Research Associate Professor
MB MMed PhDEmail mei.zhang@cdhb.health.nz
Associate Professor Mei Zhang is a Research Associate Professor employed by Clinical Pharmacology, Department of Medicine, University of Otago, Christchurch and by Toxicology, Canterbury Health Laboratories.
Originally trained as a medical doctor in China, Mei has completed a PhD from the School of Pharmacy, University of Otago entitled Chiral Studies of the metabolism of formoterol and salmeterol in humans.
Mei develops assays for drug analysis from biological matrices that are being investigated in various departmental research projects and is continuing research in drug isomerisation.
Publications
Zhang, M., Moore, G., Chin, P. K. L., & Doogue, M. (2023). An efficient HILIC-MS/MS method for monitoring metformin in human plasma. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. P510. Retrieved from https://www.asceptasm.com Conference Contribution - Published proceedings: Abstract
Spangehl, M. J., Clarke, H. D., Moore, G. A., Zhang, M., Probst, N. E., & Young, S. W. (2022). Higher tissue concentrations of Vancomycin achieved with low dose intraosseous injection versus intravenous despite limited tourniquet duration in primary TKA: A randomized trial. Journal of Arthroplasty, 37, 857-863. doi: 10.1016/j.arth.2022.01.057 Journal - Research Article
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037 Journal - Research Article
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887 Journal - Research Article
McNeill, R. P., Zhang, M., Epton, M. J., & Doogue, M. P. (2021). Drub metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study. British Journal of Clinical Pharmacology, 87, 4397-4407. doi: 10.1111/bcp.14862 Journal - Research Article
2023
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G., Chin, P. K. L., & Doogue, M. (2023). An efficient HILIC-MS/MS method for monitoring metformin in human plasma. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. P510. Retrieved from https://www.asceptasm.com
2022
Journal - Research Article
Spangehl, M. J., Clarke, H. D., Moore, G. A., Zhang, M., Probst, N. E., & Young, S. W. (2022). Higher tissue concentrations of Vancomycin achieved with low dose intraosseous injection versus intravenous despite limited tourniquet duration in primary TKA: A randomized trial. Journal of Arthroplasty, 37, 857-863. doi: 10.1016/j.arth.2022.01.057
2021
Journal - Research Article
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
McNeill, R. P., Zhang, M., Epton, M. J., & Doogue, M. P. (2021). Drub metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study. British Journal of Clinical Pharmacology, 87, 4397-4407. doi: 10.1111/bcp.14862
Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1
2020
Journal - Research Article
Zhang, M., Moore, G. A., & Chin, P. K. L. (2020). Simultaneous determination of dabigatran, rivaroxaban, and apixaban in human plasma by liquid chromatography/tandem mass spectrometry. Therapeutic Drug Monitoring, 42(3), 473-480. doi: 10.1097/ftd.0000000000000744
Chin, P. K. L., McNeill, R., Lee, H. K., Zhang, M., Jensen, B., Smith, M., & Doogue, M. P. (2020). Routine therapeutic drug monitoring of dabigatran: Experience at a tertiary center. Therapeutic Drug Monitoring, 42(3), 468-472. doi: 10.1097/ftd.0000000000000713
Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004
2019
Journal - Research Article
Stamp, L. K., O'Donnell, J. L., Frampton, C., Drake, J., Zhang, M., Barclay, M., & Chapman, P. (2019). A pilot randomized controlled double-blind trial of high- versus low-dose weekly folic acid in people with rheumatoid arthritis receiving methotrexate. Journal of Clinical Rheumatology, 25(7), 284-287. doi: 10.1097/RHU.0000000000000848
Journal - Research Other
Mortensen, J. S., Jensen, B. P., Zhang, M., & Doogue, M. (2019). Pre-analytical stability of piperacillin, tazobactam, meropenem and ceftazidime in plasma and whole blood using LC-MS/MS [Short communication]. Therapeutic Drug Monitoring, 41(4), 538-543. doi: 10.1097/ftd.0000000000000650
Conference Contribution - Published proceedings: Abstract
Drennan, P., Green, J., Gardiner, S., Metcalf, S., Kirkpatrick, C., Zhang, M., & Chambers, S. (2019). Clinical outcomes and pharmacokinetic-pharmacodynamic target attainment in patients treated with oral flucloxacillin plus probenecid for staphylococcal infections. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 22). Retrieved from https://www.asceptasm.com
Young, S. W., Clarke, H. D., Moore, G. A., Zhang, M., Probst, N. E., & Spangehl, M. J. (2019). Superior tissue levels of vancoymin are achieved with intraosseous versus intravenous administration despite limited tourniquet use in primary TKA: A prospective, randomized trial. Orthopaedic Proceedings, 101-B(Suppl. 11), (pp. 55). doi: 10.1302/1358-992X.2019.11.055
2018
Journal - Research Article
