Point-of-care technologies, Research, Centre for Bioengineering & Nanomedicine

Overview

Yusuf Cakmak Associate Professor Cakmak

We are dedicated to improving patient outcomes through innovation at the point of care. Diagnostic and therapeutic Medical Wearables, mobile Health applications for telemedicine, and optimized monitoring and objective informed decision-making software can revolutionize patient care and save lives.
Using our translational expertise, we marry biomedical engineering, computer science, and digital modelling with the aim of empowering clinicians to make better-informed decisions remotely and also at the bedside.
Our extensive team includes clinicians, neonatologists, physicists, neuroscientists, engineers, computer and data scientists, and animal technicians.

Contact

Associate Professor Yusuf Ozgur Cakmak
Tel +64 3 479 4030
Email Yusuf.cakmak@otago.ac.nz

Lab page: www.cakmaklab.com

Research

Medical Wearable Technologies (Wearables)

Wearables in healthcare is a category of electronic devices that can be worn, printed on skin or embedded in smart clothing to collect the patients' health information for e-diagnostics and to modulate organs systems as therapeutics.

Our theme researchers in Dunedin Campus are running numerous novel wearable projects, including (but not limited to) wearable olfactory nerve stimulator, wearable gastric neuromodulator, wearables for Parkinson Disease, Stroke-derived aspiration alleviation technologies funded by HRC and Medtech Core NZ in collaboration with national and international collaborators. Our theme also collaborates with the Biomaterials theme for embedded systems in smart suits. With the Internet of Things(IoT), such wearable technologies open horizons for timely intelligent medical analytics and remote management for diagnostic and therapeutic applications.

Yusuf_Wearables1

https://www.otago.ac.nz/news/news/otago760863.html
https://www.bbc.com/future/article/20210302-how-your-sense-of-smell-predicts-your-overall-health

Mobile Health (mHealth)

mHealth is defined as the "use of mobile and wireless technologies to support the achievement of health objectives." by the World Health Organisation who indicated that “mHealth has the potential to transform the face of health service delivery across the globe.”

mHealth comprises a wide range of remote technologies, including mobile phone or tablet apps to electronic displays embedded into robotics and webcams assisted tools, miniaturized systems, and (but not limited to) the Virtual Reality and Digital Humans. The rapid adoption of such devices running medical applications enabled digital health for telemedicine with the Internet of things (IoT).

In the University of Otago, Dunedin Campus, we are running novel mHealth projects on diagnostic, and monitorization for Concussion, Posttraumatic Stress Disorder, Parkinson's Disease motor symptoms and Cardiovascular Diseases in collaboration with national and international research centres.

Decision-making software

The Precision Health in Surgical and Intensive Care (PHySIC) group combines active clinical research, novel clinical databases, and machine learning to determine patient status and needs in critical care.
PHySIC is an open-source, anonymous archive database holding continuous wave-form data alongside the usual clinical information sourced from ICU's and intraoperative spaces across New Zealand's District Health Boards.
Through relationships with Wellington Regional Hospital, Capital Coast DHB, and clinical collaborators, our team is actively working towards creating a novel, New Zealand-specific medical database based on MIT's MIMIC (Multi-parameter Intelligent Monitoring in Intensive Care).
Data scientists and machine learning experts at the University of Otago, Wellington, and Victoria University Wellington are using the PHySIC database to create predictive models for sepsis, and cardiac surgery risk, the potential for innovating treatment with predictive models, extends to every corner of New Zealand critical care.

Medical engineering

Translational and clinical researchers at the University of Otago Wellington campus have partnered with physicists and engineers at Victoria University Wellington with the aim to innovate bedside brain-health detection.

Through this collaboration, they hope to validate brain diagnoses and monitoring in an accessible paradigm. Making these capabilities more available will empower more clinicians in their decision making and lead to better care of critical neurological disorders.

Research facilities

Dunedin Campus

32 channel Wireless EEG - Hybrid Multichannel transcranial Direct Current Stimulator(tDCS)
8 channel tDCS
Wireless & wearable eye tracker
taVNS (transauricular Vagal Nerve Stimulator)
Infrared non-contact muscle function monitorization (hand avatar)
Virtual Reality/Augmented Reality/Mixed Reality Systems/Headsets
fMRI compatible Olfactometer
Wireless ECG/EMG
Wireless EGG (Electrogastrography)
Near-infrared spectroscopy (Body and Brain)
BIS index monitorisation
Non-invasive peripheral Nerve stimulators (TENS, PENS)
Ultrasound
Non-contact Haptic stimulator
Multiple mobile phones and tablets for mHealth applications

Wellington Campus

The Centre for Translational Physiology at the University of Otago can offer unique research facilities such as:

Whole body room calorimeter
DXA scanner
Ultrasound (transcranial, vascular, cardiac)
Near-infrared spectroscopy
Cardiopulmonary bypass
Wireless physiological monitoring

Our people

The team, led from University of Otago Dunedin campus, includes anatomists, physiologists, psychologists, surgeons, neonatologists, computer and data scientists, and engineers.

Point-of-care research lead

Associate Professor Yusuf Ozgur Cakmak, Wearables, mHealth and non-contact systems.

Investigators

Associate Professor Max Berry (Department of Paediatrics and Child Health, Wellington)
Associate Professor Jeremiah Deng (Information Sciences, Dunedin)
Associate Professor Mei Peng (Senior Lecturer, Dept of Food Science, Dunedin)
Professor Melanie Bussey (Biomechanics and Director of the Motion Analysis Research Lab, Dunedin)
Professor Mauro Farella (Medical implants/devices, smart brasses, Dentistry, Dunedin)
Professor Micheal Schultz (Gastroenterology, Mobile Health applications, Dept of Medicine, Dunedin)
Professor John Reynolds (Wearable Ultrasound for in vivo drug delivery, Dept of Anatomy, Dunedin)
Dr Jerin Mathew (EEG neurofeedback, pain modulation, Dept of Anatomy, Dunedin)
Associate Professor Shieak Tzeng (Department of Surgery and Anaesthesia, Wellington)

External collaborators

A/Prof Paul Teal (PHySIC, Victoria University, Wellington)
A/Prof. Peng Du (Auckland Bioengineering Institute, Auckland)
Prof.Maggie-Lee Huckabee (University of Canterbury, Christchurch)
Prof.Nikola Kasabov (Auckland University of Technology, Auckland)
Dr Sergei Obruchkov (Victoria University of Wellington, Wellington)
Prof. Una McCann (Johns Hopkins University, USA)
Prof. Alexander Sack (Maastricht University, Netherlands)
A/Prof. Teresa Schuhmann (Maastricht University, Netherlands)

Publications

Yang AHX, Khwaounjoo P, Cakmak YO. Directional effects of whole-body spinning and visual flow in virtual reality on vagal neuromodulation. J Vestib Res. 2021 May 12. doi: 10.3233/VES-201574. Epub ahead of print. PMID: 34024797.

