Associate Professor Daniel Wright

Contact Details
- Phone
- +64 3 479 7290
- dan.wright@otago.ac.nz
University Links
- Position
- Associate Professor
- Qualifications
- BScPharm(Dal) MA(Brist) MSc PhD(Otago) RegPharmNZ
- Research summary
- Clinical pharmacy; individualisation of drug therapy
Research
My research focuses on the individualisation of drug therapy. The types of questions I ask are; why do people respond differently to the same dose of a drug, what are the factors which determine this variability, and how can we use this information to design dosing regimens that are safe and effective?
I am particularly interested in the time course of drug concentrations in the body (pharmacokinetics), the concentration–effect relationship (pharmacodynamics) and the influence of genetic variability on drug response (pharmacogenetics). I have expertise in pharmacometric methodology including population PKPD modelling and computer simulations.
Publications
Sinnappah, C. A., Hughes, D. A., Stocker, S. L., Aronson, J. K., & Wright, D. F. B. (2023). A framework for understanding sources of bias in medication adherence research. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15863
Wright, D. F. B., Sinnappah, K. A., & Hughes, D. A. (2023). Medication adherence research comes of age. British Journal of Clinical Pharmacology, 89, 1914-1917. doi: 10.1111/bcp.15722
Kuan, I. H. S., Wright, D. F. B., & Duffull, S. B. (2023). The influence of flip-flop in population pharmacokinetic analyses. Clinical & Translational Science. Advance online publication. doi: 10.1002/psp4.12909
Hishe, H. Z., Stocker, S. L., Stamp, L. K., Dalbeth, N., Merriman, T. R., Phipps-Green, A., & Wright, D. F. B. (2023). The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics [Brief report]. Clinical & Translational Science, 16, 422-428. doi: 10.1111/cts.13460
Smith-Diaz, N., Stocker, S. L., Stamp, L. K., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., & Wright, D. F. B. (2023). An allopurinol adherence tool using plasma oxypurinol concentrations. British Journal of Clinical Pharmacology, 89, 1956-1964. doi: 10.1111/bcp.15516
Sinnappah, C. A., Hughes, D. A., Stocker, S. L., Aronson, J. K., & Wright, D. F. B. (2023). A framework for understanding sources of bias in medication adherence research. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15863
Journal - Research Article
Smith-Diaz, N., Stocker, S. L., Stamp, L. K., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., & Wright, D. F. B. (2023). An allopurinol adherence tool using plasma oxypurinol concentrations. British Journal of Clinical Pharmacology, 89, 1956-1964. doi: 10.1111/bcp.15516
Journal - Research Article
Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2021). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy, 17, 326-331. doi: 10.1016/j.sapharm.2020.04.005
Journal - Research Article
Darwich, A. S., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., … Rostami-Hodjegan, A. (2021). Model-informed precision dosing: Background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy. Annual Review of Pharmacology & Toxicology, 61, 36.1-36.21. doi: 10.1146/annurev-pharmtox-033020-113257
Journal - Research Article
Kuan, I. H. S., Wilson, L. C., Leishman, J. C., Cosgrove, S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Metformin doses to ensure efficacy and safety in patients with reduced kidney function. PLoS ONE, 16(2), e0246247. doi: 10.1371/journal.pone.0246247
Journal - Research Article
Pradhan, S., Wright, D. F. B., & Duffull, S. B. (2021). Evaluation of designs for renal drug studies based on the European Medicines Agency and Food and Drug Administration guidelines for drugs that are predominantly secreted. British Journal of Clinical Pharmacology, 87, 1401-1410. doi: 10.1111/bcp.14536
Journal - Research Article
Donnellan, S., Wright, D. F. B., Roberts, J. A., Duffull, S. B., Schollum, J. B. W., Putt, T. L., … Walker, R. J. (2020). The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, 76, 239-247. doi: 10.1007/s00228-019-02792-0
Journal - Research Article
Stamp, L. K., Chapman, P. T., Barclay, M., Horne, A., Frampton, C., Merriman, T. R., Wright, D. F. B., … Dalbeth, N. (2020). Relationships between allopurinol dose, oxypurinol concentration and urate-lowering response: In search of a minimum effective oxypurinol concentration. Clinical & Translational Science, 13, 110-115. doi: 10.1111/cts.12686
Journal - Research Article
Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083
Journal - Research Article
Kuan, I. H. S., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The association between metformin therapy and lactic acidosis. Drug Safety, 42, 1449-1469. doi: 10.1007/s40264-019-00854-x
Journal - Research Article
Pradhan, S., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The intact nephron hypothesis as a model for renal drug handling. European Journal of Clinical Pharmacology, 75(2), 147-156. doi: 10.1007/s00228-018-2572-8
Journal - Research Article
Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2018). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy, 14(3), 309-316. doi: 10.1016/j.sapharm.2017.04.049
