Professor Madhav Bhatia

2025

Journal - Research Article

Pan, X., Ren, Z., Liang, W., Dong, X., Li, J., Wang, L., Bhatia, M., … Sun, J. (2025). Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.17435

2024

Journal - Research Article

Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2024). Novel monoclonal antibodies 1D2 and 4E4 against aspergillus glycoprotein antigens detect early invasive aspergillosis in mice. Journal of Fungi, 10(12), 832. doi: 10.3390/jof10120832

Zhu, Z., Chambers, S., & Bhatia, M. (2024). Substance P promotes leukocyte infiltration in the liver and lungs of mice with sepsis: A key role for adhesion molecules on vascular endothelial cells. International Journal of Molecular Sciences, 25(12), 6500. doi: 10.3390/ijms25126500

Zhu, Z., Chambers, S., & Bhatia, M. (2024). Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs. Antioxidants, 13, 300. doi: 10.3390/antiox13030300

Manandhar, S., Gaddam, R. R., Chambers, S., & Bhatia, M. (2024). Kupffer cell inactivation alters endothelial cell adhesion molecules in cecal ligation and puncture-induced sepsis. Biomolecules, 14, 84. doi: 10.3390/biom14010084

Journal - Research Other

Bhatia, M. (2024). The 25th anniversary of Current issues in molecular biology: Marking this significant milestone. Current Issues in Molecular Biology, 46, 14321-14323. [Editorial].

Shahid, A., Chambers, S., Scott-Thomas, A. J., & Bhatia, M. (2024). Gut microbiota and liver dysfunction in sepsis: The role of inflammatory mediators and therapeutic approaches. International Journal of Molecular Sciences, 25(24), 13415. doi: 10.3390/ijms252413415

Shahid, A., & Bhatia, M. (2024). Hydrogen sulfide: A versatile molecule and therapeutic target in health and diseases. Biomolecules, 14, 1145. doi: 10.3390/biom14091145

Relja, B., Ghezzi, P., Coldewey, S. M., Pavlov, V. A., Bhatia, M., Jungwirth, B., & Thiemermann, C. (2024). Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma: Volume III. Frontiers in Immunology, 15, 1447892. doi: 10.3389/fimmu.2024.1447892

2023

Journal - Research Article

Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650

Pan, L.-L., Ren, Z.-N., Yang, J., Li, B.-B., Huang, Y.-W., Song, D.-X., … Bhatia, M., … Sun, J. (2023). Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria. Acta Pharmaceutica Sinica B. Advance online publication. doi: 10.1016/j.apsb.2023.08.002

Tian, H., Li, J., Chen, X., Ren, Z., Pan, X., Huang, W., Bhatia, M., … Sun, J. (2023). Oral delivery of mouse β-defensin 14 (mBD14)-producing Lactococcus lactis NZ9000 attenuates experimental colitis in mice. Journal of Agricultural & Food Chemistry. Advance online publication. doi: 10.1021/acs.jafc.2c07098

Journal - Research Other

Zhu, Z., & Bhatia, M. (2023). Inflammation and organ injury the role of substance P and its receptors. International Journal of Molecular Sciences, 24, 6140. doi: 10.3390/ijms24076140

Ishii, I., & Bhatia, M. (2023). Amino acids in health and disease: The good, the bad, and the ugly. International Journal of Molecular Sciences, 24, 4931. doi: 10.3390/ijms24054931

Journal - Professional & Other Non-Research Articles

Bhatia, M. (2023). Current Issues in Molecular Biology keep evolving and getting better. Current Issues in Molecular Biology, 45, 7842. doi: 10.3390/cimb45100494

2022

Journal - Research Article

Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2022). A novel monoclonal antibody 1D2 that broadly inhibits clinically important Aspergillus species. Journal of Fungi, 8, 960. doi: 10.3390/jof8090960

Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639

Lian, X., Chambers, S., Lewis, J. G., Scott-Thomas, A., & Bhatia, M. (2022). Two monoclonal antibodies that specifically recognize aspergillus cell wall antigens and can detect circulating antigens in infected mice. International Journal of Molecular Sciences, 23, 252. doi: 10.3390/ijms23010252

Journal - Research Other

Zhu, Z., Lian, X., & Bhatia, M. (2022). Hydrogen sulfide: A gaseous mediator and its key role in programmed cell death, oxidative stress, inflammation and pulmonary disease. Antioxidants, 11, 2162. doi: 10.3390/antiox11112162

Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., MacPherson, S. A., Zeng, Y., & Chambers, S. T. (2022). Monoclonal antibodies and invasive aspergillosis: Diagnostic and therapeutic perspectives. International Journal of Molecular Sciences, 23, 5563. doi: 10.3390/ijms23105563

Kumar, R., Bhatia, M., & Pai, K. (2022). Role of chemokines in the pathogenesis of visceral leishmaniasis. Current Medicinal Chemistry, 29(33), 5441-5461. doi: 10.2174/0929867329666220509171244

Zhu, Z., Chambers, S., Zeng, Y., & Bhatia, M. (2022). Gases in sepsis: Novel mediators and therapeutic targets. International Journal of Molecular Sciences, 23, 3669. doi: 10.3390/ijms23073669

2021

Chapter in Book - Research

Manandhar, S., Sinha, P., Ejiwale, G., & Bhatia, M. (2021). Hydrogen sulfide and its interaction with other players in inflammation. In Y.-C. Zhu (Ed.), Advances in hydrogen sulfide biology: Advances in experimental medicine and biology (Vol. 1315). (pp. 129-159). Singapore: Springer. doi: 10.1007/978-981-16-0991-6_6

Journal - Research Other

Kumar, A., & Bhatia, M. (2021). Role of hydrogen sulfide, substance P and adhesion molecules in acute pancreatitis. International Journal of Molecular Sciences, 22(22), 12136. doi: 10.3390/ijms222212136

Patel, B. K., Patel, K. H., Bhatia, M., Iyer, S. G., Madhavan, K., & Moochhala, S. M. (2021). Gut microbiome in acute pancreatitis: A review based on current literature. World Journal of Gastroenterology, 27(30), 5019-5036. doi: 10.3748/wjg.v27.i30.5019

Bhatia, M., & Gaddam, R. R. (2021). Hydrogen sulfide in inflammation: A novel mediator and therapeutic target. Antioxidants & Redox Signaling, 34(17), 1368-1377. doi: 10.1089/ars.2020.8211

Mustansir Dawoodbhoy, F., Patel, B. K., Patel, K., Bhatia, M., Lee, C. N., & Moochhala, S. M. (2021). Gut microbiota dysbiosis as a target for improved post-surgical outcomes and improved patient care: A review of current literature. Shock, 55(4), 441-454. doi: 10.1097/shk.0000000000001654

2020

Journal - Research Article

Ellmers, L. J., Templeton, E. M., Pilbrow, A. P., Frampton, C., Ishii, I., Moore, P. K., Bhatia, M., Richards, A. M., & Cameron, V. A. (2020). Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. International Journal of Molecular Sciences, 21(12), 4284. doi: 10.3390/ijms21124284

Conference Contribution - Poster Presentation (not in published proceedings)

Lian, X., Scott-Thomas, A., Chambers, S., Lewis, J., Aamir, R., & Bhatia, M. (2020, December). The application of MARS spectral CT in diagnosing invasive aspergillosis. Poster session presented at the 6th One Health Aotearoa (OHA) Symposium, [Online].