Zhang, M., Moore, G. A., Chin, P. K. L., Everts, R., & Begg, E. J. (2018). Simultaneous determination of Cefalexin, Cefazolin, Flucloxacillin and Probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Therapeutic Drug Monitoring, 40(6), 682-692. doi: 10.1097/FTD.0000000000000555
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370
Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673
Chin, S. J., Moore, G. A., Zhang, M., Clarke, H. D., Spangehl, M. J., & Young, S. W. (2018). Intraosseous regional prophylaxis provides higher tissue concentrations in high BMI patients in total knee arthroplasty: A randomized trial. Journal of Arthroplasty, 33(7), S13-S18. doi: 10.1016/j.arth.2018.03.013
Munning-Schmidt, E., Zhang, M., Mulder, C. J., & Barclay, M. L. (2018). Late-onset rise of 6-MMP metabolites in IBD patients on azathioprine or mercaptopurine. Inflammatory Bowel Diseases, 24(4), 892-896. doi: 10.1093/ibd/izx081
Journal - Research Other
Stamp, L. K., Merriman, T., Frampton, C., Zhang, M., Wallace, M., Miner, J. N., & Dalbeth, N. (2018). Plasma oxypurinol as a measure of adherence in clinical trials. Annals of the Rheumatic Diseases, 77(2), 313-314. doi: 10.1136/annrheumdis-2016-210661
Conference Contribution - Published proceedings: Full paper
Young, S. W., Zhang, M., Moore, G. A., Pitto, R. P., Clarke, H. D., & Spangehl, M. J. (2018). The John N. Insall Award: Higher tissue concentrations of vancomycin achieved with intraosseous regional prophylaxis in revision TKA: A randomized controlled trial. Clinical Orthopaedics & Related Research, 476(1), (pp. 66-74). doi: 10.1007/s11999.0000000000000013
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G., Doogue, M., & Strother, M. (2018). Simultaneous determination of the phenotyping cocktail drugs and their cytochrome P450-specific probe metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Innovation in Therapeutics. 422. Retrieved from https://www.asceptasm.com/2018-annaul-scientific-meeting
Conference Contribution - Verbal presentation and other Conference outputs
Zhang, M., Thomas, P. W. A., & Barclay, M. L. (2018, August). Stability of 6-thioguanine in mesalazine enemas: A possible future proctitis treatment. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2017
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Doogue, M. P., & Barclay, M. L. (2017). Simultaneous determination of adalimumab and infliximab in human serum by liquid chromatography/tandem mass spectrometry. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 60). Retrieved from http://www.asceptasm.com/
Barclay, M. L., Munning-Schmidt, E., Zhang, M., & Mulder, C. J. (2017). Late onset rise of 6-MMP metabolites in inflammatory bowel disease patients on azathioprine or mercaptopurine. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 55). Retrieved from http://www.asceptasm.com/
Young, S. W., Clarke, H. D., Moore, G. A., Zhang, M., & Spangehl, M. J. (2017). Higher tissue concentrations of vancomycin are achieved with intraosseous versus intravenous administration in revision TKA. Knee, 24(6), (pp. XIV). doi: 10.1016/j.knee.2017.08.045
2016
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2016). Taking flucloxacillin with food does not compromise effective plasma concentrations in healthy volunteers. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/
Zhang, M., Moore, G. A., & Chin, P. (2016). Simultaneous determination of dabigatran, rivaroxaban and apixaban in human plasma by liquid chromatography/tandem mass spectrometry. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 552. Retrieved from http://www.asceptasm.com/
Keating, P., Zhang, M., & Hock, B. D. (2016). Measurement of anti-TNF biologics and anti-drug antibodies in the clinical laboratory. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 22). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/
2015
Journal - Research Article
Saffian, S. M., Zhang, M., Chin, P. K. L., & Jensen, B. P. (2015). Quantification of dabigatran and indirect quantification of dabigatran acylglucuronides in human plasma by LC-MS/MS. Bioanalysis, 7(8), 957-966. doi: 10.4155/bio.15.32
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Everts, R., & Begg, E. J. (2015). Determination of total and free concentrations of cefalexin, cefazolin, flucloxacillin and probenecid in human plasma by liquid chromatography/tandem mass spectrometry. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting: Drugs to Medicines: Up Close and Personal. 535. Retrieved from http://www.asceptasm.com/
Chin, P. K. L., Drennan, P. G., Dalton, S. C., Zhang, M., & Begg, E. J. (2015). Flucloxacillin: Total concentrations poorly reflect unbound concentrations in hospitalised patients. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting: Drugs to Medicines: Up Close and Personal. 236. Retrieved from http://www.asceptasm.com/
Conference Contribution - Verbal presentation and other Conference outputs
Begg, E., Gardiner, S., Drennan, P., Green, J., Isenman, H., Begg, R., Chambers, S., Zhang, M., & Everts, R. (2015, September). Is it bad to take flucloxacillin with food? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2014
