Professor Christine Winterbourn

Winterbourn, C. (2024). Radicals and redox biology: A journey of discovery [Lifetime Achievement Award Lecture]. Free Radical Biology & Medicine, 224(Suppl. 1), P2. doi: 10.1016/j.freeradbiomed.2024.10.264 Conference Contribution - Published proceedings: Abstract

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2025). Redox proteomic analysis of H₂O₂ -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radical Biology & Medicine, 227, 221-232. doi: 10.1016/j.freeradbiomed.2024.10.314 Journal - Research Article

Winterbourn, C. C., Peskin, A., Kleffmann, T., Radi, R., & Pace, P. E. (2023). Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide. PNAS, 120(18), e2221047120. doi: 10.1073/pnas.2221047120 Journal - Research Article

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., … Winterbourn, C. (2022). Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology [Expert recommendation]. Nature Reviews Molecular Cell Biology, 23, 499-515. doi: 10.1038/s41580-022-00456-z Journal - Research Other

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Dick, M. J., … Winterbourn, C. C., … Halliwell, B. (2022). Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nature Metabolism, 4, 651-662. doi: 10.1038/s42255-022-00591-z Journal - Research Other

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry, 1-2, 100002. doi: 10.1016/j.rbc.2023.100002 Journal - Research Article

Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183 Journal - Research Other

Queiroz, R. F., Stanley, C. P., Wolhuter, K., Kong, S. M. Y., Rajivan, R., McKinnon, N., … Winterbourn, C. C., … Stocker, R. (2021). Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation. Nature Communications, 12, 6626. doi: 10.1038/s41467-021-26991-5 Journal - Research Article

Königstorfer, A., Ashby, L. V., Bollar, G. E., Billiot, C. E., Gray, M. J., Jakob, U., Hampton, M. B., & Winterbourn, C. C. (2021). Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease, 79, ftaa079. doi: 10.1093/femspd/ftaa079 Journal - Research Article

Peskin, A. V., Meotti, F. C., Kean, K. M., Göbl, C., Peixoto, A. S., Pace, P. E., … Winterbourn, C. C. (2021). Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2. Journal of Biological Chemistry, 296, 100494. doi: 10.1016/j.jbc.2021.100494 Journal - Research Article

Parker, H. A., Jones, H. M., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021). Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants, 10, 1791. doi: 10.3390/antiox10111791 Journal - Research Article

Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., … Eccles, M. R., & Winterbourn, C. C. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology, 46, 102090. doi: 10.1016/j.redox.2021.102090 Journal - Research Article

Peskin, A. V., & Winterbourn, C. C. (2021). The enigma of 2-Cys peroxiredoxins: What are their roles? Biochemistry (Moscow), 86(1), 84-91. doi: 10.1134/S0006297921010089 Journal - Research Article

Mohammad, A., Saini, R. V., Kumar, R., Sharma, D., Saini, N. K., Gupta, A., … Winterbourn, C. C., & Saini, A. K. (2020). A curious case of cysteines in human peroxiredoxin I. Redox Biology, 37, 101738. doi: 10.1016/j.redox.2020.101738 Journal - Research Article

Winterbourn, C. C. (2020). Biological chemistry of superoxide radicals. ChemTexts, 6, 7. doi: 10.1007/s40828-019-0101-8 Journal - Research Article

Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033 Journal - Research Other

Winterbourn, C. C. (2020). Hydrogen peroxide reactivity and specificity in thiol-based cell signalling. Biochemical Society Transactions, 48, 745-754. doi: 10.1042/bst20190049 Journal - Research Other

O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092 Journal - Research Article

Peskin, A. V., Meotti, F. C., de Souza, L. F., Anderson, R. F., Winterbourn, C. C., & Salvador, A. (2020). Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2. Free Radical Biology & Medicine, 158, 115-125. doi: 10.1016/j.freeradbiomed.2020.07.007 Journal - Research Article

Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry, 295(36), 12697-12705. doi: 10.1074/jbc.RA120.014504 Journal - Research Article

Dagnell, M., Cheng, Q., Rizvi, S. H. M., Pace, P. E., Boivin, B., Winterbourn, C. C., & Arnér, E. S. J. (2019). Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades. Journal of Biological Chemistry, 294(33), 12330-12338. doi: 10.1074/jbc.RA119.009001 Journal - Research Article

Kumar, R., Mohammad, A., Saini, R. V., Chahal, A., Wong, C.-M., Sharma, D., … Winterbourn, C. C., & Saini, A. K. (2019). Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast. Free Radical Biology & Medicine, 145, 321-329. doi: 10.1016/j.freeradbiomed.2019.09.034 Journal - Research Article

Peskin, A. V., Pace, P. E., & Winterbourn, C. C. (2019). Enhanced hyperoxidation of peroxiredoxin 2 and peroxiredoxin 3 in the presence of bicarbonate/CO₂. Free Radical Biology & Medicine, 145, 1-7. doi: 10.1016/j.freeradbiomed.2019.09.010 Journal - Research Article

de Souza, L. F., Pearson, A. G., Pace, P. E., Dafre, A. L., Hampton, M. B., Meotti, F. C., & Winterbourn, C. C. (2019). Peroxiredoxin expression and redox status in neutrophils and HL-60 cells. Free Radical Biology & Medicine, 135, 227-234. doi: 10.1016/j.freeradbiomed.2019.03.007 Journal - Research Article