Spicer C, Khwaounjoo P, Cakmak YO. Human and Human-Interfaced AI Interactions: Modulation of Human Male Autonomic Nervous System via Pupil Mimicry. Sensors (Basel). 2021 Feb 3;21(4):1028. doi: 10.3390/s21041028. PMID: 33546217; PMCID: PMC7913357.

Cakmak YO, Nazim K, Thomas C, Datta A. Optimized Electrode Placements for Non-invasive Electrical Stimulation of the Olfactory Bulb and Olfactory Mucosa. Front Neurosci. 2020 Nov 12;14:581503. doi: 10.3389/fnins.2020.581503. PMID: 33262684; PMCID: PMC7688457.

Fan, J.-L., Nogueira, R. C., Brassard, P., Rickards, C. A., Page, M., Nasr, N., & Tzeng, Y.-C. (2021). Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x211033732

Fan, J.-L., Brassard, P., Rickards, C. A., Nogueira, R. C., Nasr, N., McBryde, F. D., … Tzeng, Y.-C. (2021). Integrative cerebral blood flow regulation in ischemic stroke. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x211032029

Barclay, H., Mukerji, S., Kayser, B., O'Donnell, T., Tzeng, Y.-C., Hill, S., … Fan, J.-L. (2021). Respiratory alkalinization and posterior cerebral artery dilatation predict acute mountain sickness severity during 10 h normobaric hypoxia. Experimental Physiology, 106, 175-190. doi: 10.1113/EP088938

Fan, J.-L., O'Donnell, T., Lanford, J., Croft, K., Watson, E., Smyth, D., … Tzeng, Y.-C. (2020). Dietary nitrate reduces blood pressure and cerebral artery velocity fluctuations and improve cerebral autoregulation in transient ischemic attack patients. Journal of Applied Physiology, 129, 547-557. doi: 10.1152/japplphysiol.00160.2020

Ali, H., Brooks, C., Crane, J., Beasley, R., Le Gros, G., Holgate, S., … Pattemore, P., Tzeng, S., … Douwes, J. (2020). Autonomic nervous system activity in adolescent asthma. Respirology, 25(Suppl. 1), (pp. 38). doi: 10.1111/resp.13777

Collaborators

Academic

A/Prof. Peng Du, Auckland Bioengineering Institute
Prof.Maggie-Lee Huckabee, University of Canterbury
Prof.Nikola Kasabov, Auckland University of Technology
Dr Sergei Obruchkov, Victoria University of Wellington
Capital and Coast District Health Board
Wellington Regional Hospital: Paediatrics and Child Health, NICU
Victoria University of Wellington

Industry

Elucimed Ltd (PHySIC-based technology)
Wellumio

CAPABILITIES

Realtime muscle activity tracking and display. Developed by A/Prof. Yusuf Cakmak

fMRI compatible Olfactometers_thumbnail
fMRI compatible Olfactometers

Haptics stimulators and sensors

Cerebral and Somatic perfusion monitoring

Multichannel Transcranial Electrical Stimulators and EEG_thumbnail
Transcranial stimulators and EEG

AI interfaced digital humans_Male_thumbnail
AI interfaced digital humans

Publications

Thomas, D. G., Tzeng, Y.-C., Galvosas, P., Harrison, F. G., Berry, M. J., Teal, P. D., Galvin, S. D., & Obruchkov, S. I. (2023). Single-sided magnet system for quantitative MR relaxometry and preclinical in-vivo monitoring. IEEE Transactions on Biomedical Engineering, 70(2), 671-680. doi: 10.1109/TBME.2022.3200626 Journal - Research Article

Ali, H., Brooks, C., Tzeng, Y.-C., Crane, J., Beasley, R., Gibson, P., Pattemore, P., Stanley, T., Pearce, N., & Douwes, J. (2023). Heart rate variability as a marker of autonomic nervous system activity in young people with eosinophilic and non-eosinophilic asthma. Journal of Asthma, 60(3), 534-542. doi: 10.1080/02770903.2022.2070763 Journal - Research Article

Thomas, D., Harrison, F., Little, A., King, A., Sorby-Adams, A. J., Tzeng, S., … Obruchkov, S. (2022, May). Portable magnetic resonance based monitoring of MCA occlusion in an ovine sheep stroke model. Verbal presentation at the Joint Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) & the European Society for Magnetic Resonance in Medicine & Biology (ESMRMB) and the 31st Annual Meeting of the International Society for Magnetic Resonance Radiographers & Technologists (ISMRT), [Hybrid]. Conference Contribution - Verbal presentation and other Conference outputs

Little, A., Thomas, D., Tzeng, S., & Obruchkov, S. (2022, May). Continuous perfusion measurement with single sided low-field MR. Verbal presentation at the Joint Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) & the European Society for Magnetic Resonance in Medicine & Biology (ESMRMB) and the 31st Annual Meeting of the International Society for Magnetic Resonance Radiographers & Technologists (ISMRT), [Hybrid]. Conference Contribution - Verbal presentation and other Conference outputs

Labrecque, L., Smirl, J. D., Tzeng, Y.-C., & Brassard, P. (2022). We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification [Point/counterpoint]. Journal of Cerebral Blood Flow & Metabolism, 42(12), 2351-2353. doi: 10.1177/0271678x221104868 Journal - Research Other

2023

Journal - Research Article

2022

Journal - Research Article

Thomas, D. G., Galvosas, P., Tzeng, Y.-C., Harrison, F. G., Berry, M. J., Teal, P. D., … Obruchkov, S. (2022). Oxygen saturation-dependent effects on blood transverse relaxation at low fields. Magnetic Resonance Materials in Physics, Biology & Medicine, 35, 805-815. doi: 10.1007/s10334-021-00993-2

