Marsh, J., Gloeckl, S., Tyndall, J., & Huston, W. M. (2011). The role of HtrA as a chaperone and protease in bacterial pathogenesis. In L. V. Berhardt (Ed.), Advances in Medicine and Biology (Vol. 27). (pp. 87-121). New York: Nova Science.

Chapter in Book - Research

Tyndall, J. D. A., Kelso, M. J., & Ranson, M. (2010). Inhibitors of the plasminogen activation system: Promising new agents for suppressing breast cancer metastasis. In Atta-ur-Rahman & M. I. Choudhary (Eds.), Frontiers in anti-cancer drug discovery (Vol. 1). (pp. 55-78). Bentham Science.

Chapter in Book - Research

Yin, J., Sharma, R., Tyndall, J. D. A., Grimsey, N. L., & Vernall, A. J. (2023). Synthesis and characterization of a cannabinoid type 2 receptor photoactivated prodrug. ChemPhotoChem, e202200291. Advance online publication. doi: 10.1002/cptc.202200291

Journal - Research Article

Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8

Journal - Research Article

Hwang, J., Mros, S., Gamble, A. B., Tyndall, J. D. A., & McDowell, A. (2022). Improving antibacterial activity of a HtrA protease inhibitor JO146 against Helicobacter pylori: A novel approach using microfluidics-engineered PLGA nanoparticles. Pharmaceutics, 14(2), 348. doi: 10.3390/pharmaceutics14020348

Journal - Research Article

Hwang, J., Strange, N., Mazraani, R., Phillips, M. J., Gamble, A. B., Huston, W. M., & Tyndall, J. D. A. (2022). Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia. European Journal of Medicinal Chemistry. doi: 10.1016/j.ejmech.2021.114064

Journal - Research Article

Lawer, A., Tyler, C., Hards, K., Keighley, L. M., Cheung, C.-Y., Kierek, F., Su, S., … McInnes, T., Tyndall, J. D. A., Krause, K. L., Cook, G. M., & Gamble, A. B. (2022). Synthesis and biological evaluation of aurachin D analogues as inhibitors of Mycobacterium tuberculosis cytochrome bd Oxidase. ACS Medicinal Chemistry Letters. Advance online publication. doi: 10.1021/acsmedchemlett.2c00401

Journal - Research Article

McNeil, N. M. R., Gates, E. W. J., Firoozi, N., Cundy, N. J., Leccese, J., Eisinga, S., Tyndall, J. D. A., … Keillor, J. W. (2022). Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors. European Journal of Medicinal Chemistry, 232, 114172. doi: 10.1016/j.ejmech.2022.114172

Journal - Research Article

Ruma, Y. N., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2022). Characterisation of Candida parapsilosis CYP51 as a drug target using Saccharomyces cerevisiae as host. Journal of Fungi, 8(1), 69. doi: 10.3390/jof8010069

Journal - Research Article

Graham, D. O., Wilson, R. K., Ruma, Y. N., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2021). Structural insights into the azole resistance of the Candida albicans Darlington strain using Saccharomyces cerevisiae lanosterol 14α-demethylase as a surrogate. Journal of Fungi, 7, 897. doi: 10.3390/jof7110897

Journal - Research Article

Hwang, J., Strange, N., Phillips, M. J. A., Krause, A. L., Heywood, A., Gamble, A. B., … Tyndall, J. D. A. (2021). Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues. European Journal of Medicinal Chemistry, 224(113692). doi: 10.1016/j.ejmech.2021.113692

Journal - Research Article

Liang, G., Yang, J., Liu, T., Wang, S., Wen, Y., Han, C., … Tyndall, J. D. A., … Xia, Q. (2021). A multi-strategy platform for quality control and Q-markers screen of Chaiqin chengqi decoction. Phytomedicine, 85, 153525. doi: 10.1016/j.phymed.2021.153525

Journal - Research Article

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540

Journal - Research Article

Murugayah, S. A., Evans, G. B., Tyndall, J. D. A., & Gerth, M. L. (2021). A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase. Biotechnology Letters, 43, 1467-1473. doi: 10.1007/s10529-021-03135-9