Journal - Research Article
Zhang, M., Moore, G. A., Everts, R., & Begg, E. J. (2014). Determination of total and free concentrations of flucloxacillin and cefazolin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Analytical & Bioanalytical Technique, 5(1), 1000182. doi: 10.4172/2155-9872.1000182
Pan, S., Stamp, L. K., Duffull, S. B., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Korell, J. (2014). Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis. Clinical Pharmacokinetics, 53(12), 1161-1170. doi: 10.1007/s40262-014-0179-5
Zhang, M., Moore, G. A., & Young, S. W. (2014). Determination of vancomycin in human plasma, bone and fat by liquid chromatography/tandem mass spectrometry. Journal of Analytical & Bioanalytical Technique, 5(3), 1000196. doi: 10.4172/2155-9872.1000196
Stamp, L. K., Turner, R., Khalilova, I. S., Zhang, M., Drake, J., Forbes, L. V., & Kettle, A. J. (2014). Myeloperoxidase and oxidation of uric acid in gout: Implications for the clinical consequences of hyperuricaemia. Rheumatology, 53(11), 1958-1965. doi: 10.1093/rheumatology/keu218
Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9
Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366
Korell, J., Duffull, S. B., Dalrymple, J. M., Drake, J., Zhang, M., Barclay, M. L., & Stamp, L. K. (2014). Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. British Journal of Clinical Pharmacology, 77(3), 493-497. doi: 10.1111/bcp.12209
Conference Contribution - Published proceedings: Full paper
Young, S. W., Zhang, M., Freeman, J. T., Mutu-Grigg, J., Pavlou, P., & Moore, G. A. (2014). The Mark Coventry Award: Higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: A randomised trial. Clinical Orthopaedics & Related Research, 472(1), (pp. 57-65). doi: 10.1007/s11999-013-3038-z
2013
Journal - Research Article
Stamp, L. K., O'Donnell, J. L., Frampton, C., Drake, J. M., Zhang, M., & Chapman, P. T. (2013). Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout: A pilot randomized controlled trial. Arthritis & Rheumatism, 65(6), 1636-1642. doi: 10.1002/art.37925
Korell, J., Stamp, L. K., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Duffull, S. B. (2013). A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics, 52(6), 475-485. doi: 10.1007/s40262-013-0052-y
Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2013). A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma. Antimicrobial Agents & Chemotherapy, 57(1), 484-489. doi: 10.1128/aac.00768-12
Conference Contribution - Published proceedings: Full paper
Young, S. W., Zhang, M., Freeman, J. T., Vince, K. G., & Coleman, B. (2013). Higher cefazolin concentrations with intraosseous regional prophylaxis in TKA. Clinical Orthopaedics & Related Research, 471(1), (pp. 244-249). doi: 10.1007/s11999-012-2469-2
Conference Contribution - Verbal presentation and other Conference outputs
Begg, E. J., Chambers, S. T., Zhang, M., & Everts, R. J. (2013, August). Pharmacokinetics of oral flucloxacillin alone without food, with probenecid without food, and with probenecid with food. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2012
Journal - Research Article
Zhang, M., Moore, G. A., Fernyhough, L. J., Barclay, M. L., & Begg, E. J. (2012). Determination of imatinib and its active metabolite N-desmethyl imatinib in human plasma by liquid chromatography/tandem mass spectrometry. Analytical & Bioanalytical Chemistry, 404(6-7), 2091-2096. doi: 10.1007/s00216-012-6284-0
Stamp, L. K., Barclay, M. L., O'Donnell, J. L., Zhang, M., Drake, J., Frampton, C., & Chapman, P. T. (2012). Furosemide increases plasma oxypurinol without lowering serum urate—a complex drug interaction: Implications for clinical practice. Rheumatology, 51(9), 1670-1676. doi: 10.1093/rheumatology/kes091
Van Egmond, R., Chin, P., Zhang, M., Sies, C. W., & Barclay, M. L. (2012). High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Alimentary Pharmacology & Therapeutics, 35(10), 1181-1189. doi: 10.1111/j.1365-2036.2012.05084.x
Conference Contribution - Published proceedings: Abstract
Stamp, L. K., Khalilova, I., Zhang, M., Turner, R., & Kettle, A. (2012). Oxidation of urate to allantoin by myeloperoxidase in gout. Arthritis & Rheumatism, 64(10, Suppl.), (pp. S808). doi: 10.1002/art.37735
2011
Journal - Research Article
Stamp, L. K., Barclay, M. L., O'Donnell, J. L., Zhang, M., Drake, J., Frampton, C., & Chapman, P. T. (2011). Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritis. Journal of Rheumatology, 38(12), 2540-2547. doi: 10.3899/jrheum.110481
Stamp, L. K., Barclay, M. L., O'Donnell, J. L., Zhang, M., Drake, J., Frampton, C., & Chapman, P. T. (2011). Relationship between serum urate and plasma oxypurinol in the management of gout: Determination of minimum plasma oxypurinol concentration to achieve a target serum urate level. Clinical Pharmacology & Therapeutics, 90(3), 392-398. doi: 10.1038/clpt.2011.113