Winterbourn, C. C. (2019). Reactive oxygen species in biological systems. In E. Niki (Ed.), Food chemistry, function and analysis. (pp. 98-117). London, UK: Royal Society of Chemistry. doi: 10.1039/9781788016216-00098 Chapter in Book - Research

Winterbourn, C. C. (2019). Regulation of intracellular glutathione. Redox Biology, 22, 101086. doi: 10.1016/j.redox.2018.101086 Journal - Research Other

Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038 Journal - Research Article

Winterbourn, C. C., & Cheah, F.-C. (2018). Favism and glucose-6-phosphate dehydrogenase deficiency. New England Journal of Medicine, 378(11), 1067-1068. doi: 10.1056/NEJMc1801271 Journal - Research Other

Albrett, A. M., Ashby, L. V., Dickerhof, N., Kettle, A. J., & Winterbourn, C. C. (2018). Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe. Journal of Biological Chemistry, 293(40), 15715-15724. doi: 10.1074/jbc.RA118.004789 Journal - Research Article

Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039 Journal - Research Article

Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407 Journal - Research Article

Das, A. B., Sadowska-Bartosz, I., Königstorfer, A., Kettle, A. J., & Winterbourn, C. C. (2018). Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast. Free Radical Biology & Medicine, 116, 114-122. doi: 10.1016/j.freeradbiomed.2018.01.001 Journal - Research Article

Peskin, A. V., & Winterbourn, C. C. (2017). Assay of superoxide dismutase activity in a plate assay using WST-1. Free Radical Biology & Medicine, 103, 188-191. doi: 10.1016/j.freeradbiomed.2016.12.033 Journal - Research Article

Winterbourn, C. C. (2017). Biological production, detection and fate of hydrogen peroxide. Antioxidants & Redox Signaling, 29(6), 541-551. doi: 10.1089/ars.2017.7425 Journal - Research Other

Green, J. N., Chapman, A. L. P., Bishop, C. J., Winterbourn, C. C., & Kettle, A. J. (2017). Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide. Free Radical Biology & Medicine, 113, 363-371. doi: 10.1016/j.freeradbiomed.2017.10.343 Journal - Research Article

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745 Journal - Research Article

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798 Journal - Research Article

Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995 Journal - Research Article

Poynton, R. A., Peskin, A. V., Haynes, A. C., Lowther, W. T., Hampton, M. B., & Winterbourn, C. C. (2016). Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochemical Journal, 473, 411-421. doi: 10.1042/bj20150572 Journal - Research Article

Winterbourn, C. C., & Peskin, A. V. (2016). Kinetic approaches to measuring peroxiredoxin reactivity. Molecules & Cells, 39(1), 26-30. doi: 10.14348/molcells.2016.2325 Journal - Research Article

Kettle, A. J., & Winterbourn, C. C. (2016). Myeloperoxidase: Structure and function of the green heme peroxidase of neutrophils. In E. Raven & B. Dunford (Eds.), Heme peroxidases. (pp. 272-308). Cambridge, UK: Royal Society of Chemistry. doi: 10.1039/9781782622628-00272 Chapter in Book - Research

Bekeschus, S., Winterbourn, C. C., Kolata, J., Masur, K., Hasse, S., Bröker, B. M., & Parker, H. A. (2016). Neutrophil extracellular trap formation is elicited in response to cold physical plasma. Journal of Leukocyte Biology, 100(4), 791-799. doi: 10.1189/jlb.3A0415-165RR Journal - Research Article

Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442 Journal - Research Other

Winterbourn, C. C. (2016). Revisiting the reactions of superoxide with glutathione and other thiols. Archives of Biochemistry & Biophysics, 595, 68-71. doi: 10.1016/j.abb.2015.11.028 Journal - Research Article

Bayer, S. B., Hampton, M. B., & Winterbourn, C. C. (2015). Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion, 55(8), 1909-1918. doi: 10.1111/trf.13039 Journal - Research Article

Winterbourn, C. C. (2015). Are free radicals involved in thiol-based redox signaling? Free Radical Biology & Medicine, 80, 164-170. doi: 10.1016/j.freeradbiomed.2014.08.017 Journal - Research Other

Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422 Journal - Research Article

Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19 Chapter in Book - Research

Ronsein, G. E., Winterbourn, C. C., Di Mascio, P., & Kettle, A. J. (2014). Cross-linking methionine and amine residues with reactive halogen species. Free Radical Biology & Medicine, 70, 278-287. doi: 10.1016/j.freeradbiomed.2014.01.023 Journal - Research Article

Kasperkiewicz, P., Poreba, M., Snipas, S. J., Parker, H., Winterbourn, C. C., Salvesen, G. S., & Drag, M. (2014). Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. PNAS, 111(7), 2518-2523. doi: 10.1073/pnas.1318548111 Journal - Research Article

Nedoboy, P., Morgan, P. E., Mocatta, T. J., Richards, A. M., Winterbourn, C. C., & Davies, M. J. (2014). High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research, 48(10), 1256-1266. doi: 10.3109/10715762.2014.947286 Journal - Research Article

