Contact Details
- Phone
- +64 3 479 7863
- kurt.krause@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Biochemistry
- Qualifications
- MA PhD MD
- Research summary
- Structural biology of infectious diseases
Research
Kurt Krause is a Professor of Biochemistry at the University of Otago.
He has a longstanding interest in structure and function in biology and his research areas include the structure and function of enzymes and proteins important in infectious diseases, such as bacterial pathogenesis factors, antibiotic targets, viral immunomodulatory proteins, and bioluminescence related proteins.
Publications
Seitz, C., Ahn, S.-H., Wei, H., Kyte, M., Cook, G. M., Krause, K. L., & McCammon, J. A. (2024). Targeting tuberculosis: Novel scaffolds for inhibiting cytochrome bd oxidase. Journal of Chemical Information & Modeling. Advance online publication. doi: 10.1021/acs.jcim.4c00344 Journal - Research Article
Herre, C., Ho, A., Eisenbraun, B., Vincent, J., Nicholson, T., Boutsioukis, G., … Krause, K. L., … Sliz, P. (2024). Introduction of the Capsules environment to support further growth of the SBGrid structural biology software collection. Acta Crystallographica Section D, 80, 439-450. doi: 10.1107/s2059798324004881 Journal - Research Article
Eruera, A.-R., McSweeney, A. M., McKenzie-Goldsmith, G. M., Opel-Reading, H. K., Thomas, S. X., Campbell, A. C., … Ward, V. K., & Krause, K. L. (2023). Crystal structure of inhibitor-bound GII.4 Sydney 2012 norovirus 3C-like protease. Viruses, 15(11), 2202. doi: 10.3390/v15112202 Journal - Research Article
Olivier, F., Roberts, S., Morris, A., Krause, K., & Baker, M. (2023). The arrival of Candida auris in Aotearoa NZ: Risk assessment and actions needed. The Briefing, (30 March). Retrieved from https://www.phcc.org.nz/briefing/arrival-candida-auris-aotearoa-nz-risk-assessment-and-actions-needed Journal - Research Other
Cooper, H. B., Krause, K. L., & Gardner, P. P. (2023). Finding priority bacterial ribosomes for future structural and antimicrobial research based upon global RNA and protein sequence analysis. PeerJ, 11, e14969. doi: 10.7717/peerj.14969 Journal - Research Article
2024
Journal - Research Article
Seitz, C., Ahn, S.-H., Wei, H., Kyte, M., Cook, G. M., Krause, K. L., & McCammon, J. A. (2024). Targeting tuberculosis: Novel scaffolds for inhibiting cytochrome bd oxidase. Journal of Chemical Information & Modeling. Advance online publication. doi: 10.1021/acs.jcim.4c00344
Herre, C., Ho, A., Eisenbraun, B., Vincent, J., Nicholson, T., Boutsioukis, G., … Krause, K. L., … Sliz, P. (2024). Introduction of the Capsules environment to support further growth of the SBGrid structural biology software collection. Acta Crystallographica Section D, 80, 439-450. doi: 10.1107/s2059798324004881
2023
Chapter in Book - Research
Torbati, E., Stuart, G., Krause, K., Brown, C., & Wise, L. (2023). Methods to assess chemokine binding and anti-chemotactic activity of virus proteins. In A. R. Lucas (Ed.), Chemokine-glycosaminoglycan interactions: Methods and protocols: Methods in molecular biology (Vol. 2597). (pp. 217-234). New York, N Y: Humana Press. doi: 10.1007/978-1-0716-2835-5_16
Journal - Research Article
Eruera, A.-R., McSweeney, A. M., McKenzie-Goldsmith, G. M., Opel-Reading, H. K., Thomas, S. X., Campbell, A. C., … Ward, V. K., & Krause, K. L. (2023). Crystal structure of inhibitor-bound GII.4 Sydney 2012 norovirus 3C-like protease. Viruses, 15(11), 2202. doi: 10.3390/v15112202
Cooper, H. B., Krause, K. L., & Gardner, P. P. (2023). Finding priority bacterial ribosomes for future structural and antimicrobial research based upon global RNA and protein sequence analysis. PeerJ, 11, e14969. doi: 10.7717/peerj.14969
Journal - Research Other
Olivier, F., Roberts, S., Morris, A., Krause, K., & Baker, M. (2023). The arrival of Candida auris in Aotearoa NZ: Risk assessment and actions needed. The Briefing, (30 March). Retrieved from https://www.phcc.org.nz/briefing/arrival-candida-auris-aotearoa-nz-risk-assessment-and-actions-needed
2022
Journal - Research Article
