Mel Prescott

2023

Journal - Research Article

Ruddenklau, A., Glendining, K., Prescott, M., & Campbell, R. E. (2023). Validation of a new custom polyclonal progesterone receptor antibody for immunohistochemistry in the female mouse brain. Journal of the Endocrine Society, bvad113. Advance online publication. doi: 10.1210/jendso/bvad113

Donaldson, N. M., Prescott, M., Ruddenklau, A., Campbell, R. E., & Desroziers, E. (2023). Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS. Frontiers in Endocrinology, 14, 1116482. doi: 10.3389/fendo.2023.1116482

Conference Contribution - Published proceedings: Abstract

Prescott, M., Watanabe, Y., Ruddenklau, A., Fisher, L., Jasoni, C. L., & Campbell, R. E. (2023). Kisspeptin neuron projections and expression patterns are unaltered in prenatally androgenized female mice modeling PCOS. Journal of the Endocrine Society, 7(Suppl. 1), (pp. A649-A650). doi: 10.1210/jendso/bvad114.1213

2022

Journal - Research Article

Coyle, C. S., Prescott, M., Handelsman, D. J., Walters, K. A., & Campbell, R. E. (2022). Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons. Journal of Neuroendocrinology, 34, e13110. doi: 10.1111/jne.13110

Conference Contribution - Poster Presentation (not in published proceedings)

Glendining, K. A., Prescott, M., & Campbell, R. E. (2022, August-September). GnRH neuron morphology and kisspeptin-GnRH appositions during postnatal development in a C57BL/6 Mkrn3KO mouse. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ruddenklau, A., Prescott, M., & Campbell, R. E. (2022, August-September). Chronic inhibition of arcuate nucleus GABA neurons in a preclinical model of polycystic ovary syndrome (PCOS). Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Campbell, R. E., Sati, A., Coyle, C., Prescott, M., Jasoni, C. L., & Desroziers, E. (2022, August). How androgen excess shapes the polycystic ovary syndrome (PCOS)-like brain. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Watanabe, Y., Prescott, M., Campbell, R. E., & Jasoni, C. L. (2021). Prenatal androgenization causes expression changes of progesterone and androgen receptor mRNAs in the arcuate nucleus of female mice across development. Journal of Neuroendocrinology, 33, e13058. doi: 10.1111/jne.13058

Sati, A., Prescott, M., Holland, S., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). Morphological evidence indicate a role for microglia in shaping the polycystic ovary syndrome (PCOS)-like brain. Journal of Neuroendocrinology, 33, e12999. doi: 10.1111/jne.12999

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., Silva, M. S. B., Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology, 33, e12972. doi: 10.1111/jne.12972

Conference Contribution - Published proceedings: Abstract

Sati, A., Prescott, M., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). The role of microglia in the polycystic ovary syndrome (PCOS)-like brain. Journal of the Endocrine Society, 5(Suppl. 1), (pp. A556). doi: 10.1210/jendso/bvab048.1133

2020

Journal - Research Article

Marshall, C. J., Prescott, M., & Campbell, R. E. (2020). Investigating the NPY/AgRP/GABA to GnRH neuron circuit in prenatally androgenized PCOS-like mice. Journal of the Endocrine Society, 4(11), bvaa129. doi: 10.1210/jendso/bvaa129

Coutinho, E. A., Prescott, M., Hessler, S., Marshall, C. J., Herbison, A. E., & Campbell, R. E. (2020). Activation of a classic hunger circuit slows luteinizing hormone pulsatility. Neuroendocrinology, 110(7-8), 671-687. doi: 10.1159/000504225

2019

Journal - Research Article

Holland, S., Prescott, M., Pankhurst, M., & Campbell, R. E. (2019). The influence of maternal androgen excess on the male reproductive axis. Scientific Reports, 9, 18908. doi: 10.1038/s41598-019-55436-9

