Understanding how p53 isoforms drive intestinal inflammation

Overview

Inflammatory bowel disease (IBD) is a chronic, relapsing condition with no cure, driven by persistent intestinal inflammation.

Our research has identified a p53 isoform, Δ133p53, with pro-inflammatory and immunomodulatory properties that is associated with disease progression and colorectal cancer in patients with ulcerative colitis. Using a Δ122p53 transgenic mouse model (the murine homologue of human Δ133p53), this project aims to define how aberrant p53 isoform expression promotes chronic gut inflammation.

Students will work with established mouse models of colitis to examine intestinal pathology and immune responses using histology and flow cytometry.

This project provides strong training in translational immunology, inflammation, and cancer-associated disease mechanisms.

Student requirements

• We are seeking highly motivated postgraduate students with a background in biomedical science, immunology, pathology, or a related discipline
• A one-year Master’s by thesis student is strongly preferred, but suitable Honours candidates are also encouraged to apply
• Prior experience in mouse handling and monitoring, tissue dissection/digestion, or histology is highly desirable, but full training will be provided

Funding

A stipend is available for a qualified, full-time Master’s by thesis student.

How to apply

Please send the following to Dr Kunyu Li:

• Curriculum vitae (CV)
• Academic transcript
• A brief statement outlining your research interests and motivation

Applications will be assessed on a rolling basis until the position is filled.

Useful information

• Graduate research at the University of Otago
• Scholarships at the University of Otago