Lawer, A., Tyler, C., Hards, K., Keighley, L. M., Cheung, C.-Y., Kierek, F., Su, S., … McInnes, T., Tyndall, J. D. A., Krause, K. L., Cook, G. M., & Gamble, A. B. (2022). Synthesis and biological evaluation of aurachin D analogues as inhibitors of Mycobacterium tuberculosis cytochrome bd oxidase. ACS Medicinal Chemistry Letters, 13, 1663-1669. doi: 10.1021/acsmedchemlett.2c00401
Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8
Conference Contribution - Verbal presentation and other Conference outputs
Safarian, S., Opel-Reading, H. K., Hards, K., Harold, L. K., Cook, G. M., Krause, K. L., & Michel, H. (2022, August). BD oxidase is a game-changing drug discovery target for tuberculosis. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Eruera, A., Campbell, A., Opel-Reading, H., Bostina, M., Krause, K., & Ward, V. (2022, August). Cryo-EM structural investigation of human norovirus protease-polymerase precursor. Verbal presentation at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
2021
Journal - Research Article
Campbell, A. C., Tanner, J. J., & Krause, K. L. (2021). Optimisation of neuraminidase expression for use in drug discovery by using HEK293-6E cells. Viruses, 13, 1893. doi: 10.3390/v13101893
Badart, M. P., Barnes, E. M., Cording, A. P., Gilmer, S. C. L., Billinghurst, I. D., Edupuganti, V. V. S. R., … Bland, A. R., Bower, R. L., Rana, Z., Ferguson, S. A., Opel Reading, H. K., Cook, G. M., Rosengren, R. J., Krause, K. L., Gamble, A. B., Ashton, J. C., & Hawkins, B. C. (2021). Synthesis and biological evaluation of (-) and (+)-spiroleucettadine and analogues. ChemMedChem, 16, 1308-1315. doi: 10.1002/cmdc.202000954
Safarian, S., Opel-Reading, H. K., Wu, D., Mehdipour, A. R., Hards, K., Harold, L. K., … Stewart, I., … Cook, G. M., Krause, K. L., & Michel, H. (2021). The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications, 12(1), 5236. doi: 10.1038/s41467-021-25537-z
Journal - Research Other
Torbati, E., Krause, K. L., & Ussher, J. E. (2021). The immune response to SARS-CoV-2 and variants of concern. Viruses, 13, 1911. doi: 10.3390/v13101911
Conference Contribution - Published proceedings: Abstract
Scadden, J., & Krause, K. L. (2021). Biochemical and structural characterisation of the immunomodulatory protein CrmB from variola virus. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 126). Retrieved from https://www.faobmb2021.org
Pooreydy Golaki, B., & Krause, K. (2021). The evaluation of Pseudomonas aeruginosa glutamate racemase for drug discovery. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 124). Retrieved from https://www.faobmb2021.org
Safarian, S., Opel-Reading, H. K., Hards, K., Harold, L. K., Cook, G. M., Krause, K. L., & Michel, H. (2021). Structure of BD oxidase from Mycobacteria as a game-changing target in TB drug design. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 303). Retrieved from https://www.faobmb2021.org
2020
Journal - Research Article
Murphy, E. L., Singh, K. V., Avila, B., Kleffmann, T., Gregory, S. T., Murray, B. E., Krause, K. L., … Jogl, G. (2020). Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Scientific Reports, 10, 16301. doi: 10.1038/s41598-020-73199-6
Kvach, M. V., Barzak, F. M., Harjes, S., Schares, H. A. M., Kurup, H. M., Jones, K. F., … Krause, K. L., … Filichev, V. (2020). Differential inhibition of APOBEC3 DNA-mutator isozymes by fluoro- versus non-fluoro-substituted 2'-deoxyzebularine embedded in single-stranded DNA. ChemBioChem, 21, 1028-1035. doi: 10.1002/cbic.201900505
Journal - Research Other
McDonald, S. K., Matisoo-Smith, E. A., Buckley, H. R., Walter, R. K., Aung, H. L., Collins, C. J., Cook, G. M., Kardailsky, O., Krause, K., & Knapp, M. (2020). 'TB or not TB': The conundrum of pre-European contact tuberculosis in the Pacific. Philosophical Transactions of the Royal Society B, 375, 20190583. doi: 10.1098/rstb.2019.0583
Krause, K. L., Furneaux, R., Benjes, P., Brimble, M., Davidson, T., Denny, W., … Ussher, J. E., & Ward, V. (2020). The post-lockdown period should be used to acquire effective therapies for future resurgence in SARS-Cov-2 infections. New Zealand Medical Journal, 133(1513), 107-111. Retrieved from https://www.nzma.org.nz/journal
2019
Chapter in Book - Research