Silva, M. S. B., Desroziers, E., Hessler, S., Prescott, M., Coyle, C., Herbison, A. E., & Campbell, R. E. (2019). Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome. EBioMedicine, 44, 582-596. doi: 10.1016/j.ebiom.2019.05.065

Conference Contribution - Published proceedings: Abstract

Watanabe, Y., Prescott, M., Fisher, L., & Jasoni, C. (2019). Investigating changes in androgen and progesterone receptor expression in the aetiology of PNA-induced polycystic ovary syndrome. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12725. Retrieved from https://www.ans.org.au

Watanabe, Y., Prescott, M., Fisher, L. C., Campbell, R. E., Anderson, G. M., & Jasoni, C. L. (2019). Investigating changes in androgen and progesterone receptor expression in the aetiology of PNA-induced polycystic ovary syndrome. Proceedings of the Queenstown Molecular Biology (QMB) Meetings. [Abstract]

Holland, S., Prescott, M., Desroziers, E., & Campbell, R. (2019). Elucidating the effect of prenatal androgen excess on male reproductive function and metabolism. New Zealand Medical Journal, 132(1499), (pp. 88). Retrieved from https://www.nzma.org.nz/journal

Coutinho, E., Prescott, M., Marshall, C., Hessler, S., Herbison, A., & Campbell, R. (2019). Functional role of arcuate nucleus NPY/AgRP neurons in the GnRH circuit regulating LH secretion. Journal of the Endocrine Society, 3(Suppl. 1), SUN-LB083. doi: 10.1210/js.2019-SUN-LB083

Conference Contribution - Poster Presentation (not in published proceedings)

Sati, A., Prescott, M., Desroziers, E., Jasoni, C. L., & Campbell, R. E. (2019, September). The impact of prenatal androgen excess on microglia in the female mouse brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Desroziers, E., Prescott, M., & Campbell, R. E. (2019, August-September). Prenatal androgen excess impairs sexual behavior in adult female mice: Perspective on sexual dysfunction in PCOS. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coyle, C., Jamieson, B., Prescott, M., & Campbell, R. E. (2019, August-September). Androgen receptor expression across the estrous cycle in the hypothalamus and new methods for its targeted deletion. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Ruddenklau, A., Prescott, M., & Campbell, R. E. (2019, September). Role of central progesterone signalling in PCOS pathology. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Desroziers, E., Hessler, S., Prescott, M., Coyle, C., Herbison, A. E., & Campbell, R. E. (2019, August-September). Chemogenetic activation of arcuate GABA neurons lead to reproductive dysfunction in female: Implication for polycystic ovary syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Moore, A. M., Abbott, G., Mair, J., Prescott, M., & Campbell, R. E. (2018). Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. Journal of Neuroendocrinology, 30, e12657. doi: 10.1111/jne.12657

Moore, A. M., Prescott, M., Czieselsky, K., Desroziers, E., Yip, S. H., Campbell, R. E., & Herbison, A. E. (2018). Synaptic innervation of the GnRH neuron distal dendron in female mice. Endocrinology, 159(9), 3200-3208. doi: 10.1210/en.2018-00505

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Conference Contribution - Published proceedings: Abstract

Desroziers, E., Prescott, M., & Campbell, R. E. (2018). Impaired sexual behaviour in a mouse model of PCOS. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 288-289). Retrieved from http://www.icn2018.org/

Desroziers, E., Coutinho, E., Prescott, M., Silva, M., Holland, S., & Campbell, R. E. (2018). The impact of chronic activation of arcuate GABA neurons on fertility. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 246). Retrieved from http://www.icn2018.org/

Silva, M., Hessler, S., Prescott, M., Herbison, A. E., & Campbell, R. E. (2018). Selective activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion in mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 140). Retrieved from http://www.icn2018.org/

