Translational Medicine, 16, 262. doi: 10.1186/s12967-018-1635-z
2017
Chapter in Book - Research
Lv, J., Bhatia, M., & Wang, X. (2017). Roles of mitochondrial DNA in energy metabolism. In H. Sun & X. Wang (Eds.), Mitochondrial DNA and diseases: Advances in experimental medicine and biology (Vol. 1038). (pp. 71-83). Singapore: Springer Nature. doi: 10.1007/978-981-10-6674-0_6
Journal - Research Article
Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005
Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762
Gillies, N. A., Pendharkar, S. A., Singh, R. G., Windsor, J. A., Bhatia, M., & Petrov, M. S. (2017). Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines. Archives of Physiology & Biochemistry, 123(4), 238-248. doi: 10.1080/13813455.2017.1308382
Singh, P. M., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia & Analgesia, 44(5), 1149-1155. doi: 10.1016/j.vaa.2017.01.002
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755
Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472
Journal - Research Other
Kumar, R., Bhatia, M., & Pai, K. (2017). Role of cytokines in the pathogenesis of visceral leishmaniasis. Clinical Laboratory, 63(10), 1549-1559. doi: 10.7754/Clin.Lab.2017.170404
Bhatia, M. (2017). Understanding toxicology: Mechanisms and applications. Cell Biology & Toxicology, 33(1), 1-4. doi: 10.1007/s10565-016-9363-8
2016
Journal - Research Article
Dong, Z., Shang, H., Chen, Y. Q., Pan, L.-L., Bhatia, M., & Sun, J. (2016). Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine & Cellular Longevity, 2016, 7864150. doi: 10.1155/2016/7864150
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521
Deng, Y.-Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13(5), 3881-3885. doi: 10.3892/mmr.2016.5008
Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9
Shamoon, M., Deng, Y., Chen, Y. Q., Bhatia, M., & Sun, J. (2016). Therapeutic implications of innate immune system in acute pancreatitis. Expert Opinion on Therapeutic Targets, 20(1), 73-87. doi: 10.1517/14728222.2015.1077227
Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z
Conference Contribution - Published proceedings: Abstract
Gaddam, R. R., Fraser, R., Badiei, A., Cogger, V., Le Couteur, D., Ishii, I., & Bhatia, M. (2016). The effect of hydrogen sulfide synthesized by cystathionine-gamma-lyase on inflammation and liver sinusoidal endothelial cells in polymicrobial sepsis in mice. New Zealand Medical Journal, 129(1439), (pp. 88). Retrieved from http://www.nzma.org.nz/journal
2015
Chapter in Book - Research
Bhatia, M. (2015). H2S and inflammation: An overview. In P. K. Moore & M. Whiteman (Eds.), Chemistry, biochemistry and pharmacology of hydrogen sulfide (Handbook of experimental pharmacology, Vol. 230). (pp. 165-180). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-18144-8_8
Bhatia, M. (2015). H2S and substance P in Inflammation. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen sulfide in redox biology, Part B (Vol. 555). (pp. 195-205). Elsevier. doi: 10.1016/bs.mie.2014.11.024
Journal - Research Article
Badiei, A., Gieseg, S., Davies, S., Othman, M. I., & Bhatia, M. (2015). LPS up-regulates cystathionine γ-lyase gene expression in Primary human macrophages via NF-κB/ERK pathway. Inflammation & Allergy Drug Targets, 14(2), 99-104. doi: 10.2174/1871528114666151201201719
Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007
Journal - Research Other
Du, C., Bhatia, M., Tang, S. C. W., Zhang, M., & Steiner, T. (2015). Mediators of inflammation: Inflammation in cancer, chronic diseases, and wound healing. Mediators of Inflammation, 2015, 570653. doi: 10.1155/2015/570653
Conference Contribution - Published proceedings: Abstract
Bhatia, M., Badiei, A., Gaddam, R., Fraser, R., & Chambers, S. (2015). Inhibition of hydrogen sulfide synthesis by gene silencing protects mice against caerulein-induced acute pancreatitis. Pancreatology, 15(3, Suppl.), (pp. S2). doi: 10.1016/j.pan.2015.05.048
2014
Journal - Research Other
Gaddam, R. R., Chambers, S., & Bhatia, M. (2014). ACE and ACE2 in inflammation: A tale of two enzymes. Inflammation & Allergy Drug Targets, 13(4), 224-234. [Review].
