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Contact Details

Phone
64 3 479 5410
Email
shakila.rizwan@otago.ac.nz
Position
Senior Lecturer
Qualifications
BPharm PhD(Otago)
Research summary
Delivery of pharmceuticals to the brain

Research

My primary research interests are the development and evaluation (physicochemical and biological) of novel formulations for delivering pharmaceuticals to the brain. Specifically, I am interested in self-assembled liquid crystalline nanoparticles for targeted delivery of peptides/proteins to the brain.

  • Development and validation of healthy and diseased (epilepsy) blood-brain barrier (BBB) models in the zebrafish.
  • Understand factors affecting drug permeability/transport across the healthy and diseased (epilepsy) BBB.
  • Formulation and physicochemical characterisation of self-assembled liquid crystalline nanoparticles (cubosomes and hexosomes).
  • In vivo evaluation of formulations in rodent and zebrafish models.

Dr Rizwan on Scopus

Publications

Prentice, R. N., & Rizwan, S. B. (2023). Translational considerations in the development of intranasal treatments for epilepsy. Pharmaceutics, 15(1), 233. doi: 10.3390/pharmaceutics15010233

Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231

Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425

Prentice, R. N., Younus, M., & Rizwan, S. B. (2022). A sensitive LC-MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery. Journal of Separation Science, 45(14), 2529-2542. doi: 10.1002/jssc.202200025

Gandhi, K., Barzegar-Fallah, A., Banstola, A., Rizwan, S. B., & Reynolds, J. N. J. (2022). Ultrasound-mediated blood-brain barrier disruption for drug delivery: A systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833. doi: 10.3390/pharmaceutics14040833

Rizwan, S. B., & Boyd, B. J. (2015). Cubosomes: Structure, preparation and use as an antigen delivery system. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 125-140). New York: Springer. doi: 10.1007/978-1-4939-1417-3

Chapter in Book - Research

Prentice, R. N., & Rizwan, S. B. (2023). Translational considerations in the development of intranasal treatments for epilepsy. Pharmaceutics, 15(1), 233. doi: 10.3390/pharmaceutics15010233

Journal - Research Article

Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425

Journal - Research Article

Gandhi, K., Barzegar-Fallah, A., Banstola, A., Rizwan, S. B., & Reynolds, J. N. J. (2022). Ultrasound-mediated blood-brain barrier disruption for drug delivery: A systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833. doi: 10.3390/pharmaceutics14040833

Journal - Research Article

Nakano, T., Rizwan, S. B., Myint, D. M. A., Gray, J., Mackay, S. M., Harris, P., Perk, C. G., Hyland, B. I., Empson, R., Tan, E. W., … Reynolds, J. N. J., & Wickens, J. R. (2022). An on-demand drug delivery system for control of epileptiform seizures. Pharmaceutics, 14, 468. doi: 10.3390/pharmaceutics14020468

Journal - Research Article

Prentice, R. N., Younus, M., & Rizwan, S. B. (2022). A sensitive LC-MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery. Journal of Separation Science, 45(14), 2529-2542. doi: 10.1002/jssc.202200025

Journal - Research Article

Azhari, H., Younus, M., Hook, S. M., Boyd, B. J., & Rizwan, S. B. (2021). Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish. International Journal of Pharmaceutics, 600, 120411. doi: 10.1016/j.ijpharm.2021.120411

Journal - Research Article

Mohammad, Y., Prentice, R. N., Boyd, B. J., & Rizwan, S. B. (2021). Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain. Journal of Colloid & Interface Science, 605, 146-154. doi: 10.1016/j.jcis.2021.07.070

Journal - Research Article

Prentice, R. N., Younus, M., Krittaphol-Bailey, W., & Rizwan, S. B. (2021). A sensitive LC-MS/MS method for the study of exogenously administered 13C-oleoylethanolamide in rat plasma and brain tissue. Journal of Separation Science, 44, 2693-2704. doi: 10.1002/jssc.202001210

Journal - Research Article

Mohammad, Y., Barzegar Fallah, A., Reynolds, J. N. J., Boyd, B. J., & Rizwan, S. B. (2020). Steric stabilisers govern the colloidal and chemical stability but not in vitro cellular toxicity of linoleoylethanolamide cubosomes. Colloids & Surfaces B, 192, 111063. doi: 10.1016/j.colsurfb.2020.111063

Journal - Research Article

Yarragudi, S. B., Kumar, H., Jain, R., Tawhai, M., & Rizwan, S. (2020). Olfactory targeting of microparticles through inhalation and bi-directional airflow: Effect of particle size and nasal anatomy. Journal of Aerosol Medicine & Pulmonary Drug Delivery, 33(5), 258-270. doi: 10.1089/jamp.2019.1549

Journal - Research Article

Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., … Darwish, T. A. (2019). Deuterated phytantriol: A versatile material for probing material distribution in liquid crystalline lipid phases using neutron scattering. Journal of Colloid & Interface Science, 534, 399-407. doi: 10.1016/j.jcis.2018.09.022

Journal - Research Article

Younus, M., Hawley, A., Boyd, B. J., & Rizwan, S. B. (2018). Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure. Colloids & Surfaces B, 169, 135-142. doi: 10.1016/j.colsurfb.2018.05.013

Journal - Research Article

Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195

Journal - Research Article

Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044

Journal - Research Article

Azhari, H., Strauss, M., Hook, S., Boyd, B. J., & Rizwan, S. B. (2016). Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier. European Journal of Pharmaceutics & Biopharmaceutics, 104, 148-155. doi: 10.1016/j.ejpb.2016.05.001

Journal - Research Article

Younus, M., Prentice, R. N., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Incorporation of an endogenous neuromodulatory lipid, oleoylethanolamide, into cubosomes: Nanostructural characterization. Langmuir, 32(35), 8942-8950. doi: 10.1021/acs.langmuir.6b02395

Journal - Research Article

Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020

Journal - Research Article

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Journal - Research Article

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. doi: 10.1016/j.ijpharm.2011.01.037

Journal - Research Article

Rizwan, S. B., Assmus, D., Boehnke, A., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. European Journal of Pharmaceutics & Biopharmaceutics, 79(1), 15-22. doi: 10.1016/j.ejpb.2010.12.034

Journal - Research Article

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584

Journal - Research Article

Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi: 10.1002/jps.21724

Journal - Research Article

Boyd, B. J., Rizwan, S. B., Dong, Y.-D., Hook, S., & Rades, T. (2007). Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmuir, 23(25), 12461-12464. doi: 10.1021/la7029714

Journal - Research Article

Rizwan, S. B., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). Micron, 38, 478-485. doi: 10.1016/j.micron.2006.08.003

Journal - Research Article

Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684

Journal - Research Other

Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231

Journal - Research Other

Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for vital pulp treatment. International Endodontic Journal, 54, 1263-1274. doi: 10.1111/iej.13524

Journal - Research Other

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