Dr Michael Garelja

2025

Journal - Research Article

Alexander, P. H., Davenport, A. P., Kelly, E., Gibb, A. J., Mathie, A. A., Peach, C. J., … Garelja, M. L., … Glass, M., … Hay, D. L., … Zaidman, N. (2025). The concise guide to Pharmacology 2025/26: G protein-coupled receptors. British Journal of Pharmacology, 182, S24-S151. doi: 10.1111/bph.70230

Garelja, M. L., Rees, T. A., & Hay, D. L. (2025). Calcitonin gene-related peptide and headache: Comparison of two commonly used assay kits highlights the perils of measuring neuropeptides with enzyme-linked immunosorbent assays. Headache. Advance online publication. doi: 10.1111/head.15011

Tasma, Z., Garelja, M. L., Jamaluddin, A., Alexander, T. I., & Rees, T. A. (2025). Where are we now? Biased signalling of Class B G protein-coupled receptor-targeted therapeutics. Pharmacology & Therapeutics, 270, 108846. doi: 10.1016/j.pharmthera.2025.108846

2024

Journal - Research Article

Garelja, M. L., Alexander, T. I., Walker, C. S., & Hay, D. L. (2024). Extracellular bimolecular fluorescence complementation for investigating membrane protein dimerization: A proof of concept using class B GPCRs. Bioscience Reports, 44, BSR20240449. doi: 10.1042/bsr20240449

Babych, M., Garelja, M. L., Nguyen, P. T., Hay, D. L., & Bourgault, S. (2024). Converting the amyloidogenic islet amyloid polypeptide into a potent nonaggregating peptide ligand by side chain-to-side chain macrocyclization. Journal of the American Chemical Society, 146, 25513-25526. doi: 10.1021/jacs.4c05297

Rees, T. A., Tasma, Z., Garelja, M. L., O'Carroll, S. J., Walker, C. S., & Hay, D. L. (2024). Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. Journal of Headache & Pain, 25, 36. doi: 10.1186/s10194-024-01744-z

Mazzini, G., Le Foll, C., Boyle, C. N., Garelja, M. L., Zhyvoloup, A., Miller, M. E. T., Hay, D. L., … Lutz, T. A. (2024). The processing intermediate of human amylin, pro-amylin(1–48) has in vivo and in vitro bioactivity. Biophysical Chemistry, 308, 107201. doi: 10.1016/j.bpc.2024.107201

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

Conference Contribution - Published proceedings: Abstract

Hay, D., Rizwan, M., Forrester, L., Rees, T., Rea, B., Sowers, L., … Garelja, M. (2024). Subcutaneous administration of calcitonin-gene related peptide or amylin induces non-evoked pain in female rats. Headache, 64(Suppl. 1), (pp. 13). doi: 10.1111/head.14716

Hay, D., Nimick, M., Garelja, M., Alexander, T., Walker, C., & Banerjee, P. (2024). Pharmacological characterization of ubrogepant and atogepant in cAMP assays at human, rat and mouse calcitonin family receptors in transfected cells. Headache, 64(Suppl. 1), (pp. 11-12). doi: 10.1111/head.14716

Hay, D., Alexander, T., Nimick, M., Garelja, M., Walker, C., & Banerjee, P. (2024). Antagonism by ubrogepant and atogepant of agonist-mediated human CGRP receptor β-arrestin recruitment and internalization in transfected cells. Headache, 64(Suppl. 1), (pp. 3-4). doi: 10.1111/head.14716

Conference Contribution - Verbal presentation and other Conference outputs

Reith, E., Hay, D., & Garelja, M. (2024, August). Characterisation of a naturally occurring calcitonin receptor-like receptor variant. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

Garelja, M. (2024, December). Investigating the relationship between CGRP and the calcitonin receptor in the brain. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (ASCEPT), Asia Pacific Federation of Pharmacologists (APFP), and Australasian Pharmaceutical Science Association (APSA) Joint Congress, Melbourne, Australia.

Hay, D., & Garelja, M. (2024, December). IUPHAR transparency and reproducibility. Workshop presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (ASCEPT), Asia Pacific Federation of Pharmacologists (APFP), and Australasian Pharmaceutical Science Association (APSA) Joint Congress, Melbourne, Australia.

2023

Journal - Research Other

Garelja, M. L., Hay, D., Poyner, D. R., & Walker, C. S. (2023). Calcitonin receptors in GtoPdb v.2023.1 [Citation summary]. IUPHAR/BPS Guide to Pharmacology CITE, (1). doi: 10.2218/gtopdb/F11/2023.1

Conference Contribution - Published proceedings: Abstract

Alexander, T., Garelja, M., & Hay, D. (2023). Differential interaction of β-arrestin with the CGRP and AMY₁ receptors. Cephalalgia, 43(1 Suppl.), (pp. 180). doi: 10.1177/03331024231189112

Rees, T., Tasma, Z., Garelja, M., Walker, C., & Hay, D. (2023). The trigeminal and dorsal root ganglia exhibit differences in calcitonin receptor, CGRP, and amylin expression. Cephalalgia, 43(1 Suppl.), (pp. 177). doi: 10.1177/03331024231189112