Bird, P. A., Murray, D. P., Zhang, M., & Begg, E. J. (2011). Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otology & Neurotology, 32(6), 933-936. doi: 10.1097/MAO.0b013e3182255933
Zhang, M., Moore, G. A., Jensen, B. P., Begg, E. J., & Bird, P. A. (2011). Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 879(1), 17-24. doi: 10.1016/j.jchromb.2010.11.003
Stamp, L. K., O'Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., & Chapman, P. T. (2011). Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including in those with renal impairment. Arthritis & Rheumatism, 63(2), 412-421. doi: 10.1002/art.30119
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2011). Determination of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in human red blood cells by LC-MS/MS. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 7.2. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf
Jensen, B. P., Zhang, M., Moore, G., & Begg, E. J. (2011). LC-MS in clinical pharmacology and toxicology: From niche projects to routine screening. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 6.3. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Roberts, R., Zhang, M., Gearry, R. B., & Barclay, M. L. (2011, October). Non-synonymous single nucleotide polymorphisms in guanosine 5'-monophosphate synthetase associated with altered metabolism of azathioprine. Verbal presentation at the 19th United European Gastroenterology Week (UEGW), Stockholm, Sweden.
2010
Journal - Research Article
Stamp, L. K., Chapman, P. T., O'Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics & Genomics, 20(6), 367-376. doi: 10.1097/FPC.0b013e3283398a71
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., & Barclay, M. L. (2010). Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy. Arthritis & Rheumatism, 62(2), 359-368. doi: 10.1002/art.27201
Journal - Research Other
Roberts, R. L., Zhang, M., Marinaki, A. M., & Stamp, L. K. (2010). Does genetic variability in aldehyde oxidase and molybdenum cofactor sulfurase predict nonresponse to allopurinol? [Letter to the editors]. Alimentary Pharmacology & Therapeutics, 32(2), 310-311. doi: 10.1111/j.1365-2036.2010.04349.x
Conference Contribution - Published proceedings: Abstract
Stamp, L. K., O'Donnell, J. L., Chapman, P., Zhang, M., James, J., Frampton, C., & Barclay, M. (2010). The effect on MTX polyglutamate concentration profile after changing from oral to subcutaneous methotrexate in rheumatoid arthritis. Arthritis & Rheumatism, 62(Suppl. 10). doi: 10.1002/art.30166
Begg, E. J., Zhang, M., & Bird, P. A. (2010). Intratympanic versus intravenous delivery of dexamethasone into cochlear perilymph compared with plasma. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/
Stamp, L. K., O'Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., & Chapman, P. T. (2010). Using allopurinol above the dose based on creatinine clearance is effective and safe in chronic gout, including in those with renal impairment. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/
Barclay, M. L., Stamp, L. K., O'Donnell, J. L., Zhang, M., Drake, J., Frampton, C., & Chapman, P. T. (2010). Effects of changing from oral to subcutaneous administration of methotrexate on RBC MTX polyglutamate concentrations and disease activity in patients with rheumatoid arthritis. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/
2009
Journal - Research Article
Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x
Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2009). Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877(27), 3025-3030. doi: 10.1016/j.jchromb.2009.07.021
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., James, J., & Barclay, M. L. (2009). Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment. Arthritis & Rheumatism, 60(8), 2248-2256. doi: 10.1002/art.24653
Conference Contribution - Published proceedings: Abstract
Roberts, R. L., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., Kennedy, M. A., Barclay, M. L., & Stamp, L. K. (2009). Genetic polymorphisms in the folate pathway predict red blood cell folate concentrations but not methotrexate response in rheumatoid arthritis. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Stamp, L., O'Donnell, J. L., Zhang, M., Frampton, C., Chapman, P. T., & Barclay, M. (2009). Relationship between serum urate and plasma oxypurinol: Is there a target plasma oxypurinol concentration to achieve serum urate ≤6mg/dL. Arthritis & Rheumatism, 60(Suppl. 10), (pp. S561). doi: 10.1002/art.27423
Stamp, L., O'Donnell, J. L., Zhang, M., Frampton, C., Barclay, M., & Chapman, P. T. (2009). Increasing allopurinol dose above the recommended range is effective and safe in chronic gout, including in those with renal impairment: A pilot study. Arthritis & Rheumatism, 60(Suppl. 10), (pp. S729). doi: 10.1002/art.27423