Journal - Research Article

Rana, Z., Tyndall, J. D. A., Hanif, M., Hartinger, C. G., & Rosengren, R. J. (2021). Cytostatic action of novel histone deacetylase inhibitors in androgen receptor-null prostate cancer cells. Pharmaceuticals, 14, 103. doi: 10.3390/ph14020103

Journal - Research Article

Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2021). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry, 74, 433-442. doi: 10.1071/CH20263

Journal - Research Article

Trinh, P. N. H., Chong, D. J. W., Leach, K., Hill, S. J., Tyndall, J. D. A., May, L. T., Vernall, A. J., & Gregory, K. J. (2021). Development of covalent, clickable probes for adenosine A₁ and A₃ receptors. Journal of Medicinal Chemistry, 64, 8161-8178. doi: 10.1021/acs.jmedchem.0c02169

Journal - Research Article

Wen, Y., Cai, W., Yang, J., Fu, X., Putha, L., Xia, Q., … Tyndall, J. D. A., … Huang, W. (2021). Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer. Frontiers in Pharmacology, 12, 638950. doi: 10.3389/fphar.2021.638950

Journal - Research Article

Handley, T. N. G., Tan, H.-X., Rutledge, M. T., Brewitz, H. H., Tyndall, J. D. A., Kleffmann, T., Butler, M. I., Poulter, R. T. M., & Wilbanks, S. M. (2020). Engineered biosynthesis of cyclotides. New Zealand Journal of Botany, 58(4), 358-377. doi: 10.1080/0028825X.2020.1791914

Journal - Research Article

Lamichhane, R., Galvin, H., Hannaway, R. F., de la Harpe, S. M., Munro, F., Tyndall, J. D. A., Vernall, A. J., McCall, J. L., Husain, M., & Ussher, J. E. (2020). Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology, 50, 178-191. doi: 10.1002/eji.201948279

Journal - Research Article

Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394

Journal - Research Article

Agbowuro, A. A., Hwang, J., Peel, E., Mazraani, R., Springwald, A., Marsh, J. W., … Gamble, A. B., … Tyndall, J. D. A. (2019). Structure-activity analysis of peptidic Chlamydia HtrA inhibitors. Bioorganic & Medicinal Chemistry, 27, 4185-4199. doi: 10.1016/j.bmc.2019.07.049

Journal - Research Article

Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8⁺ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054

Journal - Research Article

Monk, B. C., Keniya, M. V., Sabherwal, M., Wilson, R. K., Graham, D. O., Hassan, H. F., Chen, D., & Tyndall, J. D. A. (2019). Azole resistance reduces susceptibility to the tetrazole antifungal VT-1161. Antimicrobial Agents & Chemotherapy, 63(1), e02114-18. doi: 10.1128/AAC.02114-18

Journal - Research Article

Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), 1184-1190. doi: 10.1016/j.tet.2017.10.031

Journal - Research Article

Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076

Journal - Research Article

Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j

Journal - Research Article

Keniya, M. V., Ruma, Y. N., Tyndall, J. D. A., & Monk, B. C. (2018). Heterologous expression of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provides tools for antifungal discovery. Antimicrobial Agents & Chemotherapy, 62(11), e01131-18. doi: 10.1128/aac.01131-18

Journal - Research Article

Keniya, M. V., Sabherwal, M., Wilson, R. K., Woods, M. A., Sagatova, A. A., Tyndall, J. D. A., & Monk, B. C. (2018). Crystal structures of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provide tools for antifungal discovery. Antimicrobial Agents & Chemotherapy, 62(11), e01134-18. doi: 10.1128/aac.01134-18

Journal - Research Article

Sagatova, A. A., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2018). The impact of homologous resistance mutations from pathogenic yeast on Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 62(3), e02242-17. doi: 10.1128/aac.02242-17

Journal - Research Article

Singh, S., Cooper, S. L., Glenn, J. R., Beresford, J., Percival, L. R., Tyndall, J. D. A., … Vernall, A. J. (2018). Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. RSC Advances, 8(29), 16362-16369. doi: 10.1039/C7RA13148H

Journal - Research Article

Caramalho, R., Tyndall, J. D. A., Monk, B. C., Larentis, T., Lass-Flörl, C., & Lackner, M. (2017). Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase. Scientific Reports, 7(1), 15898. doi: 10.1038/s41598-017-16123-9

