Dr Alisa Boucsein

2025

Journal - Research Article

Michaels, V. R., Boucsein, A., Haszard, J. J., Galland, B., Meredith-Jones, K. A., Zhou, Y., Jones, S. D., … Wiltshire, E., … de Bock, M. I., & Wheeler, B. J. (2025). Impact of automated insulin delivery on subjective and objective sleep in children and young adults with very high HbA1c: Sleep outcomes from the CO-PILOT randomised controlled trial. Diabetic Medicine. Advance online publication. doi: 10.1111/dme.70093

Michaels, V. R., Boucsein, A., Zhou, Y., Jones, S. D., Paul, R. G., Wiltshire, E. J., Jefferies, C., de Bock, M. I., & Wheeler, B. J. (2025). Impact of Simplera Sync™ sensors and Extended™ Wear Infusion Sets on glycaemia and system performance of the MiniMed™ 780G system in children and young adults with previously high HbA1c. Diabetic Medicine, e70048. Advance online publication. doi: 10.1111/dme.70048

Lever, C. S., Williman, J. A., Boucsein, A., Watson, A., Sampson, R. S., Sergel-Stringer, O. T., Keesing, C., Wheeler, B. J., de Bock, M. I., & Paul, R. G. (2025). Extended use of real-time continuous glucose monitoring in adults with insulin-requiring type 2 diabetes: Results from the first 26 weeks of the 2GO-CGM trial. Diabetic Medicine. Advance online publication. doi: 10.1111/dme.70025

Johansson, M. M. E., March de Ribot, F., Sime, M.-J., Boucsein, A., Zhou, Y., Jefferies, C. A., … Wiltshire, E. J., … de Bock, M. I., & Wheeler, B. J. (2025). Short-term diabetic retinopathy status in people with type 1 diabetes commencing automated insulin delivery. Diabetes Technology & Therapeutics. Advance online publication. doi: 10.1089/dia.2024.0568

Zhou, Y., Boucsein, A., Michaels, V. R., Gray, M. K., Jefferies, C., Wiltshire, E., … Parry-Strong, A., … de Bock, M. I., & Wheeler, B. J. (2025). Predictors of glycaemic improvement in children and young adults with type 1 diabetes and very elevated HbA1c using the MiniMed 780G system. Diabetes, Obesity & Metabolism. Advance online publication. doi: 10.1111/dom.16210

Journal - Research Other

Warunyuwong, W., Boucsein, A., & Wheeler, B. J. (2025). MiniMed 780G provides safe and effective short- and long-term management of a person with type 1 diabetes with an extremely elevated HbA1c and multiple hospital admissions for cannabis intoxication: A case report. Diabetes Technology & Obesity Medicine, 1(1), 42-49. doi: 10.1089/dtom.2025.0006

Wheeler, B. J., & Boucsein, A. (2025). Automated insulin delivery for people with type 1 diabetes and high HbA_1c: Is it time? Diabetes Care, 48(1), 50-51. doi: 10.2337/dci24-0076

2024

Journal - Research Article

Zhou, Y., Wheeler, B. J., Boucsein, A., Styles, S. E., Chamberlain, B., Michaels, V. R., … Wiltshire, E. J., … Jefferies, C. A. (2024). Use of Freestyle Libre 2.0 in children with type 1 diabetes mellitus and elevated HbA(1c): Extension phase results after a 12-week randomized controlled trial. Diabetic Medicine. Advance online publication. doi: 10.1111/dme.15494

Lai, S.-t. T., Styles, S. E., Boucsein, A., Zhou, Y., Michaels, V., Jefferies, C., Wiltshire, E., De Bock, M. I., & Wheeler, B. J. (2024). Parental perspectives following the implementation of advanced hybrid closed-loop therapy in children and adolescents with type 1 diabetes and elevated glycaemia. Diabetic Medicine. Advance online publication. doi: 10.1111/dme.15448

Wong, J. Y., Styles, S. E., Wiltshire, E. J., de Bock, M. I., Boucsein, A., Palmer, O. J., & Wheeler, B. J. (2024). Experiences of adolescents and young adults with type 1 diabetes and chronically elevated glucose levels following the transition from multiple daily injections to advanced hybrid closed-loop: A qualitative study. Diabetic Medicine. Advance online publication. doi: 10.1111/dme.15449

