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Pharmacy staff profile

Dr Daniel Wright

PositionSenior Lecturer
QualificationsBScPharm(Dal) MA(Brist) MSc PhD(Otago) RegPharmNZ
Research summaryClinical pharmacy; individualisation of drug therapy

Research

My research focuses on the individualisation of drug therapy. The types of questions I ask are; why do people respond differently to the same dose of a drug, what are the factors which determine this variability, and how can we use this information to design dosing regimens that are safe and effective?

I am particularly interested in the time course of drug concentrations in the body (pharmacokinetics), the concentration–effect relationship (pharmacodynamics) and the influence of genetic variability on drug response (pharmacogenetics). I have expertise in pharmacometric methodology including population PKPD modelling and computer simulations.

Publications

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Cremers, S., & Wright, D. F. B. (2021). Nonmedical use of prescription drugs. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14797

Kuan, I. H. S., Wilson, L. C., Leishman, J. C., Cosgrove, S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Metformin doses to ensure efficacy and safety in patients with reduced kidney function. PLoS ONE, 16(2), e0246247. doi: 10.1371/journal.pone.0246247

Darwich, A. S., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., … Rostami-Hodjegan, A. (2021). Model-informed precision dosing: Background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy. Annual Review of Pharmacology & Toxicology, 61, 36.1-36.21. doi: 10.1146/annurev-pharmtox-033020-113257

Baker, E. H., Gnjidic, D., Kirkpatrick, C. M. J., Pirmohamed, M., Wright, D. F. B., & Zecharia, A. Y. (2021). A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments. British Journal of Clinical Pharmacology, 87(3), 707-711. doi: 10.1111/bcp.14416

Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2021). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy, 17, 326-331. doi: 10.1016/j.sapharm.2020.04.005

Journal - Research Article

Darwich, A. S., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., … Rostami-Hodjegan, A. (2021). Model-informed precision dosing: Background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy. Annual Review of Pharmacology & Toxicology, 61, 36.1-36.21. doi: 10.1146/annurev-pharmtox-033020-113257

Journal - Research Article

Kuan, I. H. S., Wilson, L. C., Leishman, J. C., Cosgrove, S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Metformin doses to ensure efficacy and safety in patients with reduced kidney function. PLoS ONE, 16(2), e0246247. doi: 10.1371/journal.pone.0246247

Journal - Research Article

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Journal - Research Article

Anakin, M., Cuthbert, A. M., Luo, Q., Mwangi, B. M., Scoggins, R. J., Tang, A., Wong, V., & Wright, D. F. B. (2020). How do pharmacy students describe decision-making about drug therapy? MedEdPublish, 9(1), 20. doi: 10.15694/mep.2020.000020.1

Journal - Research Article

Donnellan, S., Wright, D. F. B., Roberts, J. A., Duffull, S. B., Schollum, J. B. W., Putt, T. L., … Walker, R. J. (2020). The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, 76, 239-247. doi: 10.1007/s00228-019-02792-0

Journal - Research Article

Pradhan, S., Wright, D. F. B., & Duffull, S. B. (2020). Evaluation of designs for renal drug studies based on the EMA and FDA guidelines for drugs that are predominantly secreted. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14536

Journal - Research Article

Stamp, L. K., Chapman, P. T., Barclay, M., Horne, A., Frampton, C., Merriman, T. R., Wright, D. F. B., … Dalbeth, N. (2020). Relationships between allopurinol dose, oxypurinol concentration and urate-lowering response: In search of a minimum effective oxypurinol concentration. Clinical & Translational Science, 13, 110-115. doi: 10.1111/cts.12686

Journal - Research Article

Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083

Journal - Research Article

Kuan, I. H. S., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The association between metformin therapy and lactic acidosis. Drug Safety, 42, 1449-1469. doi: 10.1007/s40264-019-00854-x

Journal - Research Article

Pradhan, S., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The intact nephron hypothesis as a model for renal drug handling. European Journal of Clinical Pharmacology, 75(2), 147-156. doi: 10.1007/s00228-018-2572-8

