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Pharmacy staff profile

Dr Greg Walker

Position
  • Senior Lecturer
  • Head of the Bayer Centre for Dairy Animal Health / Pharmaceutical Science and Product Innovations at the School of Pharmacy (2019-present)
QualificationsBSc MSc PhD(Otago)
Research summaryDrug delivery and formulation
Teaching
  • PHCY211: Fundamental Pharmaceutical Sciences (Dosage forms module coordinator)
  • PHCY220: Integrated modules A
  • PHCY430: Elective Projects B
  • PHCY485: Honours
Memberships
  • Controlled Release Society (2012-present)
  • New Zealand Chapter of the Controlled Release Society (2012 to present): President of the Society (November 2017 to present)

Research

Dr Walker’s general area of research interest is in formulation and delivery of bioactive molecules. Particular interests are in physico-chemical principles relating to how delivery systems can influence the absorption, disposition and fate of bioactives in the body and how such systems can increase the efficacy of bioactives.

He has extensive experience in polymeric drug delivery systems, engineering formulations for biopharmaceuticals, project management and pre-clinical studies.

Prior to joining University of Otago as a lecturer, he was the Research and Development Manager at a UK biotech company where he invented the lead technology of a new class of topical haemostat (PeproStat) which has completed successful phase two clinical trials.

As head of the Bayer Centre for Dairy Animal Health / Pharmaceutical Science and Product Innovations at the School of Pharmacy, he applies his formulation and drug delivery expertise to issues relating to veterinary and animal health.

Dr Walker is a key researcher in three Ministry of Business, Innovation and Employment (MBIE) grants totalling to over NZ $19 million. These projects focus on the formulation and delivery of: vaccines, a new class of antimicrobials and bioactives to crops.

PhD projects are available, please contact me if you are interested in conducting PhD research in the field of formulation and drug delivery.

Publications

McGowan, J. E., Harper, A. D., Davison, E. K., Jeong, J. Y., Mros, S., Harbison-Price, N., Van Zuylen, E. M., Knottenbelt, M. K., … Ferguson, S. A., McConnell, M. A., Cook, G. M., Krittaphol, W., Walker, G. F., … Rennison, D. (2020). Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds. Bioorganic & Medicinal Chemistry Letters. Advance online publication. doi: 10.1016/j.bmcl.2020.127110

Poller, B., Painter, G. F., & Walker, G. F. (2019). Influence of albumin in the microfluidic synthesis of PEG-PLGA nanoparticles. Pharmaceutical Nanotechnology. Advance online publication. doi: 10.2174/2211738507666191023091938

Zawari, M., Poller, B., Walker, G., Pearson, A., & Carr, A. C. (2019). Formulation of broccoli sprout powder in gastro-resistant capsules protects against the acidic pH of the stomach in vitro but does not increase isothiocyanate bioavailability in vivo. Antioxidants, 8(9), 359. doi: 10.3390/antiox8090359

Kramer, K., Young, S. L., & Walker, G. F. (2019). Data on the uptake of reducible antigen-adjuvant conjugates by dendritic cells [Data article]. Data in Brief. Advance online publication. doi: 10.1016/j.dib.2019.103759

Donaldson, B., Lateef, Z., Walker, G. F., Young, S. L., & Ward, V. K. (2018). Virus-like particle vaccines: Immunology and formulation for clinical translation. Expert Review of Vaccines, 17(9), 833-849. doi: 10.1080/14760584.2018.1516552

Journal - Research Article

McGowan, J. E., Harper, A. D., Davison, E. K., Jeong, J. Y., Mros, S., Harbison-Price, N., Van Zuylen, E. M., Knottenbelt, M. K., … Ferguson, S. A., McConnell, M. A., Cook, G. M., Krittaphol, W., Walker, G. F., … Rennison, D. (2020). Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds. Bioorganic & Medicinal Chemistry Letters. Advance online publication. doi: 10.1016/j.bmcl.2020.127110

Poller, B., Painter, G. F., & Walker, G. F. (2019). Influence of albumin in the microfluidic synthesis of PEG-PLGA nanoparticles. Pharmaceutical Nanotechnology. Advance online publication. doi: 10.2174/2211738507666191023091938