Bekeschus, S., Kolata, J., Winterbourn, C., Kramer, A., Turner, R., Weltmann, K. D., … Masur, K. (2014). Hydrogen peroxide: A central player in physical plasma-induced oxidative stress in human blood cells. Free Radical Research, 48(5), 542-549. doi: 10.3109/10715762.2014.892937 Journal - Research Article

Cheah, F.-C., Peskin, A. V., Wong, F.-L., Ithnin, A., Othman, A., & Winterbourn, C. C. (2014). Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants. FASEB Journal, 28(7), 3205-3210. doi: 10.1096/fj.14-250050 Journal - Research Article

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025 Journal - Research Article

Kettle, A. J., Turner, R., Gangell, C. L., Harwood, D. T., Khalilova, I. S., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2014). Oxidation contributes to low glutathione in the airways of children with cystic fibrosis. European Respiratory Journal, 44, 122-129. doi: 10.1183/09031936.00170213 Journal - Research Article

Green, J. N., Kettle, A. J., & Winterbourn, C. C. (2014). Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radical Biology & Medicine, 77, 49-56. doi: 10.1016/j.freeradbiomed.2014.08.013 Journal - Research Article

Das, A. B., Nauser, T., Koppenol, W. H., Kettle, A. J., Winterbourn, C. C., & Nagy, P. (2014). Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition. Free Radical Biology & Medicine, 70, 86-95. doi: 10.1016/j.freeradbiomed.2014.02.006 Journal - Research Article

Schwarzländer, M., Wagner, S., Ermakova, Y. G., Belousov, V. V., Radi, R., Beckman, J. S., … Winterbourn, C. C., … Murphy, M. P. (2014). The 'mitoflash' probe cpYFP does not respond to superoxide [Brief communication arising]. Nature, 514(7523), E12-E14. doi: 10.1038/nature13858 Journal - Research Article

Winterbourn, C. C. (2014). The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells. Biochimica et Biophysica Acta: General Subjects, 1840(2), 730-738. doi: 10.1016/j.bbagen.2013.05.004 Journal - Research Article

Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970 Journal - Research Article

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881 Journal - Research Article

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030 Journal - Research Article

Klebanoff, S. J., Kettle, A. J., Rosen, H., Winterbourn, C. C., & Nauseef, W. M. (2013). Myeloperoxidase: A front-line defender against phagocytosed microorganisms. Journal of Leukocyte Biology, 93(2), 185-198. doi: 10.1189/jlb.0712349 Journal - Research Article

Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB Journal, 27(8), 3315-3322. doi: 10.1096/fj.13-227298 Journal - Research Article

Parker, H., & Winterbourn, C. C. (2013). Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps. Frontiers in Immunology, 3, 424. doi: 10.3389/fimmu.2012.00424 Journal - Research Article

Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2013). Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biology & Medicine, 58, 109-117. doi: 10.1016/j.freeradbiomed.2013.01.021 Journal - Research Article

Winterbourn, C. C., & Kettle, A. J. (2013). Redox reactions and microbial killing in the neutrophil phagosome. Antioxidants & Redox Signaling, 18(6), 642-660. doi: 10.1089/ars.2012.4827 Journal - Research Article

Winterbourn, C. C. (2013). The biological chemistry of hydrogen peroxide. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen peroxide and cell signaling: Part C (Vol. 528). (pp. 3-25). Waltham, MA: Academic Press. doi: 10.1016/B978-0-12-405881-1.00001-X Chapter in Book - Research

Kelso, G. F., Maroz, A., Cochemé, H. M., Logan, A., Prime, T. A., Peskin, A. V., Winterbourn, C. C., James, A. M., … Brooker, S., Porteous, C. M., … Smith, R. A. J. (2012). A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chemistry & Biology, 19(10), 1237-1246. doi: 10.1016/j.chembiol.2012.08.005 Journal - Research Article

Winterbourn, C. C. (2012). Biological chemistry of reactive oxygen species. In C. Chatgilialoglu & A. Studer (Eds.), Encyclopedia of radicals in chemistry, biology and materials. (pp. 1259-1281). Chichester, UK: Wiley. doi: 10.1002/9781119953678.rad077 Chapter in Book - Research

Nagy, P., Lechte, T. P., Das, A. B., & Winterbourn, C. C. (2012). Conjugation of glutathione to oxidized tyrosine residues in peptides and proteins. Journal of Biological Chemistry, 287(31), 26068-26076. doi: 10.1074/jbc.M112.371690 Journal - Research Article

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. Journal of Leukocyte Biology, 91(3), 369-376. doi: 10.1189/jlb.0711387 Journal - Research Article

Stacey, M. M., Vissers, M. C., & Winterbourn, C. C. (2012). Oxidation of 2-Cys peroxiredoxins in human endothelial cells by hydrogen peroxide, hypochlorous acid and chloramines. Antioxidants & Redox Signaling, 17(3), 411-421. doi: 10.1089/ars.2011.4348 Journal - Research Article