2019

Journal - Research Article

Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191

Pan, L.-L., Niu, W., Fang, X., Liang, W., Li, H., Chen, W., … Bhatia, M., & Sun, J. (2019). Clostridium butyricum strains suppress experimental acute pancreatitis by maintaining intestinal homeostasis. Molecular Nutrition & Food Research, 63, 1801419. doi: 10.1002/mnfr.201801419

2018

Journal - Research Article

Pan, L.-L., Deng, Y.-Y., Wang, R., Wu, C., Li, J., Niu, W., … Bhatia, M., … Sun, J. (2018). Lactose induces phenotypic and functional changes of neutrophils and macrophages to alleviate acute pancreatitis in mice. Frontiers in Immunology, 9, 751. doi: 10.3389/fimmu.2018.00751

Journal - Research Other

Yan, F., Gao, H., Zhao, H., Bhatia, M., & Zeng, Y. (2018). Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease. Journal of Translational Medicine, 16, 262. doi: 10.1186/s12967-018-1635-z

2017

Chapter in Book - Research

Lv, J., Bhatia, M., & Wang, X. (2017). Roles of mitochondrial DNA in energy metabolism. In H. Sun & X. Wang (Eds.), Mitochondrial DNA and diseases: Advances in experimental medicine and biology (Vol. 1038). (pp. 71-83). Singapore: Springer Nature. doi: 10.1007/978-981-10-6674-0_6

Journal - Research Article

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762

Gillies, N. A., Pendharkar, S. A., Singh, R. G., Windsor, J. A., Bhatia, M., & Petrov, M. S. (2017). Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines. Archives of Physiology & Biochemistry, 123(4), 238-248. doi: 10.1080/13813455.2017.1308382

Singh, P. M., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia & Analgesia, 44(5), 1149-1155. doi: 10.1016/j.vaa.2017.01.002

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472

Journal - Research Other

Kumar, R., Bhatia, M., & Pai, K. (2017). Role of cytokines in the pathogenesis of visceral leishmaniasis. Clinical Laboratory, 63(10), 1549-1559. doi: 10.7754/Clin.Lab.2017.170404

Bhatia, M. (2017). Understanding toxicology: Mechanisms and applications. Cell Biology & Toxicology, 33(1), 1-4. doi: 10.1007/s10565-016-9363-8

2016

Journal - Research Article

Dong, Z., Shang, H., Chen, Y. Q., Pan, L.-L., Bhatia, M., & Sun, J. (2016). Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine & Cellular Longevity, 2016, 7864150. doi: 10.1155/2016/7864150

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Deng, Y.-Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13(5), 3881-3885. doi: 10.3892/mmr.2016.5008

Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9

Shamoon, M., Deng, Y., Chen, Y. Q., Bhatia, M., & Sun, J. (2016). Therapeutic implications of innate immune system in acute pancreatitis. Expert Opinion on Therapeutic Targets, 20(1), 73-87. doi: 10.1517/14728222.2015.1077227

Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z

Conference Contribution - Published proceedings: Abstract

Gaddam, R. R., Fraser, R., Badiei, A., Cogger, V., Le Couteur, D., Ishii, I., & Bhatia, M. (2016). The effect of hydrogen sulfide synthesized by cystathionine-gamma-lyase on inflammation and liver sinusoidal endothelial cells in polymicrobial sepsis in mice. New Zealand Medical Journal, 129(1439), (pp. 88). Retrieved from http://www.nzma.org.nz/journal

2015

Chapter in Book - Research

Bhatia, M. (2015). H₂S and inflammation: An overview. In P. K. Moore & M. Whiteman (Eds.), Chemistry, biochemistry and pharmacology of hydrogen sulfide (Handbook of experimental pharmacology, Vol. 230). (pp. 165-180). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-18144-8_8

Bhatia, M. (2015). H₂S and substance P in Inflammation. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen sulfide in redox biology, Part B (Vol. 555). (pp. 195-205). Elsevier. doi: 10.1016/bs.mie.2014.11.024