Fagerlund, R. D., Ferguson, T. J., Maxwell, H. W. R., Opel-Reading, H. K., Krause, K. L., & Fineran, P. C. (2019). Reconstitution of CRISPR adaptation in vitro and its detection by PCR. In S. Bailey (Ed.), Methods in enzymology (Vol. 616: CRISPR-Cas enzymes). (pp. 411-433). Cambridge, MA: Academic Press. doi: 10.1016/bs.mie.2018.10.024
Journal - Research Article
Opel-Reading, H. K., Mortuza, R., & Krause, K. L. (2019). Detection of D-glutamate production from the dual function enzyme, 4-amino-4-deoxychorismate lyase/D-amino acid transaminase, in Mycobacterium smegmatis. Bio-protocol, 9(1), e3135. doi: 10.21769/BioProtoc.3135
Journal - Professional & Other Non-Research Articles
Perry, N., Watkins, O., Sharpe, M., & Krause, K. (2019). Southern lights: The unique bioluminescent chemistry of New Zealand's glowworms. Chemistry in Australia, (March-April), 21-23.
2018
Journal - Research Article
Watkins, O. C., Sharpe, M. L., Perry, N. B., & Krause, K. L. (2018). New Zealand glowworm (Arachnocampa luminosa) bioluminescence is produced by a firefly-like luciferase but an entirely new luciferin. Scientific Reports, 8(3278). doi: 10.1038/s41598-018-21298-w
Mortuza, R., Aung, H. L., Taiaroa, G., Opel-Reading, H. K., Kleffmann, T., Cook, G. M., & Krause, K. L. (2018). Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology, 107(2), 198-213. doi: 10.1111/mmi.13877
Journal - Professional & Other Non-Research Articles
Perry, N., Watkins, O., Sharpe, M., & Krause, K. (2018). Southern lights: The unique bioluminescent chemistry of New Zealand's glowworms. Australasian Science, (July-August), 24-25.
Conference Contribution - Published proceedings: Abstract
Keats, T. W. D., Krause, M., & Krause, K. (2018). Characterising the immunomodulatory protein: GIF, encoded by orf virus. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 118). Retrieved from https://www.nzmsconference.org.nz
Krause, K. L., Jogl, G., Khayat, R., Murphy, E. L., Murray, B. E., Singh, K., & Kleffmann, T. (2018). Exploring the enterococcal ribosome structure as a template for antibiotic development. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 61-62). Retrieved from https://www.nzmsconference.org.nz
Krause, K. L. (2018). Exploring the Enterococcus Ribosome as a target for antibiotic development. Proceedings of the Australasian Society for Infectious Diseases (ASID) New Zealand Annual Meeting. Retrieved from https://www.asid.net.au
Conference Contribution - Poster Presentation (not in published proceedings)
Keats, T., Krause, M., & Krause, K. (2018, September). Characterising the immunomodulatory protein; GIF, encoded by orf virus. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. (2018, September). New anti-microbial development based on targeting the enzyme, glutamate racemase. Verbal presentation at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
2017
Journal - Research Article
Nakatani, Y., Opel-Reading, H. K., Merker, M., Machado, D., Andres, S., Kumar, S. S., … Aung, H. L., Cook, G. M., … Krause, K., & Köser, C. U. (2017). Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance. Antimicrobial Agents & Chemotherapy, 61(12), e01575-17. doi: 10.1128/aac.01575-17
Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Kieper, S. N., Maxwell, H. W. R., … Krause, K. L., Bostina, M., … Staals, R. H. J., & Fineran, P. C. (2017). Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex. PNAS, 114(26), E5122-E5128. doi: 10.1073/pnas.1618421114
Christensen, E. M., Patel, S. M., Korasick, D. A., Campbell, A. C., Krause, K. L., Becker, D. F., & Tanner, J. J. (2017). Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. Journal of Biological Chemistry, 292(17), 7233-7243. doi: 10.1074/jbc.M117.780288
Conference Contribution - Published proceedings: Abstract
Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Kieper, S. N., … Krause, K. L., … Fineran, P. C. (2017). Spacer capture and integration by a type I-F Cas1: Cas2-3 CRISPR adaptation complex. Proceedings of the 22nd Biennial Evergreen Bacteriophage Conference. (pp. 139). Retrieved from http://blogs.evergreen.edu/phage/about/meetings/2017-evergreen-meeting
