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Martina Paumann-PageSenior Research Fellow

MSc PhD (Vienna)

Email martina.paumann-page@otago.ac.nz
Tel 64 3 364 1559

Research interests

Dr Martina Paumann-Page's main research interest is how oxidants of mammalian peroxidases are involved in health and disease. Currently, she investigates the role of peroxidasin, a recently identified extracellular peroxidase, which is upregulated in numerous types of cancers including metastatic melanoma. Her work showed that high peroxidasin is associated with increased invasiveness in metastatic melanoma and recent results highlighted a causative role of PXDN in invasion by promoting an invasive phenotype.

Dr Paumann-Page seeks to understand the underlying molecular mechanisms of how peroxidasin regulates invasion and what its effects are on cancer cells and the tumour microenvironment. Her work aims at providing a basis for novel therapeutic approaches to reduce metastasis.

More recently she has become interested how oxidative stress can be exploited to make cancer cells more susceptible to cell death by targeting their oxidative defence mechanisms.

Her work has been supported by a Marsden project grant (AI), Canterbury Medical Research Foundation project grants (PI), a Health Research Council project grant (AI) and a Cancer Research Trust NZ project grant (PI).

Publications

Paumann-Page, M., Obinger, C., Winterbourn, C. C., & Furtmüller, P. G. (2024). Peroxidasin inhibition by phloroglucinol and other peroxidase inhibitors. Antioxidants, 13, 23. doi: 10.3390/antiox13010023

Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008

Paumann-Page, M. (2022, December). Peroxidasin as a modulator of cancer cell invasion. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

Paumann-Page, M. (2022, August). A new role for peroxidasin in modulating the invasive potential of cancer cells. Poster session presented at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Featherston, T., Khor, C., Paumann-Page, M., & Hampton, M. (2022, August). Reprogrammed antioxidant defences in metastatic melanoma cells. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

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