Journal - Research Article

Cooper, A., Singh, S., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2017). Chemical tools for studying lipid-binding class A G protein-coupled receptors. Pharmacological Reviews, 69(3), 316-353. doi: 10.1124/pr.116.013243

Journal - Research Article

Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695

Journal - Research Article

Lawrence, A., Fraser, T., Gillett, A., Tyndall, J. D. A., Timms, P., Polkinghorne, A., & Huston, W. M. (2016). Chlamydia serine protease inhibitor, targeting HtrA, as a new treatment for Koala Chlamydia infection. Scientific Reports, 6, 31466 . doi: 10.1038/srep31466

Journal - Research Article

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Sabherwal, M., Tyndall, J. D. A., & Monk, B. C. (2016). Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase. Scientific Reports, 6, 26213. doi: 10.1038/srep26213

Journal - Research Article

Tyndall, J. D. A., Sabherwal, M., Sagatova, A. A., Keniya, M. V., Negroni, J., Wilson, R. K., Woods, M. A., … Monk, B. C. (2016). Structural and functional elucidation of yeast lanosterol 14α-demethylase in complex with agrochemical antifungals. PLoS ONE, 11(12), e0167485. doi: 10.1371/journal.pone.0167485

Journal - Research Article

Hellyer, S. D., Indurthi, D., Balle, T., Runder-Varga, V., Selwood, A. I., Tyndall, J. D. A., … Kerr, D. S. (2015). Pinnatoxins E, F and G target multiple nicotinic receptor subtypes. Journal of Neurochemistry, 135(3), 479-491. doi: 10.1111/jnc.13245

Journal - Research Article

Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., … Tyndall, J. D. A., & Anderson, G. M. (2015). Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14. Endocrinology, 156(11), 4152-4162. doi: 10.1210/en.2015-1532

Journal - Research Article

Marsh, J. W., Wee, B. A., Tyndall, J. D. A., Lott, W. B., Bastidas, R. J., Caldwell, H. D., … Huston, W. M. (2015). A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production. BMC Microbiology, 15, 194. doi: 10.1186/s12866-015-0533-2

Journal - Research Article

Sagatova, A. A., Keniya, M. V., Wilson, R. K., Monk, B. C., & Tyndall, J. D. A. (2015). Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 59(8), 4982-4989. doi: 10.1128/aac.00925-15

Journal - Research Article

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Journal - Research Article

Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612

Journal - Research Article

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Journal - Research Article

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

Journal - Research Article

Gloeckl, S., Ong, V. A., Patel, P., Tyndall, J. D. A., Timms, P., Beagley, K. W., … Huston, W. M. (2013). Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology, 89(4), 676-689. doi: 10.1111/mmi.12306

Journal - Research Article

Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035

Journal - Research Article

Marsh, J. W., Lott, W. B., Tyndall, J. D. A., & Huston, W. M. (2013). Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5. Cellular & Molecular Biology Letters, 18(4), 522-537. doi: 10.2478/s11658-013-0103-2

Journal - Research Article

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353

Journal - Research Article

Shankar, M., Wilbanks, S. M., Nakatani, Y., Monk, B. C., & Tyndall, J. D. A. (2013). Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallographica Section D, 69(8), 1580-1586. doi: 10.1107/S0907444913010949

Journal - Research Article

Vellas, S. K., Lewis, J. E. M., Shankar, M., Sagatova, A., Tyndall, J. D. A., Monk, B. C., Fitchett, C. M., Hanton, L. R., & Crowley, J. D. (2013). [Fe₂L₃]⁴⁺ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: Synthesis, structures and exploration of biological activity. Molecules, 18(6), 6383-6407. doi: 10.3390/molecules18066383

Journal - Research Article

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x

Journal - Research Article

Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552

Journal - Research Article

Beggs, K. T., Tyndall, J. D. A., & Mercer, A. R. (2011). Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship. PLoS ONE, 6(11), e26809. doi: 10.1371/journal.pone.0026809

Journal - Research Article

Huston, W. M., Tyndall, J. D. A., Lott, W. B., Stansfield, S. H., & Timms, P. (2011). Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis. PLoS ONE, 6(9), e24547. doi: 10.1371/journal.pone.0024547