Krause, K. L. (2017). Evaluating a new target for antituberculosis drug design: Glutamate racemase from Mycobacterium tuberculosis. Proceedings of the Australasian Society for Infectious Diseases (ASID) New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au
Conference Contribution - Poster Presentation (not in published proceedings)
Opel-Reading, H., Nakatani, Y., Aung, H. L., Cook, G. M., & Krause, K. L. (2017, September). The impact of Mycobacterium tuberculosis alanine racemase mutations on D-cycloserine inhibition. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Keats, T. W. D., & Krause, K. L. (2017, September). Characterisation of the immunomodulatory protein, GIF, encoded by Orf Virus. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Maxwell, H. W. R., … Krause, K. L., Bostina, M., … Staals, R. H. J., & Fineran, P. C. (2017, September). DNA capture and integration by the type I-F CRISPR-Cas adaptation complex from Pectobacterium atrosepticum. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Sowerby, S. J., Crump, J. A., Johnstone, M. C., Krause, K. L., & Hill, P. C. (2016). Smartphone microscopy of parasite eggs accumulated into a single field of view. American Journal of Tropical Medicine & Hygiene, 94(1), 227-230. doi: 10.4269/ajtmh.15-0427
Sharif, S., Nakatani, Y., Wise, L., Corbett, M., Real, N. C., Stuart, G. S., Lateef, Z., Krause, K., Mercer, A. A., & Fleming, S. B. (2016). A broad-spectrum chemokine-binding protein of bovine papular stomatitis virus inhibits neutrophil and monocyte infiltration in inflammatory and wound models of mouse skin. PLoS ONE, 11(12), e0168007. doi: 10.1371/journal.pone.0168007
Poen, S., Nakatani, Y., Opel-Reading, H. K., Lassé, M., Dobson, R. C. J., & Krause, K. L. (2016). Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery. Biochemical Journal, 473, 1267-1280. doi: 10.1042/bcj20160186
Wilkinson, M. E., Nakatani, Y., Staals, R. H. J., Kieper, S. N., Opel-Reading, H. K., McKenzie, R. E., Fineran, P. C., & Krause, K. L. (2016). Structural plasticity and in vivo activity of Cas1 from the type I-F CRISPR-Cas system. Biochemical Journal, 473, 1063-1072. doi: 10.1042/bcj20160078
2015
Journal - Research Article
Sharpe, M. L., Dearden, P. K., Gimenez, G., & Krause, K. L. (2015). Comparative RNA seq analysis of the New Zealand glowworm Arachnocampa luminosa reveals bioluminescence-related genes. BMC Genomics, 16, 825. doi: 10.1186/s12864-015-2006-2
Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023
Conference Contribution - Published proceedings: Abstract
Krause, K., Poen, S., Mortuza, R., Nakatani, Y., Aung, H., Opel-Reading, H., & Cook, G. (2015). Glutamate racemase from Mycobacterium tuberculosis: New genetic and structural insights into a target for antituberculosis drug design. Open Forum Infectious Diseases, 2(Suppl. 1), 881. doi: 10.1093/ofid/ofv133.598
Conference Contribution - Poster Presentation (not in published proceedings)
Wilkinson, M. E., Staals, R. H. J., Nakatani, Y., Fagerlund, R. D., Kieper, S., Opel-Reading, H. K., Krause, K. L., & Fineran, P. C. (2015, August-September). The structure of Cas1 and its role in adaptation in Type I-F CRISPR-Cas systems. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Torbati, E., Krause, K. L., & Brown, C. M. (2015, August-September). The evolution of poxvirus immuno-modulatory proteins. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. (2015, August-September). Glutamate racemase as a target for antibiotic design in tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Chapter in Book - Research
Sharpe, M. L., Hastings, J. W., & Krause, K. L. (2014). Luciferases and light-emitting accessory proteins: Structural biology. In eLS. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0003064.pub2
Journal - Research Article
Li, Y., Mortuza, R., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2014). Investigation of the essentiality of glutamate racemase in Mycobacterium smegmatis. Journal of Bacteriology, 196(24), 4239-4244. doi: 10.1128/jb.02090-14
Davis, E., Scaletti-Hutchinson, E., Opel-Reading, H., Nakatani, Y., & Krause, K. L. (2014). The structure of alanine racemase from Acinetobacter baumannii. Acta Crystallographica Section F, 70(9), 1199-1205.