Journal - Research Article
Ooi, Q. X., Wright, D. F. B., Isbister, G. K., & Duffull, S. B. (2018). A factor VII-based method for the prediction of anticoagulant response to warfarin. Scientific Reports, 8, 12041. doi: 10.1038/s41598-018-30516-4
Journal - Research Article
Wright, D. F. B., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., Barclay, M. L., Drake, J., … Stamp, L. K. (2018). The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. British Journal of Clinical Pharmacology, 84(5), 937-943. doi: 10.1111/bcp.13516
Journal - Research Article
Kannangara, D. R. W., Graham, G. G., Wright, D. F. B., Stocker, S. L., Portek, I., Pile, K. D., Barclay, M. L., … Stamp, L. K., & Day, R. O. (2017). Individualising the dose of allopurinol in patients with gout. British Journal of Clinical Pharmacology, 83(9), 2015-2026. doi: 10.1111/bcp.13307
Journal - Research Article
Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x
Journal - Research Article
Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5
Journal - Research Article
Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649
Journal - Research Article
Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics, 44(5), 415-423. doi: 10.1007/s10928-017-9530-4
Journal - Research Article
Wright, D. F. B., Doogue, M. P., Barclay, M. L., Chapman, P. T., Cross, N. B., Irvine, J. H., & Stamp, L. K. (2017). A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis. European Journal of Clinical Pharmacology, 73, 71-78. doi: 10.1007/s00228-016-2133-y
Journal - Research Article
Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347
Journal - Research Article
Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799
Journal - Research Article
Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233
Journal - Research Article
Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177
Journal - Research Article
Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366
Journal - Research Article
Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364
Journal - Research Article
Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9
Journal - Research Article
Roberts, R. L., Wallace, M. C., Wright, D. F. B., Cadzow, M., Dalbeth, N., Jones, P. B., Stamp, L. K., Harrison, A. A., Black, M. A., & Merriman, T. R. (2014). Frequency of CYP2C9 polymorphisms in Polynesian people and potential relevance to management of gout with benzbromarone. Joint Bone Spine, 81(2), 160-163. doi: 10.1016/j.jbspin.2013.07.006
Journal - Research Article
Stamp, L. K., Merriman, T. R., Barclay, M. L., Singh, J. A., Roberts, R. L., Wright, D. F. B., & Dalbeth, N. (2014). Impaired response or insufficient dosage? Examining the potential causes of ”inadequate response” to allopurinol in the treatment of gout. Seminars in Arthritis & Rheumatism, 44(2), 170-174. doi: 10.1016/j.semarthrit.2014.05.007
Journal - Research Article
Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6
Journal - Research Article
Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8
Journal - Research Article
Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834
Journal - Research Article
Duffull, S. B., Wright, D. F. B., & Winter, H. R. (2011). Interpreting population pharmacokinetic-pharmacodynamic analyses: A clinical viewpoint. British Journal of Clinical Pharmacology, 71(6), 807-814. doi: 10.1111/j.1365-2125.2010.03891.x
Journal - Research Article
Wright, D. F. B., & Duffull, S. B. (2011). Development of a Bayesian forecasting method for warfarin dose individualisation. Pharmaceutical Research, 28(5), 1100-1111. doi: 10.1007/s11095-011-0369-x
Journal - Research Article
Wright, D. F. B., Pavan Kumar, V. V., Al-Sallami, H. S., & Duffull, S. B. (2011). The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Basic & Clinical Pharmacology & Toxicology, 109(6), 494-498. doi: 10.1111/j.1742-7843.2011.00757.x
Journal - Research Article
Wright, D. F. B., Winter, H. R., & Duffull, S. B. (2011). Understanding the time course of pharmacological effect: A PKPD approach. British Journal of Clinical Pharmacology, 71(6), 815-823. doi: 10.1111/j.1365-2125.2011.03925.x
Journal - Research Article
Wright, D. F. B., & Begg, E. J. (2010). The 'apparent clearance' of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138. doi: 10.1111/j.1365-2125.2010.03673.x
Journal - Research Article
Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x
Journal - Research Article
Hishe, H. Z., Stocker, S. L., Stamp, L. K., Dalbeth, N., Merriman, T. R., Phipps-Green, A., & Wright, D. F. B. (2023). The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics [Brief report]. Clinical & Translational Science, 16, 422-428. doi: 10.1111/cts.13460
Journal - Research Other
Kuan, I. H. S., Wright, D. F. B., & Duffull, S. B. (2023). The influence of flip-flop in population pharmacokinetic analyses. Clinical & Translational Science. Advance online publication. doi: 10.1002/psp4.12909
Journal - Research Other
Wright, D. F. B., Sinnappah, K. A., & Hughes, D. A. (2023). Medication adherence research comes of age. British Journal of Clinical Pharmacology, 89, 1914-1917. doi: 10.1111/bcp.15722