Journal - Research Other

Fan, J.-L., Nogueira, R. C., Brassard, P., Rickards, C. A., Page, M., Nasr, N., & Tzeng, Y.-C. (2022). Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. Journal of Cerebral Blood Flow & Metabolism, 42(3), 454-470. doi: 10.1177/0271678x211033732

Conference Contribution - Verbal presentation and other Conference outputs

2021

Journal - Research Article

Ali, H., Brooks, C., Crane, J., Beasley, R., Holgate, S., Gibson, P., Pattemore, P., Tzeng, Y.-C., Stanley, T., … Douwes, J. (2021). Enhanced airway sensory nerve reactivity in non-eosinophilic asthma. BMJ Open Respiratory Research, 8, e000974. doi: 10.1136/bmjresp-2021-000974

Barclay, H., Mukerji, S., Kayser, B., O'Donnell, T., Tzeng, Y.-C., Hill, S., … Fan, J.-L. (2021). Respiratory alkalinization and posterior cerebral artery dilatation predict acute mountain sickness severity during 10 h normobaric hypoxia. Experimental Physiology, 106, 175-190. doi: 10.1113/EP088938

Journal - Research Other

Fong, D., Gradon, K., Barrett, C. J., Guild, S.-J., Tzeng, Y. C., Paton, J. F. R., & McBryde, F. D. (2021). A method to evaluate dynamic cerebral pressure-flow relationships in the conscious rat. Journal of Applied Physiology, 131, 1361-1369. doi: 10.1152/japplphysiol.00289.2021

Fan, J.-L., Brassard, P., Rickards, C. A., Nogueira, R. C., Nasr, N., McBryde, F. D., … Tzeng, Y.-C. (2021). Integrative cerebral blood flow regulation in ischemic stroke. Journal of Cerebral Blood Flow & Metabolism, 42(3), 387-403. doi: 10.1177/0271678x211032029

2020

Journal - Research Article

Fan, J.-L., O'Donnell, T., Lanford, J., Croft, K., Watson, E., Smyth, D., … Tzeng, Y.-C. (2020). Dietary nitrate reduces blood pressure and cerebral artery velocity fluctuations and improve cerebral autoregulation in transient ischemic attack patients. Journal of Applied Physiology, 129, 547-557. doi: 10.1152/japplphysiol.00160.2020

Conference Contribution - Published proceedings: Abstract

Ali, H., Brooks, C., Crane, J., Beasley, R., Le Gros, G., Holgate, S., … Pattemore, P., Tzeng, S., … Douwes, J. (2020). Autonomic nervous system activity in adolescent asthma. Respirology, 25(Suppl. 1), (pp. 38). doi: 10.1111/resp.13777

2019

Journal - Research Article

Fan, J.-L., O'Donnell, T., Gray, C. L., Croft, K., Noakes, A. K., Koch, H., & Tzeng, Y.-C. (2019). Dietary nitrate supplementation enhances cerebrovascular CO₂ reactivity in a sex-specific manner. Journal of Applied Physiology, 127, 760-769. doi: 10.1152/japplphysiol.01116.2018

Journal - Research Other

Saleem, S., Sarafis, Z. K., Lee, A. H. X., Squair, J. W., Barak, O. F., Sober-Williams, E., … Tzeng, Y.-C., & Phillips, A. A. (2019). Spinal cord disruption is associated with a loss of Cushing-like blood pressure interactions. Journal of Neurotrauma, 36, 1487-1490. doi: 10.1089/neu.2018.5931

Saito-Benz, M., Gray, C., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2019). Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates [Brief report]. Acta Paediatrica, 108, 559-561. doi: 10.1111/apa.14631

Conference Contribution - Verbal presentation and other Conference outputs

Allan, P. D., Saleem, S., O'Donnell, T., Fan, J.-L., Larsen, P. D., Berry, M. J., & Tzeng, Y.-C. (2019, September). New approaches to assessing and optimising cerebral perfusion. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Article

Allan, P. D., Tzeng, Y.-C., Gowing, E. K., Clarkson, A. N., & Fan, J.-L. (2018). Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. Journal of Applied Physiology, 125(3), 862-869. doi: 10.1152/japplphysiol.01081.2017

Saleem, S., Vucina, D., Sarafis, Z., Lee, A. H. X., Squair, J. W., Barak, O. F., … Tzeng, Y.-C., & Phillips, A. A. (2018). Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1108-H1114. doi: 10.1152/ajpheart.00152.2017

Saleem, S., Teal, P. D., Howe, C. A., Tymko, M. M., Ainslie, P. N., & Tzeng, Y.-C. (2018). Is Cushing mechanism a dynamic blood pressure stabilizing system? Insights from Granger causality analysis of spontaneous blood pressure and cerebral blood flow. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 315(3), R484-R495. doi: 10.1152/ajpregu.00032.2018

Allan, P. D., O'Donnell, T., & Tzeng, Y.-C. (2018). Agreement between finger plethysmography- and brachial oscillometry-derived blood pressure measurements. Clinical Physiology & Functional Imaging, 38(3), 439-446. doi: 10.1111/cpf.12435

Journal - Research Other

Saito-Benz, M., Murphy, W. G., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2018). Storage after gamma irradiation affects in vivo oxygen delivery capacity of transfused red blood cells in preterm infants. Transfusion, 58, 2108-2112. doi: 10.1111/trf.14764

Tzeng, Y. C., & Panerai, R. B. (2018). CrossTalk proposal: Dynamic cerebral autoregulation should be quantified using spontaneous blood pressure fluctuations: Rebuttal from Y. C. Tzeng and R. B. Panerai. Journal of Physiology, 596(1), 11-12. doi: 10.1113/jp275040

Tzeng, Y. C., & Panerai, R. B. (2018). CrossTalk proposal: Dynamic cerebral autoregulation should be quantified using spontaneous blood pressure fluctuations. Journal of Physiology, 596(1), 3-5. doi: 10.1113/jp273899

Conference Contribution - Published proceedings: Full paper

Smirl, J. D., Wright, A. D., Ainslie, P. N., Tzeng, Y.-C., & van Donkelaar, P. (2018). Differential systolic and diastolic regulation of the cerebral pressure-flow relationship during squat-stand manoeuvres. In T. Heldt (Ed.), Intracranial Pressure & Neuromonitoring XVI (Acta Neurochirurgica Suppl. 126). (pp. 263-268). Cham, Switzerland: Springer International. doi: 10.1007/978-3-319-65798-1_52