Journal - Research Article

Badiei, A., Gieseg, S., Davies, S., Othman, M. I., & Bhatia, M. (2015). LPS up-regulates cystathionine γ-lyase gene expression in Primary human macrophages via NF-κB/ERK pathway. Inflammation & Allergy Drug Targets, 14(2), 99-104. doi: 10.2174/1871528114666151201201719

Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007

Journal - Research Other

Du, C., Bhatia, M., Tang, S. C. W., Zhang, M., & Steiner, T. (2015). Mediators of inflammation: Inflammation in cancer, chronic diseases, and wound healing. Mediators of Inflammation, 2015, 570653. doi: 10.1155/2015/570653

Conference Contribution - Published proceedings: Abstract

Bhatia, M., Badiei, A., Gaddam, R., Fraser, R., & Chambers, S. (2015). Inhibition of hydrogen sulfide synthesis by gene silencing protects mice against caerulein-induced acute pancreatitis. Pancreatology, 15(3, Suppl.), (pp. S2). doi: 10.1016/j.pan.2015.05.048

2014

Journal - Research Other

Gaddam, R. R., Chambers, S., & Bhatia, M. (2014). ACE and ACE2 in inflammation: A tale of two enzymes. Inflammation & Allergy Drug Targets, 13(4), 224-234. [Review].

Conference Contribution - Published proceedings: Abstract

Fraser, R., Bhatia, M., Gaddam, R. R., Jamieson, H. A., Dobbs, B. R., Wade, R. T., … Le Couteur, D. G. (2014). Arsenic containing water from Bangladeshi wells relates to local heart disease and stroke. Internationally, mining and exploratory fracking may lead to arsenical contamination of aquifers. Arsenical drinking-water, by closing the "liver sieve" causes dyslipidaemia and atherosclerosis? Proceedings of the 7th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 9-10). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/index.html

Conference Contribution - Poster Presentation (not in published proceedings)

Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Inhibition of hydrogen sulfide production through gene silencing attenuates inflammation in LPS-activated macrophages via NF-κB pathway. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Alteration of metalloprotease enzymes of the renin-angiotensin system in acute pancreatitis in a mouse model. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

2013

Journal - Research Article

Ang, A. D., Rivers-Auty, J., Hegde, A., Ishii, I., & Bhatia, M. (2013). The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. American Journal of Physiology: Gastrointestinal & Liver Physiology, 305, G712-G721. doi: 10.1152/ajpgi.00044.2013

Badiei, A., Rivers-Auty, J., Ang, A. D., & Bhatia, M. (2013). Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Applied Microbiology & Biotechnology, 97(17), 7845-7852. doi: 10.1007/s00253-013-5080-x

Conference Contribution - Published proceedings: Abstract

Bhatia, M., Ang, A., Rivers, J., & Hegde, A. (2013). Effect of cystathionine-gamma-lyase gene deletion in caerulein-induced acute pancreatitis in the mouse. Pancreatology, 13(Suppl. 3), (pp. S91). doi: 10.1016/j.pan.2013.04.318

2012

Journal - Research Article

Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044

Sidhapuriwala, J. N., Hegde, A., Ang, A. D., Zhu, Y. Z., & Bhatia, M. (2012). Effects of S-Propargyl-Cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS ONE, 7(3), e32574. doi: 10.1371/journal.pone.0032574

Rivers, J. R., Badiei, A., & Bhatia, M. (2012). Hydrogen sulfide as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets, 16(5), 439-449. doi: 10.1517/14728222.2012.673591

Bhatia, M., Zemans, R. L., & Jeyaseelan, S. (2012). Role of chemokines in the pathogenesis of acute lung injury. American Journal of Respiratory Cell & Molecular Biology, 46(5), 566-572. doi: 10.1165/rcmb.2011-0392TR

Koh, Y.-H., Moochhala, S., Bian, J.-S., & Bhatia, M. (2012). Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 16(7), 1582-1592. doi: 10.1111/j.1582-4934.2011.01475.x

