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Martin KennedyHead of Department of Pathology and Biomedical Science
Director, Carney Centre for Pharmacogenomics
Laboratory Director, Gene Structure and Function Laboratory

BSc(Hons)(Cant), PhD(Auck)

Email martin.kennedy@otago.ac.nz
Tel +64 3 364 0590

Research interests

Professor Martin Kennedy's main research interests are psychiatric genetics, pharmacogenomics, and the genetics of complex disease.

His current research largely focuses on pharmacogenomics, which aims to understand how drugs and genes interact with the goal of improving drug treatments and reducing adverse drug reactions. For example, analysis of genetic variation in genes such as those that encode drug metabolising liver enzymes like CYP2D6 and CYP2C19, is helping to determine genetic factors that impact on response to treatments for various diseases.

For a more comprehensive analysis of genetic factors impacting drug response or risks of adverse drug reactions, they are also applying Next Generation DNA sequencing methods including exome sequencing and other genomic approaches to explore drug response phenotypes.

In order to understand severe adverse drug reactions, his lab has developed a biobank for collecting biological samples of people who have suffered such reactions, called UDRUGS. This biobank is growing, and will enhance efforts to understand genetic factors that contribute to severe adverse drug reactions.

Other research interests include work with the Christchurch Health and Development Study looking at genetic contributions to a range of complex human traits, and a study focusing on the genetics of anorexia nervosa. 

In addition, Martin's laboratory is examining the impact of G-quadruplex DNA structures and their relevance to genomic imprinting and other aspects of genome biology.

Education

Professor Kennedy obtained his BSc(Hons) at University of Canterbury, and his PhD in bacterial genetics at the University of Auckland, and carried out postdoctoral research in leukaemia genetics at the Laboratory of Molecular Biology, Cambridge (UK) before returning to University of Otago, Christchurch in 1991.

In the media

Professor Martin Kennedy was interviewed for Radio New Zealand's Our Changing World series in May 2013.

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Publications

Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M. A., … Agrawal, A. (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. Advance online publication. doi: 10.1111/adb.12880

Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022

Bryois, J., Skene, N. G., Folmann Hansen, T., Kogelman, L. J. A., Watson, H. J., Liu, Z., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J., … Jordan, J., … Kennedy, M., … Pearson, J., … Sullivan, P. F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52, 482-493. doi: 10.1038/s41588-020-0610-9

Vallerga, C. L., Zhang, F., Fowdar, J., McRae, A. F., Qi, T., Nabais, M. F., … Kennedy, M., … Gratten, J. (2020). Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease. Nature Communications, 11, 1238. doi: 10.1038/s41467-020-15065-7

Bulik, C., Kennedy, M., & Wade, T. (2020). ANGI: Anorexia Nervosa Genetics Initiative. Twin Research & Human Genetics. Advance online publication. doi: 10.1017/thg.2020.24

Chapter in Book - Research

Chua, E. W., Maggo, S., & Kennedy, M. A. (2017). Long fragment polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods in molecular biology (Vol. 1620). (pp. 65-74). New York, NY: Springer. doi: 10.1007/978-1-4939-7060-5_3

Kennedy, M. A., Rogers, G. R., & Joyce, P. R. (2004). Pharmacogenetics of antidepressants and mood stabilisers. In P. R. Joyce & P. B. Mitchell (Eds.), Mood disorders: Recognition and treatment. (pp. 223-237). Sydney, Australia: The University of New South Wales Press Ltd.

Kennedy, M. A. (2000). Mendelian Genetic Disorders. In The Encyclopedia of Life Sciences. London: Nature Publishing Group.

Kennedy, M. A. (1996). Internet resources for human and mouse molecular genetics. In S. R. Swindell, R. Miller & G. S. A. Myers (Eds.), Internet for the Molecular Biologist. (pp. 123-149). Norfolk: Horizon Scientific Press.

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Chapter in Book - Other

Kennedy, M., Joyce, P., & Begg, E. (2013). Carney Centre for Pharmacogenomics. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 100-104). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M. A., … Agrawal, A. (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. Advance online publication. doi: 10.1111/adb.12880

Bulik, C., Kennedy, M., & Wade, T. (2020). ANGI: Anorexia Nervosa Genetics Initiative. Twin Research & Human Genetics. Advance online publication. doi: 10.1017/thg.2020.24

Vallerga, C. L., Zhang, F., Fowdar, J., McRae, A. F., Qi, T., Nabais, M. F., … Kennedy, M., … Gratten, J. (2020). Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease. Nature Communications, 11, 1238. doi: 10.1038/s41467-020-15065-7