Conference Contribution - Published proceedings: Abstract
Fraser, R., Bhatia, M., Gaddam, R. R., Jamieson, H. A., Dobbs, B. R., Wade, R. T., … Le Couteur, D. G. (2014). Arsenic containing water from Bangladeshi wells relates to local heart disease and stroke. Internationally, mining and exploratory fracking may lead to arsenical contamination of aquifers. Arsenical drinking-water, by closing the "liver sieve" causes dyslipidaemia and atherosclerosis? Proceedings of the 7th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 9-10). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/index.html
Conference Contribution - Poster Presentation (not in published proceedings)
Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Inhibition of hydrogen sulfide production through gene silencing attenuates inflammation in LPS-activated macrophages via NF-κB pathway. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Alteration of metalloprotease enzymes of the renin-angiotensin system in acute pancreatitis in a mouse model. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
2013
Journal - Research Article
Ang, A. D., Rivers-Auty, J., Hegde, A., Ishii, I., & Bhatia, M. (2013). The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. American Journal of Physiology: Gastrointestinal & Liver Physiology, 305, G712-G721. doi: 10.1152/ajpgi.00044.2013
Badiei, A., Rivers-Auty, J., Ang, A. D., & Bhatia, M. (2013). Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Applied Microbiology & Biotechnology, 97(17), 7845-7852. doi: 10.1007/s00253-013-5080-x
Conference Contribution - Published proceedings: Abstract
Bhatia, M., Ang, A., Rivers, J., & Hegde, A. (2013). Effect of cystathionine-gamma-lyase gene deletion in caerulein-induced acute pancreatitis in the mouse. Pancreatology, 13(Suppl. 3), (pp. S91). doi: 10.1016/j.pan.2013.04.318
2012
Journal - Research Article
Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044
Sidhapuriwala, J. N., Hegde, A., Ang, A. D., Zhu, Y. Z., & Bhatia, M. (2012). Effects of S-Propargyl-Cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS ONE, 7(3), e32574. doi: 10.1371/journal.pone.0032574
Rivers, J. R., Badiei, A., & Bhatia, M. (2012). Hydrogen sulfide as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets, 16(5), 439-449. doi: 10.1517/14728222.2012.673591
Bhatia, M., Zemans, R. L., & Jeyaseelan, S. (2012). Role of chemokines in the pathogenesis of acute lung injury. American Journal of Respiratory Cell & Molecular Biology, 46(5), 566-572. doi: 10.1165/rcmb.2011-0392TR
Koh, Y.-H., Moochhala, S., Bian, J.-S., & Bhatia, M. (2012). Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 16(7), 1582-1592. doi: 10.1111/j.1582-4934.2011.01475.x
2011
Journal - Research Article
Koh, Y.-H., Moochhala, S., & Bhatia, M. (2011). The role of neutral endopeptidase in caerulein-induced acute pancreatitis. Journal of Immunology, 187, 5429-5439. doi: 10.4049/jimmunol.1102011
Ang, S.-F., Sio, S. W. S., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. Journal of Immunology, 187(9), 4778-4787. doi: 10.4049/jimmunol.1101559
Ang, S.-F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: Involvement of substance P and ERK-NF-κB signaling. PLoS ONE, 6(9), e24535. doi: 10.1371/journal.pone.0024535
Koh, Y.-H., Tamizhselvi, R., Moochhala, S., Bian, J.-S., & Bhatia, M. (2011). Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 15(10), 2139-2149. doi: 10.1111/j.1582-4934.2010.01205.x
Hegde, A., & Bhatia, M. (2011). Hydrogen sulfide in inflammation: Friend or foe? Inflammation & Allergy Drug Targets, 10(2), 118-122.