Forrester, L. M., Garelja, M. L., Dalldorf, L. K., Dawson, A. M., Leen, A. J., Rees, T. A., & Hay, D. L. (2023). Potential paracrine interactions between CGRP and the AMY₁ receptor in the parabrachial nucleus and amygdala of rodents. Cephalalgia, 43(1 Suppl.), (pp. 40-41). doi: 10.1177/03331024231189112

Garelja, M. L., Rees, T. A., & Hay, D. L. (2023). Investigation of CGRP and AMY₁ receptor subunit expression using RNA-fluorescence in situ hybridization in migraine associated tissue. Cephalalgia, 43(1 Suppl.), (pp. 32-33). doi: 10.1177/03331024231189112

Leen, A. J., Garelja, M. L., Forrester, L. M., & Hay, D. L. (2023). Identifying a new migraine-relevant receptor: Potential paracrine interaction between calcitonin gene-related peptide and the amylin 1 receptor in the parabrachial nucleus. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Edited volume of conference proceedings

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 266th Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

2022

Journal - Research Article

Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., … Hay, D. L. (2022). Characterization of antibodies against receptor activity-modifying protein 1 (RAMP1): A cautionary tale. International Journal of Molecular Sciences, 23, 16035. doi: 10.3390/ijms232416035

Garelja, M. L., & Hay, D. L. (2022). A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond. Headache, 62(9), 1093-1104. doi: 10.1111/head.14388

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., … Hay, D. L. (2022). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. British Journal of Pharmacology, 179, 416-434. doi: 10.1111/bph.15628

Conference Contribution - Edited volume of conference proceedings

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 264th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Verbal presentation and other Conference outputs

Alexander, T. I., Garelja, M. L., Gingell, J. J., & Hay, D. L. (2022, September). Differential interaction of β-arrestin for two CGRP-responsive receptors. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Garelja, M. L., Alexander, T., Walker, C. S., & Hay, D. L. (2022, August-September). Extracellular bimolecular fluorescence complementation assays for investigating receptor dimerization: A proof of concept with receptors for calcitonin gene-related peptide. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

2021

Journal - Research Other

Garelja, M. L., Walker, C. S., & Hay, D. L. (2021). CGRP receptor antagonists for migraine: Are they also AMY₁ receptor antagonists? British Journal of Pharmacology, 179, 454-459. doi: 10.1111/bph.15585

Conference Contribution - Published proceedings: Abstract

Garelja, M., Walker, C., & Hay, D. (2021). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. Cephalalgia, 41(1 Suppl.), (pp. 72). doi: 10.1177/03331024211034005

Conference Contribution - Verbal presentation and other Conference outputs

Garelja, M. (2021, December). CGRP blocking drugs for migraine: Towards a better understanding of mechanisms of action. Verbal presentation at the Pain@Otago Research Symposium, [Online].

2020

Journal - Research Article

Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., … Hay, D. L. (2020). Molecular mechanisms of class B GPCR activation: Insights from adrenomedullin receptors. ACS Pharmacology & Translational Science, 3(2), 246-262. doi: 10.1021/acsptsci.9b00083

2019

Journal - Research Article

Musa, H., Hendrikse, E. R., Brimble, M. A., Garelja, M. L., Watkins, H. A., Harris, P. W. R., & Hay, D. L. (2019). Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. Biochemistry, 58(32), 3468-3474. doi: 10.1021/acs.biochem.9b00571

Yule, L. R., Garelja, M. L., Hendrikse, E. R., Gingell, J. J., Poyner, D. R., Harris, P. W. H., Brimble, M. A., & Hay, D. L. (2019). A potent fluorescent calcitonin gene-related peptide analogue enables visualization of receptor internalization. Peptide Science, 111(6), e2416. doi: 10.1002/pep2.24126

Awarded Doctoral Degree

Garelja, M. (2019). Molecular insights into the signalling of calcitonin receptor-like receptor: Receptor activity-modifying protein complexes (PhD). University of Auckland, Auckland, New Zealand. Retrieved from http://hdl.handle.net/2292/50390

2018

Journal - Research Article

Garelja, M. L., Walker, C. A., Siow, A., Yang, S. H., Harris, P. W. R., Brimble, M. A., … Hay, D. L. (2018). Receptor activity modifying proteins have limited effects on the class B G protein-coupled receptor calcitonin receptor-like receptor stalk. Biochemistry, 57(8), 1410-1422. doi: 10.1021/acs.biochem.7b01180

Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., … Poyner, D. R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the CalcitoninRreceptor-Like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) complex. Biochemistry, 57(32), 4915-4922. doi: 10.1021/acs.biochem.8b00502

Journal - Research Other

Hay, D. L., Garelja, M. L., Poyner, D. R., & Walker, C. S. (2018). Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. British Journal of Pharmacology, 175(1), 3-17. doi: 10.1111/bph.14075

Conference Contribution - Published proceedings: Abstract

Walker, C. S., Garelja, M., Rees, T. A., & Hay, D. (2018). Profiling calcitonin gene-related peptide receptor dignalling in transfected cells and trigeminal ganglia neurons. Headache, 58(Suppl. 2), (pp. 69-70). doi: 10.1111/head.13306

2017

Journal - Research Article

Woolley, M. J., Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., … Hay, D. L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142, 96-110. doi: 10.1016/j.bcp.2017.07.005

2016

Journal - Research Article

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M. L., Pardamwar, M., … Hay, D. L. (2016). Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291(22), 11657-11675. doi: 10.1074/jbc.M115.688218