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Many laboratories with the Department of Physiology conduct research concerned with the regulation of cardiovascular and respiratory function in both health and disease.

Specific areas of interest include:

  • How hormonal, neuronal, and intrinsic processes control the heart
  • Understanding the vasculature of the lungs
  • Describing calcium regulation of heart rhythms
  • Identifying pathogenic mechanisms operating in diseases such as obesity, diabetes, heart failure, hypertension, and cardiac arrhythmia

Cardiovascular and respiratory physiology research techniques

We use a range of whole animal, whole organ, cellular, molecular, and genetic techniques to investigate heart, lung, and blood vessel function.

Researchers in this group have expertise in the following techniques:

  • Animal models of disease (eg diabetes, cardiac arrhythmias, myocardial and limb ischemia, obesity, vascular calcification)
  • Cardiac haemodynamics (eg echocardiography)
  • Cell culture (eg stem cells, cell differentiation)
  • Cell signalling (eg phosphorylation, oxidation, inflammation)
  • Genetic modulation of the heart (e.g., microRNA, hereditary mutations)
  • Histochemistry (eg atherosclerosis plaque assessment, collagen deposition)
  • Isolated and innervated heart preparations (eg Langendorff, trabeculae)
  • Microangiography
  • Protein analysis (eg immunohistochemistry, western blotting)
  • Radiotelemetry (eg sympathetic nerve activity, blood pressure)
  • Tissue engineering (eg iPSC derived cardiac progenitor cells)

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