2017

Journal - Research Article

Malenfant, S., Brassard, P., Paquette, M., Le Blanc, O., Chouinard, A., Nadeau, V., Allan, P. D., Tzeng, Y.-C., … Provencher, S. (2017). Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension. Journal of the American Heart Association, 6(10), e006126. doi: 10.1161/jaha.117.006126

Witter, T., Tzeng, Y.-C., O'Donnell, T., Kusel, J., Walker, B., Berry, M., & Taylor, C. E. (2017). Inter-individual relationships between sympathetic arterial baroreflex function and cerebral perfusion control in healthy males. Frontiers in Neuroscience, 11, 457. doi: 10.3389/fnins.2017.00457

Saleem, S., Tzeng, Y.-C., Kleijn, W. B., & Teal, P. D. (2017). Detection of impaired sympathetic cerebrovascular control using functional biomarkers based on principal dynamic mode analysis. Frontiers in Physiology, 7, 685. doi: 10.3389/fphys.2016.00685

Phillips, A. A., Squair, J., Currie, K., Tzeng, Y.-C., Ainslie, P., & Krassioukov, A. V. (2017). 2015 ParaPan American Games: Autonomic function, but not physical activity, is associated with vascular-cognitive impairment in spinal cord injury. Journal of Neurotrauma, 34(6), 1283-1288. doi: 10.1089/neu.2016.4751

Faulkner, J., Tzeng, Y.-C., Lambrick, D., Woolley, B., Allan, P. D., O'Donnell, T., Lanford, J., Wong, L., & Stoner, L. (2017). A randomized controlled trial to assess the central hemodynamic response to exercise in patients with transient ischaemic attack and minor stroke. Journal of Human Hypertension, 31, 172-177. doi: 10.1038/jhh.2016.72

Conference Contribution - Published proceedings: Abstract

Saito Benz, M., Tzeng, Y. C., Gately, C., Elder, D., & Berry, M. (2017). Effect of elective blood transfusion on cerebral and somatic tissue oxygenation and cardio-respiratory stability in infants with anaemia of prematurity. Journal of Paediatrics & Child Health, 53(Suppl. 2), (pp. 87). doi: 10.1111/jpc.13494_255

Conference Contribution - Verbal presentation and other Conference outputs

Saito Benz, M., Murphy, W. G., Tzeng, S. Y. C., Atkinson, G., & Berry, M. J. (2017, September). Effects of irradiation and storage on the oxygen carrying capacity of red blood cells given to preterm infants with anaemia of prematurity. Verbal presentation at the Fetal and Neonatal Physiological Society 44th Annual Meeting, Osaka, Japan.

2016

Journal - Research Article

Saleem, S., Teal, P. D., Kleijn, W. B., Ainslie, P. N., & Tzeng, Y.-C. (2016). Identification of human sympathetic neurovascular control using multivariate wavelet decomposition analysis. American Journal of Physiology: Heart & Circulatory Physiology, 311(3), H837-H848. doi: 10.1152/ajpheart.00254.2016

Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2016). The relationship between blood pressure and cerebral blood flow during supine cycling: Influence of aging. Journal of Applied Physiology, 120(5), 552-563. doi: 10.1152/japplphysiol.00667.2015

Conference Contribution - Published proceedings: Abstract

Phillips, A., Squair, J. W., Currie, K., Tzeng, S. Y. C., Ainslie, P. N., & Krassioukov, A. V. (2016). 2015 Parapan American Games: Does physical activity participation improve cerebrovascular function after high-level spinal cord injury? FASEB Journal, 30(1, Suppl.), 1288.9. doi: 10.1096/fj.1530-6860

2015

Journal - Research Article

Allan, P. D., Faulkner, J., O'Donnell, T., Lanford, J., Wong, L., Saleem, S., … Tzeng, Y.-C. (2015). Hemodynamic variability and cerebrovascular control after transient cerebral ischemia. Physiological Reports, 3(11), e12602. doi: 10.14814/phy2.12602

Saleem, S., Teal, P. D., Kleijn, W. B., O'Donnell, T., Witter, T., & Tzeng, Y.-C. (2015). Non-linear characterisation of cerebral pressure-flow dynamics in humans. PLoS ONE, 10(9), e0139470. doi: 10.1371/journal.pone.0139470

Horsman, H. M., Peebles, K. C., & Tzeng, Y. C. (2015). Interactions between breathing rate and low-frequency fluctuations in blood pressure and cardiac intervals. Journal of Applied Physiology, 119, 793-798. doi: 10.1152/japplphysiol.00525.2015

Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2015). Methodological comparison of active- and passive-driven oscillations in blood pressure: Implications for the assessment of cerebral pressure-flow relationships. Journal of Applied Physiology, 119(5), 487-501. doi: 10.1152/japplphysiol.00264.2015

Rickards, C. A., Sprick, J. D., Colby, H. B., Kay, V., & Tzeng, Y.-C. (2015). Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations. Physiological Measurement, 36(4), 785-801. doi: 10.1088/0967-3334/36/4/785

Conference Contribution - Published proceedings: Abstract

Allan, P., Faulkner, J., O'Donnell, T., Lanford, J., Witter, T., Woolley, B., Berry, M., … Tzeng, Y.-C. (2015). Cerebrovascular function is preserved following transient ischaemic attack and minor stroke. FASEB Journal, 29(1, Suppl.), 833.7. Retrieved from http://www.fasebj.org/content/29/1_Supplement/833.7.abstract

Witter, T., Taylor, C., O'Donnell, T., Kusel, J., Allan, P., Berry, M., Walker, B., & Tzeng, Y.-C. (2015). Inter-individual relationships between sympathetic arterial baroreflex function and cerebral perfusion control in healthy males. FASEB Journal, 29(1, Suppl.), 833.6. Retrieved from http://www.fasebj.org/content/29/1_Supplement/833.6.abstract

Saleem, S., Teal, P., Kleijn, W. B., O'Donnell, T., Witter, T., & Tzeng, Y.-C. (2015). Non-linear relationships between blood pressure and cerebral blood flow. FASEB Journal, 29(1, Suppl.), 833.3. Retrieved from http://www.fasebj.org/content/29/1_Supplement/833.3.abstract

