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Pharmacy staff profile

Dr Allan Gamble

PositionSenior Lecturer
QualificationsPhD
Research summaryMedicinal chemistry; design and synthesis of biologically active molecules

Research

My primary research interests are the design and synthesis of biologically active molecules for the treatment of chronic and infectious disease. I have experience in a range of disciplines including organic and medicinal chemistry, molecular biology and chemical biology.

Current research is focused on new technologies for targeted drug delivery and medicinal chemistry.

Dr Gamble on Scopus

Publications

Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a

Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695

Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2017). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron. Advance online publication. doi: 10.1016/j.tet.2017.10.031

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Cao, F., Gamble, A. B., Onagi, H., Howes, J., Hennessy, J. E., Gu, C., … Easton, C. J. (2017). Detection of biosynthetic precursors, discovery of glycosylated forms, and homeostasis of calcitonin in human cancer cells. Analytical Chemistry, 89(13), 6992-6999. doi: 10.1021/acs.analchem.7b00457

Journal - Research Article

Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2017). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron. Advance online publication. doi: 10.1016/j.tet.2017.10.031

Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695

Cao, F., Gamble, A. B., Onagi, H., Howes, J., Hennessy, J. E., Gu, C., … Easton, C. J. (2017). Detection of biosynthetic precursors, discovery of glycosylated forms, and homeostasis of calcitonin in human cancer cells. Analytical Chemistry, 89(13), 6992-6999. doi: 10.1021/acs.analchem.7b00457

Alimoradi, H., Matikonda, S. S., Gamble, A. B., Giles, G. I., & Greish, K. (2016). Hypoxia responsive drug delivery systems in tumor therapy. Current Pharmaceutical Design, 22(19), 2808-2820.

Chiluka, R., Gamble, A. B., Lucas, N. T., Hawkins, B. C., Bhumkar, A., Achanta, P. S., & Bobbala, R. K. (2016). Flavone C-glycosides from Trichuriella monsoniae (L.f.) Bennet. Natural Product Research. doi: 10.1080/14786419.2016.1149707

Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Morris, K. M., Cao, F., Onagi, H., Altamore, T. M., Gamble, A. B., & Easton, C. J. (2012). Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorganic & Medicinal Chemistry Letters, 22, 7015-7018. doi: 10.1016/j.bmcl.2012.10.004

Cao, F., Gamble, A. B., Kim, H.-K., Onagi, H., Gresser, M. J., Kerr, J., & Easton, C. J. (2011). Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase. MedChemComm, 2, 760-763. doi: 10.1039/c1md00079a

Gamble, A. B., & Keller, P. A. (2010). Synthesis of reaction-ready 6,6′-biindole and 6,6′-biisatin via palladium(II)-catalysed intramolecular C–H functionalisation. Chemical Communications, 46(23), 4076-4078. doi: 10.1039/C002098B

Locke, J. M., Stutchbury, T. K., Vine, K. L., Gamble, A. B., Clingan, P. R., Bremner, J. B., & Ranson, M. (2009). Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate. Anti-Cancer Drugs, 20(9), 822-831. doi: 10.1097/CAD.0b013e32832fd78e

Gamble, A. B., Garner, J., Gordon, C. P., O'Conner, S. M. J., & Keller, P. A. (2007). Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation. Synthetic Communications, 37(16), 2777-2786. doi: 10.1080/00397910701481195

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Journal - Research Other

Agbowuro, A. A., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2017). Proteases and protease inhibitors in infectious diseases. Medicinal Research Reviews. Advance online publication. doi: 10.1002/med.21475

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