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Contact Details

Phone
+64 3 479 7324
Email
allan.gamble@otago.ac.nz

University Links

Position
Associate Professor
Qualifications
PhD
Research summary
Synthetic and medicinal chemistry, bioorganic chemistry, drug delivery and chemical biology
Teaching
Allan teaches chemical biology, medicinal chemistry and analytical chemistry in the Bachelor of Pharmaceutical Sciences (BPharmSc) and Bachelor of Pharmacy (BPharm) undergraduate programmes. He is paper coordinator for PSCI201 (Pharmaceutical Chemistry) and PSCI301 (Chemical Biology).
Memberships
Chair of the New Zealand Institute of Chemistry (NZIC) Otago branch and the Chair of NZIC-24, the institutes national biennial conference to be held in Dunedin on 24-28 November 2024.

Research

Allan Gamble's research interests are in bioorganic and medicinal chemistry, chemical biology, and drug delivery, with external funding from various agencies including the Health Research Council (HRC), Marsden, Maurice Wilkins Centre, Breast Cancer Cure, Lotteries Health and Otago Medical Research Foundation.

Biography

Allan Gamble received his PhD in organic chemistry from the University of Wollongong, under the supervision of Professor Paul Keller in 2008. He then moved to Canberra to take up a postdoctoral position in the Research School of Chemistry at the Australian National University with Professor Chris Easton where he worked on peptide hormone regulation in cancer.

In 2011, he was awarded an American-Australian Sir Keith Murdoch Postdoctoral Fellowship to work with Professor Paul Wender at Stanford University in the area of drug delivery.

In May 2012 he was appointed Lecturer in Medicinal Chemistry in the School of Pharmacy at the University of Otago, and was promoted to Senior Lecturer in 2016 and in 2023 promoted to Associate Professor.

Allan Gamble’s recent awards include:

  • 2023 The School of Pharmacy Research Excellence Award
  • 2018 The University of Otago Early Career Award for Distinction in Research
  • 2017 The School of Pharmacy Emerging Researcher Award
  • 2016 The OUSA Health Sciences and New Supervisor of the Year Award

Additional details

Research group members

  • Baxter Blair (honours)
  • Thomi Brind (PhD)
  • Julia Camilli (PhD)
  • Dr Jessica Fairhall (Research Fellow)
  • Harry Lewin (PhD)
  • Dr Ian Liddle (Postdoctoral Fellow)
  • Shuaijiang Liu (Visiting Researcher)
  • Kerry Mei (master's)
  • Parul Rani (Assistant Research Fellow)
  • Kathy Sircombe (PhD)
  • Simon Su (PhD)
  • Chelsea Tyler (PhD)
  • Ke Wu (PhD)

Publications

Matikonda, S. S., Fairhall, J. M., Fiedler, F., Sanhajariya, S., Tucker, R. A. J., Hook, S., Garden, A. L., & Gamble, A. B. (2018). Mechanistic evaluation of bioorthogonal decaging with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging from the 1,2,3-triazoline. Bioconjugate Chemistry, 29(2), 324-334. doi: 10.1021/acs.bioconjchem.7b00665 Journal - Research Article

Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695 Journal - Research Article

Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a Journal - Research Article

Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), 1184-1190. doi: 10.1016/j.tet.2017.10.031 Journal - Research Article

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012 Journal - Research Article

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