Tzeng, Y.-C. (2015). Evidence for bi-directional feedback regulation of blood pressure and cerebral blood flow in humans. FASEB Journal, 29(1, Suppl.), 833.8. Retrieved from http://www.fasebj.org/content/29/1_Supplement/833.8.abstract

O'Donnell, T., MacRae, B., Berry, M., & Tzeng, Y.-C. (2015). The effects of preterm brith on cerebral pressure-flow dynamics. FASEB Journal, 29(1, Suppl.), 684.5. Retrieved from http://www.fasebj.org/content/29/1_Supplement/684.5.abstract

2014

Journal - Research Article

Smirl, J. D., Haykowsky, M. J., Nelson, M. D., Tzeng, Y.-C., Marsden, K. R., Jones, H., & Ainslie, P. N. (2014). Relationship between cerebral blood flow and blood pressure in long-term heart transplant recipients. Hypertension, 64, 1314-1320. doi: 10.1161/hypertensionaha.114.04236

Horsman, H. M., Tzeng, Y. C., Galletly, D. C., & Peebles, K. C. (2014). The repeated sit-to-stand manoeuvre is a superior method for cardiac baroreflex assessment: A comparison with the modified Oxford method and Valsalva manoeuvre. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(11), R1345-R1352. doi: 10.1152/ajpregu.00376.2014

Tzeng, Y. C., MacRae, B. A., Ainslie, P. N., & Chan, G. S. H. (2014). Fundamental relationships between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 117(9), 1037-1048. doi: 10.1152/japplphysiol.00366.2014

Berry, M., Tzeng, Y., & Marsland, C. (2014). Percutaneous transtracheal ventilation in an obstructed airway model in post-apnoeic sheep. British Journal of Anaesthesia, 113(6), 1039-1045. doi: 10.1093/bja/aeu188

Rickards, C. A., & Tzeng, Y.-C. (2014). Arterial pressure and cerebral blood flow variability: Friend or foe? A review. Frontiers in Physiology, 5, 120. doi: 10.3389/fphys.2014.00120

Taylor, C. E., Willie, C. K., Ainslie, P. N., & Tzeng, Y.-C. (2014). Assessment of human baroreflex function using carotid ultrasonography: What have we learnt? Acta Physiologica, 211(2), 297-313. doi: 10.1111/apha.12302

Meel-van den Abeelen, A. S. S., Simpson, D. M., Wang, L. J. Y., Slump, C. H., Zhang, R., Tarumi, T., … Tzeng, Y.-C., … Claassen, J. A. H. R. (2014). Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: The CARNet study. Medical Engineering & Physics, 36(5), 620-627. doi: 10.1016/j.medengphy.2014.02.002

Smirl, J. D., Tzeng, Y. C., Monteleone, B. J., & Ainslie, P. N. (2014). Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 116(12), 1614-1622. doi: 10.1152/japplphysiol.01266.2013

Willie, C. K., Tzeng, Y.-C., Fisher, J. A., & Ainslie, P. N. (2014). Integrative regulation of human brain blood flow. Journal of Physiology, 592(5), 841-859. doi: 10.1113/jphysiol.2013.268953

Tzeng, Y.-C., & Ainslie, P. N. (2014). Blood pressure regulation IX: Cerebral autoregulation under blood pressure challenges. European Journal of Applied Physiology, 114(3), 545-559. doi: 10.1007/s00421-013-2667-y

Journal - Research Other

Berretta, A., Tzeng, Y.-C., & Clarkson, A. N. (2014). Post-stroke recovery: The role of activity-dependent release of brain-derived neurotrophic factor. Expert Review of Neurotherapeutics, 14(11), 1335-1344. doi: 10.1586/14737175.2014.969242

Conference Contribution - Published proceedings: Full paper

Rickards, C. A., & Tzeng, Y.-C. (2014). Blood pressure and cerebral blood flow oscillations: Friend or foe? Proceedings of the 8th European Study Group on Cardiovascular Oscillations (ESGCO) Conference. (pp. 179-180). IEEE. doi: 10.1109/esgco.2014.6847578

Conference Contribution - Published proceedings: Abstract

Allan, P., O'Donnell, T., Berry, M., Faulkner, J., Lambrick, D., Stoner, L., … Tzeng, Y.-C. (2014). Fundamental relationships between blood pressure and cerebral blood flow following acute ischaemic stroke. Proceedings of the Medical Sciences Congress (MedSci). (pp. 39). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Tzeng, Y.-C. (2014). Integrative regulation of brain blood flow: Translating physiological curiosities into clinical applications. Proceedings of the Medical Sciences Congress (MedSci). (pp. 11). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Witter, T., MacRae, B., O'Donnell, T., Berry, M., & Tzeng, Y. C. (2014). Interindividual relationships between blood pressure and cerebral blood flow variability. FASEB Journal, 28(1, Suppl.), 1184.11. [Abstract]

Horsman, H., Tzeng, S., Galletly, D., & Peebles, K. (2014). Reliability of the repeated sit-to-stand manoeuvre for assessing baroreflex sensitivity and its suitability for assessing hysteresis. FASEB Journal, 28(1, Suppl.), 852.4. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Allan, P., O'Donnell, T., Berry, M., Faulkner, J., Lambrick, D., Stoner, L., … Tzeng, Y.-C. (2014, September). Fundamental relationships between blood pressure and cerebral blood flow following acute ischaemic stroke. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Tzeng, S. (2014, June). Intergrative regulation of brain blood flow: Translating physiological curiosities into clinical applications. Verbal presentation at the 8th Annual Brain Health Research Centre Conference, Dunedin, New Zealand.

Tzeng, S. (2014, September). Information matters: Identifying new targets for management and therapy in acute stroke. Plenary presentation at the New Zealand Applied Neurosciences Conference (NZANC), Auckland, New Zealand.