Journal - Research Article

Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2018). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy, 14(3), 309-316. doi: 10.1016/j.sapharm.2017.04.049

Journal - Research Article

Ooi, Q. X., Wright, D. F. B., Isbister, G. K., & Duffull, S. B. (2018). A factor VII-based method for the prediction of anticoagulant response to warfarin. Scientific Reports, 8, 12041. doi: 10.1038/s41598-018-30516-4

Journal - Research Article

Wright, D. F. B., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., Barclay, M. L., Drake, J., … Stamp, L. K. (2018). The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. British Journal of Clinical Pharmacology, 84(5), 937-943. doi: 10.1111/bcp.13516

Journal - Research Article

Kannangara, D. R. W., Graham, G. G., Wright, D. F. B., Stocker, S. L., Portek, I., Pile, K. D., Barclay, M. L., … Stamp, L. K., & Day, R. O. (2017). Individualising the dose of allopurinol in patients with gout. British Journal of Clinical Pharmacology, 83(9), 2015-2026. doi: 10.1111/bcp.13307

Journal - Research Article

Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x

Journal - Research Article

Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5

Journal - Research Article

Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649

Journal - Research Article

Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics, 44(5), 415-423. doi: 10.1007/s10928-017-9530-4

Journal - Research Article

Wright, D. F. B., Doogue, M. P., Barclay, M. L., Chapman, P. T., Cross, N. B., Irvine, J. H., & Stamp, L. K. (2017). A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis. European Journal of Clinical Pharmacology, 73, 71-78. doi: 10.1007/s00228-016-2133-y

Journal - Research Article

Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347

Journal - Research Article

Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799

Journal - Research Article

Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233

Journal - Research Article

Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177

Journal - Research Article

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9

Journal - Research Article

Roberts, R. L., Wallace, M. C., Wright, D. F. B., Cadzow, M., Dalbeth, N., Jones, P. B., Stamp, L. K., Harrison, A. A., Black, M. A., & Merriman, T. R. (2014). Frequency of CYP2C9 polymorphisms in Polynesian people and potential relevance to management of gout with benzbromarone. Joint Bone Spine, 81(2), 160-163. doi: 10.1016/j.jbspin.2013.07.006

Journal - Research Article

Stamp, L. K., Merriman, T. R., Barclay, M. L., Singh, J. A., Roberts, R. L., Wright, D. F. B., & Dalbeth, N. (2014). Impaired response or insufficient dosage? Examining the potential causes of ”inadequate response” to allopurinol in the treatment of gout. Seminars in Arthritis & Rheumatism, 44(2), 170-174. doi: 10.1016/j.semarthrit.2014.05.007

Journal - Research Article

Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6

Journal - Research Article

Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8

Journal - Research Article

Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834

Journal - Research Article

Duffull, S. B., Wright, D. F. B., & Winter, H. R. (2011). Interpreting population pharmacokinetic-pharmacodynamic analyses: A clinical viewpoint. British Journal of Clinical Pharmacology, 71(6), 807-814. doi: 10.1111/j.1365-2125.2010.03891.x

Journal - Research Article

Wright, D. F. B., & Duffull, S. B. (2011). Development of a Bayesian forecasting method for warfarin dose individualisation. Pharmaceutical Research, 28(5), 1100-1111. doi: 10.1007/s11095-011-0369-x

Journal - Research Article

Wright, D. F. B., Pavan Kumar, V. V., Al-Sallami, H. S., & Duffull, S. B. (2011). The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Basic & Clinical Pharmacology & Toxicology, 109(6), 494-498. doi: 10.1111/j.1742-7843.2011.00757.x

Journal - Research Article

Wright, D. F. B., Winter, H. R., & Duffull, S. B. (2011). Understanding the time course of pharmacological effect: A PKPD approach. British Journal of Clinical Pharmacology, 71(6), 815-823. doi: 10.1111/j.1365-2125.2011.03925.x

Journal - Research Article

Wright, D. F. B., & Begg, E. J. (2010). The 'apparent clearance' of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138. doi: 10.1111/j.1365-2125.2010.03673.x

