2021
Journal - Research Other
Jennings, M. J., Molteno, T. C. A., Walker, R. J., Bedford, J. J., Leader, J. P., & Poole, T. (2021). Transmission electron microscopy tilt-series data from in-situ chondrocyte primary cilia [Data descriptor]. Data, 6(11), 118. doi: 10.3390/data6110118
2019
Journal - Research Article
Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1
Journal - Research Other
Leader, J., Bedford, J., & Walker, R. J. (2019). Drowning in data: Early responses of renal cortical collecting duct cells to lithium. Annals of Translational Medicine, 8(Suppl. 8), S322. doi: 10.21037/atm.2019.09.120
2018
Journal - Research Article
Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929
2017
Journal - Research Article
de Groot, T., Doornebal, J., Christensen, B. M., Cockx, S. C., Sinke, A. P., Baumgarten, R., Bedford, J. J., Walker, R. J., … Deen, P. M. T. (2017). Lithium-induced NDI: Acetazolamide reduces polyuria, but does not improve urine concentrating ability. American Journal of Physiology: Renal Physiology, 313(3), F669-F676. doi: 10.1152/ajprenal.00147.2017
2016
Journal - Research Article
Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240
Conference Contribution - Verbal presentation and other Conference outputs
Leader, J., Bedford, J., van der Tholen, L., Weiner, D., & Walker, R. (2016, December). Lithium in the renal cortex. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
2014
Journal - Research Article
Weiner, I. D., Leader, J. P., Bedford, J. J., Verlander, J. W., Ellis, G., Kalita, P., Vos, F., de Jong, S., & Walker, R. J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reports, 2(12), e12242. doi: 10.14814/phy2.12242
2013
Journal - Research Article
Walker, R. J., Leader, J. P., Bedford, J. J., Gobe, G., Davis, G., Vos, F. E., deJong, S., & Schollum, J. B. W. (2013). Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium. American Journal of Physiology: Renal Physiology, 304(3), F300-F307. doi: 10.1152/ajprenal.00182.2012
Conference Contribution - Published proceedings: Abstract
Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013). Amiloride modifies renal fibrosis induced by long term lithium treatment. Nephrology, 18(Suppl. 1), (pp. 57). doi: 10.1111/nep.12121
Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013). Long-term modulation of lithium-induced nephrogenic diabetes isipidus by amiloride. Nephrology, 18(Suppl. 1), (pp. 37). doi: 10.1111/nep.12121
Conference Contribution - Poster Presentation (not in published proceedings)
Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013, September). Long term amiloride therapy attenuates lithium-induced kidney interstitial fibrosis. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.
2012
Conference Contribution - Published proceedings: Abstract
Anagnostopoulou, A., Walker, R., Jeffs, A., Scherer, A., Bedford, J., Leader, J., … Marti, H.-P. (2012). A subset of metzincins and related genes constitutes a marker of solid organ fibrosis across species. Nephrology Dialysis Transplantation, 27(Suppl. 2), (pp. 44). doi: 10.1093/ndt/gfs198
Marti, H. P., Jeffs, A., Scherer, A., Leader, J., Bedford, J., Davis, G., … Walker, R. (2012). Solid organ fibrosis: Evidence for a common pathway across species! Nephrology, 17(Suppl. 2), (pp. 57). doi: 10.1111/j.1440-1797.2012.01632.x
Conference Contribution - Verbal presentation and other Conference outputs
Leader, J., Bedford, J., & Walker, R. (2012, August). Morphological changes in kidneys of rats after long term (six months) exposure to lithium. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.
Kalita, P., Bahn, A., Walker, R., Leader, J., & Bedford, J. (2012, August). Mechanism underlying kidney fibrosis in rats due to prolonged lithium treatment. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.
2010
Conference Contribution - Verbal presentation and other Conference outputs
Walker, R., Bedford, J., Davis, G., Gobe, G., Schollum, J., & Leader, J. (2010, August-September). Long term lithium-induced chronic interstitial fibrosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Davis, G., Bedford, J., Leader, J., & Walker, R. (2010, November-December). Lithium treated rats have an impaired ability to acidify their urine. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2008
Journal - Research Article
Bedford, J. J., Leader, J. P., Jing, R., Walker, L. J., Klein, J. D., Sands, J. M., & Walker, R. J. (2008). Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. American Journal of Physiology: Renal Physiology, 294, F812-F820. doi: 10.1152/ajprenal.00554.2007
Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.