Stamp, L., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., Barclay, M., Kennedy, M., & Roberts, R. (2009). Functional polymorphisms within the folate pathway predict red blood cell folate concentrations but are not associated with methotrexate response in RA. Arthritis & Rheumatism, 60(Suppl. 10), (pp. S150). doi: 10.1002/art.27423
Barclay, M. L., Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., & James, J. (2009). Determinants of red blood cell methotrexate polyglutamate concentrations in patients with rheumatoid arthritis on long-term methotrexate. In D. Hay & S. Ngo (Eds.), Proceedings of the 43rd Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 14. ASCEPT. [Abstract]
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., James, J., & Barclay, M. L. (2009). Determinants of methotrexate red blood cell polyglutamates in patients with rheumatoid arthritis on long-term MTX. Internal Medicine Journal, 39(Suppl. 2), (pp. A43). doi: 10.1111/j.1445-5994.2009.01951_1.x
Stamp, L. K., O'Donnell, J. L., Zhang, M., Frampton, C., James, J., Barclay, M., & Chapman, P. T. (2009). Relationship between allopurinol dose, plasma oxypurinol concentration and serum urate. Internal Medicine Journal, 39(Suppl. 2), (pp. A43). doi: 10.1111/j.1445-5994.2009.01951_1.x
Conference Contribution - Verbal presentation and other Conference outputs
Roberts, R. L., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., Kennedy, M. A., Barclay, M. L., & Stamp, L. K. (2009, September). Genetic polymorphisms in the folate pathway are predictive of red blood cell folate concentrations but not methotrexate response in rheumatoid arthritis patients. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2009, September). Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/ tandem mass spectrometry. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., & Barclay, M. L. (2009, September). Methotrexate polygutamate concentrations are not associated with disease control or toxicity in rheumatoid arthritis patients on long-term MTX. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Barclay, M. L., Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., & James, J. (2009, September). Determinants of red blood cell methotrexate polyglutamate concentrations in patients with rheumatoid arthritis on long-term MTX. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
2008
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032
Dalrymple, J. M., Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Zhang, M., & Barclay, M. L. (2008). Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis. Arthritis & Rheumatism, 58(11), 3299-3308.
Journal - Research Other
Sung, E. Y. Y., Moore, M. P., Lunt, H., Doogue, M., Zhang, M., & Begg, E. J. (2008). Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin? [Letter to the editor]. British Journal of Clinical Pharmacology, 67(1), 130-131. doi: 10.1111/j.1365-2125.2008.03302.x
Gardiner, S. J., Kirkpatrick, C. M. J., Zhang, M., & Begg, E. J. (2008). Cimetidine does not appear to influence the distribution of metformin into human milk [Letter to the editor]. British Journal of Clinical Pharmacology, 66(4), 564-565. doi: 10.1111/j.1365-2125.2008.03190.x
Conference Contribution - Published proceedings: Abstract
Roberts, R. L., Gearry, R. B., Zhang, M., Begg, E. J., & Barclay, M. L. (2008). Optimisation of methotrexate in inflammatory bowel disease patients. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Gearry, R. B., Roberts, R. L., Kennedy, M. A., Zhang, M., & Barclay, M. L. (2008). Thiopurine metabolites, intermediate steps on the way to complete thiopurine pharmacogenetics. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Zhang, M., Moore, G. A., Banks, J. C., Rogers, G. R., & Begg, E. J. (2008). HPLC assay for the determination of nortriptyline and its hydroxylated metabolites in plasma. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Stamp, L. K., O'Donnell, J., Chapman, P., Zhang, M., Frampton, C., & Barclay, M. (2008). Methotrexate polyglutamates and disease activity in rheumatoid arthritis. Arthritis & Rheumatism, 58(Suppl. 9), (pp. S544). [Abstract]
Dalrymple, J., Stamp, L. K., O'Donnell, J., Chapman, P., Zhang, M., & Barclay, M. (2008). Pharmacokinetics of oral MTX in RA patients. Arthritis & Rheumatism, 58(Suppl.9), (pp. S311). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Gearry, R. B., Roberts, R. L., Kennedy, M. A., Zhang, M., & Barclay, M. L. (2008, October). Thiopurine metabolites, intermediate steps on the way to complete thiopurine pharmacogenetics. Verbal presentation at the 4th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Roberts, R. L., Gearry, R. B., Zhang, M., Begg, E. J., & Barclay, M. L. (2008, October). Optimisation of methotrexate in inflammatory bowel disease patients. Verbal presentation at the 4th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
2007
Journal - Research Article
Brooks, A. J., Begg, E. J., Zhang, M., Frampton, C. M., & Barclay, M. L. (2007). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Therapeutic Drug Monitoring, 29(5), 619-625.
