Division of Health Sciences

Aitken-Buck, H. M., Khaing, E. P., Lamberts, R. R., & Jones, P. P. (2023). Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling. Journal of Cellular & Molecular Medicine. Advance online publication. doi: 10.1111/jcmm.17949

Journal - Research Article

Gonano, L. A., Aitken-Buck, H. M., Chakraborty, A. D., Worthington, L. P. I., Cully, T. R., Lamberts, R. R., … Jones, P. P. (2022). Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G. Current Research in Physiology, 5, 171-178. doi: 10.1016/j.crphys.2022.03.004

Journal - Research Article

Ng, Y. H., Lamberts, R. R., Jones, P. P., Sammut, I. A., Diffee, G. M., Wilkins, G. T., & Baldi, J. C. (2022). Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Scientific Reports, 12(1), 16904. doi: 10.1038/s41598-022-20520-0

Journal - Research Article

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APP_swe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876

Journal - Research Article

Parveen, S., Cheah, P. H. S., Worthington, L. P. I., Smither, R. A., Munro, M. L., Bussey, C. T., Lamberts, R. R., & Jones, P. P. (2022). Depressed HCN4 function in the type 2 diabetic sinoatrial node. Molecular & Cellular Biochemistry. Advance online publication. doi: 10.1007/s11010-022-04635-6

Journal - Research Article

Satthenapalli, R., Lee, S., Bellae Papannarao, J., Hore, T. A., Chakraborty, A., Jones, P. P., Lamberts, R. R., & Katare, R. (2022). Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage. Stem Cell Research & Therapy, 13(1), 185. doi: 10.1186/s13287-022-02845-9

Journal - Research Article

Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021

Journal - Research Article

Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044

Journal - Research Article

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

Journal - Research Article

Ng, Y. H., Okolo, C. A., Erickson, J. R., Baldi, J. C., & Jones, P. P. (2021). Protein O-GlcNAcylation in the heart. Acta Physiologica, 233, e13696. doi: 10.1111/apha.13696

Journal - Research Article

Zhong, X., Guo, W., Wei, J., Tang, Y., Liu, Y., Zhang, J. Z., … Jones, P. P., … Wayne Chen, S. R. (2021). Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Bioscience Reports, 41, BSR20210209. doi: 10.1042/bsr20210209

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, E540-E547. doi: 10.1152/ajpendo.00202.2020

Journal - Research Article

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Journal - Research Article

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

Journal - Research Article

McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd₂ (hextrz)₄]⁴⁺ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061

Journal - Research Article

Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003

Journal - Research Article

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Journal - Research Article

Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562

Journal - Research Article

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Journal - Research Article

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Journal - Research Article

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Journal - Research Article

Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799

Journal - Research Article

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Journal - Research Article

Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036

Journal - Research Article

Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca²⁺ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528

Journal - Research Article

Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca²⁺ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389

Journal - Research Article

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Journal - Research Article

Liu, Y., Sun, B., Xiao, Z., Wang, R., Guo, W., Zhang, J. Z., … Jones, P. P., … Chen, S. R. W. (2015). Roles of the NH₂-terminal domains of cardiac ryanodine receptor in Ca²⁺ release activation and termination. Journal of Biological Chemistry, 290(12), 7736-7746. doi: 10.1074/jbc.M114.618827

Journal - Research Article

Mi, T., Xiao, Z., Guo, W., Tang, Y., Hiess, F., Xiao, J., … Zhang, J. Z., … Jones, P. P., & Chen, S. R. W. (2015). Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor. Biochemical Journal, 467(1), 177-190. doi: 10.1042/BJ20141263

Journal - Research Article

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Journal - Research Article

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Journal - Research Article

Chen, W., Wang, R., Chen, B., Zhong, X., Kong, H., Bai, Y., … Jones, P. P., … Chen, S. R. W. (2014). The ryanodine receptor store-sensing gate controls Ca²⁺ waves and Ca²⁺-triggered arrhythmias. Nature Medicine, 20(2), 184-192. doi: 10.1038/nm.3440

Journal - Research Article

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Journal - Research Article

Zhang, J. Z., McLay, J. C., & Jones, P. P. (2014). The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca²⁺ release due to an impaired ability to buffer store Ca²⁺. Journal of Molecular & Cellular Cardiology, 74, 22-31. doi: 10.1016/j.yjmcc.2014.04.019