Journal - Research Other
Al-Sallami, H. S., Wright, D. F. B., & Duffull, S. B. (2022). The propagation of between-subject variability from dose to response. British Journal of Clinical Pharmacology, 88, 1414-1417. doi: 10.1111/bcp.14699
Journal - Research Other
Bies, R. R., & Wright, D. F. B. (2022). Perspectives on the past, present, and future of pharmacometrics. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15289
Journal - Research Other
Sinnappah, K. A., Stocker, S. L., Chan, J. S., Hughes, D. A., & Wright, D. F. B. (2022). Clinical interventions to improve adherence to urate-lowering therapy in patients with gout: A systematic review. International Journal of Pharmacy Practice, 30, 215-225. doi: 10.1093/ijpp/riac025
Journal - Research Other
Baker, E. H., Gnjidic, D., Kirkpatrick, C. M. J., Pirmohamed, M., Wright, D. F. B., & Zecharia, A. Y. (2021). A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments. British Journal of Clinical Pharmacology, 87(3), 707-711. doi: 10.1111/bcp.14416
Journal - Research Other
Cremers, S., & Wright, D. F. B. (2021). Nonmedical use of prescription drugs. British Journal of Clinical Pharmacology, 87, 1635-1636. doi: 10.1111/bcp.14797
Journal - Research Other
Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? [Short communication]. British Journal of Clinical Pharmacology, 87, 4871-4879. doi: 10.1111/bcp.14919
Journal - Research Other
Wright, D. F. B., & Kirkpatrick, D. F. B. (2021). Science fiction has become reality: Best practice for future viral pandemics. British Journal of Clinical Pharmacology. doi: 10.1111/bcp.14997
Journal - Research Other
Anakin, M., Cuthbert, A. M., Luo, Q., Mwangi, B. M., Scoggins, R. J., Tang, A., Wong, V., & Wright, D. F. B. (2020). How do pharmacy students describe decision-making about drug therapy? MedEdPublish, 9(1), 20. doi: 10.15694/mep.2020.000020.1
Journal - Research Other
Kuan, I. H. S., Wright, D. F. B., Duffull, S. B., & Zhu, X. (2020). Understanding the association between metformin plasma concentrations and lactate. British Journal of Clinical Pharmacology, 87(2), 700-701. doi: 10.1111/bcp.14394
Journal - Research Other
Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154
Journal - Research Other
Sinnappah, K. A., Kuan, I. H. S., Thynne, T. R. J., Doogue, M. P., & Wright, D. F. B. (2020). The pharmacokinetics of metformin in patients receiving intermittent haemodialysis [Short report]. British Journal of Clinical Pharmacology, 86, 1430-1443. doi: 10.1111/bcp.14244
Journal - Research Other
Duffull, S. B., Anakin, M. G., & Wright, D. F. B. (2019). Understanding the process of clinical judgement for pharmacists when making clinical decisions. Research in Social & Administrative Pharmacy, 15(5), 607-614. doi: 10.1016/j.sapharm.2018.08.005
Journal - Research Other
Stamp, L. K., Wright, D. F. B., & Dalbeth, N. (2019). Restricting maintenance allopurinol dose according to kidney function in patients with gout is inappropriate! [Letter to the editor]. British Journal of Clinical Pharmacology, 85, 1378-1379. doi: 10.1111/bcp.13798
Journal - Research Other
Wright, D. F. B., Anakin, M. G., & Duffull, S. B. (2019). Clinical decision-making: An essential skill for 21st century pharmacy practice. Research in Social & Administrative Pharmacy, 15(5), 600-606. doi: 10.1016/j.sapharm.2018.08.001
Journal - Research Other
Chiew, A. L., Wright, D. F. B., Dobos, N. M., McArdle, K., Mostafa, A. A., Newth, A., … Isbister, G. (2018). "Massive" metformin overdose. British Journal of Clinical Pharmacology, 84(12), 2923-2927. doi: 10.1111/bcp.13582
Journal - Research Other
Chiew, A. L., Wright, D. F. B., Roberts, M. S., & Isbister, G. K. (2018). Response to ‘Comment on ‘‘Massive’ metformin overdose’ by Chiew et al'. British Journal of Clinical Pharmacology, 84, 2940-2941. doi: 10.1111/bcp.13747
Journal - Research Other
Wright, D. F. B., & Duffull, S. B. (2017). A general empirical model for renal drug handling in pharmacokinetic analyses. British Journal of Clinical Pharmacology, 83(9), 1869-1872. doi: 10.1111/bcp.13306
Journal - Research Other
Chin, P. K. L., & Wright, D. F. B. (2014). [Letter by Chin et al regarding article, "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial analysis"]. Circulation, 130(22), e194. doi: 10.1161/circulationaha.114.010099
Journal - Research Other
Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2014). Dabigatran in patients with mechanical heart valves. New England Journal of Medicine, 370, 382-383. doi: 10.1056/NEJMc1315004
Journal - Research Other
Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069
Journal - Research Other
Wright, D. F. B., Al-Sallami, H. S., & Duffull, S. B. (2013). Is the dose of dabigatran really more predictable than warfarin? British Journal of Clinical Pharmacology, 76(6), 997-998. doi: 10.1111/bcp.12144
Journal - Research Other
Duffull, S. B., Wright, D. F. B., Al-Sallami, H. S., Zufferey, P. J., & Faed, J. M. (2012). Dabigatran: Rational dose individualisation and monitoring guidance is needed. New Zealand Medical Journal, 125(1357). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other