Coutinho, E., Prescott, M., Desroziers, E., Hessler, S., & Campbell, R. E. (2018). Activation of ARN AgRP/NPY neurons slows LH pulsality in control and PCOS mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 133). Retrieved from http://www.icn2018.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Holland, S., Prescott, M., & Campbell, R. (2018, November). Elucidating the effect of prenatal androgen excess on male reproductive function. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Coutinho, E. A., Prescott, M., Desroziers, E., Marshall, C., Hessler, S., Herbison, A. E., & Campbell, R. E. (2018, August). Role of arcuate nucleus AgRP/NPY neurons in LH secretion and fertility. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Holland, S., Prescott, M., Desroziers, E., & Campbell, R. E. (2018, August). Elucidating the effect of prenatal androgen excess on male reproductive function metabolism. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Desroziers, E., Prescott, M., & Campbell, R. E. (2018, August). Impaired sexual behaviour in a mouse model of PCOS. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Silva, M. S. B., Hessler, S., Prescott, M., Herbison, A. E., & Campbell, R. E. (2018, August). Selective activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion in mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Ross, P. G., Desroziers, E., Prescott, M., Silva, M., & Campbell, R. E. (2018, August). Long term effects of androgen receptor blockade in a mouse model of polycystic ovarian syndrome. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ruddenklau, A. L., Desroziers, E., Prescott, M., Silva, M. S., & Campbell, R. E. (2018, August). Can androgen receptor blockade restore progesterone sensitivity in a mouse model of polycystic ovary syndrome (PCOS)? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Desroziers, E., Coutinho, E., Prescott, M., Silva, M., Holland, S., & Campbell, R. E. (2018, August). The impact of chronic activation of arcuate GABA neurons on fertility. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Conference Contribution - Published proceedings: Abstract

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017). Chemogenetic activation of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Endocrine Reviews, 38(3, Suppl.), SAT 447. [Abstract]

Nair, B., Khant Aung, Z., Porteous, R., Prescott, M., Ng, J., Yip, S., Augustine, R., Glendining, K., Bouwer, G., Kim, J., Jenkins, D., Silva, M., Brown, C., Campbell, R., Jasoni, C., Bunn, S., Anderson, G., Grattan, D., Herbison, A., & Iremonger, K. (2017). Impact of chronic stress on the neuroendocrine axis in the mouse. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 49). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Conference Contribution - Poster Presentation (not in published proceedings)

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activation of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Prescott, M., Czieselsky, K., Desroziers, E., Herbison, A. E., & Campbell, R. E. (2017, September). Finding CLARITY: Visualising the gonadotrophin-releasing hormone neuron. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2017, September). Optogenetic activation of arcuate nucleus GABA neurons in vivo elicits luteinizing hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Holland, S. L., Desroziers, E., Silva, M., Prescott, M., & Campbell, R. E. (2017, September). Investigating the role of microglia in polycystic ovary syndrome (PCOS). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Desroziers, E., Coutinho, E., Prescott, M., Silva, S., Holland, S., & Campbell, R. E. (2017, September). Deciphering the role of arcuate GABA neurons in fertility regulation with chemogenetic tools in vivo. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activations of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2017, September). Dissecting the functional relevance and ontogeny of altered GABAergic circuitry in polycystic ovary syndrome (PCOS). Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351

Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S. P., … Prescott, M., Campbell, R., Herbison, A. E., … Giacobini, P. (2016). Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nature Communications, 7, 10055. doi: 10.1038/ncomms10055

Conference Contribution - Published proceedings: Abstract

Silva, M. S., Prescott, M., & Campbell, R. (2016). Development of gabaergic altered brain wiring and plasticity in a mouse model of polycystic ovary syndrome (PCOS). Proceedings of the Society for Neuroscience 46th Annual Meeting. 60.19/KK14. SfN. Retrieved from https://www.sfn.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Desroziers, E., Marshall, C. J., Prescott, M., & Campbell, R. E. (2016, August). Sexually differentiated co-expression of neuronal nitric oxide synthase (nNOS) in arcuate nucleus GABA neurons. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2016, August). Development of GABAergic altered wiring and plasticity in a mouse model of Polycystic Ovary Syndrome (PCOS). Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