Journal - Research Article

Bai, Y., Jones, P. P., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. W. (2013). Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research, 113, 517-526. doi: 10.1161/circresaha.113.301678

Journal - Research Article

Liu, Y., Kimlicka, L., Heiss, F., Tian, X., Wang, R., Zhang, L., Jones, P. P., … Chen, S. R. W. (2013). The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca²⁺ release and destabilizes the N-terminal domains. Biochemical Journal, 454(1), 123-131. doi: 10.1042/BJ20130594

Journal - Research Article

Beca, S., Helliwell, P. B., Simpson, J. A., Zhao, D., Farman, G. P., Jones, P. P., … Backx, P. H. (2011). Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca²⁺ release and cardiac contractility, independently of L-Type Ca²⁺ current. Circulation Research, 109(9), 1024-1030. doi: 10.1161/CIRCRESAHA.111.250464

Journal - Research Article

Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P. P., … Chen, S. R. W. (2011). Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14), 12202-12212. doi: 10.1074/jbc.M110.194316

Journal - Research Article

Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011). Carvedilol and its new analogs suppress arrhythmogenic store overload—induced Ca²⁺ release. Nature Medicine, 17, 1003-1009. doi: 10.1038/nm.2406

Journal - Research Article

Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., … Gollob, M. H. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666

Journal - Research Article

Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. A., Anfinogenova, Y., El-Yazbi, A., … Jones, P. P., … Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca²⁺ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300

Journal - Research Article

Jiang, D., Chen, W., Xiao, J., Wang, R., Kong, H., & Jones, P. P. (2008). Reduced threshold for luminal Ca²⁺ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. Journal of Biological Chemistry, 283(30), 20813-20820. doi: 10.1074/jbc.M801944200

Journal - Research Article

Jones, P. P., Jiang, D., Bolstad, J., Hunt, D. J., Zhang, L., Demaurex, N., & Chen, S. R. W. (2008). Endoplasmic reticulum Ca²⁺ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca²⁺ release. Biochemical Journal, 412, 171-178. doi: 10.1042/BJ20071287

Journal - Research Article

Jones, P. P., Meng, X., Xiao, B., Cai, S., Bolstad, J., Wagenknecht, T., … Chen, S. R. W. (2008). Localization of PKA phosphorylation site, Ser²⁰³⁰, in the three-dimensional structure of cardiac ryanodine receptor. Biochemical Journal, 410, 261-270. doi: 10.1042/BJ20071257

Journal - Research Article

Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008). Caffeine induces Ca²⁺ release by reducing the threshold for luminal Ca²⁺ activation of the ryanodine receptor. Biochemical Journal, 414, 441-452. doi: 10.1042/BJ20080489

Journal - Research Article

Hunt, D. J., Jones, P. P., Wang, R., Chen, W., Bolstad, J., Chen, K., … Chen, S. R. W. (2007). K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochemical Journal, 404, 431-438. doi: 10.1042/BJ20070135

Journal - Research Article

Xiao, B., Tian, X., Xie, W., Jones, P. P., Cai, S., Wang, X., … Chen, S. R. W. (2007). Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store overload-induced Ca²⁺ release. Journal of Biological Chemistry, 282(41), 30256-30264. doi: 10.1074/jbc.M703510200

Journal - Research Article

Xiao, J., Tian, X., Jones, P. P., Bolstad, J., Kong, H., Wang, R., … Chen, S. R. W. (2007). Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Journal of Biological Chemistry, 282(48), 34828-34838. doi: 10.1074/jbc.M707423200

Journal - Research Article

Jones, P. P., Bazzazi, H., Kargacin, G. J., & Colyer, J. (2006). Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca²⁺ transient. Biophysical Journal, 91, 433-443. doi: 10.1529/biophysj.106.083931

Journal - Research Article

Sibbles, E. T., Waddell, H. M. M., Mereacre, V., Jones, P. P., & Munro, M. L. (2022). The function and regulation of calsequestrin-2: Implications in calcium-mediated arrhythmias. Biophysical Reviews, 14, 329-352. doi: 10.1007/s12551-021-00914-6

Journal - Research Other

Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856

Journal - Research Other

Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569

Journal - Research Other

Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773

Journal - Research Other

Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca²⁺. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805

Journal - Research Other

Jones, P. P., & Braun, A. P. (2009). Store operated Ca²⁺ entry (SOCE) [Commentary]. Channels, 3(1), 1-2. doi: 10.4161/chan.3.1.7983

Journal - Research Other