Journal - Research Other
Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. (2011). Lack of evidence for a causal association between the type of alcoholic beverage and the incidence of acute pancreatitis Reply [Letter]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2
Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. T. P. (2011). Reply [Letter to the editor]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2
Conference Contribution - Published proceedings: Abstract
Ang, S. F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulphide regulates transient receptor potential vanilloid 1-mediated neurogenic inflammation in sepsis-associated lung injury through enhancement of substance P production. Inflammation Research. 60(Suppl. 1), (pp. S122). doi: 10.1007/s00011-011-0341-6
Bhatia, M., Hegde, A., Sidhapuriwala, J., & Zhu, Y. Z. (2011). S-propargyl-cysteine protects mice against caerulein-induced acute pancreatitis. Inflammation Research. 60(Suppl. 1), (pp. S278-S279). doi: 10.1007/s00011-011-0341-6
Other Research Output
Bhatia, M. (2011, February). Inflammation: A new frontier of medicine. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture].
2010
Journal - Research Article
Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739
Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027
Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995
Koh, Y.-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-κB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416
Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9
Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004
Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166
Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927
Hegde, A., Uttamchandani, M., Bhatia, M., & Moochhala, S. M. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112
Tamizhselvi, R., Koh, Y.-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-κB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044
Ang, S.-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/CCM.0b013e3181c0df00
Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory & Critical Care Medicine, 181(1), 36-46. doi: 10.1164/rccm.200907-1073OC
Conference Contribution - Published proceedings: Abstract
Hegde, A., Koh, Y., Moochhala, S., & Bhatia, M. (2010). Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis in mice. Proceedings of the Human Proteome World Congress (HUPO): Launch of the Human Proteome Project. (pp. 215). Retrieved from http://www.hupo.org/congress/congress_2010/downloads/HUPO2010%20World%20Congress%20Abstract%20Book.pdf
2009
Journal - Research Article
Ang, A. D., Adhikari, S., Ng, S. W., & Bhatia, M. (2009). Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology, 9(1-2), 150-159. doi: 10.1159/000178886
Ramnath, R. D., Sun, J., & Bhatia, M. (2009). Involvement of Src family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. Journal of Pharmacology & Experimental Therapeutics, 329, 418-428. doi: 10.1124/jpet.108.148684
Zhang, H., & Bhatia, M. (2009). Role of hydrogen sulfide in acute lung injury and acute respiratory distress syndrome. Open Critical Care Medicine Journal, 2, 13-17. doi: 10.2174/1874828700902010013
Ynsa, M. D., Ren, M. Q., Rajendran, R., Sidhapuriwala, J. N., van Kan, J. A., Bhatia, M., & Watt, F. (2009). Zinc mapping and density imaging of rabbit pancreas endocrine tissue sections using nuclear microscopy. Microscopy & Microanalysis, 15, 345-352. doi: 10.1017/S1431927609090795
Tamizhselvi, R., Sun, J., Koh, Y.-H., & Bhatia, M. (2009). Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 329, 1166-1178. doi: 10.1124/jpet.109.150532
Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2009). Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB Journal, 23, 997-1010. doi: 10.1096/fj.08-121756
Sidhapuriwala, J. N., Ng, S. W., & Bhatia, M. (2009). Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of Inflammation, 6, 35. doi: 10.1186/1476-9255-6-35
2008
Journal - Research Article
Adhikari, S., Ramnath, R. D., Wallig, M., & Bhatia, M. (2008). Role of mitogen-activated protein kinases in crambene-induced pancreatic acinar cell apoptosis. International Journal of Integrative Biology, 3(1), 25-35.
Zhang, H., & Bhatia, M. (2008). Hydrogen sulfide: A novel mediator of leukocyte activation. Immunopharmacology & Immunotoxicology, 30, 631-645. doi: 10.1080/08923970802278045
Zhang, H., Moochhala, S. M., & Bhatia, M. (2008). Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. Journal of Immunology, 181, 4320-4331.