Bird, P. A., Begg, E. J., Zhang, M., Keast, A. T., Murray, D. P., & Balkany, T. J. (2007). Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otology & Neurotology, 28, 1124-1130.
Vella-Brincat, J. W. A., Begg, E. J., Kirkpatrick, C. M. J., Zhang, M., Chambers, S. T., & Gallagher, K. (2007). Protein binding of cefazolin is saturable in vivo both between and within patients. British Journal of Clinical Pharmacology, 63(6), 753-757.
Journal - Research Other
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Breast-feeding during maternal use of azathioprine [Comment]. Annals of Pharmacotherapy, 41(4), 719-720.
Conference Contribution - Published proceedings: Abstract
Barclay, M. L., Brooks, A. J., Begg, E. J., Zhang, M., & Frampton, C. M. (2007). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Journal of Gastroenterology and Hepatology. 22(Suppl. 3), (pp. A315). [Abstract]
Stamp, L., Barclay, M., Zhang, M., James, J., Frampton, C., O'Donnell, J., & Chapman, P. (2007). Red cell folate may be an important determinant of response to methotrexate in rheumatoid arthritis. Internal Medicine Journal, 37(Suppl. 2), (pp. A54). doi: 10.1111/j.1445-5994.2007.01428.x
Haines, M. L., Rose, R., Sparrow, M., Irving, P., Zhang, M., Gearry, R., & Gibson, P. R. (2007). Thiopurine metabolite testing: Clinical utility in an Australian cohort of IBD patients with inadequately controlled disease. Journal of Gastroenterology & Hepatology, 22(Suppl. 3), (pp. A322). doi: 10.1111/j.1440-1746.2007.05172.x
Conference Contribution - Verbal presentation and other Conference outputs
Dalrymple, J., Barclay, M., Chapman, P., O'Donnell, J., Zhang, M., & Stamp, L. (2007, August-September). The elimination of red blood cell methotrexate polyglutamates in patients with rheumatoid arthritis. Verbal presentation at the New Zealand Rheumatology Association Conference, Dunedin, New Zealand.
Zhang, M., Moore, G. A., Stamp, L., Barclay, M. L., & Begg, E. J. (2007, August). Rapid and simple HPLC assay for the determination of allopurinol and oxypurinol in human plasma. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Barclay, M. L., Roberts, R. L., Gearry, R. B., Zhang, M., & Kennedy, M. A. (2007, August). Novel gene mutations for enzymes in the thiopurine metabolic pathway in patients with inflammatory bowel disease and severe azathioprine resistance. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Dalrymple, J. M., Stamp, L. K., Zhang, M., Chapman, P. T., O'Donnell, J. L., & Barclay, M. L. (2007, August). The elimination of red blood cell methotrexate polyglutamates in patients with rheumatoid arthritis. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
2006
Journal - Research Article
Vella-Brincat, J., Begg, E., Zhang, M., & Chambers, S. (2006). Cooling enhances benzylpenicillin stability during continuous home intravenous administration. Hospital Pharmacist, 13, 56-57.
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.
Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048
Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x
Conference Contribution - Published proceedings: Abstract
Barclay, M. L., Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. Journal of Gastroenterology & Hepatology, 21(Suppl. 4), (pp. A252). doi: 10.1111/j.1440-1746.2006.04686.x
Conference Contribution - Verbal presentation and other Conference outputs
Brooks, A. J., Barclay, M. L., Begg, E. J., Zhang, M., & Frampton, C. M. A. (2006, November). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Verbal presentation at the New Zealand Society of Gastroenterology NZNO Gastroenterology Nurses Section Annual Scientific Meeting, Blenheim, New Zealand.
Stamp, L., Dalrymple, J., Barclay, M., Zhang, M., James, J., Frampton, C., Chapman, P., & O'Donnell, J. (2006, August-September). Methotrexate management in rheumatoid arthritis: Is there a role for methotrexate polyglutamate measurement? Verbal presentation at the New Zealand Rheumatology Association Annual Scientific Meeting, Queenstown, New Zealand.
Brooks, A. J., Begg, E. J., Barclay, M. L., & Zhang, M. (2006, August-September). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (New Zealand) Annual Scientific Meeting, Auckland, New Zealand.
Dalrymple, J., Barclay, M., Zhang, M., Chapman, P., O'Donnell, J., Frampton, C., & Stamp, L. (2006, November). The pharmacokinetics of accumulation of methotrexate polyglutamates in patients with rheumatoid arthritis. Verbal presentation at the Society of Hospital Pharmacists of Australia 5th Biennial Clinical Conference, Melbourne, Australia.