Stacey, M. M., Cuddihy, S. L., Hampton, M. B., & Winterbourn, C. C. (2012). Protein thiol oxidation and formation of S-glutathionylated cyclophilin A in cells exposed to chloramines and hypochlorous acid. Archives of Biochemistry & Biophysics, 527(1), 45-54. doi: 10.1016/j.abb.2012.07.011 Journal - Research Article

Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601 Journal - Research Article

Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2011). Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling. Antioxidants & Redox Signaling, 15(1), 167-174. doi: 10.1089/ars.2010.3843 Journal - Research Article

Harwood, D. T., Darlow, B. A., Cheah, F. C., McNeill, N., Graham, P., & Winterbourn, C. C. (2011). Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: Association with bacterial infection. Pediatric Research, 69(1), 28-33. doi: 10.1203/PDR.0b013e3181ff2378 Journal - Research Article

Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355 Journal - Research Article

Parker, A., Cuddihy, S. L., Son, T. G., Vissers, M. C. M., & Winterbourn, C. C. (2011). Roles of superoxide and myeloperoxidase in ascorbate oxidation in stimulated neutrophils and H₂O₂-treated HL60 cells. Free Radical Biology & Medicine, 51(7), 1399-1405. doi: 10.1016/j.freeradbiomed.2011.06.029 Journal - Research Article

Kettle, A. J., Maroz, A., Woodroffe, G., Winterbourn, C. C., & Anderson, R. F. (2011). Spectral and kinetic evidence for reaction of superoxide with compound I of myeloperoxidase. Free Radical Biology & Medicine, 51(12), 2190-2194. doi: 10.1016/j.freeradbiomed.2011.09.019 Journal - Research Article

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., … Winterbourn, C. C. (2011). Unraveling the biological roles of reactive oxygen species. Cell Metabolism, 13(4), 361-366. doi: 10.1016/j.cmet.2011.03.010 Journal - Research Article

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028 Journal - Research Article

Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044 Journal - Research Article

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0 Chapter in Book - Research

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541 Journal - Research Article

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2010). Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide. Free Radical Biology & Medicine, 49, 792-799. doi: 10.1016/j.freeradbiomed.2010.05.033 Journal - Research Article

Nagy, P., & Winterbourn, C. C. (2010). Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfides. Chemical Research in Toxicology, 23(10), 1541-1543. doi: 10.1021/tx100266a Journal - Research Article

Das, A. B., Nagy, P., Abbott, H. F., Winterbourn, C. C., & Kettle, A. J. (2010). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology & Medicine, 48, 1540-1547. doi: 10.1016/j.freeradbiomed.2010.02.039 Journal - Research Article

Nagy, P., & Winterbourn, C. C. (2010). Redox chemistry of biological thiols. In J. C. Fishbein (Ed.), Advances in molecular toxicology (Vol. 4). (pp. 223-266). Amsterdam, The Netherlands: Elsevier. Chapter in Book - Research

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313-321. doi: 10.1042/BJ20101156 Journal - Research Article

Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2010). Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochemical Journal, 425(1), 285-293. doi: 10.1042/BJ20090776 Journal - Research Article

Stacey, M. M., Peskin, A. V., Vissers, M. C., & Winterbourn, C. C. (2009). Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2. Free Radical Biology & Medicine, 47(10), 1468-1476. doi: 10.1016/j.freeradbiomed.2009.08.022 Journal - Research Article

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092 Journal - Research Article

Nagy, P., Jameson, G. N. L., & Winterbourn, C. C. (2009). Kinetics and mechanisms of the reaction of hypothiocyanous acid with 5-thio-2-nitrobenzoic acid and reduced glutathione. Chemical Research in Toxicology, 22(11), 1833-1840. doi: 10.1021/tx900249d Journal - Research Article

Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242 Journal - Research Article

Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009). Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry, 48(42), 10175-10182. doi: 10.1021/bi901266w Journal - Research Article

Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23 Journal - Research Article

Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g Journal - Research Article

Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j.febslet.2009.02.018 Journal - Research Article

Harwood, D. T., Kettle, A. J., Brennan, S., & Winterbourn, C. C. (2009). Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877, 3393-3399. doi: 10.1016/j.jchromb.2009.04.018 Journal - Research Article

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009). Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer. Journal of Biological Chemistry, 284(22), 14723-14733. doi: 10.1074/jbc.M809396200 Journal - Research Article

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31 Journal - Research Article

Cuddihy, S. L., Parker, A., Harwood, D. T., Vissers, M. C. M., & Winterbourn, C. C. (2008). Ascorbate interacts with reduced glutathione to scavenge phenoxyl radicals in HL60 cells. Free Radical Biology & Medicine, 44(8), 1637-1644. doi: 10.1016/j.freeradbiomed.2008.01.021 Journal - Research Article

Fraser, M., Bennet, L., Van Zijl, P. L., Mocatta, T. J., Williams, C. E., Gluckman, P. D., Winterbourn, C. C., & Gunn, A. J. (2008). Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep. Journal of Neurochemistry, 105(6), 2214-2223. doi: 10.1111/j.1471-4159.2008.05313.x Journal - Research Article

Harwood, D. T., Nimmo, S. L., Kettle, A. J., Winterbourn, C. C., & Ashby, M. T. (2008). Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid. Chemical Research in Toxicology, 21(5), 1011-1016. Journal - Research Article

Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2008). Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxidants & Redox Signaling, 10(9), 1621-1629. doi: 10.1089/ars.2008.2081 Journal - Research Article

Winterbourn, C. C. (2008). Reconciling the chemistry and biology of reactive oxygen species. Nature Chemical Biology, 4(5), 278-286. doi: 10.1038/nchembio.85 Journal - Research Article

Winterbourn, C. C., & Hampton, M. B. (2008). Thiol chemistry and specificity in redox signaling. Free Radical Biology & Medicine, 45(5), 549-561. doi: 10.1016/j.freeradbiomed.2008.05.004 Journal - Research Article

Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Neutrophil methods and protocols. (pp. 319-332). Totowa, USA: Humana Press. Chapter in Book - Research

Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617. Journal - Research Article

Mocatta, T. J., Pilbrow, A. P., Cameron, V. A., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. JACC, 49(20), 1993-2000. doi: 10.1016/j.jacc.2007.02.040 Journal - Research Article

Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897. Journal - Research Article

Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H₂O₂ is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892. Journal - Research Article

Åkerström, B., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2007). The lipocalin α₁-microglobulin has radical scavenging activity. Journal of Biological Chemistry, 282(43), 31493-31503. Journal - Research Article

Cameron, V. A., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension, 47(6), 1155-1161. Journal - Research Article

Midwinter, R. G., Cheah, F.-C., Moskovitz, J., Vissers, M. C., & Winterbourn, C. C. (2006). IκB is a sensitive target for oxidation by cell-permeable chloramines: Inhibition of NF-κB activity by glycine chloramine through methionine oxidation. Biochemical Journal, 396, 71-78. Journal - Research Article

van Dalen, C. J., Winterbourn, C. C., & Kettle, A. J. (2006). Mechanism of nitrite oxidation by eosinophil peroxidase: Implications for oxidant production and nitration by eosinophils. Biochemical Journal, 394, 707-713. Journal - Research Article

Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869. Journal - Research Article

Harwood, D. T., Kettle, A. J., & Winterbourn, C. C. (2006). Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method. Biochemical Journal, 399, 161-168. Journal - Research Article

Peskin, A. V., & Winterbourn, C. C. (2006). Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde-3-phosphate dehydrogenase. Free Radical Biology & Medicine, 40, 45-53. Journal - Research Article

Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-_KB activation. Journal of Leukocyte Biology, 77, 432-437. Journal - Research Article

Kettle, A. J., & Winterbourn, C. C. (2005). Do neutrophils produce ozone? An appraisal of current evidence. BioFactors, 24, 41-45. Journal - Research Article

Cheah, F. C., Winterbourn, C. C., Darlow, B. A., Mocatta, T. J., & Vissers, M. C. M. (2005). Nuclear factor κB activation in pulmonary leukocytes from infants with hyaline membrane disease: Associations with chorioamnionitis and Ureaplasma urealyticum colonization. Pediatric Research, 57(5), 616-623. doi: 10.1203/01.PDR.0000156209.37627.82 Journal - Research Article

Kalogerakis, G., Baker, A. M., Christov, S., Rowley, K. G., Dwyer, K., Winterbourn, C., … Jenkins, A. J. (2005). Oxidative stress and high-density lipoprotein function in type 1 diabetes and end-stage renal disease. Clinical Science, 108, 497-506. Journal - Research Article

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2005). Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochemical Journal, 390(3), 785-795. Journal - Research Article

Ellison, V. J., Mocatta, T. J., Winterbourn, C. C., Darlow, B. A., Volpe, J. J., & Inder, T. E. (2005). The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatric Research, 57(2), 282-286. Journal - Research Article

Darlow, B. A., Buss, H., McGill, F., Fletcher, L., Graham, P., & Winterbourn, C. C. (2005). Vitamin C supplementation in very preterm infants: A randomised controlled trial. Archives of Disease in Childhood: Fetal & Neonatal Edition, 90(2), F117-F122. doi: 10.1136/adc.2004.056440 Journal - Research Article

Midwinter, R. G., Peskin, A. V., Vissers, M. C. M., & Winterbourn, C. C. (2004). Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor. Journal of Biological Chemistry, 279(31), 32205-32211. Journal - Research Article

Munday, R., Munday, C. M., & Winterbourn, C. C. (2004). Inhibition of copper-catalyzed cysteine oxidation by nanomolar concentrations of iron salts. Free Radical Biology & Medicine, 36(6), 757-764. Elsevier. Journal - Research Article

Winterbourn, C. C., & Kettle, A. J. (2004). Reactions of superoxide with myeloperoxidase and its products. Japanese Journal of Infectious Diseases, 57, S31-S33. Journal - Research Article

Winterbourn, C. C., Parsons-Mair, H. N., Gebicki, S., Gebicki, J. M., & Davies, M. J. (2004). Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides. Biochemical Journal, 381, 241-248. Journal - Research Article

Kettle, A. J., Clark, B. M., & Winterbourn, C. C. (2004). Superoxide converts indigo carmine to isatin sulfonic acid. Journal of Biological Chemistry, 279(18), 18521-18525. Journal - Research Article

Mocatta, T., Winterbourn, C. C., Inder, T. E., & Darlow, B. A. (2004). The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma. Free Radical Research, 38(2), 185-191. Journal - Research Article