Boucsein, A., Zhou, Y., Michaels, V., Haszard, J. J., Jefferies, C., Wiltshire, E., … Parry-Strong, A., … de Bock, M. I., & Wheeler, B. J. (2024). Automated insulin delivery for young people with type 1 diabetes and elevated A1c. NEJM Evidence, 3(10). doi: 10.1056/EVIDoa2400185

Lever, C. S., Williman, J. A., Boucsein, A., Watson, A., Sampson, R. S., Sergel-Stringer, O. T., Keesing, C., … Wheeler, B. J., de Bock, M. I., & Paul, R. G. (2024). Real time continuous glucose monitoring in high-risk people with insulin-requiring type 2 diabetes: A randomised controlled trial. Diabetic Medicine, 41(8), e15348. doi: 10.1111/dme.15348

Sergel-Stringer, O. T., Wheeler, B. J., Styles, S. E., Boucsein, A., Lever, C. S., Paul, R. G., Sampson, R., Watson, A., & de Bock, M. I. (2024). Acceptability and experiences of real-time continuous glucose monitoring in adults with type 2 diabetes using insulin: A qualitative study. Journal of Diabetes & Metabolic Disorders. Advance online publication. doi: 10.1007/s40200-024-01403-9

Bowden, N., Dixon, R., Anderson, V., de Bock, M., Boucsein, A., Kewene-Edwards, M., Gibb, S., Kokaua, J., Palmer, O., Paul, R., Taylor, B., Vu, H., & Wheeler, B. J. (2024). Associations between type 1 diabetes and educational outcomes: An Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure. Diabetologia, 67, 62-73. doi: 10.1007/s00125-023-06026-y

Michaels, V. R., Boucsein, A., Watson, A. S., Frewen, C. M., Sanders, O. J., Haszard, J. J., Jones, S. D., Milford-Hughes, P. J., de Bock, M., & Wheeler, B. J. (2024). Glucose and psychosocial outcomes 12-months following transition from multiple daily injections to advanced hybrid closed loop in youth with type 1 diabetes and suboptimal glycemia. Diabetes Technology & Therapeutics, 26(1), 40-48. doi: 10.1089/dia.2023.0334

Sehgal, S., Boucsein, A., Styles, S., Palmer, O., Paul, R. G., Crocket, H., de Bock, M., & Wheeler, B. J. (2024). Do-it-yourself continuous glucose monitoring in people aged 16 to 69 years with type 1 diabetes: A qualitative study. Diabetic Medicine, 41(2), e15168. doi: 10.1111/dme.15168

Journal - Research Other

Boucsein, A., Zhou, Y., Haszard, J. J., Jefferies, C. A., Wiltshire, E. J., Styles, S. E., … Galland, B. C., … de Bock, M. I., & Wheeler, B. J. (2024). Protocol for a prospective, multicenter, parallel-group, open-label randomized controlled trial comparing standard care with Closed lOoP In chiLdren and yOuth with Type 1 diabetes and high-risk glycemic control: The CO-PILOT trial. Journal of Diabetes & Metabolic Disorders, 23, 1397-1407. doi: 10.1007/s40200-024-01397-4

Conference Contribution - Published proceedings: Abstract

Boucsein, A., Zhou, Y., Michaels, V., Haszard, J. J., Jefferies, C., Wiltshire, E., … Watson, A. S., … de Bock, M. I., & Wheeler, B. J. (2024). Automated insulin delivery is the gold standard in children and youth with type 1 diabetes and suboptimal glycaemic control: Results from the CO-PILOT randomised controlled trial. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. OP3. Retrieved from https://www.nzssd.org.nz/

Gray, M., Boucsein, A., Zhou, Y., Haszard, J. J., Jefferies, C. A., Wiltshire, E. J., Styles, S. E., … de Bock, M. I., & Wheeler, B. J. (2024). Relationship between carbohydrate counting and carbohydrate announcement to glycaemic control in young people using AHCL insulin delivery. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. O23. Retrieved from https://www.nzssd.org.nz/

Michaels, V., Boucsein, A., Watson, A., Frewen, C., Sanders, O., Haszard, J., Jones, S., Milford-Hughes, P., de Bock, M., & Wheeler, B. (2024). Glucose and psychosocial outcomes 12 months following transition from multiple daily injections to advanced hybrid closed loop in youth with type 1 diabetes and suboptimal glycemia. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. O22. Retrieved from https://www.nzssd.org.nz/