2013

Journal - Research Article

Peebles, K. C., Horsman, H., & Tzeng, Y.-C. (2013). The influence of tobacco smoking on the relationship between pressure and flow in the middle cerebral artery in humans. PLoS ONE, 8(8), e72624. doi: 10.1371/journal.pone.0072624

Tan, C. O., Tzeng, Y.-C., Hamner, J. W., Tamisier, R., & Taylor, J. A. (2013). Alterations in sympathetic neurovascular transduction during acute hypoxia in humans. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 304(11), R959-R965. doi: 10.1152/ajpregu.00071.2013

Willie, C. K., Ainslie, P. N., Taylor, C. E., Eves, N. D., & Tzeng, Y.-C. (2013). Maintained cerebrovascular function during post-exercise hypotension. European Journal of Applied Physiology, 113(6), 1597-1604. doi: 10.1007/s00421-012-2578-3

Tzeng, Y.-C., & MacRae, B. A. (2013). Interindividual relationships between blood pressure and cerebral blood flow variability with intact and blunted cerebrovascular control. Journal of Applied Physiology, 114(7), 888-895. doi: 10.1152/japplphysiol.01388.2012

Taylor, C. E., Willie, C. K., Atkinson, G., Jones, H., & Tzeng, Y.-C. (2013). Postural influences on the mechanical and neural components of the cardiovagal baroreflex. Acta Physiologica, 208(1), 66-73. doi: 10.1111/apha.12087

Horsman, H. M., Peebles, K. C., Galletly, D. C., & Tzeng, Y.-C. (2013). Cardiac baroreflex gain is frequency dependent: Insights from repeated sit-to-stand maneuvers and the modified Oxford Method. Applied Physiology, Nutrition & Metabolism, 38(7), 753-759. doi: 10.1139/apnm-2012-0444

Journal - Research Other

Tzeng, Y. C., & Ainslie, P. N. (2013). Quantification of cerebral hemodynamics. European Journal of Applied Physiology, 113(11), 2869-2870. doi: 10.1007/s00421-013-2719-3

Conference Contribution - Published proceedings: Abstract

Tzeng, Y. C. (2013). New insights into the physiology and pathology of autoregulation. Cerebrovascular Diseases, 35(Suppl. 2), (pp. 5). doi: 10.1159/000351748

Serrador, J. M., Tosto, J., & Tzeng, S. (2013). Effects of binge drinking on brain blood flow. FASEB Journal, 27(Meeting Abstract Suppl.), 1186.12. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Tzeng, S. (2013, September). A role for translational physiology? Verbal presentation at the Linking Businesses with Academia Forum: Smart Materials and Devices, Dunedin, New Zealand.

Tzeng, S. (2013, September). Lullabies or Lady Gaga? How your blood pressure variability affects your brain. Verbal presentation at the Ozone Research Group Public Symposium, Dunedin, New Zealand.

Peebles, K. C., Ball, O. G., Horsman, H. M., MacRae, B. A., & Tzeng, Y. C. (2013, August). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Tzeng, S. (2013, August). Brain under pressure: Challenges to cerebral blood flow regulation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Journal - Research Article

Hamner, J. W., Tan, C. O., Tzeng, Y.-C., & Taylor, J. A. (2012). Cholinergic control of the cerebral vasculature in humans. Journal of Physiology, 590(24), 6343-6352. doi: 10.1113/jphysiol.2012.245100

Ainslie, P. N., Lucas, S. J. E., Fan, J.-L., Thomas, K. N., Cotter, J. D., Tzeng, Y. C., & Burgess, K. R. (2012). Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology, 113(7), 1058-1067. doi: 10.1152/japplphysiol.00463.2012

Sin, P. Y. W., Webber, M. R., Galletly, D. C., & Tzeng, Y. C. (2012). Relationship between cardioventilatory coupling and pulmonary gas exchange. Clinical Physiology & Functional Imaging, 32(6), 476-480. doi: 10.1111/j.1475-097X.2012.01144.x

Tzeng, Y. C., Ainslie, P. N., Cooke, W. H., Peebles, K. C., Willie, C. K., MacRae, B. A., … Horsman, H. M., & Rickards, C. A. (2012). Assessment of cerebral autoregulation: The quandary of quantification. American Journal of Physiology: Heart & Circulatory Physiology, 303(6), H658-H671. doi: 10.1152/ajpheart.00328.2012

Peebles, K. C., Ball, O. G., MacRae, B. A., Horsman, H. M., & Tzeng, Y. C. (2012). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. Journal of Applied Physiology, 113(5), 700-706. doi: 10.1152/japplphysiol.00614.2012

Gelinas, J. C., Marsden, K. R., Tzeng, Y. C., Smirl, J. D., Smith, K. J., Willie, C. K., … Ainslie, P. N. (2012). Influence of posture on the regulation of cerebral perfusion. Aviation, Space, & Environmental Medicine, 83(8), 751-757. doi: 10.3357/asem.3269.2012

Willie, C. K., Macleod, D. B., Shaw, A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., … Ainslie, P. N. (2012). Regional brain blood flow in man during acute changes in arterial blood gases. Journal of Physiology, 590(14), 3261-3275. doi: 10.1113/jphysiol.2012.228551

Marsden, K. R., Haykowsky, M. J., Smirl, J. D., Jones, H., Nelson, M. D., Altamirano-Diaz, L. A., … Tzeng, Y. C., … Ainslie, P. N. (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age, 34(3), 725-735. doi: 10.1007/s11357-011-9258-9

Journal - Research Other

Tzeng, Y.-C., MacRae, B., & Rickards, C. (2012). A recipe for reducing blood pressure variability: Adding blood flow to the mix. Hypertension, 60(2), e12. doi: 10.1161/hypertensionaha.112.198531

2011

Journal - Research Article

Bellapart, J., Chan, G. S., Tzeng, Y.-C., Ainslie, P., Barnett, A. G., Dunster, K. R., … Fraser, J. F. (2011). The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study. BMC Anesthesiology, 11, 4. doi: 10.1186/1471-2253-11-4

Bellapart, J., Chan, G. S. H., Tzeng, Y.-C., Ainslie, P. N., Dunster, K. R., Barnett, A. G., … Fraser, J. F. (2011). The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality. Physiological Measurement, 32(9), 1361-1372. doi: 10.1088/0967-3334/32/9/001

Tzeng, Y.-C., & Chan, G. S. H. (2011). Unraveling the human cerebral circulation: Insights from cerebral blood pressure and flow recordings. Journal of Applied Physiology, 111(2), 349-350. doi: 10.1152/japplphysiol.00715.2011

Jones, H., Lewis, N. C. S., Green, D. J., Ainslie, P. N., Lucas, S. J. E., Tzeng, Y.-C., Grant, E. J. M., & Atkinson, G. (2011). α₁-adrenoreceptor activity does not explain lower morning endothelial-dependent, flow-mediated dilation in humans. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 300(6), R1437-R1442. doi: 10.1152/ajpregu.00042.2011