Bryois, J., Skene, N. G., Folmann Hansen, T., Kogelman, L. J. A., Watson, H. J., Liu, Z., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J., … Jordan, J., … Kennedy, M., … Pearson, J., … Sullivan, P. F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52, 482-493. doi: 10.1038/s41588-020-0610-9

Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022

Heft, I. E., Mostovoy, Y., Levy-Sakin, M., Ma, W., Stevens, A. J., Pastor, S., … Kennedy, M. A., … Sikela, J. M. (2020). The driver of extreme human-specific Olduvai repeat expansion remains highly active in the human genome. Genetics, 214, 179-191. doi: 10.1534/genetics.119.302782

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition. Advance online publication. doi: 10.1016/j.nut.2020.110761

Schierding, W., Farrow, S., Fadason, T., Graham, O. E. E., Pitcher, T. L., Qubisi, S., … Anderson, T. J., Kennedy, M. A., … O'Sullivan, J. M. (2020). Common variants coregulate expression of GBA and modifier genes to delay Parkinson's disease onset. Movement Disorders. Advance online publication. doi: 10.1002/mds.28144

Osborne, A. J., Pearson, J. F., Noble, A. J., Gemmell, N. J., Horwood, L. J., Boden, J. M., … Kennedy, M. A. (2020). Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. Translational Psychiatry, 10, 114. doi: 10.1038/s41398-020-0800-3

Searchfield, G. D., Poppe, T. N. E. R., Durai, M., Jensen, M., Kennedy, M. A., Maggo, S., Miller, A. L., … Russell, B. R., … Wise, K. (2019). A proof-of-principle study of the short-term effects of MDMA (3,4-methylenedioxymethamphetamine) on tinnitus and neural connectivity. International Journal of Neuroscience. Advance online publication. doi: 10.1080/00207454.2019.1702544

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Liau, Y., Cree, S. L., Maggo, S., Miller, A. L., Pearson, J. F., Gladding, P. A., & Kennedy, M. A. (2019). A multiplex pharmacogenetics assay using the MinION nanopore sequencing device. Pharmacogenetics & Genomics, 29(9), 207-215. doi: 10.1097/fpc.0000000000000385

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., … Kennedy, M., Pitcher, T., Pearson, J., … Anderson, T., … Visscher, P. M. (2019). Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine, 11(1), 54. doi: 10.1186/s13073-019-0667-1

Balasubramanian, D., Pearson, J. F., & Kennedy, M. A. (2019). Gene expression effects of lithium and valproic acid in a serotonergic cell line. Physiological Genomics, 51, 43-50. doi: 10.1152/physiolgenomics.00069.2018

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Adehin, A., Adeagbo, B. A., Kennedy, M. A., Bolaji, O. O., Olugbade, T. A., Bolarinwa, R. A., & Durosinmi, M. A. (2019). Inter-individual variation in imatinib disposition: Any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in Nigerian CML patients? Leukemia & Lymphoma, 60(1), 216-221. doi: 10.1080/10428194.2018.1466291

Watson, G. M., Chan, C. W., Belluscio, L., Doudney, K., Lacey, C. J., Kennedy, M. A., & Bridgman, P. (2019). Comparing the variants of takotsubo syndrome: An observational study of the ECG and structural changes from a New Zealand tertiary hospital. BMJ Open, 9(5), e025253. doi: 10.1136/bmjopen-2018-025253

Richards, A., Horwood, J., Boden, J., Kennedy, M., Sellers, R., Riglin, L., … Harold, G. T. (2019). Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study. British Journal of Psychiatry, 214, 96-102. doi: 10.1192/bjp.2018.227

Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9, 10128. doi: 10.1038/s41598-019-46146-3

Reynolds, R. H., Botía, J., Nalls, M. A., International Parkinson's Disease Genomics Consortium (IPDGC), including System Genomics of Parkinson's Disease (SGPD), Anderson, T., … Kennedy, M., Pearson, J., … Ryten, M. (2019). Moving beyond neurons: The role of cell type-specific gene regulation in Parkinson's disease heritability. npj Parkinson's Disease, 5, 6. doi: 10.1038/s41531-019-0076-6

Liau, Y., Maggo, S., Miller, A. L., Pearson, J. F., Kennedy, M. A., & Cree, S. L. (2019). Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications. Pharmacogenomics, 20(14), 1033-1047. doi: 10.2217/pgs-2019-0080

Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139

Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., … Roberts, M., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M., … Bulik, C. M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51, 1207-1214. doi: 10.1038/s41588-019-0439-2

Rucklidge, J. J., Eggleston, M. J. F., Darling, K., Stevens, A., Kennedy, M., & Frampton, C. M. (2019). Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 89, 181-192. doi: 10.1016/j.pnpbp.2018.09.007

