Dr Martina Paumann-Page graduated from the University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria, with a Master of Science in Biotechnology and Food Science, followed by a PhD in Biochemistry at the University of Vienna, Austria. As recipient of an Erwin Schrödinger Fellowship from the FWF Austrian Science Fund for research abroad, she joined the Centre for Free Radical Research as a postdoctoral research fellow in 2009. After a postdoctoral position in Vienna from 2013-2016 she permanently joined the Centre for Free Radical Research in 2017.
In 2017, Dr Paumann-Page was the recipient of the Freemasons Carrell-Espiner Research Fellowship and a CMRF Canterbury Medical Research Foundation Major Project Grant. Since 2019 she has been an associate investigator on a Mardsen grant. Since 2017 she has co-supervised one PhD student, one honours student and two summer students.
Dr Paumann-Page's main research interest is how the reactions of mammalian peroxidases are involved in health and disease. Currently she investigates a newly identified extracellular peroxidase called peroxidasin, which was shown to be upregulated in invasive metastatic melanoma and other cancers. The mechanism by which peroxidasin contributes to tumour cell invasion is unknown, but most likely connected to its enzymatic activity. Peroxidasin generates hypobromous acid, a strong oxidant similar to chlorine bleach, which reacts with a multitude of biological molecules and modifies intra- and extracellular components. Dr Paumann-Page is investigating well-characterized cell lines from the New Zealand melanoma cell panel to characterize peroxidasin expression levels, activity, cellular location and the effect of modulation of peroxidasin protein levels and activity on cell invasiveness.
Her expertise lies in protein biochemistry (including cloning, expression and characterization of proteins) and enzymology with a particular focus on structure, function and reactivity of mammalian peroxidases and their reaction products.
Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008
Journal - Research Article
Paumann-Page, M. (2022, August). A new role for peroxidasin in modulating the invasive potential of cancer cells. Poster session presented at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Featherston, T., Khor, C., Paumann-Page, M., & Hampton, M. (2022, August). Reprogrammed antioxidant defences in metastatic melanoma cells. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Featherston, T., Paumann-Page, M., Dickerhof, N., Kaldor, C., Winterbourn, C. C., & Hampton, M. B. (2021). Measuring and exploiting oxidative stress in metastatic melanoma. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 281). Retrieved from https://www.faobmb2021.org
Conference Contribution - Published proceedings: Abstract
Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org
Conference Contribution - Published proceedings: Abstract
Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., … Eccles, M. R., & Winterbourn, C. C. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology, 46, 102090. doi: 10.1016/j.redox.2021.102090
Journal - Research Article
Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry, 295(36), 12697-12705. doi: 10.1074/jbc.RA120.014504
Journal - Research Article
Sevcnikar, B., Paumann-Page, M., Hofbauer, S., Pfanzagl, V., Furtmüller, P. G., & Obinger, C. (2020). Reaction of human peroxidasin 1 compound I and compound II with one-electron donors. Archives of Biochemistry & Biophysics, 681, 108267. doi: 10.1016/j.abb.2020.108267
Journal - Research Article
Sevcnikar, B., Schaffner, I., Chaung, C. Y., Gamon, L., Paumann-Page, M., Hofbauer, S., … Obinger, C. (2020). The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes. Archives of Biochemistry & Biophysics, 689, 108443. doi: 10.1016/j.abb.2020.108443
Journal - Research Article
Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038
Journal - Research Article
Paumann-Page, M., Bathish, B., Eccles, M., & Winterbourn, C. (2018). Peroxidasin, a newly identified peroxidase, and its role in invasive metastatic melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Conference Contribution - Published proceedings: Abstract
Grishkovskaya, I., Paumann-Page, M., Tscheliessnig, R., Stampler, J., Hofbauer, S., Soudi, M., … Obinger, C. (2017). Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation. Journal of Biological Chemistry, 292(20), 8244-8261. doi: 10.1074/jbc.M117.775031
Journal - Research Article
Paumann-Page, M., Katz, R.-S., Bellei, M., Schwartz, I., Edenhofer, E., Sevcnikar, B., … Obinger, C. (2017). Pre-steady-state kinetics reveal the substrate specificity and mechanism of halide oxidation of truncation human peroxidasin 1. Journal of Biological Chemistry, 292(11), 4583-4592. doi: 10.1074/jbc.M117.775213
Journal - Research Article
Soudi, M., Paumann-Page, M., Delporte, C., Pirker, K. F., Bellei, M., Edenhofer, E., … Obinger, C. (2015). Multidomain human peroxidasin 1 is a highly glycosylated and stable homotrimeric high spin ferric peroxidase. Journal of Biological Chemistry, 290(17), 10876-10890. doi: 10.1074/jbc.M114.632273
Journal - Research Article
Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970
Journal - Research Article
Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004
Journal - Research Article
Burner, U., Obinger, C., Paumann, M., Furtmuller, P. G., & Kettle, A. J. (1999). Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. Journal of Biological Chemistry, 274, 9494-9592. doi: 10.1074/jbc.274.14.9494
Journal - Research Article