Conference Contribution - Published proceedings: Abstract
Krause, K. L., Poen, S., Mortuza, R., Li, Y., Aung, H., Milligan, D., Robson, J., Opel-Reading, H., … Cook, G. M. (2014). Glutamate racemase as a target for antibiotic design in tuberculosis. Proceedings of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Retrieved from http://www.asm.org/index.php/meetings
Watkins, O. C., Sharpe, M., Krause, K., & Perry, N. (2014). The unique bioluminescent chemistry of the New Zealand glowworm, (Titiwai, Arachnocampa luminosa). Luminescence, 29(Suppl. 1), (pp. 52). doi: 10.1002/bio.2699_2
Sharpe, M., Dearden, P., Gimenez, G., & Krause, K. (2014). Transcriptome of the New Zealand glowworm, Arachnocampa luminosa. Luminescence, 29(Suppl. 1), (pp. 45-46). doi: 10.1002/bio.2699_2
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. L. (2014, May). Orf virus chemokine binding protein: Structural basis of chemokine binding. Verbal presentation at the 4th Asia Pacific Protein Association (APPA) Conference, Jeju, Korea.
Krause, K. L. (2014, October). Target recognition by the chemokine binding protein from orf virus. Verbal presentation at the International Conference of the Korean Society for Molecular and Cellular Biology, Seoul, Korea.
Krause, K. (2014, June-July). Target recognition by the chemokine binding protein from orf virus. Verbal presentation at the New Zealand Structural Biology Meeting, Hanmer Springs, New Zealand.
2013
Conference Contribution - Published proceedings: Abstract
Opel-Reading, H., Luckner, S., Schaller, R., Kurtz, D., & Krause, K. (2013). Rubrerythrin from Trichomonas vaginalis: Structural insights into the mechanism of a potential parasitic virulence factor. Proceedings of the Infectious Diseases Society of America (IDSA) Infectious Diseases Week: Advancing Science, Improving Care. Retrieved from http://www.idsociety.org/Meetings.aspx
Huschmann, F. U., Tomasiak, T. M., Keniya, M. V., O'Connell, III, J. D., Luckner, S. R., Krause, K., Cannon, R. D., … Tyndall, J. D. A., & Monk, B. C. (2013). Antifungal drug discovery: Crystallization of the cytochrome P450 triazole target. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html
Huschmann, F. U., Tomasiak, T. M., Keniya, M. V., O'Connell, III, J. D., Luckner, S. R., Krause, K., Cannon, R. D., … Tyndall, J. D. A., & Monk, B. C. (2013). Crystallization of Erg11p: The cytochrome P450 target of triazole antifungals. Acta Crystallographica Section A, A69, (pp. s64). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. (2013, August). Chemokines and host-viral interactions. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2012
Journal - Research Article
Baker, E. S., Luckner, S. R., Krause, K. L., Lambden, P. R., Clarke, I. N., & Ward, V. K. (2012). Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein. PLoS ONE, 7(2), e30534. doi: 10.1371/journal.pone.0030534
Scaletti, E. R., Luckner, S. R., & Krause, K. L. (2012). Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50). Acta Crystallographica Section D, 68, 82-92. doi: 10.1107/S0907444911050682
Conference Contribution - Published proceedings: Abstract
Kumar, A., Knapp, K., Krause, K., & Marshall, C. (2012). Revisiting the structure of lactate dehydrogenase from Spiny Dogfish. Protein Science, 21(S1), (pp. 95). doi: 10.1002/pro.2113
Conference Contribution - Poster Presentation (not in published proceedings)
Luckner, S., Opel-Reading, H. K., Dixon, E., Schaller, R., Kurtz, D., & Krause, K. (2012, August). Crystal structures of red and lavender variants of rubrerythrin from Trichomonas vaginalis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. (2012, December). Update on the chemokine binding protein from orf virus. Verbal presentation at the Asian Crystallographic Association (AsCA) and the Society of Crystallographers in Australia and New Zealand (SCANZ) Joint Meeting, Adelaide, Australia.