Taylor, C. E., Atkinson, G., Willie, C. K., Jones, H., Ainslie, P. N., & Tzeng, Y.-C. (2011). Diurnal variation in the mechanical and neural components of the baroreflex. Hypertension, 58(1), 51-56. doi: 10.1161/HYPERTENSIONAHA.111.171512

Tzeng, Y.-C., Chan, G. S. H., Willie, C. K., & Ainslie, P. N. (2011). Determinants of human cerebral pressure-flow velocity relationships: New insights from vascular modelling and Ca²⁺ channel blockade. Journal of Physiology, 589(13), 3263-3274. doi: 10.1113/jphysiol.2011.206953

Chan, G. S. H., Ainslie, P. N., Willie, C. K., Taylor, C. E., Atkinson, G., Jones, H., … Tzeng, Y.-C. (2011). Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure. Journal of Applied Physiology, 110(4), 917-925. doi: 10.1152/japplphysiol.01407.2010

Willie, C. K., Cowan, E. C., Ainslie, P. N., Taylor, C. E., Smith, K. J., Sin, P. Y. W., & Tzeng, Y. C. (2011). Neurovascular coupling and distribution of cerebral blood flow during exercise. Journal of Neuroscience Methods, 198(2), 270-273. doi: 10.1016/j.jneumeth.2011.03.017

Willie, C. K., Ainslie, P. N., Taylor, C. E., Jones, H., Sin, P. Y. W., & Tzeng, Y.-C. (2011). Neuromechanical features of the cardiac baroreflex after exercise. Hypertension, 57, 927-933. doi: 10.1161/HYPERTENSIONAHA.110.164616

Willie, C. K., Colino, F. L., Bailey, D. M., Tzeng, Y. C., Binsted, G., Jones, L. W., … Lucas, S. J., … Ainslie, P. N. (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. Journal of Neuroscience Methods, 196(2), 221-237. doi: 10.1016/j.jneumeth.2011.01.011

Atkinson, G., Batterham, A. M., Jones, H., Taylor, C. E., Willie, C. K., & Tzeng, Y.-C. (2011). Appropriate within-subjects statistical models for the analysis of baroreflex sensitivity. Clinical Physiology & Functional Imaging, 31(1), 80-82. doi: 10.1111/j.1475-097X.2010.00974.x

Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y. C., Horsman, H., & Ainslie, P. N. (2011). Is there diurnal variation in initial and delayed orthostatic hypotension during standing and head-up tilt? Chronobiology International, 28(2), 135-145. doi: 10.3109/07420528.2010.536283

Journal - Research Other

Tzeng, Y. C. (2011). Assessment of cerebral autoregulation in human research [Letter to the editor]. Acta Neurologica Scandinavica, 123(6), 434. doi: 10.1111/j.1600-0404.2010.01470.x

2010

Journal - Research Article

Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y. C., Horsman, H., & Ainslie, P. N. (2010). Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 68(1), R55-R61. doi: 10.1152/ajpregu.00030.2010

Sin, P. Y. W., Webber, M. R., Galletly, D. C., Ainslie, P. N., Brown, S. J., Willie, C. K., Sasse, A., Larsen, P. D., & Tzeng, Y.-C. (2010). Interactions between heart rate variability and pulmonary gas exchange efficiency in humans. Experimental Physiology, 95(7), 788-797. doi: 10.1113/expphysiol.2010.052910

Tzeng, Y.-C., Willie, C. K., Atkinson, G., Lucas, S. J. E., Wong, A., & Ainslie, P. N. (2010). Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension, 56, 268-273. doi: 10.1161/HYPERTENSIONAHA.110.152066

Larsen, P. D., Tzeng, Y. C., Sin, P. Y. W., & Galletly, D. C. (2010). Respiratory sinus arrhythmia in conscious humans during spontaneous respiration. Respiratory Physiology & Neurobiology, 174(1-3), 111-118. doi: 10.1016/j.resp.2010.04.021

Sin, P. Y. W., Galletly, D. C., & Tzeng, Y. C. (2010). Influence of breathing frequency on the pattern of respiratory sinus arrhythmia and blood pressure: Old questions revisited. American Journal of Physiology: Heart & Circulatory Physiology, 298, H1588-H1599. doi: 10.1152/ajpheart.00036.2010

Tzeng, Y.-C., Lucas, S. J. E., Atkinson, G., Willie, C. K., & Ainslie, P. N. (2010). Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. Journal of Applied Physiology, 108, 1162-1168. doi: 10.1152/japplphysiol.01390.2009

Lucas, S. J. E., Tzeng, Y. C., Galvin, S. D., Thomas, K. N., Ogoh, S., & Ainslie, P. N. (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension, 55, 698-705. doi: 10.1161/HYPERTENSIONAHA.109.146290

Ogoh, S., Tzeng, Y.-C., Lucas, S. J. E., Galvin, S. D., & Ainslie, P. N. (2010). Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans. Journal of Physiology, 588(2), 365-371. doi: 10.1113/jphysiol.2009.180844

Journal - Research Other

Ainslie, P. N., & Tzeng, Y. C. (2010). On the regulation of the blood supply to the brain: Old age concepts and new age ideas [Invited editorial]. Journal of Applied Physiology, 108(6), 1447-1449. doi: 10.1152/japplphysiol.00257.2010

Lucas, S. J. E., Tzeng, Y. C., & Ainslie, P. N. (2010). Response to The cerebrovascular pressure-flow relationship: A simple concept but a complex phenomenon [Letter]. Hypertension, 56, e3. doi: 10.1161/HYPERTENSIONAHA.110.153312

Tzeng, Y. C., Willie, C. K., & Ainslie, P. N. (2010). Baroreflex, cerebral perfusion, and stroke: Integrative physiology at its best [Letter to the editor]. Stroke, 41(5), e429. doi: 10.1161/STROKEAHA.109.570853

Journal - Professional & Other Non-Research Articles

Willie, C. K., & Tzeng, Y. C. (2010). Study of the heterogeneity of cardiovascular function should extend to the human cerebral circulation [Letter]. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 298(6), R1705. doi: 10.1152/ajpregu.00166.2010