Journal - Research Article

Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x

Journal - Research Article

Baker, E. H., Gnjidic, D., Kirkpatrick, C. M. J., Pirmohamed, M., Wright, D. F. B., & Zecharia, A. Y. (2021). A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments. British Journal of Clinical Pharmacology, 87(3), 707-711. doi: 10.1111/bcp.14416

Journal - Research Other

Cremers, S., & Wright, D. F. B. (2021). Nonmedical use of prescription drugs. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14797

Journal - Research Other

Al-Sallami, H. S., Wright, D. F. B., & Duffull, S. B. (2020). The propagation of between-subject variability from dose to response. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14699

Journal - Research Other

Kuan, I. H. S., Wright, D. F. B., Duffull, S. B., & Zhu, X. (2020). Understanding the association between metformin plasma concentrations and lactate. British Journal of Clinical Pharmacology, 87(2), 700-701. doi: 10.1111/bcp.14394

Journal - Research Other

Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154

Journal - Research Other

Sinnappah, K. A., Kuan, I. H. S., Thynne, T. R. J., Doogue, M. P., & Wright, D. F. B. (2020). The pharmacokinetics of metformin in patients receiving intermittent haemodialysis [Short report]. British Journal of Clinical Pharmacology, 86, 1430-1443. doi: 10.1111/bcp.14244

Journal - Research Other

Duffull, S. B., Anakin, M. G., & Wright, D. F. B. (2019). Understanding the process of clinical judgement for pharmacists when making clinical decisions. Research in Social & Administrative Pharmacy, 15(5), 607-614. doi: 10.1016/j.sapharm.2018.08.005

Journal - Research Other

Stamp, L. K., Wright, D. F. B., & Dalbeth, N. (2019). Restricting maintenance allopurinol dose according to kidney function in patients with gout is inappropriate! [Letter to the editor]. British Journal of Clinical Pharmacology, 85, 1378-1379. doi: 10.1111/bcp.13798

Journal - Research Other

Wright, D. F. B., Anakin, M. G., & Duffull, S. B. (2019). Clinical decision-making: An essential skill for 21st century pharmacy practice. Research in Social & Administrative Pharmacy, 15(5), 600-606. doi: 10.1016/j.sapharm.2018.08.001

Journal - Research Other

Chiew, A. L., Wright, D. F. B., Dobos, N. M., McArdle, K., Mostafa, A. A., Newth, A., … Isbister, G. (2018). "Massive" metformin overdose. British Journal of Clinical Pharmacology, 84(12), 2923-2927. doi: 10.1111/bcp.13582

Journal - Research Other

Chiew, A. L., Wright, D. F. B., Roberts, M. S., & Isbister, G. K. (2018). Response to ‘Comment on ‘‘Massive’ metformin overdose’ by Chiew et al'. British Journal of Clinical Pharmacology, 84, 2940-2941. doi: 10.1111/bcp.13747

Journal - Research Other

Wright, D. F. B., & Duffull, S. B. (2017). A general empirical model for renal drug handling in pharmacokinetic analyses. British Journal of Clinical Pharmacology, 83(9), 1869-1872. doi: 10.1111/bcp.13306

Journal - Research Other

Chin, P. K. L., & Wright, D. F. B. (2014). [Letter by Chin et al regarding article, "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial analysis"]. Circulation, 130(22), e194. doi: 10.1161/circulationaha.114.010099

Journal - Research Other

Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2014). Dabigatran in patients with mechanical heart valves. New England Journal of Medicine, 370, 382-383. doi: 10.1056/NEJMc1315004

Journal - Research Other

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Journal - Research Other

Wright, D. F. B., Al-Sallami, H. S., & Duffull, S. B. (2013). Is the dose of dabigatran really more predictable than warfarin? British Journal of Clinical Pharmacology, 76(6), 997-998. doi: 10.1111/bcp.12144

Journal - Research Other

Duffull, S. B., Wright, D. F. B., Al-Sallami, H. S., Zufferey, P. J., & Faed, J. M. (2012). Dabigatran: Rational dose individualisation and monitoring guidance is needed. New Zealand Medical Journal, 125(1357). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Other

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