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: Association with adverse respiratory outcome. Pediatric Research, 53(3), 455-462. Journal - Research Article

Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40. Journal - Research Article

Winterbourn, C. C., Bonham, M. J. D., Buss, I. H., Abu-Zidan, F. M., & Windsor, J. A. (2003). Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis. Pancreatology, 3, 375-382. Journal - Research Article

Peskin, A. V., & Winterbourn, C. C. (2003). Histamine chloramine reactivity with thiol compounds, ascorbate, and methionine and with intracellular glutathione. Free Radical Biology & Medicine, 35(10), 1252-1260. Journal - Research Article

Winterbourn, C. C. (2003). Radical scavenging by thiols: Biological significance and implications for redox signaling and antioxidant defense. In C. Gitler & A. Danon (Eds.), Cellular implications of redox signaling. (pp. 175-190). London: Imperial College Press. Chapter in Book - Research

Winterbourn, C. C., & Kettle, A. J. (2003). Radical-radical reactions of superoxide: A potential route to toxicity. Biochemical & Biophysical Research Communications, 305, 729-736. Journal - Research Article

Winterbourn, C. C. (2002). Biomarkers to probe oxidative damage by myeloperoxidase. Toxicology, 181(2), 223-227. Journal - Research Article

Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762. Journal - Research Article

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2002). Detection of oxidant-sensitive thiol proteins by fluorescent labeling and two dimensional electrophoresis. Proteomics, 2, 1261-1266. Journal - Research Article

Inder, T. E., Mocatta, T., Darlow, B. A., Spencer, C., Volpe, J. J., & Winterbourn, C. C. (2002). Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury. Pediatric Research, 52(2), 213-218. Journal - Research Article

Hampton, M. B., Stamenkovic, G., & Winterbourn, C. C. (2002). Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Letters, 517, 229-232. Journal - Research Article

Inder, T. E., Mocatta, T., Darlow, B. A., Spencer, C. A., Senthilmohan, R., Winterbourn, C. C., & Volpe, J. J. (2002). Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia. Journal of Pediatrics, 140(5), 617-621. Journal - Research Article

Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781. Journal - Research Article

Buss, I. H., Winterbourn, C. C., & Armstrong, D. A. (2002). Protein carbonyl measurement by ELISA. In Free Radicals and Antioxidants Protocols, Volume 186, Totowa. (pp. 123-128). Gainsville, Florida: The Humana Press Inc. Chapter in Book - Research

Hampton, M. B., & Winterbourn, C. C. (2002). Redox regulation of neutrophil function. Antioxidants & Redox Signaling, 4(1), 1-3. Journal - Research Article

Pullar, J., Winterbourn, C. C., & Vissers, M. C. M. (2002). The effect of hypochlorous acid on the expression of adhesion molecules and activation of NF-_κ in cultured human endothelial cells. Antioxidants & Redox Signaling, 4(1), 5-15. Journal - Research Article

Winterbourn, C. C., Peskin, A. V., & Parsons-Mair, H. N. (2002). Thiol oxidase activity of copper, zinc superoxide dismutase. Journal of Biological Chemistry, 277(3), 1906-1911. Journal - Research Article

Kettle, A. J., & Winterbourn, C. C. (2001). A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry, 40, 10204-10212. Journal - Research Article

Vissers, M. C. M., Carr, A. C., & Winterbourn, C. C. (2001). Fatty acid chlorohydrins and bromohydrins are cytotoxic to human endothelial cells. Redox Report, 6, 49-55. doi: 10.1179/135100001101536030 Journal - Research Article

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001). Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide. Journal of Biological Chemistry, 276(25), 22120-22125. doi: 10.1074/jbc.M102088200 Journal - Research Article

Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001). Hypochlorous acid stimulation of the MAP-kinase pathway enhances cell survival. Archives of Biochemistry & Biophysics, 394(1), 13-20. doi: 10.1006/abbi.2001.2530 Journal - Research Article

Peskin, A. V., & Winterbourn, C. C. (2001). Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate. Free Radical Biology & Medicine, 30, 572-579. Journal - Research Article

Silvers, K. M., Sluis, K. B., Darlow, B. A., McGill, F. M., Stocker, R., & Winterbourn, C. C. (2001). Limiting light-induced lipid peroxidation and vitamin loss in infant parenteral nutrition by adding multivitamin preparations to Intralipid. Acta Paediatrica, 90, 242-249. Journal - Research Article

Silvers, K. M., Darlow, B. A., & Winterbourn, C. C. (2001). Lipid peroxide and hydrogen peroxide formation in parenteral nutrition solutions containing multivitamins. Journal of Parenteral & Enteral Nutrition, 25, 14-17. Journal - Research Article

Buss, I. H., McGill, F. M., Darlow, B. A., & Winterbourn, C. C. (2001). Vitamin C is reduced in human milk after storage. Acta Paediatrica, 90, 813-815. Journal - Research Article

Peskin, A., & Winterbourn, C. C. (2000). A microtiter plate assay for superoxide dismutase using a water soluble tetrazolium salt (WST-1). Clinica Chimica Acta, 293, 157-166. Journal - Research Article