2007
Journal - Research Article
Bedford, J. J., & Leader, J. P. (2007). Organic osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part A, 147, 1047-1052. doi: 10.1016/j.cbpa.2007.03.015
2006
Conference Contribution - Published proceedings: Abstract
Leader, J., Jing, R., Walker, R., & Bedford, J. (2006). The effect of amiloride in lithium-induced nephrogenic diabetes insipidus in rats. FASEB Journal, 20(5), 754.17, (pp. A1222). [Abstract]
Bedford, J. J., Yang, B. S., Walker, R. J., & Leader, J. P. (2006). Upregulation of the taurine transporter, TAUT, in the renal medulla of thirsted rats. FASEB Journal, 20(5), 754.16, (pp. A1221). [Abstract]
Jing, R., Bedford, J., Walker, R., & Leader, J. (2006). Correction of the urine concentrating defect in rats with lithium-induced nephrogenic diabetes insipidus by amiloride. Journal of the American Society of Nephrology. 17, (pp. 537A). [Abstract]
2005
Journal - Research Article
Samuelsson, L. M., Bedford, J. J., Smith, R. A. J., & Leader, J. P. (2005). A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution. Comparative Biochemistry & Physiology Part A, 141, 22-28.
Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.
Conference Contribution - Published proceedings: Abstract
Bedford, J. J., Jing, R., Walker, R. J., & Leader, J. P. (2005). The effect of amiloride on aquaporins 1-4 in rats with lithium-induced nephrogenic diabetes insipidus. Proceedings of the Cell Volume Control in Health and Disease Conference. (pp. 77). Copenhagen, Denmark. [Abstract]
Jing, Y., Bedford, J. J., Walker, R. J., & Leader, J. P. (2005). The effect of amiloride on lithium-induced nephrogenic diabetes insipidus in rats. Proceedings of the Medical Sciences Congress. (pp. 39). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Yang, S. S., Bedford, J. J., & Leader, J. P. (2005, December). Abundance of osmolytes and osmolyte transporter distribution in the thirsting rat kidney. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.
2004
Conference Contribution - Published proceedings: Abstract
Walker, R., Bedford, J., MacDonald, F., Weggery, S., & Leader, J. (2004). Lithium induced reducation of urinary aquaporin (AQP2) excretion and urinary concentrating ability in normal human volunteers. Proceedings of the 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. (pp. A33). Adelaide, Australia: ANZSN. [Abstract]
2003
Journal - Research Article
Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Aquaporin expression in normal human kidney and in renal disease. Journal of the American Society of Nephrology, 14, 2581-2587.
Al-Dameh, A. O., Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Urinary aquaporin-2 levels in healthy volunteers. Nephrology, 8, 139-141.
Conference Contribution - Published proceedings: Abstract
Leader, J. P., Bedford, J. J., & Walker, R. J. (2003). Sidedness of expression of AQP1 in mIMCD cells. Proceedings of the Experimental Biology Late-Breaking. [Abstract]
Walker, R. J., Bedford, J. J., & Leader, J. P. (2003). Lithium induced reducation of urinary aquaporin (AQP2) excretion and urinary concentrating ability in normal human volunteers. Journal of American Society of Nephrology. 14, (pp. 750A). [Abstract]
Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Glomerulart endothelium shows increased expression of AQP1 in renal disease. Proceedings of the Experimental Biology Late-Breaking. [Abstract]
2002
Journal - Research Article
Bedford, J. J., Schofield, J. C., Yancey, P. H., & Leader, J. P. (2002). The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 645-652.
Bedford, J. J., Burg, M. B., Peters, E., Smith, R. A. J., & Leader, J. P. (2002). Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 635-644.
Conference Contribution - Published proceedings: Abstract
Leader, J. P., Bedford, J. J., & Neufeld, D. S. (2002). Tolerance to freezing if the malpighian tubules of the New Zealand weta. Proceedings of the Experimental Biology Late-Breaking. [Abstract]
Walker, R. J., Bedford, J. J., & Leader, J. P. (2002). Aquaporin expression in renal disease. Journal of the American Society of Nephrology. 13, (pp. 472A). [Abstract]
Leader, J. P., Bedford, J. J., & Neufeld, D. (2002). Tolerance to freezing of the Malpighian tubules of the New Zealand weta, Hemideina maori. Experimental Biology. (pp. LB49). New Orleans: Federation of American Society for Experimental Biology. [Abstract]
2001
Journal - Research Article
Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2001). A taurine transporter isolated from rat cardiac muscle. Advances in Experimental Medicine & Biology, 483, 523-534.