Maggo, S. D. S., Sycamore, K. L. V., Miller, A. L., & Kennedy, M. A. (2019). The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand. Frontiers in Psychiatry, 10, 690. doi: 10.3389/fpsyt.2019.00690

Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, including Kennedy, M. A., Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, including Horwood, L. J., Pearson, J. F., … Polderman, T. J. C. (2019). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, 49(7), 1166-1173. doi: 10.1017/S0033291718002039

Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., … Kennedy, M. A., … Gearry, R. B., … Barclay, M. (2018). Nonsynonymous polymorphism in guanine monophosphate synthetase is a risk factor for unfavorable thiopurine metabolite ratios in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 24(12), 2606-2612. doi: 10.1093/ibd/izy163

Lacey, C. J., Doudney, K., Bridgman, P. G., George, P. M., Mulder, R. T., Zarifeh, J. J., Kimber, B., Cadzow, M. J., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2018). Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. Scientific Reports, 8, 7548. doi: 10.1038/s41598-018-25827-5

Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2018). Epigenetics, nutrition and mental health: Is there a relationship? [Review]. Nutritional Neuroscience, 21(9), 602-613. doi: 10.1080/1028415x.2017.1331524

Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2018). Genetic polymorphism of CYP2C9 and VKORC1 in the Nigerian population: Significance for warfarin therapy in the population. Polish Annals of Medicine, 25(2), 180-183. doi: 10.29089/2017.17.00041

Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., … Kennedy, M. A., … Pearson, J. F., … Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience, 21(12), 1656-1669. doi: 10.1038/s41593-018-0275-1

Stevens, A. J., Rucklidge, J. J., Darling, K. A., Eggleston, M. J. F., Pearson, J. F., & Kennedy, M. A. (2018). Methylomic changes in response to micronutrient supplementation and MTHFR genotype. Epigenomics, 10(9), 1201-1214. doi: 10.2217/epi-2018-0029

Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., … Horwood, L. J., Boden, J. M., Pearson, J. F., … Jordan, J., Kennedy, M. A., … Bulik, C. M. (2018). The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials, 74, 61-69. doi: 10.1016/j.cct.2018.09.015

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., … Horwood, J., … Fergusson, D. M., … Kennedy, M., … Bierut, L. J. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23, 133-142. doi: 10.1038/mp.2017.44

Ton, K. N. T., Cree, S. L., Gronert-Sum, S. J., Merriman, T. R., Stamp, L. K., & Kennedy, M. A. (2018). Multiplexed nanopore sequencing of HLA-B locus in Māori and Pacific Island samples. Frontiers in Genetics, 9, 152. doi: 10.3389/fgene.2018.00152

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Stevens, A. J., Taylor, M. G., Pearce, F. G., & Kennedy, M. A. (2017). Allelic dropout during polymerase chain reaction due to G-quadruplex structures and DNA methylation is widespread at imprinted human loci. Genes Genomes Genetics, 7(3), 1019-1025. doi: 10.1534/g3.116.038687

Kirk, K. M., Martin, F. C., Mao, A., Parker, R., Maguire, S., Thornton, L. M., … Jordan, J., Kennedy, M. A., … Martin, N. G. (2017). The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm. Australian & New Zealand Journal of Psychiatry, 51(6), 583-594. doi: 10.1177/0004867417700731

Adehin, A., Bolaji, O. O., Kennedy, M. A., & Adeagbo, B. A. (2017). Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population. Polish Annals of Medicine, 24(2), 144-147. doi: 10.1016/j.poamed.2016.06.007

Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2017). Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population. Drug Metabolism & Personalized Therapy, 32(1), 39-47. doi: 10.1515/dmpt-2016-0041

Shchepetkina, A. A., Hock, B. D., Miller, A., Kennedy, M. A., & Gieseg, S. P. (2017). Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. International Journal of Biochemistry & Cell Biology, 87, 27-33. doi: 10.1016/j.biocel.2017.03.017

Bagshaw, A. T. M., Horwood, L. J., Fergusson, D. M., Gemmell, N. J., & Kennedy, M. A. (2017). Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. BMC Medical Genetics, 18, 12. doi: 10.1186/s12881-017-0374-y

Appleby, S., Pearson, J. F., Aitchison, A., Spittlehouse, J. K., Joyce, P. R., & Kennedy, M. A. (2017). Mean telomere length is not associated with current health status in a 50-year-old population sample. American Journal of Human Biology, 29(1), e22906. doi: 10.1002/ajhb.22906

Whitefield, J., & Kennedy, M. (2017). Above the threshold. Junctures, 2017(18), 9-18.

Adehin, A., Bolaji, O. O., & Kennedy, M. A. (2017). Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population. Drug Metabolism & Pharmacokinetics, 32(3), 189-191. doi: 10.1016/j.dmpk.2016.09.001

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