Richter, C., Gristwood, T., Clulow, J., Luckner, S., Opel-Reading, H.-K., Chang, J., Krause, K., & Fineran, P. (2012, November). Protein complexes related to CRISPR/Cas resistance in Pectobacterium atrosepticum. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.
Krause, K., Couñago, R., Fleming, S., Corbett, M., Wise, L., Knapp, K., & Mercer, A. (2012, November). The structure of the chemokine binding protein from orf virus reveals clues to its broad binding specificity. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.
2011
Journal - Research Article
Im, H., Sharpe, M. L., Strych, U., Davlieva, M., & Krause, K. L. (2011). The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. BMC Microbiology, 11, 116. doi: 10.1186/1471-2180-11-116
Anthony, K. G., Strych, U., Yeung, K. R., Shoen, C. S., Perez, O., Krause, K. L., … Koski, R. A. (2011). New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis. PLoS ONE, 6(5), e20374. doi: 10.1371/journal.pone.0020374
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. L., Counago, R., Fleming, S., & Mercer, A. (2011, September). Orf virus chemokine binding protein maintains tight binding across chemokine families. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Krause, K. (2011, December). Structural biology of infectious diseases. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.
2010
Journal - Research Article
Couñago, R. M., Fleming, S. B., Mercer, A. A., & Krause, K. L. (2010). Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica Section F, F66, 819-823. doi: 10.1107/S1744309110018166
2009
Journal - Research Article
Couñago, R. M., Davlieva, M., Strych, U., Hill, R. E., & Krause, K. L. (2009). Biochemical and structural characterization of alanine racemase from Bacillus anthracis (ames). BMC Structural Biology, 9, 53. doi: 10.1186/1472-6807-9-53
Chen, C., Krause, K., & Pettitt, B. M. (2009). Advantage of being a dimer for Serratia marcescens endonuclease. Journal of Physical Chemistry B, 113(2), 511-521. doi: 10.1021/jp8057838
Journal - Professional & Other Non-Research Articles
Wilson, N., Baker, M., Jennings, L., Murdoch, D., Krause, K., Edwards, R., … Douwes, J., … Rice, G. (2009). A design fault in New Zealand's health research funding system exposed by pandemic influenza [Letter]. New Zealand Medical Journal, 122(1304). Retrieved from http://journal.nzma.org.nz/journal/122-1304/3839/content.pdf
Conference Contribution - Published proceedings: Abstract
Counago, R. M., Davlieva, M., Strych, U., Hill, R. E., & Krause, K. L. (2009). Structural characterization of alanine racemase from Bacillus anthracis, a putative target for spore remediation. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Li, Y., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2009). The glutamate racemase of Mycobacterium smegmatis is essential for growth in the absence of D-glutamate. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Dixon, E., Schaller, R., Davlieva, M., Kurtz, D., & Krause, K. (2009). Crystallization and preliminary diffraction analysis of Rubrerythrin from Trichomonas vaginalis. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Couñago, R. M., Hill, R. E., Davlieva, M., Strych, U., & Krause, K. L. (2009). Structural characterization of alanine racemase from Bacillus anthracis. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K. (2009, December). Alanine racemase from Mycobacterium smegmatis: For drug discovery in Tuberculosis. Verbal presentation at the ComBio2009 Conference, Christchurch, New Zealand.
Krause, K. (2009, September). Solving molecular puzzles to aid understanding of human disease. Verbal presentation at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.
2007
Chapter in Book - Other
Hastings, J. W., & Krause, K. L. (2007). Luciferases and light-emitting accessory proteins: Structural biology. In Encyclopedia of Life Sciences. New York: John Wiley & Sons.
Journal - Research Article
Chen, C., Beck, B. W., Krause, K., Weksberg, T. E., & Pettitt, B. M. (2007). Effects of dimerization of Serratia marcescens endonuclease on water dynamics. Biopolymers, 85(3), 241-252.
Weksberg, T. E., Lynch, G. C., Krause, K. L., & Pettitt, B. M. (2007). Molecular dynamics simulations of Trichomonas vaginalis ferredoxin show a loop-cap transition. Biophysical Journal, 92(10), 3337-3345.