Winterbourn, C. C., & Kettle, A. J. (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biology & Medicine, 29, 403-409. Journal - Research Article

Chapman, A. L. P., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2000). Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins. Archives of Biochemistry & Biophysics, 377(1), 95-100. Journal - Research Article

Buss, I. H., Darlow, B. A., & Winterbourn, C. C. (2000). Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants. Pediatric Research, 47, 640-645. Journal - Research Article

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2000). Living with a killer: The effects of hypochlorous acid on mammalian cells. IUBMB Life, 50, 259-266. Journal - Research Article

Winterbourn, C. C., Vissers, M. C., & Kettle, A. J. (2000). Myeloperoxidase. Current Opinion in Hematology, 7, 53-58. [Review]. Journal - Research Other

van Dalen, C. J., Winterbourn, C. C., Senthilmohan, R., & Kettle, A. J. (2000). Nitrite as a substrate and inhibitor of myeloperoxidase: Implications for nitration and hypochlorous acid production at sites of inflammation. Journal of Biological Chemistry, 275, 11638-11644. Journal - Research Article

Winterbourn, C. C., Buss, I. H., Chan, T., Plank, L. D., Clark, M. A., & Windsor, J. A. (2000). Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients. Critical Care Medicine, 28, 143-149. Journal - Research Article

Winterbourn, C. C., Chan, T., Buss, H., Inder, T. E., Mogridge, N., & Darlow, B. A. (2000). Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: Associations with chronic lung disease and retinopathy and effects of selenium supplementation. Pediatric Research, 48, 84-90. Journal - Research Article

Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer. Chapter in Book - Research

Darlow, B. A., Winterbourn, C. C., Inder, T. E., Graham, P. J., Harding, J. E., Weston, P. J., Austin, N. C., Elder, D. E., Mogridge, N., Buss, I. H., & Sluis, K. B. (2000). The effect of selenium supplementation on outcome in very low birth weight infants: A randomized controlled trial. Journal of Pediatrics, 136, 473-480. Journal - Research Article

Bonham, M. J. D., Abu-Zidan, F. M., Simovic, M. O., Sluis, K. B., Winterbourn, C. C., Wilkinson, A., & Windsor, J. A. (1999). Early ascorbic acid depletion is related to the severity of acute pancreatitis. British Journal of Surgery, 86, 1296-1301. Journal - Research Article

Pullar, J. M., Winterbourn, C. C., & Vissers, M. C. M. (1999). Loss of GSH and thiol enzymes in endothelial cellls exposed to sublethal concentrations of hypochlorous acid. American Journal of Physiology: Heart & Circulatory Physiology, 277, H1505-H1512. Journal - Research Article

Hampton, M. B., & Winterbourn, C. C. (1999). Methods for quantifying phagocytosis and bacterial killing by human neutrophils. Journal of Immunological Methods, 232, 15-22. Journal - Research Article

Winterbourn, C. C., & Buss, H. (1999). Protein Carbonyl Measurement by Enzyme-Linked Immunosorbent Assay. Methods in Enzymology, 300, 106-111. Journal - Research Article

Winterbourn, C. C., & Metodiewa, D. (1999). Reactivity of biologically relevant thiol compounds with superoxide and hydrogen peroxide. Free Radical Biology & Medicine, 27, 322-328. Journal - Research Article

Abu-Zidan, F. M., Winterbourn, C. C., Bonham, M. J. D., Simovic, M. O., Buss, H., & Windsor, J. A. (1999). Small bowel ischaemia-reperfusion increases plasma concentrations of oxidised proteins in rats. European Journal of Surgery, 165, 383-389. Journal - Research Article

Vollebregt, M., Hampton, M. B., & Winterbourn, C. C. (1998). Activation of NF-KB in human neutrophils during phagocytosis of bacteria independently of oxidant generation. FEBS Letters, 432, 40-44. Journal - Research Article

Carr, A., van den Berg, J. J. M., & Winterbourn, C. C. (1998). Differential reactivities of hypochlorous and hypobromous acids with purified E.coli phospholipid: formation of haloamines and halohydrins. Biochimica et Biophysica Acta: General Subjects, 1392, 254-264. Journal - Research Article

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017. Journal - Research Article

Silvers, K. M., Darlow, B. A., & Winterbourn, C. C. (1998). Pharmacological levels of heparin do not destabilize neonatal parenteral nutrition. Journal of Parenteral & Enteral Nutrition, 22, 311-314. Journal - Research Article

Inder, T. E., Graham, P. J., Winterbourn, C. C., Austin, N. C., & Darlow, B. A. (1998). Plasma vitamin A levels in the very low birthweight infant - relationship to respiratory outcome. Early Human Development, 52, 155-168. Journal - Research Article

Domigan, N. M., Carr, A. C., Lewis, J. G., Elder, P. A., & Winterbourn, C. C. (1997). A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury. Redox Report, 3(2), 111-117. Journal - Research Article

Winterbourn, C. C., & Brennan, S. O. (1997). Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid. Biochemical Journal, 326(1), 87-92. Journal - Research Article

