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Contact Details

Phone
+64 3 479 8207
Email
jenny.clarkson@otago.ac.nz
Position
Research Fellow
Department
Department of Physiology
Qualifications
BPhEd MPhEd PhD
Research summary
Investigating the neural control of hot flushes in menopause

Research

I am a Research Fellow leading a research project that is investigating the neural mechanism that drives hot flushes in menopause.

Publications

McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z

Clarkson, J., Han, S. Y., Piet, R., McLennan, T., Kane, G. M., Ng, J., Porteous, R. W., Kim, J. S., … Iremonger, K. J., & Herbison, A. E. (2017). Definition of the hypothalamic GnRH pulse generator in mice. PNAS, 114(47), E10216-E10223. doi: 10.1073/pnas.1713897114

Han, S. Y., Clarkson, J., Piet, R., & Herbison, A. E. (2018). Optical approaches for interrogating neural circuits controlling hormone secretion [Mini-review]. Endocrinology, 159(11), 3822-3833. doi: 10.1210/en.2018-00594

Clarkson, J., Busby, E. R., Kirilov, M., Schütz, G., Sherwood, N. M., & Herbison, A. E. (2014). Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. Journal of Neuroscience, 34(46), 15297-15305. doi: 10.1523/JNEUROSCI.3061-14.2014

Kirilov, M., Clarkson, J., Liu, X., Roa, J., Campos, P., Porteous, R., … Herbison, A. E. (2013). Dependence of fertility on kisspeptin—Gpr54 signalling at the GnRH neuron. Nature Communications, 4, 2492. doi: 10.1038/ncomms3492

McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z

Journal - Research Article

Clarkson, J., Han, S. Y., Piet, R., McLennan, T., Kane, G. M., Ng, J., Porteous, R. W., Kim, J. S., … Iremonger, K. J., & Herbison, A. E. (2017). Definition of the hypothalamic GnRH pulse generator in mice. PNAS, 114(47), E10216-E10223. doi: 10.1073/pnas.1713897114

Journal - Research Article

Han, S. Y., Clarkson, J., Piet, R., & Herbison, A. E. (2018). Optical approaches for interrogating neural circuits controlling hormone secretion [Mini-review]. Endocrinology, 159(11), 3822-3833. doi: 10.1210/en.2018-00594

Journal - Research Other

Clarkson, J., Busby, E. R., Kirilov, M., Schütz, G., Sherwood, N. M., & Herbison, A. E. (2014). Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. Journal of Neuroscience, 34(46), 15297-15305. doi: 10.1523/JNEUROSCI.3061-14.2014

Journal - Research Article

Kirilov, M., Clarkson, J., Liu, X., Roa, J., Campos, P., Porteous, R., … Herbison, A. E. (2013). Dependence of fertility on kisspeptin—Gpr54 signalling at the GnRH neuron. Nature Communications, 4, 2492. doi: 10.1038/ncomms3492

Journal - Research Article

Clarkson, J. (2013). Effects of estradiol on kisspeptin neurons during puberty. Frontiers in Neuroendocrinology, 34, 120-131. doi: 10.1016/j.yfrne.2013.02.002

Journal - Research Article

Clarkson, J., d'Anglemont de Tassigny, X., Santos Moreno, A., Colledge, W. H., & Herbison, A. E. (2008). Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. Journal of Neuroscience, 28(35), 8691-8697. doi: 10.1523/JNEUROSCI.1775-08.2008

Journal - Research Article

Clarkson, J., & Herbison, A. E. (2006). Postnatal development of kisspeptin neurons in mouse hypothalamus: Sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology, 147(12), 5817-5825.

Journal - Research Article

Steyn, F. J., Wan, Y., Clarkson, J., Veldhuis, J. D., Herbison, A. E., & Chen, C. (2013). Development of methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice. Endocrinology, 154(12), 4939-4945. doi: 10.1210/en.2013-1502

Journal - Research Article

Clarkson, J., & Herbison, A. E. (2011). Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones. Journal of Neuroendocrinology, 23(4), 293-301. doi: 10.1111/j.1365-2826.2011.02107.x

Journal - Research Article

Clarkson, J., d'Anglemont de Tassigny, X., Colledge, W. H., Caraty, A., & Herbison, A. E. (2009). Distribution of kisspeptin neurones in the adult female mouse brain. Journal of Neuroendocrinology, 21(8), 673-682. doi: 10.1111/j.1365-2826.2009.01892.x

Journal - Research Article

Clarkson, J., & Herbison, A. E. (2016). Hypothalamic control of the male neonatal testosterone surge. Philosophical Transactions of the Royal Society B, 371(1688), 20150115. doi: 10.1098/rstb.2015.0115

Journal - Research Article

Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351

Journal - Research Article

Clarkson, J., Shamas, S., Mallinson, S., & Herbison, A. E. (2012). Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse. Journal of Neuroendocrinology, 24(6), 907-915. doi: 10.1111/j.1365-2826.2012.02294.x

Journal - Research Article

Clarkson, J., Boon, W. C., Simpson, E. R., & Herbison, A. E. (2009). Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology, 150(7), 3214-3220. doi: 10.1210/en.2008-1733

Journal - Research Article

Yeo, S.-H., Clarkson, J., & Herbison, A. E. (2014). Kisspeptin-Gpr54 signaling at the GnRH neuron is necessary for negative feedback regulation of luteinizing hormone secretion in female mice. Neuroendocrinology, 100, 191-197. doi: 10.1159/000368608

Journal - Research Article

Clarkson, J., Han, S.-K., Liu, X., Lee, K., & Herbison, A. E. (2010). Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Molecular & Cellular Endocrinology, 324, 45-50. doi: 10.1016/j.mce.2010.01.026

Journal - Research Article

Constantin, S., Piet, R., Iremonger, K., Yeo, S. H., Clarkson, J., Porteous, R., & Herbison, A. E. (2012). GnRH neuron firing and response to GABA in vitro depend on acute brain slice thickness and orientation. Endocrinology, 153(8), 3758-3769. doi: 10.1210/en.2012-1126

Journal - Research Article

Clarkson, J., & Herbison, A. E. (2009). Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. Journal of Neuroendocrinology, 21(4), 305-311. doi: 10.1111/j.1365-2826.2009.01835.x

Journal - Research Article

Kuo, J., Hamid, N., Bondar, G., Dewing, P., Clarkson, J., & Micevych, P. (2010). Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biology of Sex Differences, 1, 7. doi: 10.1186/2042-6410-1-7

Journal - Research Article

Clarkson, J., & Herbison, A. E. (2006). Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty. Molecular & Cellular Endocrinology, 254-255, 32-38.

Journal - Research Article

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