2015

Journal - Research Article

Moore, A. M., Prescott, M., Marshall, C. J., Yip, S. H., & Campbell, R. E. (2015). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. PNAS, 112(2), 596-601. doi: 10.1073/pnas.1415038112

Conference Contribution - Verbal presentation and other Conference outputs

Campbell, R. E., Prescott, M., Yip, S.-H., Marshall, C. J., McLennan, T., & Moore, A. M. (2015, August-September). Arcuate nucleus GABA neurons and the regulation of fertility. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Shin, J., Prescott, M., Mair, J., & Campbell, R. E. (2014). Roles for primary cilia in gonadotropin-releasing hormone neurons in the mouse. Journal of Neuroendocrinology, 26(1), 18-25. doi: 10.1111/jne.12122

Conference Contribution - Published proceedings: Abstract

Prescott, M., Marshall, C. J., & Campbell, R. E. (2014). Increased luteinising hormone pulse frequency in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Moore, A. M., Prescott, M., & Campbell, R. E. (2014). Defining the neuronal network mediating impaired progesterone negative feedback in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Marshall, C. J., Prescott, M., & Campbell, R. E. (2014). Pulsatile luteinizing hormone secretion is increased in a prenatal androgen (PNA) treated model of polycystic ovarian syndrome (PCOS). Proceedings of the Medical Sciences Congress (MedSci). (pp. 35). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Moore, A. M., Prescott, M., & Campbell, R. E. (2014). Investigating changes in the gonadotropin-releasing hormone neuronal network in a model of polycystic ovarian syndrome. Proceedings of the Medical Sciences Congress (MedSci). (pp. 23). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Campbell, R. E., Prescott, M., Marshall, C., & Moore, A. (2014). Prenatal androgen exposure re-wires the gonadotropin-releasing hormone (GnRH) neuronal network. Proceedings of the Medical Sciences Congress (MedSci). (pp. 9). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Moore, A., Prescott, M., & Campbell, R. (2014). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Marshall, C., Prescott, M., & Campbell, R. (2014). Measuring pulsatile luteinizing hormone secretion in a prenatal androgen treated model of polycystic ovarian syndrome. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

2013

Journal - Research Article

Moore, A. M., Prescott, M., & Campbell, R. E. (2013). Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology, 154(2), 796-806. doi: 10.1210/en.2012-1954

2012

Conference Contribution - Published proceedings: Abstract

Campbell, R. E., Prescott, M., Constantin, S. S., & Moore, A. M. (2012). Altered hypothalamic gonadal steroid hormone receptor expression in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Moore, A. M., Prescott, M., & Campbell, R. E. (2012). Investigating gonadal steroid hormone feedback in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Moore, A. M., Prescott, M., & Campbell, R. E. (2012). Investigating changes in the gonadotropin-releasing hormone neuronal network in a mouse model of polycystic ovarian syndrome. Proceedings of the Medical Sciences Congress (MedSci). (pp. 58). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Campbell, R. E., Prescott, M., & Moore, A. M. (2012). Understanding the neuroendocrine abnormalities of polycystic ovarian syndrome in a mouse model. Proceedings of the Medical Sciences Congress (MedSci). (pp. 12). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

2011

Journal - Research Article

Chan, H., Prescott, M., Ong, Z. Y., Herde, M. K., Herbison, A. E., & Campbell, R. E. (2011). Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology, 152(12), 4906-4914. doi: 10.1210/en.2011-1522

Conference Contribution - Published proceedings: Abstract

Shin, J., Prescott, M., & Campbell, R. E. (2011). Is there a role for primary cilia in gonadotropin-releasing hormone (GnRH) neurons? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.19. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Moore, A. M., Prescott, M., & Campbell, R. E. (2011). Investigating steroid hormone feedback in a mouse model of polycystic ovarian syndrome. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.10. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html