Darlow, B. A., Sluis, K. B., Inder, T. E., & Winterbourn, C. C. (1997). Endotracheal suctioning of the neonate: comparison of two methods as a source of mucus material for research. Pediatric Pulmonology, 23(3), 217-221. Journal - Research Article

Kettle, A. J., Gedye, C. A., & Winterbourn, C. C. (1997). Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochemical Journal, 321(2), 503-508. Journal - Research Article

Carr, A. C., Vissers, M. C., Domigan, N. M., & Winterbourn, C. C. (1997). Modification of red cell membrane lipids by hypochlorus acid and haemolysis by preformed lipid chlorohydrins. Redox Report, 3, 263-271. Journal - Research Article

Winterbourn, C. C., Pichorner, H., & Kettle, A. J. (1997). Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils. Archives of Biochemistry & Biophysics, 338(1), 15-21. Journal - Research Article

Kettle, A. J., & Winterbourn, C. C. (1997). Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Report, 3(1), 3-15. doi: 10.1080/13510002.1997.11747085 Journal - Research Other

Carr, A., Winterbourn, C. C., Blunt, J. W. W., Phillips, A., & Abell, A. D. (1997). Nuclear magnetic resonance characterization of 6a-chloro-5b-cholestane-3b, 5-diol formed from the reaction of hypochlorous acid with cholesterol. Lipids, 32(4), 363-367. Journal - Research Article

Carr, A., & Winterbourn, C. C. (1997). Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid. Biochemical Journal, 327(1), 275-281. Journal - Research Article

Buss, H., Chan, T. P., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997). Protein carbonyl measurement by a sensitive Elisa method. Free Radical Biology & Medicine, 23(3), 361-366. Journal - Research Article

Van Dalen, C. J., Whitehead, M. W., Winterbourn, C. C., & Kettle, A. J. (1997). Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochemical Journal, 327(2), 487-492. Journal - Research Article

Carr, A., van den Berg, J. J. M., & Winterbourn, C. C. (1996). Chlorination of cholesterol in cell membranes by hypochlorous acid. Archives of Biochemistry & Biophysics, 332, 63-69. Journal - Research Article

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517. Journal - Research Article

Carr, A., Winterbourn, C. C., & van den Berg, J. J. M. (1996). Peroxidase-mediated bromination of unsaturated fatty acids to form bromohydrins. Archives of Biochemistry & Biophysics, 327, 227-233. Journal - Research Article

Inder, T. E., Darlow, B. A., Sluis, K. B. M., Winterbourn, C. C., Graham, P. J., Sanderson, K. J., & Taylor, B. J. (1996). The correction of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant. Acta Paediatrica, 85, 1116-1122. Journal - Research Article

Winterbourn, C. C. (1996). Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicology Letters, 82/83, 969-974. Journal - Research Article

Winterbourn, C. C. (1995). Free radical toxicology and antioxidant defence. Clinical & Experimental Pharmacology & Physiology, 22, 877-880. Journal - Research Article

Pichorner, H., Metodiewa, D., & Winterbourn, C. C. (1995). Generation of superoxide and tyrosine peroxide as a result of tyrosyl radical scavenging by glutathione. Archives of Biochemistry & Biophysics, 323, 429-437. Journal - Research Article

Winterbourn, C. C. (1995). Nutritional antioxidants: their role in disease prevention. New Zealand Medical Journal, 95, 447-449. Journal - Research Article

Darlow, B. A., Inder, T. E., Sluis, K. B. M., Nuthall, G., Mogridge, N., & Winterbourn, C. C. (1995). Selenium status of New Zealand infants fed either a selenium supplemented or a standard formula. Journal of Paediatrics & Child Health, 31, 339-344. Journal - Research Article

Darlow, B. A., Inder, T. E., Graham, P. J., Sluis, K. B., Malpas, T. J., Taylor, B. J., & Winterbourn, C. C. (1995). The relationship of selenium status to respiratory outcome in the very low birth weight infant: relationship to maternal status, infant nutrition and respiratory outcome. Pediatrics, 96, 314-319. Journal - Research Article

Inder, T. E., Carr, A. C., Winterbourn, C. C., Austin, N. C., & Darlow, B. A. (1995). Vitamin A and E status in very low birth weight infants: Development of an improved parenteral delivery system. Journal of Pediatrics, 126(1), 128-131. doi: 10.1016/S0022-3476(95)70515-5 Journal - Research Article

Kettle, A. J., Carr, A. C., & Winterbourn, C. C. (1994). Assays using horseradish peroxidase and phenolic substrates require superoxide dismutase for accurate determination of hydrogen peroxide production by neutrophils. Free Radical Biology & Medicine, 17(2), 161-164. Journal - Research Article

Thomas, C., Carr, A. C., & Winterbourn, C. C. (1994). Free radical inactivation of rabbit muscle creatinine kinase: Catalysis by physiological and hydrolized ICRF-187 (ICRF-198) iron chelates. Free Radical Research, 21(6), 387-397. Journal - Research Article

Winterbourn, C. C., & Carr, A. C. (1993). Myeloperoxidase-dependent loss of malondialdehyde: A limitation for detecting neutrophil-mediated lipid peroxidation. Archives of Biochemistry & Biophysics, 302(2), 461-467. doi: 10.1006/abbi.1993.1240 Journal - Research Article