Webb, G. D., Lim, L. H., Oh, V. M. S., Yeo, S. B., Cheong, Y. P., Ali, M. Y., … Bhatia, M., … Moore, P. K. (2008). Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. Journal of Pharmacology & Experimental Therapeutics, 324, 876-882. doi: 10.1124/jpet.107.133538
Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2008). Neurokinin A engages neurokinin-1 receptor to induce NF-κB-dependent gene expression in murine macrophages: Implications of ERK1/2 and PI 3-kinase/Akt pathways. American Journal of Physiology: Cell Physiology, 295, C679-C691. doi: 10.1152/ajpcell.00042.2008
Sun, J., Ramnath, R. D., Zhi, L., Tamizhselvi, R., & Bhatia, M. (2008). Substance P enhances NF-κB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. American Journal of Physiology: Cell Physiology, 294, C1586-C1596. doi: 10.1152/ajpcell.00129.2008
Sio, S. W. S., Puthia, M. K., Lu, J., Moochhala, S., & Bhatia, M. (2008). The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Journal of Immunology, 180, 8333-8341.
Ramnath, R. D., Ng, S. W., Guglielmotti, A., & Bhatia, M. (2008). Role of MCP-1 in endotoxemia and sepsis. International Immunopharmacology, 8(6), 810-818. doi: 10.1016/j.intimp.2008.01.033
Ramnath, R. D., Sun, J., Adhikari, S., Zhi, L., & Bhatia, M. (2008). Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells. American Journal of Physiology: Cell Physiology, 294, C683-C692. doi: 10.1152/ajpcell.00360.2007
Ramnath, R. D., Sun, J., & Bhatia, M. (2008). Role of calcium in substance P-induced chemokine synthesis in mouse pancreatic acinar cells. British Journal of Pharmacology, 154(6), 1339-1348. doi: 10.1038/bjp.2008.188
Ng, S. W., Zhang, H., Hegde, A., & Bhatia, M. (2008). Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. Journal of Leukocyte Biology, 83, 288-295. doi: 10.1189/jlb.0807575
Bhatia, M., Landolfi, C., Basta, F., Bovi, G., Ramnath, R. D., Capezzone de Joannon, A., & Guglielmotti, A. (2008). Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis. Inflammation Research, 57(10), 464-471. doi: 10.1007/s00011-008-7210-y
Ang, A. D., Adhikari, S., Wei, N. S., & Bhatia, M. (2008). NFkappaB mediated expression of iNOS in pancreatic acinar cells contributes to the severity of acute pancreatitis and associated lung injury. International Journal of Integrative Biology, 2(2), 70-78.
2007
Journal - Research Article
Zhang, H., Hegde, A., Ng, S. W., Adhikari, S., Moochhala, S. M., & Bhatia, M. (2007). Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. Journal of Immunology, 179, 4153-4160.
Zhi, L., Ang, A. D., Zhang, H., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway. Journal of Leukocyte Biology, 81, 1322-1332. doi: 10.1189/jlb.1006599
Bhatia, M., & Hegde, A. (2007). Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regulatory Peptides, 138(1), 40-48. doi: 10.1016/j.regpep.2006.08.006
Zhang, H., Zhi, L., Moochhala, S. M., Moore, P. K., & Bhatia, M. (2007). Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. Journal of Leukocyte Biology, 82, 894-905. doi: 10.1189/jlb.0407237
Zhang, H., Zhi, L., Moochhala, S., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-κB. American Journal of Physiology: Lung Cellular & Molecular Physiology, 292, L960-L971. doi: 10.1152/ajplung.00388.2006
Sun, J., Ramnath, R. D., & Bhatia, M. (2007). Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. American Journal of Physiology: Cell Physiology, 293, C696-C704. doi: 10.1152/ajpcell.00060.2007
Sun, J., & Bhatia, M. (2007). Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G143-G153. doi: 10.1152/ajpgi.00271.2006
Sidhapuriwala, J., Li, L., Sparatore, A., Bhatia, M., & Moore, P. K. (2007). Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. European Journal of Pharmacology, 569, 149-154. doi: 10.1016/j.ejphar.2007.05.003
Liew, H. C., Khoo, H. E., Moore, P. K., Bhatia, M., Lu, J., & Moochhala, S. M. (2007). Synergism between hydrogen sulfide (H2S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom. Life Sciences, 80(18), 1664-1668. doi: 10.1016/j.lfs.2007.01.058
Lau, H. Y., & Bhatia, M. (2007). Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1283-G1292. doi: 10.1152/ajpgi.00429.2006
Hegde, A., Zhang, H., Moochhala, S., & Bhatia, M. (2007). Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Journal of Leukocyte Biology, 82, 678-685. doi: 10.1189/jlb.0407217
He, M., Horuk, R., Moochhala, S. M., & Bhatia, M. (2007). Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1173-G1180. doi: 10.1152/ajpgi.00420.2006
He, M., Lau, H. Y., Ng, S. W., & Bhatia, M. (2007). Chemokines in acute inflammation: Regulation, function and therapeutic strategies. International Journal of Integrative Biology, 1(1), 18-27.
Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2007). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology, 170(5), 1521-1534. doi: 10.2353/ajpath.2007.061149
2006
Journal - Research Article
Cao, Y., Adhikari, S., Ang, A. D., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G95-G101. doi: 10.1152/ajpgi.00520.2005
Cao, Y., Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. American Journal of Physiology: Cell Physiology, 291, 503-510. doi: 10.1152/ajpcell.00547.2005
Lau, H. Y., & Bhatia, M. (2006). The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Journal of Pathology, 208, 364-371. doi: 10.1002/path.1899
Li, L., Bhatia, M., & Moore, P. K. (2006). Hydrogen sulphide: A novel mediator of inflammation? Current Opinion in Pharmacology, 6(2), 125-129. doi: 10.1016/j.coph.2005.10.007
Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., & et al (2006). Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (mangrove catsnake) with bird-specific activity. Journal of Biological Chemistry, 281(39), 29030-29041. doi: 10.1074/jbcM605850200
Puneet, P., Hegde, A., Ng, S. W., Lau, H. Y., Lu, J., Moochhala, S. M., & Bhatia, M. (2006). Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. Journal of Immunology, 176, 3813-3820.
Ramnath, R. D., Weing, S., He, M., Sun, J., Zhang, H., Bawa, M. S., & Bhatia, M. (2006). Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases. Journal of Organ Dysfunction, 2(2), 80-92. doi: 10.1080/17471060500435662
Ramnath, R. D., & Bhatia, M. (2006). Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-κB. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G1113-G1119. doi: 10.1152/ajpgi.00177.2006
Whiteman, M., Li, L., Kostetski, I., Chu, S. H., Siau, J. L., Bhatia, M., & Moore, P. K. (2006). Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochemical & Biophysical Research Communications, 343(1), 303-310. doi: 10.1016/j.bbrc.2006.02.154
Zhang, H., Zhi, L., Moore, P. K., & Bhatia, M. (2006). Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. American Journal of Physiology: Lung Cellular & Molecular Physiology, 290, L1193-L1201. doi: 10.1152/ajplung.00489.2005
Ali, M. Y., Ping, C. Y., Mok, Y.-Y., Ling, L., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Regulation of vascular nitric oxide in vitro and in vivo: A new role for endogenous hydrogen sulphide? British Journal of Pharmacology, 149(6), 625-634. doi: 10.1038/sj.bjp.0706906
Anuar, F., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation Research, 55(11), 498-503. doi: 10.1007/s00011-006-5150-y
Anuar, F., Whiteman, M., Siau, J. L., Kwong, S. E., Bhatia, M., & Moore, P. K. (2006). Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British Journal of Pharmacology, 147(8), 966-974. doi: 10.1038/sj.bjp.0706696
Bhatia, M., Zhi, L., Zhang, H., Ng, S.-W., & Moore, P. (2006). Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. American Journal of Physiology: Lung Cellular & Molecular Physiology, 291, L896-L904. doi: 10.1152/ajplung.00053.2006
Bhatia, M., Li, L., & Moore, P. K. (2006). The role of hydrogen sulfide in lung inflammation. Drug Discovery Today: Disease Mechanisms, 3(1), 71-75. doi: 10.1016/j.ddmec.2006.02.010
Conference Contribution - Published proceedings: Abstract
Ramnath, R., & Bhatia, M. (2006). Treatment with substance P and caerulein induces chemokine synthesis in pancreatic acinar cells. FEBS Journal, 273(Suppl. 1), (pp. 82-83). doi: 10.1111/j.1742-4658.2006.05277.x