Strych, U., Davlieva, M., Longtin, J. P., Murphy, E. L., Im, H., Benedik, M. J., & Krause, K. L. (2007). Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae. BMC Microbiology, 7, 40. doi: 10.1186/1471-2180-7-40
Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2007). The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine. Journal of Bacteriology, 189(22), 8381-8386.
Other Research Output
Krause, K. (2007, August). Meeting the antibiotic crisis: Can university scientists help design new drugs for our future?. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2006
Chapter in Book - Research
Hastings, J. W., & Krause, K. L. (2006). Luciferases and light-emitting accessory proteins: Structural biology. In Encyclopedia of Life Sciences. New York: John Wiley & Sons. doi: 10.1038/npg.els.0003064
Journal - Research Other
Chen, C., Beck, B. W., Krause, K., & Pettitt, B. M. (2006). Solvent participation in Serratia marcescens endonuclease complexes. Proteins, 62, 982-995.
2005
Chapter in Book - Research
Hastings, J. W., & Krause, K. L. (2005). Luciferase and light-emitting accessory proteins: Structural biology. In Encyclopedia of life sciences. John Wiley & Sons. doi: 10.1038/npg.els.0003064
Journal - Research Article
Shelburne, S. A., Visnegarwala, F., Adams, C., Krause, K. L., Hamill, R. J., & White, A. C. (2005). Unusual manifestations of disseminated Histoplasmosis in patients responding to antiretroviral therapy. American Journal of Medicine, 118, 1038-1041.
LeMagueres, P., Im, H., Ebalunode, J., Strych, U., Benedik, M. J., Briggs, J. M., … Krause, K. L. (2005). The 1.9 Å crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry, 44, 1471-1481.
Conference Contribution - Poster Presentation (not in published proceedings)
Lindeman, S. V., Miller, M. D., & Krause, K. L. (2005, May). Sub-atomic mechanisms of disorder and multiple order in proteins from high-resolution X-ray diffraction data: Serratia endonuclease structure at 0.92 Å. Poster session presented at the 10th UTMB Structural Biology Symposium, Galveston, Texas.
Yang, C., Fan, H., Su, X., Rose, J., Liu, Z.-J., Wang, B. C., Krause, K., … Ferrara, J. D. (2005, August). In-house S-SAD and Se-SAD phasing with Cr Kα radiation. Poster session presented at the 20th Congress of the International Union of Crystallography, Florence, Italy.
Krause, K., Magueres, P., Im, H., Briggs, J., Strych, U., Ebalunode, J., & et al (2005, May). Alanine racemase as a template for drug design. Poster session presented at the American Crystallographic Association Annual Meeting, Orlando, FL, USA.
Lindeman, S., Miller, M., & Krause, K. (2005, May). Ultra-high resolution refinement of proteins: Serratia marcescens endonuclease at 0.92 Å. Poster session presented at the American Crystallographic Association Annual Meeting, Orlando, FL, USA.
2004
Conference Contribution - Published proceedings: Abstract
Krause, K. L., LeMagueres, P., & Im, H. (2004). Structural biology of tuberculosis drug targets. Proceedings of the 42nd Annual Meeting of the Infectious Diseases Society of America. (pp. 257). Boston, USA: IDSA. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K., Benedik, M., Briggs, J., & Kohn, H. (2004, August). Alanine racemase as a template for TB drug design. Verbal presentation at the 18th Symposium of the Protein Society, San Diego, CA, USA.
2003
Journal - Research Article
Kim, M. G., Strych, U., Krause, K., Benedik, M., & Kohn, H. (2003). N(2)-substituted D,L-cycloserine derivatives: Synthesis and evaluation as alanine racemase inhibitors. Journal of Antibiotics, 56(2), 160-168.
Vidakovic, M., Crossnoe, C. R., Neidre, C., Kim, K., Krause, K. L., & Germanas, J. P. (2003). Reactivity of reduced [2Fe-2S] Ferredoxins parallels host susceptibility to nitroimidazoles. Antimicrobial Agents & Chemotherapy, 47(1), 302-308.
Liu, L., Im, H., Cegielski, M., LeMagueres, P., Schultz, L. W., Krause, K. L., & Hastings, J. W. (2003). Characterization and crystallization of active domains of a novel luciferase from a marine dinoflagellate. Acta Crystallographica Section D, D59, 761-764.