2011

Journal - Research Article

Koh, Y.-H., Moochhala, S., & Bhatia, M. (2011). The role of neutral endopeptidase in caerulein-induced acute pancreatitis. Journal of Immunology, 187, 5429-5439. doi: 10.4049/jimmunol.1102011

Ang, S.-F., Sio, S. W. S., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. Journal of Immunology, 187(9), 4778-4787. doi: 10.4049/jimmunol.1101559

Ang, S.-F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: Involvement of substance P and ERK-NF-κB signaling. PLoS ONE, 6(9), e24535. doi: 10.1371/journal.pone.0024535

Koh, Y.-H., Tamizhselvi, R., Moochhala, S., Bian, J.-S., & Bhatia, M. (2011). Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 15(10), 2139-2149. doi: 10.1111/j.1582-4934.2010.01205.x

Hegde, A., & Bhatia, M. (2011). Hydrogen sulfide in inflammation: Friend or foe? Inflammation & Allergy Drug Targets, 10(2), 118-122.

Journal - Research Other

Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. (2011). Lack of evidence for a causal association between the type of alcoholic beverage and the incidence of acute pancreatitis Reply [Letter]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2

Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. T. P. (2011). Reply [Letter to the editor]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2

Conference Contribution - Published proceedings: Abstract

Ang, S. F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulphide regulates transient receptor potential vanilloid 1-mediated neurogenic inflammation in sepsis-associated lung injury through enhancement of substance P production. Inflammation Research. 60(Suppl. 1), (pp. S122). doi: 10.1007/s00011-011-0341-6

Bhatia, M., Hegde, A., Sidhapuriwala, J., & Zhu, Y. Z. (2011). S-propargyl-cysteine protects mice against caerulein-induced acute pancreatitis. Inflammation Research. 60(Suppl. 1), (pp. S278-S279). doi: 10.1007/s00011-011-0341-6

Other Research Output

Bhatia, M. (2011, February). Inflammation: A new frontier of medicine. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture].

2010

Journal - Research Article

Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739

Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027

Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995

Koh, Y.-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH₂-terminal kinase, through nuclear factor-κB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416

Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9

Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004

Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A^-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166

Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927

Hegde, A., Uttamchandani, M., Bhatia, M., & Moochhala, S. M. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112

Tamizhselvi, R., Koh, Y.-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-κB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044

Ang, S.-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/CCM.0b013e3181c0df00

Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory & Critical Care Medicine, 181(1), 36-46. doi: 10.1164/rccm.200907-1073OC

Conference Contribution - Published proceedings: Abstract

Hegde, A., Koh, Y., Moochhala, S., & Bhatia, M. (2010). Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis in mice. Proceedings of the Human Proteome World Congress (HUPO): Launch of the Human Proteome Project. (pp. 215). Retrieved from http://www.hupo.org/congress/congress_2010/downloads/HUPO2010%20World%20Congress%20Abstract%20Book.pdf

2009

Journal - Research Article

Ang, A. D., Adhikari, S., Ng, S. W., & Bhatia, M. (2009). Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology, 9(1-2), 150-159. doi: 10.1159/000178886

Ramnath, R. D., Sun, J., & Bhatia, M. (2009). Involvement of Src family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. Journal of Pharmacology & Experimental Therapeutics, 329, 418-428. doi: 10.1124/jpet.108.148684

Zhang, H., & Bhatia, M. (2009). Role of hydrogen sulfide in acute lung injury and acute respiratory distress syndrome. Open Critical Care Medicine Journal, 2, 13-17. doi: 10.2174/1874828700902010013

Ynsa, M. D., Ren, M. Q., Rajendran, R., Sidhapuriwala, J. N., van Kan, J. A., Bhatia, M., & Watt, F. (2009). Zinc mapping and density imaging of rabbit pancreas endocrine tissue sections using nuclear microscopy. Microscopy & Microanalysis, 15, 345-352. doi: 10.1017/S1431927609090795

