Dr Dan Wright
|Qualifications||BScPharm(Dal) MA(Brist) MSc PhD(Otago) RegPharmNZ|
|Research summary||Clinical pharmacy; individualisation of drug therapy|
My research focuses on the individualisation of drug therapy. The types of questions I ask are; why do people respond differently to the same dose of a drug, what are the factors which determine this variability, and how can we use this information to design dosing regimens that are safe and effective?
I am particularly interested in the time course of drug concentrations in the body (pharmacokinetics), the concentration–effect relationship (pharmacodynamics) and the influence of genetic variability on drug response (pharmacogenetics). I have expertise in pharmacometric methodology including population PKPD modelling and computer simulations.
Wright, D. F. B., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., Barclay, M. L., Drake, J., … Stamp, L. K. (2018). The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. British Journal of Clinical Pharmacology, 84(5), 937-943. doi: 10.1111/bcp.13516
Chiew, A. L., Wright, D. F. B., Dobos, N. M., McArdle, K., Mostafa, A. A., Newth, A., … Isbister, G. (2018). "Massive" metformin overdose. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.13582
Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649
Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5
Kannangara, D. R. W., Graham, G. G., Wright, D. F. B., Stocker, S. L., Portek, I., Pile, K. D., Barclay, M. L., … Stamp, L. K., & Day, R. O. (2017). Individualising the dose of allopurinol in patients with gout. British Journal of Clinical Pharmacology, 83(9), 2015-2026. doi: 10.1111/bcp.13307