Journal - Research Article

Matthews, H., Ranson, M., Tyndall, J. D. A., & Kelso, M. J. (2011). Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA). Bioorganic & Medicinal Chemistry Letters, 21(22), 6760-6766. doi: 10.1016/j.bmcl.2011.09.044

Journal - Research Article

Suetani, R. J., Sorrenson, B., Tyndall, J. D. A., Williams, M. J. A., & McCormick, S. P. A. (2011). Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease. Atherosclerosis, 218(2), 404-410. doi: 10.1016/j.atherosclerosis.2011.06.019

Journal - Research Article

Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., Hill, T. A., & Fairlie, D. P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110(6), PR32-PR69. doi: 10.1021/cr900395y

Journal - Research Article

Madala, P. K., Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2010). Update 1 of: Proteases universally recognize beta strands in their active sites. Chemical Reviews, 110(6), PR1-PR31. doi: 10.1021/cr900368a

Journal - Research Article

Nisa, S., Blokpoel, M. C. J., Robertson, B. D., Tyndall, J. D. A., Lun, S., Bishai, W. R., & O'Toole, R. (2010). Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. Journal of Antimicrobial Chemotherapy, 65(11), 2347-2358. doi: 10.1093/jac/dkq311

Journal - Research Article

Ruiz-Gómez, G., Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2010). Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110, PR1-PR41. doi: 10.1021/cr900344w

Journal - Research Article

Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j.neuropharm.2010.03.019

Journal - Research Article

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092

Journal - Research Article

Fry, B. G., Roelants, K., Champagne, D. E., Scheib, H., Tyndall, J. D. A., …, & Rodríguez de la Vega, R. C. (2009). The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms. Annual Review of Genomics & Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356

Journal - Research Article

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08

Journal - Research Article

Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1

Journal - Research Article

Ashton, J. C., Wright, J. L., McPartland, J. M., & Tyndall, J. D. A. (2008). Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current Medicinal Chemistry, 15, 1428-1443.

Journal - Research Article

Tyndall, J. D. A., Kelso, M. J., Clingan, P., & Ranson, M. (2008). Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer. Recent Patents on Anti-Cancer Drug Discovery, 3(1), 1-13.

Journal - Research Article

Tyndall, J. D. A., Pattenden, L. K., Reid, R. C., Hu, S.-H., Alewood, D., Alewood, P. F., … Martin, J. L. (2008). Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease: Implications for the catalytic mechanism. Biochemistry, 47, 3736-3744.

Journal - Research Article

Gee, C. L., Drinkwater, N., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2007). Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 50(20), 4845-4853.

Journal - Research Article

Pearl, E. J., Tyndall, J. D. A., Poulter, R. T. M., & Wilbanks, S. M. (2007). Sequence requirements for splicing by the Cne PRP8 intein. FEBS Letters, 581, 3000-3004.

Journal - Research Article

Kahnberg, P., Lucke, A. J., Glenn, M. P., Boyle, G. M., Tyndall, J. D. A., Parsons, P. G., & Fairlie, D. P. (2006). Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from α-aminosuberic acid. Journal of Medicinal Chemistry, 49, 7611-7622.

Journal - Research Article

Sobhani, A. M., Amini, S. R., Tyndall, J. D. A., Azizi, E., Daneshtalab, M., & Khalaj, A. (2006). A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking. Journal of Molecular Graphics & Modelling, 25, 459-469.

Journal - Research Article

Chappell, K. J., Nall, T. A., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Fairlie, D. P., & Young, P. R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280(4), 2896-2903.

Journal - Research Article

Gee, C. L., Nourse, A., Hsin, A.-Y., Wu, Q., Tyndall, J. D., Grunewald, G. L., … Martin, J. L. (2005). Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active. Biochimica et Biophysica Acta: Proteins & Proteomics, 1750, 82-92.

Journal - Research Article

Gee, C. L., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2005). Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis. Biochemistry, 44, 16875-16885.

Journal - Research Article

Higginbottom, A., Cain, S. A., Woodruff, T. M., Proctor, L. M., Madala, P. K., Tyndall, J. D. A., … Monk, P. N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280(18), 17831-17840.

Journal - Research Article

Tyndall, J. D. A., & Sandilya, R. (2005). GPCR agonists and antagonists in the clinic. Medicinal Chemistry, 1, 405-421.

Journal - Research Article

Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2005). Proteases universally recognize beta strands in their active sites. Chemistry Review, 105, 973-999.