Dalrymple, J., Barclay, M., Zhang, M., Chapman, P., O'Donnell, J., Frampton, C., & Stamp, L. (2006, August-September). The pharmacokinetics of accumulation of methotrexate polyglutamates in patients with rheumatoid arthritis. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (New Zealand) Annual Scientific Meeting, Auckland, New Zealand.
2005
Journal - Research Article
Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.
Gearry, R. B., Barclay, M. L., Roberts, R. L., Harraway, J., Zhang, M., Pike, L. S., George, P. M., & Florkowski, C. M. (2005). Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: Early experience of use in clinical practice. Internal Medicine Journal, 35, 580-585.
Conference Contribution - Published proceedings: Abstract
Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Zhang, M., & Pemberton, C. (2005). Metformin pharmacokinetics and the effect on hormones involved in appetite regulation. Proceedings of the Joint Meeting of ASCEPT and APSA. ASCEPT: Melbourne, Australia. [Abstract]
Zhang, M., Moore, G. A., Barclay, M. L., & Stamp, L. (2005). HPLC assay for erythrocyte methotrexate polyglutamates. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Scientific Meeting. Wellington, New Zealand: ASCEPT. [Abstract]
Begg, E. J., Bird, P. A., Keast, A. T., Murray, D. P., & Zhang, M. (2005). Intratympanic delivery of methylprednisolone into the cochlear perilymph. Proceeding of the Joint Meeting of ASCEPT and APSA. ASCEPT: Melbourne, Australia. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Begg, E. J., Bird, P. A., Keast, A. T., Murray, D. P., & Zhang, M. (2005, December). Intratympanic delivery of methylprednisolone into the cochlear perilymph. Poster session presented at the Joint Meeting of Ascept and APSA, Melbourne, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Zhang, M., Moore, G. A., Barclay, M. L., & Stamp, L. (2005, August). HPLC assay for erythrocyte methotrexate polyglutamates. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Scientific Meeting, Wellington, New Zealand.
Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., & Zhang, M. (2005, December). Metformin pharmacokinetics and the effect on hormones involved in appetite regulation. Verbal presentation at the Joint Meeting of ASCEPT and APSA, Melbourne, Australia.
2004
Journal - Research Article
Vella-Brincat, J. W. A., Begg, E. J., Gallagher, K., Kirkpatrick, C. M. J., Zhang, M., Frampton, C., & Chambers, S. T. (2004). Stability of benzylpenicillin during continuous home intravenous therapy. Journal of Antimicrobial Chemotherapy, 53(4), 675-677. British Society for Antimicrobial Chemotherapy.
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Lever, M., Barclay, M. L., & Begg, E. J. (2004). Therapeutic drug monitoring of fluoxetine and norfluoxetine enantiomers. Clinical and Experimental Pharmacology and Physiology. 31(Suppl.), (pp. A56). [Abstract]
2003
Journal - Research Article
Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.
Barclay, M. L., Sawyers, S. M., Begg, E. J., Zhang, M., Roberts, R., Kennedy, M. A., & Elliott, J. M. (2003). Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics, 13(10), 627-632.
Journal - Research Other
Gearry, R., Barclay, M., Gardiner, S., & Zhang, M. (2003). 6-thioguanine nucleotides and thiopurine methyltransferase activity: Important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP [Letter]. New Zealand Medical Journal, 116(1178). Retrieved from http://journal.nzma.org.nz/journal/116-1178/531/content.pdf
Conference Contribution - Published proceedings: Abstract
Fawcett, J. P., & Zhang, M. (2003). Aliphatic oxidation of salmeterol enantiomers by human liver microsomes. Drug Metabolism Reviews. 35(Suppl. 1), (pp. 51). [Abstract]
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2003). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 10, (pp. 77). [Abstract]
Barclay, M. L., Gearry, R. B., Zhang, M., Roberts, R. L., Harraway, J., Pike, L., & Gardiner, S. J. (2003). Early New Zealand experience of monitoring TPMT activity and RBC 6-thioguanine nucleotides in patients on azathioprine or 6-MP. In E. A. Davis & C. G. Sobey (Eds.), Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists. 10. Victoria, Australia: ASCEPT. [Abstract]
2002
Journal - Research Article
Howard, G. W., Begg, E. J., Chambers, S. T., Vella-Brincat, J., Zhang, M., & Kirkpatrick, C. M. J. (2002). Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion. Journal of Antimicrobial Chemotherapy, 50, 429-432.
Zhang, M., Fawcett, J. P., & Shaw, J. P. (2002). Stereoselective urinary excretion of formoterol and its glucuronide conjugate in human. British Journal of Clinical Pharmacology, 54, 246-250.
Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.