Conference Contribution - Published proceedings: Abstract

Willie, C. K., Taylor, C., Ainslie, P. N., Sin, P. Y., Jones, H., & Tzeng, Y. C. (2010). Exacerbation of post-exercise cardiovagal baroreflex hysteresis is explained by selective reductions in carotid baroreflex neural transduction. Proceedings of The Physiological Society. 19. London: Physiological Society. Retrieved from http://www.physoc.org/custom2/publications/proceedings/search/rsindex.asp

Webber, M. R., Sin, P. Y., Ainslie, P. N., Tzeng, Y. C., Brown, S. J., Willie, C. K., Sasse, A. S., & Larsen, P. (2010). Heart rate variability and cardiorespiratory efficiency in humans. Heart, Lung & Circulation, 19(Suppl. 1), (pp. S34). doi: 10.1016/j.hlc.2010.04.073

Conference Contribution - Poster Presentation (not in published proceedings)

Sin, P., Webber, M., Galletly, D., Ainslie, P., Brown, S., Willie, C., Sasse, A., Larsen, P., & Tzeng, Y.-C. (2010, September). Interactions between heart rate variability and pulmonary gas exchange efficiency in humans. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Sin, P. Y. W., Webber, M. R., Galletly, D. C., Ainslie, P. N., Brown, S. J., Willie, C. K., Sasse, A., Larsen, P. D., & Tzeng, Y.-C. (2010, November-December). Interactions between heart rate variability and pulmonary gas exchange efficiency in humans. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2009

Journal - Research Article

Tzeng, Y. C., Sin, P. Y. W., Lucas, S. J. E., & Ainslie, P. N. (2009). Respiratory modulation of cardio-vagal baroreflex sensitivity. Journal of Applied Physiology, 107, 718-724. doi: 10.1152/japplphysiol.00548.2009

Tzeng, Y.-C., Sin, P. Y. W., & Galletly, D. C. (2009). Human sinus arrhythmia: Inconsistencies of a teleological hypothesis. American Journal of Physiology: Heart & Circulatory Physiology, 296(1), H65-H70. doi: 10.1152/ajpheart.00716.2008

Journal - Research Other

Ainslie, P. N., Willie, C. K., & Tzeng, Y. C. (2009). Role of SNA in the pathophysiology of cardiovascular collapse during syncope: Muscle vs. Brain [Letter]. Journal of Physiology, 587(23), 5795-5796. doi: 10.1113/jphysiol.2009.182667

Tzeng, S. Y. C., Sin, P. Y. W., & Ainslie, P. N. (2009). Sinus arrhythmia and baroreflex sensitivity: Intimate relationship or separate identities? [Letter to the editor]. Journal of Applied Physiology, 106(5), 1745-1746.

Conference Contribution - Published proceedings: Abstract

Tzeng, Y. C., Sin, P. Y. W., Lucas, S. J. E., & Ainslie, P. N. (2009). Respiratory modulation of baroreflex sensitivity. Autonomic Neuroscience. 149(1-2), (pp. 110-111). doi: 10.1016/j.autneu.2009.05.209

Sin, P. Y. W., Tzeng, Y. C., & Galletly, D. (2009). Cardioventilatory coupling and pulmonary gas exchange efficiency in humans. Autonomic Neuroscience. 149(1-2), (pp. 75). doi: 10.1016/j.autneu.2009.05.133

Conference Contribution - Verbal presentation and other Conference outputs

Galvin, S. D., Lucas, S. J. E., Thomas, K. N., Tzeng, Y.-C., & Ainslie, P. N. (2009, April). Identification of static cerebral autoregulation in healthy humans. Verbal presentation at the Tongariro Cardiac Surgery Meeting, Rotorua, New Zealand.

2008

Conference Contribution - Published proceedings: Abstract

Sin, P. Y., Tzeng, Y. C., & Galletly, D. C. (2008). Respiratory sinus arrhythmia and the distribution of heartbeats throughout the respiratory cycle. Proceedings of The Physiological Society. 11. London: Physiological Society. Retrieved from http://www.physoc.org/custom2/publications/proceedings/search/rsindex.asp

Conference Contribution - Verbal presentation and other Conference outputs

Sin, P. Y. W., Tzeng, Y. C., & Galletly, D. C. (2008, November). Respiratory sinus arrhythmia in the anaesthetized rat model. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2007

Journal - Research Article

Tzeng, Y. C., Larsen, P. D., & Galletly, D. C. (2007). Mechanism of cardioventilatory coupling: Insights from cardiac pacing, vagotomy, and sinoaortic denervation in the anesthetized rat. American Journal of Physiology: Heart & Circulatory Physiology, 292, H1967-H1977. doi: 10.1152/ajpheart.01049.2006

Tzeng, Y. C., Larsen, P. D., & Galletly, D. C. (2007). Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respiration. American Journal of Physiology: Heart & Circulatory Physiology, 292, H2397-H2407. doi: 10.1152/ajpheart.00817.2006

2005

Journal - Research Article

Tzeng, Y.-C., Galletly, D. C., & Larsen, P. D. (2005). Paradoxical respiratory sinus arrhythmia in the anesthetized rat. Autonomic Neuroscience, 118(1-2), 25-31.

Williamson, L. J., Larsen, P. D., Tzeng, Y.-C., & Galletly, D. C. (2005). Effect of automatic external defibrillator audio prompts on cardiopulmonary resuscitation performance. Emergency Medicine Journal, 22(2), 140-143.

2004

Journal - Research Article

Larsen, P. D., Elder, D. E., Tzeng, Y.-C., Campbell, A., & Galletly, D. C. (2004). Fractal characteristics of breath to breath timing in sleeping infants. Respiratory Physiology & Neurobiology, 139(3), 263-270.

2003

Journal - Research Article

Larsen, P. D., Tzeng, Y.-C., & Galletly, D. C. (2003). Quantal ventilatory variability during spontaneous breathing anaesthesia. British Journal of Anaesthesia, 91(2), 184-189.

Tzeng, Y.-C., Larsen, P. D., & Galletly, D. C. (2003). Cardioventilatory coupling in resting human subjects. Experimental Physiology, 88.6, 775-782.

Larsen, P. D., Tzeng, Y.-C., & Galletly, D. C. (2003). Inspiratory coupling to cardiac activity and to somatic afferent nerve stimulation in the anaesthetised rat. Autonomic Neuroscience, 108, 45-49.