He, M., Horuk, R., & Bhatia, M. (2006). Protective role of BX471, a non-peptide CCR1 antagonist, in acute pancreatitis and sepsis. FEBS Journal, 273(Suppl. 1), (pp. 286). doi: 10.1111/j.1742-4658.2006.05277.x
Lau, H. Y., & Bhatia, M. (2006). Effect of CP96 345 treatment on the expression of adhesion molecules in acute pancreatitis. FEBS Journal, 273(Suppl. 1), (pp. 285-286). doi: 10.1111/j.1742-4658.2006.05277.x
Zhang, H. L., Zhi, L., Moore, P. K., & Bhatia, M. (2006). The role of hydrogen sulfide in cecal ligation and puncture induced sepsis in the mouse. FEBS Journal, 273(Suppl. 1), (pp. 284). doi: 10.1111/j.1742-4658.2006.05277.x
Sun, J., & Bhatia, M. (2006). Blockade of neurokinin 1 receptor attenuates CC and CXC chemokine production in acute pancreatitis. FEBS Journal, 273(Suppl. 1), (pp. 284). doi: 10.1111/j.1742-4658.2006.05277.x
Cao, Y., Adhikari, S., Moore, P. K., & Bhatia, M. (2006). Pro-apoptotic effect of the hydrogen sulfide (h2s) in isolated pancreatic acinar cells. FEBS Journal, 273(Suppl. 1), (pp. 111). doi: 10.1111/j.1742-4658.2006.05277.x
Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). The role of nitric oxide in caerulein-induced acute pancreatitis in mice. Pancreatology. 6(6), (pp. 556). doi: 10.1159/000096550
Adhikari, S., Cao, Y., Ang, A. D., Clement, M. V., Wallig, M., & Bhatia, M. (2006). Mechanism of pancreatic acinar cell apoptosis induced by crambene. FEBS Journal, 273(Suppl. 1), (pp. 47). doi: 10.1111/j.1742-4658.2006.05276.x
Bhatia, M., Puneet, P., & Moochhala, S. (2006). Pre-protachykinin-A gene products play a critical role in the pathogenesis of sepsis. FEBS Journal, 273(Suppl. 1), (pp. 67). doi: 10.1111/j.1742-4658.2006.05277.x
Sun, J., & Bhatia, M. (2006). Blockade of neurokinin-1 receptor attentuates CC and CXC chemokine production in acute pancreatitis and associated lung injury. Pancreatology. 6(4), (pp. 344). doi: 10.1159/000093601
He, M., Horuk, R., & Bhatia, M. (2006). Treatment with BX471, a non-peptide CCR1 antagonist, protect mice against acute pancreatitis-associated lung injury by modulating neutrophils recruitment. Pancreatology. 6(4), (pp. 349). doi: 10.1159/000093601
Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Treatment with a neutralizing anti-IL-10 reverses crambene mediated protection against acute pancreatitis. Pancreatology. 6(4), (pp. 350). doi: 10.1159/000093601
Bhatia, M., & Hegde, A. (2006). Treatment with the CXCR2 antagonist antileukinate protects mice against acute pancreatitis and associated lung injury. Pancreatology. 6(4), (pp. 351). doi: 10.1159/000093601
Ramnath, R. D., & Bhatia, M. (2006). Treatment with caerulein and substance P induces chemokine synthesis on pancreatic acinar cells. Pancreatology. 6(4), (pp. 376). doi: 10.1159/000093601
Lau, H. Y., & Bhatia, M. (2006). Neurokinin-1 receptor antagonist treatment alters the expression of adhesion molecules in acute pancreatitis. Pancreatology. 6(4), (pp. 378). doi: 10.1159/000093601
Whiteman, M., Ali, M., Li, L., Cheong, Y. P., Mok, Y.-Y. P., Kostetski, I., … Bhatia, M., & Moore, P. K. (2006). Hydrogen sulfide regulates the availability of nitric oxide through the formation of a novel nitrosothiol: Implications for cardiovascular function and human disease. Nitric Oxide. 14, (pp. A40). doi: 10.1016/j.niox.2006.04.136