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Eccles Laboratory: Developmental Genetics and Pathology

Supported by the NZ Institute for Cancer Research Trust Chair in Cancer Pathology, Professor Michael Eccles and his research group in the Department of Pathology are carrying out ground breaking research into cancer and polycystic kidney disease (PKD).

Cancer is the leading cause of mortality in NZ, while PKD is the most common familial inherited disease that affects adults aged 50 years or more. The group is currently pioneering a relatively new research approach (called reduced representation bisulphite sequencing, or RRBS) to investigate the role of genome-wide epigenetic changes (particularly of DNA methylation) involved in both melanoma, and PKD.

Melanoma is an important cancer in New Zealand; this country the highest incidence rate per capita in the world, and consequently it is the most common cause of death for young adult males and females in NZ. Melanoma metastasizes very early in its evolution, and this feature of melanoma is currently being put to the test by the research team.

As an exemplar type of metastasizing cancer, the research team is trying to understand the epigenetic changes that underpin melanoma metastasis. The team has already made somAniruddha_Mike_QMBe excellent headway on this, and has published gene expression signatures that distinguish invasive from non-invasive melanoma types. Right now the research team is incorporating this into their quest for relevant epigenetic features of metastasis.

Image: Principle investigator Mike Eccles congratulates Research Fellow Aniruddha Chatterjee on winning the Illumina Emerging Researcher Award at Queenstown Molecular Biology Week. 

Key people

Professor Mike Eccles (Principal Investigator)

Dr Cherie Stayner (Research Fellow)

Dr Aniruddha Chatterjee (Research Fellow)

Dr Euan Rodger (Research Fellow)

Britt Kunnen (Assistant Research Fellow)

Antonio Ahn (Assistant Research Fellow)

Anna Leichter (Assistant Research Fellow)

Francesco Mainini (PhD candidate)

Jyoti Motwani (PhD candidate)

Michael Bates (MSc student)

Ashish Pinnapureddy (MSc student)

Sarah Bowden (MSc student)