Lever, C., Williman, J., Boucsein, A., Watson, A., Sampson, R., Milford-Hughes, P., … Wheeler, B. J., de Bock, M., & Paul, R. (2024). Extended use of real-time continuous glucose monitoring in adults with insulin-requiring type 2 diabetes: The 12-week continuation phase following the 2GO-CGM randomised controlled trial. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. O20. Retrieved from https://www.nzssd.org.nz/

Eglinton, H., Lever, C., Williman, J., Boucsein, A., Watson, A., Sampson, R., Sergel-Stringer, O., … Wheeler, B., de Bock, M., & Paul, R. (2024). Specialist nursing care and real-time continuous glucose monitoring in reducing cardiovascular risk in high-risk adults with insulin-requiring type 2 diabetes: A sub-analysis of the 2GO-CGM study. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. O19. Retrieved from https://www.nzssd.org.nz/

Wilkinson, T., Meier, R., Boucsein, A., Jones, S., Ballagh, D., van Rensburg, R., … Wheeler, B., & de Bock, M. (2024). First in human feasibility study: Automated insulin delivery utilizing the Dexcom new generation algorithm in adults with type 1 diabetes. Proceedings of the 47th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. O7. Retrieved from https://www.nzssd.org.nz/

Wheeler, B., Jones, S., & Boucsein, A. (2024). Prospective, single arm study to evaluate the performance of the 'CareSens Air' real-time continuous glucose monitoring system in adults with type 1 and type 2 diabetes. Diabetes Technology & Therapeutics, 26(Suppl. 2), (pp. A-211). doi: 10.1089/dia.2024.2525.abstracts

Michaels, V., Boucsein, A., Haszard, J., De Bock, M., & Wheeler, B. (2024). Glucose and psychosocial outcomes 12-months following transition from multiple daily injections to advance hybrid closed loop in youth with type 1 diabetes and suboptimal glycemia. Diabetes Technology & Therapeutics, 26(Suppl. 2), (pp. A-200). doi: 10.1089/dia.2024.2525.abstracts

Sehgal, S., De Bock, M., Grossman, B., Williman, J., Kurtz, N., Guzman, V., … Jones, S., Frewen, C., Watson, A., Boucsein, A., Taylor, B., & Wheeler, B. (2024). Use of decision support tool and quick start onboarding tools for type 1 diabetes using Advanced Hybrid Closed Loop (AHCL): A single-arm multi-phase intervention study. Diabetes Technology & Therapeutics, 26(Suppl. 2), (pp. A-155). doi: 10.1089/dia.2024.2525.abstracts

Wheeler, B., Wiltshire, E., Boucsein, A., Crockett, H., de Lange, M., & Jefferies, C. (2024). Effects of 12-weeks FreeStyle Libre 2.0 in children with type 1 diabetes and elevated HBA1C: A multi-center randomized controlled trial. Diabetes Technology & Therapeutics, 26(Suppl. 2), (pp. A-110). doi: 10.1089/dia.2024.2525.abstracts

2023

Journal - Research Article

Sergel-Stringer, O. T., Al-Sallami, H. S., Styles, S. E., Boucsein, A., de Bock, M. I., & Wheeler, B. J. (2023). Knowledge, safety, and impact of alcohol consumption in young adults with type 1 diabetes mellitus: A qualitative study. BMC Endocrine Disorders, 23, 229. doi: 10.1186/s12902-023-01471-7

Jefferies, C. A., Boucsein, A., Styles, S. E., Chamberlain, B., Michaels, V. R., Crockett, H. R., … Wiltshire, E. J., … Wheeler, B. J. (2023). Effects of 12-weeks Freestyle Libre 2.0 in children with type 1 diabetes and elevated HbA1c: A multi-centre randomized controlled trial. Diabetes Technology & Therapeutics, 25(12), 827-835. doi: 10.1089/dia.2023.0292

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B., & Tups, A. (2023). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Life Metabolism, 2(4), load026. doi: 10.1093/lifemeta/load026