Journal - Research Article

Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2005). Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemistry Review, 105, 793-826.

Journal - Research Article

Wu, Q., Gee, C. L., Lin, F., Tyndall, J. D., Martin, J. L., Grunewald, G. L., & McLeish, M. J. (2005). Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 48(23), 7243-7252.

Journal - Research Article

Dutertre, S., Nicke, A., Tyndall, J. D. A., & Lewis, R. J. (2004). Determination of α-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition, 17, 339-347.

Journal - Research Article

Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., & Fairlie, D. P. (2004). Beta-strand mimetics. Chemical Reviews, 104, 6085-6117.

Journal - Research Article

March, D. R., Proctor, L. M., Stoermer, M. J., Sbaglia, R., Abbenante, G., Reid, R. C., … Tyndall, J. D. A., … Fairlie, D. P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes: Relationships between structures and activity. Molecular Pharmacology, 65(4), 868-879.

Journal - Research Article

Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Young, P. R., & Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile Virus NS3 protease. Journal of Biological Chemistry, 279(47), 48535-48542.

Journal - Research Article

Reid, R. C., Pattenden, L. K., Tyndall, J. D. A., Martin, J. L., Walsh, T., & Fairlie, D. P. (2004). Countering cooperative effects in protease inhibitors using constrained β-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47, 1641-1651.

Journal - Research Article

van den Brenk, A. L., Tyndall, J. D. A., Cusack, R. M., Jones, A., Fairlie, D. P., Gahan, L. R., & Hanson, G. R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: Influence of anion and solvent. Journal of Inorganic Biochemistry, 98, 1857-1866.

Journal - Research Article

Glenn, M. P., Kelso, M. J., Tyndall, J. D. A., & Fairlie, D. P. (2003). Conformationally homogeneous cyclic tetrapeptides: Useful new three-dimensional scaffolds. Journal of the American Chemical Society, 125(3), 640-641.

Journal - Research Article

Hansford, K. A., Reid, R. C., Clark, C. I., Tyndall, J. D. A., Whitehouse, M. W., Guthrie, T., … Fairlie, D. P. (2003). D-tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A₂ (IIa) with antiinflammatory activity. ChemBioChem, 4(2-3), 181-185.

Journal - Research Article

Lucke, A. J., Tyndall, J. D. A., Singh, Y., & Fairlie, D. P. (2003). Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. Journal of Molecular Graphics & Modelling, 21, 341-355.

Journal - Research Article

Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278(33), 31105-31110.

Journal - Research Article

Glenn, M. P., Pattenden, L. K., Reid, R. C., Tyssen, D. P., Tyndall, J. D. A., Birch, C. J., & Fairlie, D. P. (2002). β-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity. Journal of Medicinal Chemistry, 45, 371-381.

Journal - Research Article

Sinchaikul, S., Tyndall, J. D. A., Fothergill-Gilmore, L. A., Taylor, P., Phutrakul, S., Chen, S.-T., & Walkinshaw, M. D. (2002). Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1. Acta Crystallographica Section D, D58, 182-185.

Journal - Research Article

Tyndall, J. D. A., Sinchaikul, S., Fothergill-Gilmore, L. A., Taylor, P., & Walkinshaw, M. D. (2002). Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. Journal of Molecular Biology, 323, 859-869.

Journal - Research Article

Tyndall, J. D. A., & Fairlie, D. P. (2001). Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases. Current Medicinal Chemistry, 8(8), 893-907.

Journal - Research Article

Fairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., … Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43, 1271-1281.

Journal - Research Article

Tyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., … Fairlie, D. P. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43, 3495-3504.

Journal - Research Article

Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., … Bush, A. I. (1999). Cu(II) potentiation of Alzheimer Aβ neurotoxicity: Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry, 274(52), 37111-37116.

Journal - Research Article

Tyndall, J. D. A., & Fairlie, D. P. (1999). Conformational homogeneity in molecular recognition by proteolytic enzymes. Journal of Molecular Recognition, 12, 363-370.

Journal - Research Article

Liddle, I., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2022). Covalent cannabinoid receptor ligands: Structural insight and selectivity challenges. RSC Medicinal Chemistry. Advance online publication. doi: 10.1039/D2MD00006G

Journal - Research Other