Conference Contribution - Published proceedings: Abstract
Palmer, H. R., Bedford, J. J., Leader, J. P., Smith, R. A. J., & Gao, Z. (2001). Understanding counteracting osmolytes: An investigation based on nuclear magnetic resonance spectroscopy. Proceedings of the Molecuar Mechanism in Cell Volume Regulation. [Abstract]
Leader, J. P., Bedford, J. J., & Neufeld, D. (2001). Cell volume regulation in the malpighian tubules of the freezing-tolerant New Zealand montane weta, Hemideina. Proceedings of the Molecuar Mechanism in Cell Volume Regulation. [Abstract]
2000
Journal - Research Article
Yin, M., Palmer, H. R., Fyfe-Johnson, A. L., Bedford, J. J., Smith, R. A. J., & Yancey, P. H. (2000). Hypotaurine, N-methyltaurine, taurine, and glycine betaine as dominant osmolytes of vestimentiferan tubeworms from hydrothermal vents and cold seeps. Physiological & Biochemical Zoology, 73(5), 629-637.
Palmer, H. R., Bedford, J. J., Leader, J. P., & Smith, R. A. J. (2000). 31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A. Journal of Biological Chemistry, 275, 27708-27711.
Leader, J. P., & Bedford, J. J. (2000). What happens to an insect when it freezes and does it matter? New Zealand Science Monthly, 11(7), 6-8.
Conference Contribution - Published proceedings: Abstract
Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2000). Expression and properties of a taurine transporter from rat heart. Federation of American Societies for Experimental Biology Journal. 14(4), (pp. A99). [Abstract]
1999
Conference Contribution - Published proceedings: Abstract
Yin, M., Palmer, H. R., Bedford, J. J., Fyfe-Johnson, A. L., Santoso, F., Suko, J., & Yancey, P. H. (1999). Unusual osmolytes in deep-sea vestimentiferans, gastropods and echinoderms. American Zoologist. 39, (pp. 65). [Abstract]
Bedford, J. J., & Leader, J. P. (1999). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Federation of American Societies for Experimental Biology Journal. 13(348.10). [Abstract]
Leader, J. P., Harper, J. L., Biyouki, M. A. A., Bedford, J. J., & Smith, R. A. J. (1999). Organo-fluorine compunds for the determination of intracellular pH using NMR spectroscopy. Experimental Biology Journal. 13(348.09). [Abstract]
1998
Journal - Research Article
Bedford, J. J., Harper, J. L., Leader, J. P., Yancey, P. H., & Smith, R. A. J. (1998). Betaine is the principal counteracting osmolyte in tissues of the elephant fish, Callorhincus millii (Elasmobranchii, Holocephali). Comparative Biochemistry & Physiology Part B, 119(3), 521-526.
Bedford, J. J., Harper, J. L., Leader, J. P., & Smith, R. A. J. (1998). Identification and measurement of methylamines in elasmobranch tissues using proton nuclear magnetic resonance (1H-NMR) spectroscopy. Journal of Comparative Physiology B, 168(2), 123-131.
Biyouki, M. A. A., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1998). Hydroxymethylation and carbamoylation of di- and tetramethylpyridines using radical (Minisci) reactions. Synthetic Communications, 28, 3817-3825.
1997
Journal - Research Article
Harper, J. L., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1997). Synthesis, acidity and 19F-NMR characteristics of 1-substituted fluoroimidazoles with potential application as probes for intracellular pH determination. Tetrahedron, 53(24), 8211-8224.
Conference Contribution - Published proceedings: Abstract
Neufeld, D., & Bedford, J. J. (1997). The survival in vitro of Malpighian tubules of a freeze-tolerant insect, the montane weta, Hemideina maori. Proceedings of the University of Otago Medical School Research Society. (pp. 25). [Abstract]
Leader, J. P., & Bedford, J. J. (1997). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Proceedings of the International Congress of Physiology. (pp. P025.09). [Abstract]
Bedford, J. J., Leader, J. P., & Walker, R. J. (1997). Glomerular endothelium shows increased expression of AQP1 in renal disease. Federation of American Soceities for Experimental Biology Journal. (pp. 17). [Abstract]
Leader, J. P., & Bedford, J. J. (1997). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Proceedings of the University of Otago Medical School Research Society. (pp. 15). [Abstract]
1996
Journal - Research Article
Ferraris, J. D., Williams, C. K., Jung, K. Y., Bedford, J. J., Burg, M. B., & Garcia-Perez, A. (1996). ORE, a eukaryotic minimal essential osmotic response element: The aldose reductase gene in hyperosmotic stress. Journal of Biological Chemistry, 271, 18318-18321.