Kim, M. G., Strych, U., Krause, K., Benedik, M., & Kohn, H. (2003). Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors. Medicinal Chemistry Research, 12(3), 130-138.
LeMagueres, P., Im, H., Dvorak, A., Strych, U., Benedik, M., & Krause, K. L. (2003). Crystal structure at 1.45 Å resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry, 42(50), 14752-14761.
Journal - Research Other
Krause, K. L. (2003). Review of the Nanotech 2003 - Nanotechnology Conference and Trade Show. IDrugs, 6(4), 309-311.
Conference Contribution - Verbal presentation and other Conference outputs
Krause, K., Le Magueres, P., Im, H., Schultz, W., Hastings, J. W., & Liu, L. (2003, July). Three-dimensional structure analysis of the D2 domain of lingulodinium luciferase. Verbal presentation at the 31st Annual Meeting of the American Society for Photobiology, Baltimore, MD, USA.
Intellectual Property
Krause, K. L., Kohn, H., Kim, M. G., Briggs, J., & Benedik, M. (2003). Protein structure for drug design-DadX. Provisional United States Patent (60/498,823).
Krause, K. L., Kohn, H., Kim, M. G., Briggs, J., & Benedik, M. (2003). Hydroxamates as antimicrobial agents. Provisional United States Patent (60/499,174).
2002
Chapter in Book - Research
Krause, K. L., & Miller, M. D. (2002). A new engine for cleaving nucleic acid. In G. R. Eaton, D. C. Wiley & O. Jardetzky (Eds.), Structures and mechanisms: From ashes to enzymes. (pp. 270-293). Washington, DC, USA: American Chemical Society.
Journal - Research Article
Musher, D. M., Dowell, M. E., Shortridge, V. D., Flamm, R. K., Jorgensen, J. H., Le Magueres, P., & Krause, K. L. (2002). Emergence of macrolide resistance during treatment of pneumococcal pneumonia. New England Journal of Medicine, 346(8), 630-631.
Crossnoe, C. R., Germanas, J. P., LeMagueres, P., Mustata, G., & Krause, K. L. (2002). The crystal structure of Trichomonas vaginalis ferredoxin provides insight into metronidazole activation. Journal of Molecular Biology, 318(2), 503-518.
Conference Contribution - Published proceedings: Full paper
Bussiere, D., & Krause, K. (2002). Biotechnology and drug discovery: Two years into the third millennium. Nanotech. 2, (pp. 44-49). Nano Science and Technology Institute. Retrieved from http://www.nsti.org/procs/ICCN2002/3/W24.01
Conference Contribution - Poster Presentation (not in published proceedings)
Le Magueres, P., Im, H., Crossnoe, C., & Krause, K. L. (2002, May). The crystal structure of the alanine racemase DadX. Poster session presented at the American Crystallographic Association and American Association for Crystal Growth Annual Meeting, San Antonio, TX, USA.
Krause, K. L., Miller, M. D., & Le Magueres, P. (2002, May). Ultra high resolution Serratia endonuclease. Poster session presented at the American Crystallographic Association and American Association for Crystal Growth Annual Meeting, San Antonio, TX, USA.
Krause, K. L., Crossnoe, C. R., & Le Magueres, P. (2002, May). The crystal structure of Trichomonas vaginalis ferredoxin: Insight into metronidazole activation. Poster session presented at the American Crystallographic Association and American Association for Crystal Growth Annual Meeting, San Antonio, TX, USA.
2001
Chapter in Book - Research
Krause, K. L., & Miller, M. D. (2001). Using electrostatics to define the active site of Serratia endonuclease. In C. H. Schein (Ed.), Methods in molecular biology, Volume 160: Nuclease methods and protocols. (pp. 249-262). Totowa, NJ, USA: Humana Press.
Journal - Research Article
Strych, U., Penland, R. L., Jimenez, M., Krause, K. L., & Benedik, M. J. (2001). Characterization of the alanine racemases from two Mycobacteria. FEMS Microbiology Letters, 196, 93-98.
2000
Journal - Research Article
Strych, U., Huang, H. C., Krause, K. L., & Benedik, M. J. (2000). Characterization of the alanine racemases from Pseudomonas aeruginosa PAO1. Current Microbiology, 41, 290-294.