Conference Contribution - Published proceedings: Abstract
Begg, E. J., Kirkpatrick, C. M. J., Howard, G. W., Zhang, M., Vella-Brincat, J. W. A., & Metcalf, S. (2002). Saturable protein binding of cephazolin in -vivo - implications for dosing. Proceedings of the ASCEPT Annual Meeting. [Abstract]
Zhang, M., Moore, G. A., & Barclay, M. L. (2002). High-performance liquid chromatographic assay for the determination of 6-thioguanine nucleotides of azathioprine in human red blood cells. Proceedings of the Australasian Society of Clinical and Experiemental Pharmacologists and Toxicologists Annual Meeting. [Abstract]
Phillips, M., van Rij, A. M., Zhang, M., & Jones, G. T. (2002). Micro-venous valve morphology differences between normal limbs and limbs with venous ulceration. Australia and New Zealand Journal of Surgery. 72(Suppl.), (pp. A121). [Abstract]
Gardiner, S. J., Kirkpatrick, C. M. J., Begg, E. J., Zhang, M., & Moore, M. P. (2002). Metformin and human milk: Unexpectedly low transfer and infant dose. Australian Health and Medical Research Congress. (A1162). [Abstract]
Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2002). Restricted penetration of metformin into human milk. Proceedings of the Australasian Society of Clinical and Experiemental Pharmacologists and Toxicologists. [Abstract]
2001
Journal - Research Article
Williams, J., Patsalos, P. N., Zhang, M., Schapel, G., Wilson, J. F., & Richens, A. (2001). Relation between dosage of carbamazepine and concentration in hair and plasma samples from a compliant inpatient epileptic population. Therapeutic Drug Monitoring, 23, 15-20.
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Rapid and simple high-performance liqid chromatographic assay for the determination of metformin in human plasma and breast milk. Proceedings of Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 9. [Abstract]
Begg, E. J., Howard, G. W., Vella-Brincat, J., Zhang, M., Kirkpatrick, C. M. J., & Chambers, S. T. (2001). Free concentrations of cephazolin in plasma and tissue fluid during continuous intravenous infusion. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 9, (pp. 99). [Abstract]
Fawcett, J. P., & Zhang, M. (2001). Metabolism of salmeterol enantiomers by human liver microsomes. Proceedings of the Australasian Pharmaceutical Science Association Annual Conference. (pp. 96). Melbourne: APSA. [Abstract]
2000
Journal - Research Article
Zhang, M., Fawcett, J. P., Kennedy, J. M., & Shaw, J. P. (2000). Stereoselective glucuronidation of formoterol by human liver microsomes. British Journal of Clinical Pharmacology, 49, 152-157.
Journal - Research Other
Zhang, M., Fawcett, J. P., Kennedy, J. M., & Shaw, J. P. (2000). [Review of the book Stereoselective glucuronidation of salbutamol by human liver microsomes]. Journal of Clinical Pharmacology, 49. [Book Review].
1999
Journal - Research Article
Zhang, M., Fawcett, J. P., & Shaw, J. P. (1999). Rapid chiral high-performance liquid chromatographic assay for salmeterol and α-hydroxysalmeterol. Application to in vitro metabolism studies. Journal of Chromatography B: Biomedical Sciences & Applications, 729, 225-230.
Conference Contribution - Published proceedings: Abstract
Fawcett, J. P., Zhang, M., Kennedy, J. M., & Shaw, J. P. (1999). Stereoselective glucuronidation of formoterol in humans. Proceedings of the Annual Meeting of The Australasain Society of Clinical and Experimental Pharmacologists and Toxicologists (NZ Section). Auckland. [Abstract]
Fawcett, J. P., Zhang, M., & Aberg, A. K. G. (1999). Stereoselective glucuronidation of salbutamol by cow and sheep liver microsomes. Abstracts of AIMECS 99 International Medicinal Chemistry Symposium. Beijing. [Abstract]
Zhang, M., Fawcett, J. P., & Shaw, J. P. (1999). Stereoselective glucuronidation of salbutamol by human liver microsomes. Abstracts of AIMECS 99 International Medicinal Chemistry Symposium. Beijing. [Abstract]
1998
Conference Contribution - Published proceedings: Abstract
Fawcett, J. P., Zhang, M., & Shaw, J. P. (1998). Human hepatic metabolism of fenoterol enantiomers in vitro. Proceedings of the Annual Meeting of The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (NZ Section). Auckland. [Abstract]
1997
Conference Contribution - Published proceedings: Abstract
Zhang, M., Fawcett, J. P., & Shaw, J. P. (1997). In vitro hepatic metabolism of salmeterol enantiomers in human. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 4. Canberra: Blackwell Scientific Publications. [Abstract]
Zhang, M., Fawcett, J. P., & Shaw, J. P. (1997). A chiral HPLC assay for the simultaneous determination of salmeterol and metabolities. Proceedings of the Annual Meeting of the Australasian Pharmaceutical Science Association Sydney. [Abstract]