Associate Professor Allan Gamble
| Position | Associate Professor |
|---|---|
| Qualifications | PhD |
| Research summary | Synthetic and medicinal chemistry, bioorganic chemistry, drug delivery and chemical biology |
| Teaching | Allan teaches medicinal chemistry and analytical chemistry in the Pharmacy undergraduate programme, and is Examinations and Assessment Coordinator for the School of Pharmacy. |
Research
Allan Gamble’s expertise is in the areas of synthetic and medicinal chemistry, bioorganic chemistry, drug delivery, and chemical biology.
Current projects in the Gamble group focus on the design of new bioorthogonal chemical reactions and self-immolative linkers for controlled drug delivery, and the design and synthesis of biologically active molecules for the treatment of chronic and infectious disease.
Recent PhD students
- Sumit Dadhwal
- Jessica Fairhall
- Shivaji Edupuganti
- Jasmine Hwang
- Daniel Paterson
Additional information
Are you looking for a PhD supervisor?
Students with a strong background in organic, bioorganic or medicinal chemistry are encouraged to contact Allan via email regarding potential PhD positions.
Biography
Allan Gamble received his PhD in organic chemistry from the University of Wollongong, under the supervision of Professor Paul Keller in 2008. He then moved to Canberra to take up a postdoctoral position in the Research School of Chemistry at the Australian National University with Professor Chris Easton where he worked on peptide hormone regulation in cancer.
In 2011, he was awarded an American-Australian Sir Keith Murdoch Postdoctoral Fellowship to work with Professor Paul Wender at Stanford University in the area of drug delivery.
In May 2012 he was appointed Lecturer in Medicinal Chemistry in the School of Pharmacy at the University of Otago, and was promoted to Senior Lecturer in 2016.
His current research interests are in bioorganic and medicinal chemistry, chemical biology, and drug delivery.
Allan Gamble’s recent awards include:
- 2018 The University of Otago Early Career Award for Distinction in Research
- 2017 The School of Pharmacy Emerging Researcher Award
- 2016 The OUSA Health Sciences and New Supervisor of the Year Award
Publications
Matikonda, S. S., Fairhall, J. M., Fiedler, F., Sanhajariya, S., Tucker, R. A. J., Hook, S., Garden, A. L., & Gamble, A. B. (2018). Mechanistic evaluation of bioorthogonal decaging with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging from the 1,2,3-triazoline. Bioconjugate Chemistry, 29(2), 324-334. doi: 10.1021/acs.bioconjchem.7b00665
Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695
Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a
Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), 1184-1190. doi: 10.1016/j.tet.2017.10.031
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012
Matikonda, S. S., Fairhall, J. M., Fiedler, F., Sanhajariya, S., Tucker, R. A. J., Hook, S., Garden, A. L., & Gamble, A. B. (2018). Mechanistic evaluation of bioorthogonal decaging with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging from the 1,2,3-triazoline. Bioconjugate Chemistry, 29(2), 324-334. doi: 10.1021/acs.bioconjchem.7b00665
Journal - Research Article
Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695
Journal - Research Article
Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a
Journal - Research Article
Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), 1184-1190. doi: 10.1016/j.tet.2017.10.031
Journal - Research Article
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012
Journal - Research Article
Bobbala, S., Gibson, B., Gamble, A. B., McDowell, A., & Hook, S. (2018). Poloxamer 407-chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single-shot vaccines. Immunology & Cell Biology, 96(6), 656-665. doi: 10.1111/imcb.12031
Journal - Research Article
Cao, F., Gamble, A. B., Onagi, H., Howes, J., Hennessy, J. E., Gu, C., … Easton, C. J. (2017). Detection of biosynthetic precursors, discovery of glycosylated forms, and homeostasis of calcitonin in human cancer cells. Analytical Chemistry, 89(13), 6992-6999. doi: 10.1021/acs.analchem.7b00457
Journal - Research Article
Agbowuro, A. A., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Proteases and protease inhibitors in infectious diseases. Medicinal Research Reviews, 38(4), 1295-1331. doi: 10.1002/med.21475
Journal - Research Other
Chiluka, R., Gamble, A. B., Lucas, N. T., Hawkins, B. C., Bhumkar, A., Achanta, P. S., & Bobbala, R. K. (2016). Flavone C-glycosides from Trichuriella monsoniae (L.f.) Bennet. Natural Product Research. doi: 10.1080/14786419.2016.1149707
Journal - Research Article
Alimoradi, H., Matikonda, S. S., Gamble, A. B., Giles, G. I., & Greish, K. (2016). Hypoxia responsive drug delivery systems in tumor therapy. Current Pharmaceutical Design, 22(19), 2808-2820.
Journal - Research Article
Morris, K. M., Cao, F., Onagi, H., Altamore, T. M., Gamble, A. B., & Easton, C. J. (2012). Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorganic & Medicinal Chemistry Letters, 22, 7015-7018. doi: 10.1016/j.bmcl.2012.10.004
Journal - Research Article
Gamble, A. B., & Keller, P. A. (2010). Synthesis of reaction-ready 6,6′-biindole and 6,6′-biisatin via palladium(II)-catalysed intramolecular C–H functionalisation. Chemical Communications, 46(23), 4076-4078. doi: 10.1039/C002098B
Journal - Research Article
Cao, F., Gamble, A. B., Kim, H.-K., Onagi, H., Gresser, M. J., Kerr, J., & Easton, C. J. (2011). Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase. MedChemComm, 2, 760-763. doi: 10.1039/c1md00079a
Journal - Research Article
Gamble, A. B., Garner, J., Gordon, C. P., O'Conner, S. M. J., & Keller, P. A. (2007). Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation. Synthetic Communications, 37(16), 2777-2786. doi: 10.1080/00397910701481195
Journal - Research Article
Locke, J. M., Stutchbury, T. K., Vine, K. L., Gamble, A. B., Clingan, P. R., Bremner, J. B., & Ranson, M. (2009). Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate. Anti-Cancer Drugs, 20(9), 822-831. doi: 10.1097/CAD.0b013e32832fd78e
Journal - Research Article
Alimoradi, H., Matikonda, S. S., Gamble, A. B., Giles, G. I., & Greish, K. (2017). Redox activated polymeric nanoparticles in tumor therapy. In E. Andronescu & A. M. Grumezescu (Eds.), Nanostructures for drug delivery. (pp. 327-354). Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-46143-6.00010-5
Chapter in Book - Research