Zawari, M., Poller, B., Walker, G., Pearson, A., & Carr, A. C. (2019). Formulation of broccoli sprout powder in gastro-resistant capsules protects against the acidic pH of the stomach in vitro but does not increase isothiocyanate bioavailability in vivo. Antioxidants, 8(9), 359. doi: 10.3390/antiox8090359

Kramer, K., Shields, N. J., Poppe, V., Young, S. L., & Walker, G. F. (2017). Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity. Molecular Therapy, 25(1), 62-70. doi: 10.1016/j.ymthe.2016.10.001

Walker, G., Römann, P., Poller, B., Löbmann, K., Grohganz, H., Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, T., Gordon, K. C., Strachan, C. J., & Fraser-Miller, S. J. (2017). Probing pharmaceutical mixtures during milling: The potency of low frequency Raman spectroscopy in identifying disorder. Molecular Pharmaceutics, 14(12), 4675-4684. doi: 10.1021/acs.molpharmaceut.7b00803

Smith, G. P. S., McLaughlin, A., Clarkson, A. N., Gordon, K. C., & Walker, G. F. (2017). Raman microscopic imaging of electrospun fibers made from a polycaprolactone and polyethylene oxide blend. Vibrational Spectroscopy, 92, 27-34. doi: 10.1016/j.vibspec.2017.05.002

Kramer, K., Young, S. L., & Walker, G. F. (2017). Comparative study of 5′- and 3′-linked CpG–antigen conjugates for the induction of cellular immune responses. ACS Omega, 2(1), 227-235. doi: 10.1021/acsomega.6b00368

Poller, B., Strachan, C., Broadbent, R., & Walker, G. F. (2017). A minitablet formulation made from electrospun nanofibers. European Journal of Pharmaceutics & Biopharmaceutics, 114, 213-220. doi: 10.1016/j.ejpb.2017.01.022

Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044

Fella, C., Walker, G. F., Ogris, M., & Wagner, E. (2008). Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding. European Journal of Pharmaceutical Sciences, 34(4-5), 309-320. doi: 10.1016/j.ejps.2008.05.004

DeRouchey, J., Schmidt, C., Walker, G. F., Koch, C., Plank, C., Wagner, E., & Rädler, J. O. (2008). Monomolecular assembly of siRNA and Poly(ethylene glycol)—peptide copolymers. Biomacromolecules, 9(2), 724-732. doi: 10.1021/bm7011482

Knorr, V., Allmendinger, L., Walker, G. F., Paintner, F. F., & Wagner, E. (2007). An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes. Bioconjugate Chemistry, 18, 1218-1225. doi: 10.1021/bc060327a

Ledger, R., Tucker, I. G., & Walker, G. F. (2002). Quantitative capillary electrophoresis assay for the proteolytic stability of luteinizing hormone-releasing hormones. Journal of Chromatography B, 769, 235-242.

Ledger, R., Tucker, I. G., & Walker, G. F. (2002). The metabolic barrier of the lower intestinal tract of salmon to the oral delivery of protein and peptide drugs. Journal of Controlled Release, 85, 91-103.

Walker, G. F., Ledger, R., & Tucker, I. G. (2001). Activity of pancreatic endopeptidases towards luteinizing hormone-releasing hormones. International Journal of Pharmaceutics, 216, 77-82.

Walker, G., Ledger, R., & Tucker, I. G. (1999). Garbomer inhibits tryptic proteolysis of luteinizing hormone-releasing hormone and N-alpha-benzoyl-L-arginine ethyl ester by binding the enzyme. Pharmaceutical Research, 16(7), 1074-1080.

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Journal - Research Other

Kramer, K., Young, S. L., & Walker, G. F. (2019). Data on the uptake of reducible antigen-adjuvant conjugates by dendritic cells [Data article]. Data in Brief. Advance online publication. doi: 10.1016/j.dib.2019.103759

Donaldson, B., Lateef, Z., Walker, G. F., Young, S. L., & Ward, V. K. (2018). Virus-like particle vaccines: Immunology and formulation for clinical translation. Expert Review of Vaccines, 17(9), 833-849. doi: 10.1080/14760584.2018.1516552

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