Dr Shakila Rizwan
Position | Senior Lecturer |
---|---|
Qualifications | BPharm PhD(Otago) |
Research summary | Delivery of pharmceuticals to the brain |
Research
My primary research interests are the development and evaluation (physicochemical and biological) of novel formulations for delivering pharmaceuticals to the brain. Specifically, I am interested in self-assembled liquid crystalline nanoparticles for targeted delivery of peptides/proteins to the brain.
- Development and validation of healthy and diseased (epilepsy) blood-brain barrier (BBB) models in the zebrafish.
- Understand factors affecting drug permeability/transport across the healthy and diseased (epilepsy) BBB.
- Formulation and physicochemical characterisation of self-assembled liquid crystalline nanoparticles (cubosomes and hexosomes).
- In vivo evaluation of formulations in rodent and zebrafish models.
Publications
Gandhi, K., Barzegar-Fallah, A., Banstola, A., Rizwan, S. B., & Reynolds, J. N. J. (2023). Ultrasound-mediated blood-brain barrier disruption for drug delivery: A systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833. doi: 10.3390/pharmaceutics14040833
Prentice, R. N., & Rizwan, S. B. (2023). Translational considerations in the development of intranasal treatments for epilepsy. Pharmaceutics, 15(1), 233. doi: 10.3390/pharmaceutics15010233
Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Prentice, R. N., Younus, M., & Rizwan, S. B. (2022). A sensitive LC-MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery. Journal of Separation Science. Advance online publication. doi: 10.1002/jssc.202200025
Rizwan, S. B., & Boyd, B. J. (2015). Cubosomes: Structure, preparation and use as an antigen delivery system. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 125-140). New York: Springer. doi: 10.1007/978-1-4939-1417-3
Chapter in Book - Research
Prentice, R. N., & Rizwan, S. B. (2023). Translational considerations in the development of intranasal treatments for epilepsy. Pharmaceutics, 15(1), 233. doi: 10.3390/pharmaceutics15010233
Journal - Research Article
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Journal - Research Article
Gandhi, K., Barzegar-Fallah, A., Banstola, A., Rizwan, S. B., & Reynolds, J. N. J. (2022). Ultrasound-mediated blood-brain barrier disruption for drug delivery: A systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833. doi: 10.3390/pharmaceutics14040833
Journal - Research Article
Nakano, T., Rizwan, S. B., Myint, D. M. A., Gray, J., Mackay, S. M., Harris, P., Perk, C. G., Hyland, B. I., Empson, R., Tan, E. W., … Reynolds, J. N. J., & Wickens, J. R. (2022). An on-demand drug delivery system for control of epileptiform seizures. Pharmaceutics, 14, 468. doi: 10.3390/pharmaceutics14020468
Journal - Research Article
Prentice, R. N., Younus, M., & Rizwan, S. B. (2022). A sensitive LC-MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery. Journal of Separation Science. Advance online publication. doi: 10.1002/jssc.202200025
Journal - Research Article
Azhari, H., Younus, M., Hook, S. M., Boyd, B. J., & Rizwan, S. B. (2021). Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish. International Journal of Pharmaceutics, 600, 120411. doi: 10.1016/j.ijpharm.2021.120411
Journal - Research Article
Mohammad, Y., Prentice, R. N., Boyd, B. J., & Rizwan, S. B. (2021). Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain. Journal of Colloid & Interface Science, 605, 146-154. doi: 10.1016/j.jcis.2021.07.070
Journal - Research Article
Prentice, R. N., Younus, M., Krittaphol-Bailey, W., & Rizwan, S. B. (2021). A sensitive LC-MS/MS method for the study of exogenously administered 13C-oleoylethanolamide in rat plasma and brain tissue. Journal of Separation Science, 44, 2693-2704. doi: 10.1002/jssc.202001210
Journal - Research Article
Mohammad, Y., Barzegar Fallah, A., Reynolds, J. N. J., Boyd, B. J., & Rizwan, S. B. (2020). Steric stabilisers govern the colloidal and chemical stability but not in vitro cellular toxicity of linoleoylethanolamide cubosomes. Colloids & Surfaces B, 192, 111063. doi: 10.1016/j.colsurfb.2020.111063
Journal - Research Article
Yarragudi, S. B., Kumar, H., Jain, R., Tawhai, M., & Rizwan, S. (2020). Olfactory targeting of microparticles through inhalation and bi-directional airflow: Effect of particle size and nasal anatomy. Journal of Aerosol Medicine & Pulmonary Drug Delivery, 33(5), 258-270. doi: 10.1089/jamp.2019.1549
Journal - Research Article
Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., … Darwish, T. A. (2019). Deuterated phytantriol: A versatile material for probing material distribution in liquid crystalline lipid phases using neutron scattering. Journal of Colloid & Interface Science, 534, 399-407. doi: 10.1016/j.jcis.2018.09.022
Journal - Research Article
Younus, M., Hawley, A., Boyd, B. J., & Rizwan, S. B. (2018). Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure. Colloids & Surfaces B, 169, 135-142. doi: 10.1016/j.colsurfb.2018.05.013
Journal - Research Article
Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195
Journal - Research Article
Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044
Journal - Research Article
Azhari, H., Strauss, M., Hook, S., Boyd, B. J., & Rizwan, S. B. (2016). Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier. European Journal of Pharmaceutics & Biopharmaceutics, 104, 148-155. doi: 10.1016/j.ejpb.2016.05.001
Journal - Research Article
Younus, M., Prentice, R. N., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Incorporation of an endogenous neuromodulatory lipid, oleoylethanolamide, into cubosomes: Nanostructural characterization. Langmuir, 32(35), 8942-8950. doi: 10.1021/acs.langmuir.6b02395
Journal - Research Article
Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020
Journal - Research Article
Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502
Journal - Research Article
Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. doi: 10.1016/j.ijpharm.2011.01.037
Journal - Research Article
Rizwan, S. B., Assmus, D., Boehnke, A., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. European Journal of Pharmaceutics & Biopharmaceutics, 79(1), 15-22. doi: 10.1016/j.ejpb.2010.12.034
Journal - Research Article
Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584
Journal - Research Article
Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi: 10.1002/jps.21724
Journal - Research Article
Boyd, B. J., Rizwan, S. B., Dong, Y.-D., Hook, S., & Rades, T. (2007). Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmuir, 23(25), 12461-12464. doi: 10.1021/la7029714
Journal - Research Article
Rizwan, S. B., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). Micron, 38, 478-485. doi: 10.1016/j.micron.2006.08.003
Journal - Research Article
Gandhi, K., Barzegar-Fallah, A., Banstola, A., Rizwan, S. B., & Reynolds, J. N. J. (2023). Ultrasound-mediated blood-brain barrier disruption for drug delivery: A systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833. doi: 10.3390/pharmaceutics14040833
Journal - Research Other
Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684
Journal - Research Other
Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231
Journal - Research Other
Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for vital pulp treatment. International Endodontic Journal, 54, 1263-1274. doi: 10.1111/iej.13524
Journal - Research Other