Boucsein, A., Watson, A. S., Frewen, C. M., Sanders, O. J., Haszard, J. J., Jones, S. D., Milford-Hughes, P. J., de Bock, M. I., & Wheeler, B. J. (2023). Impact of advanced hybrid closed loop on youth with high-risk type 1 diabetes using multiple daily injections. Diabetes Care, 46(3), 628-632. doi: 10.2337/dc22-1971

Journal - Research Other

Lever, C. S., Williman, J. A., Boucsein, A., Watson, A., Sampson, R. S., Sergel-Stringer, O. T., … Wheeler, B. J., de Bock, M. I., & Paul, R. G. (2023). Study protocol: Glycaemic outcomes in people with type 2 diabetes initiating continuous glucose monitoring: The 2GO-CGM study. Journal of Diabetes & Metabolic Disorders, 22, 1779-1792. doi: 10.1007/s40200-023-01244-y

Conference Contribution - Published proceedings: Abstract

Lever, C. S., Williman, J. A., Boucsein, A., Watson, A., Sampson, R. S., Sergel-Stringer, O. T., Keesing, C., Wheeler, B. J., de Bock, M. I., & Paul, R. G. (2023). Randomised controlled trial of real time continuous glucose monitoring in people with type 2 diabetes on insulin (the 2GO-CGM study). Diabetologia, 66(Suppl. 1), 802. doi: 10.1007/s00125-023-05969-6

Sergel-Stringer, O. T., Wheeler, B. J., Styles, S. E., Boucsein, A., Lever, C. S., Paul, R. G., Sampson, R., Watson, A., & de Bock, M. I. (2023). Acceptability and experiences of real-time continuous glucose monitoring in adults with type 2 diabetes using insulin: A qualitative study. Proceedings of the 46th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. Poster 12. Retrieved from https://www.nzssd.org.nz/home.html

Sergel-Stringer, O. T., Al-Sallami, H. S., Styles, S. E., Boucsein, A., de Bock, M., & Wheeler, B. J. (2023). Knowledge, safety, and impact of alcohol consumption in young adults with type 1 diabetes mellitus: A qualitative study. Proceedings of the 46th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. Poster 1. Retrieved from https://www.nzssd.org.nz/home.html

Boucsein, A., Watson, A., Frewen, C., Sanders, O., Haszard, J., Jones, S., Milford-Hughes, P., de Bock, M., & Wheeler, B. (2023). Impact of advanced hybrid closed-loop on youth with high-risk type 1 diabetes using multiple daily injections. Proceedings of the 46th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. Oral 5. Retrieved from https://www.nzssd.org.nz/home.html

Boucsein, A., Wheeler, B., Chamberlain, B., Styles, S., Crocket, H., Wiltshire, E., … de Bock, M., & Jefferies, C. (2023). A comparison of FreeStyle Libre 2 to self-monitoring of blood glucose in children with type 1 diabetes and sub-optimal glycaemic control: A 12-week randomised controlled trial. Proceedings of the 46th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. Oral 4. Retrieved from https://www.nzssd.org.nz/home.html

Conference Contribution - Verbal presentation and other Conference outputs

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Perry, N. B., & Tups, A. (2023, August-September). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Verbal presentation at the Queenstown Molecular Biology (QMB) Hypothalamic Neuroscience & Neuroendocrinology Australasia (HNNA) Satellite, Queenstown, New Zealand.

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., … Boer, G. A., Perry, N. B., & Tups, A. (2023, August). From mechanistic biomedical research on hypothalamic inflammation to a dietary supplement for glucose support. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Conference Contribution - Published proceedings: Abstract

Palmer, O., Sehgal, S., Boucsein, A., Styles, S., Crocket, H., Paul, R. G., & Wheeler, B. J. (2022). Smart watch integrated do-it-yourself continuous glucose monitoring (DIY-CGM) in adults with type 1 diabetes: A qualitative study. New Zealand Medical Journal, 135(1557), (pp. 105-106). Retrieved from https://journal.nzma.org.nz/

Palmer, O., Sehgal, S., Boucsein, A., Styles, S., Crocket, H., Paul, R. G., & Wheeler, B. J. (2022). Smart watch integrated do-it-yourself continuous glucose monitoring (DIY-CGM) in adults with type 1 diabetes: A qualitative study. Proceedings of the 45th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. (pp. 48). Retrieved from https://www.ivvy.com.au/event/NZSSD22/welcome.html

2021

Journal - Research Other

Sehgal, S., De Bock, M., Williman, J., Taylor, B., Elbalshy, M., Galland, B., Hall, R., Paul, R., Boucsein, A., Jones, S., Frewen, C., & Wheeler, B. J. (2021). Safety and efficacy of smart watch integrated do-it-yourself continuous glucose monitoring in adults with Type 1 diabetes, a randomised controlled trial. Journal of Diabetes & Metabolic Disorders, 20, 2103-2113. doi: 10.1007/s40200-021-00923-y

Styles, S., Wheeler, B., Boucsein, A., Crocket, H., de Lange, M., Signal, D., Wiltshire, E., … de Bock, M., … Jefferies, C. (2021). A comparison of FreeStyle Libre 2 to self-monitoring of blood glucose in children with type 1 diabetes and sub-optimal glycaemic control: A 12-week randomised controlled trial protocol. Journal of Diabetes & Metabolic Disorders, 20, 2093-2101. doi: 10.1007/s40200-021-00907-y

Boucsein, A., Kamstra, K., & Tups, A. (2021). Central signalling cross-talk between insulin and leptin in glucose and energy homeostasis [Invited]. Journal of Neuroendocrinology, 33, e12944. doi: 10.1111/jne.12944

2020

Journal - Research Article

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

2019

Journal - Research Article

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB Journal, 33, 12175-12187. doi: 10.1096/fj.201901004R

Journal - Research Other

Loehfelm, A., Boucsein, A., Pretz, D., & Tups, A. (2019). Timing matters: Circadian effects on energy homeostasis and Alzheimer's disease. Trends in Endocrinology & Metabolism, 30(2), 132-143. doi: 10.1016/j.tem.2018.12.001

Conference Contribution - Poster Presentation (not in published proceedings)

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, July). Time of day-dependent action of hypothalamic leptin signalling. Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.

Conference Contribution - Verbal presentation and other Conference outputs

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, August-September). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Conference Contribution - Verbal presentation and other Conference outputs

Boucsein, A., Rizwan, M., & Tups, A. (2018, February). Circadian regulation of leptin action. Verbal presentation at the 9th Swiss Winter Conference on Ingestive Behavior, St. Moritz, Switzerland.

2017

Conference Contribution - Verbal presentation and other Conference outputs

Boucsein, A. (2017, October). Daily rhythms of leptin action. Verbal presentation at the Australasian Chronobiology Society 14th Annual Scientific Meeting, Waiheke Island, New Zealand.

Boucsein, A., Rizwan, M., & Tups, A. (2017, September). Circadian rhythmicity of leptin sensitivity in the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2016

Journal - Research Article

Boucsein, A., Benzler, J., Hempp, C., Stöhr, S., Helfer, G., & Tups, A. (2016). Photoperiodic and diurnal regulation of WNT signaling in the arcuate nucleus of the female Djungarian hamster, Phodopus sungorus. Endocrinology, 157(2), 799-809. doi: 10.1210/en.2015-1708

Conference Contribution - Published proceedings: Abstract

Boucsein, A., Rizwan, M., Skinner, N., & Tups, A. (2016). Temporal rhythms of metabolic pathways in the hypothalamus. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. 34, (pp. 64). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Tups, A., Boucsein, A., Skinner, N., & Rizwan, M. (2016). Leptin resistance: Cause or consequence of hypothalamic inflammation? In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 63). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

2015

Conference Contribution - Poster Presentation (not in published proceedings)

Boucsein, A., Benzler, J., Hempp, C., Helfer, G., & Tups, A. (2015, August-September). Photoperiodic regulation of Wnt signalling in the arcuate nucleus of the Djungarian hamster, Phodopus sungorus. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Koch, C. E., Lowe, C., Legler, K., Benzler, J., Boucsein, A., Böttiger, G., Grattan, D. R., … Tups, A. (2014). Central adiponectin acutely improves glucose tolerance in male mice. Endocrinology, 155(5), 1806-1816. doi: 10.1210/en.2013-1734

2013

Journal - Research Article

Ganjam, G. K., Benzler, J., Pinkenburg, O., Boucsein, A., Stöhr, S., Steger, J., … Tups, A. (2013). Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes. Journal of Comparative Physiology B, 183(8), 1101-1111. doi: 10.1007/s00360-013-0772-1