Tamizhselvi, R., Sun, J., Koh, Y.-H., & Bhatia, M. (2009). Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 329, 1166-1178. doi: 10.1124/jpet.109.150532

Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2009). Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB Journal, 23, 997-1010. doi: 10.1096/fj.08-121756

Sidhapuriwala, J. N., Ng, S. W., & Bhatia, M. (2009). Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of Inflammation, 6, 35. doi: 10.1186/1476-9255-6-35

2008

Journal - Research Article

Adhikari, S., Ramnath, R. D., Wallig, M., & Bhatia, M. (2008). Role of mitogen-activated protein kinases in crambene-induced pancreatic acinar cell apoptosis. International Journal of Integrative Biology, 3(1), 25-35.

Zhang, H., & Bhatia, M. (2008). Hydrogen sulfide: A novel mediator of leukocyte activation. Immunopharmacology & Immunotoxicology, 30, 631-645. doi: 10.1080/08923970802278045

Zhang, H., Moochhala, S. M., & Bhatia, M. (2008). Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. Journal of Immunology, 181, 4320-4331.

Webb, G. D., Lim, L. H., Oh, V. M. S., Yeo, S. B., Cheong, Y. P., Ali, M. Y., … Bhatia, M., … Moore, P. K. (2008). Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. Journal of Pharmacology & Experimental Therapeutics, 324, 876-882. doi: 10.1124/jpet.107.133538

Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2008). Neurokinin A engages neurokinin-1 receptor to induce NF-κB-dependent gene expression in murine macrophages: Implications of ERK1/2 and PI 3-kinase/Akt pathways. American Journal of Physiology: Cell Physiology, 295, C679-C691. doi: 10.1152/ajpcell.00042.2008

Sun, J., Ramnath, R. D., Zhi, L., Tamizhselvi, R., & Bhatia, M. (2008). Substance P enhances NF-κB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. American Journal of Physiology: Cell Physiology, 294, C1586-C1596. doi: 10.1152/ajpcell.00129.2008

Sio, S. W. S., Puthia, M. K., Lu, J., Moochhala, S., & Bhatia, M. (2008). The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Journal of Immunology, 180, 8333-8341.

Ramnath, R. D., Ng, S. W., Guglielmotti, A., & Bhatia, M. (2008). Role of MCP-1 in endotoxemia and sepsis. International Immunopharmacology, 8(6), 810-818. doi: 10.1016/j.intimp.2008.01.033

Ramnath, R. D., Sun, J., Adhikari, S., Zhi, L., & Bhatia, M. (2008). Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells. American Journal of Physiology: Cell Physiology, 294, C683-C692. doi: 10.1152/ajpcell.00360.2007

Ramnath, R. D., Sun, J., & Bhatia, M. (2008). Role of calcium in substance P-induced chemokine synthesis in mouse pancreatic acinar cells. British Journal of Pharmacology, 154(6), 1339-1348. doi: 10.1038/bjp.2008.188

Ng, S. W., Zhang, H., Hegde, A., & Bhatia, M. (2008). Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. Journal of Leukocyte Biology, 83, 288-295. doi: 10.1189/jlb.0807575

Bhatia, M., Landolfi, C., Basta, F., Bovi, G., Ramnath, R. D., Capezzone de Joannon, A., & Guglielmotti, A. (2008). Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis. Inflammation Research, 57(10), 464-471. doi: 10.1007/s00011-008-7210-y

Ang, A. D., Adhikari, S., Wei, N. S., & Bhatia, M. (2008). NFkappaB mediated expression of iNOS in pancreatic acinar cells contributes to the severity of acute pancreatitis and associated lung injury. International Journal of Integrative Biology, 2(2), 70-78.

2007

Journal - Research Article

Zhang, H., Hegde, A., Ng, S. W., Adhikari, S., Moochhala, S. M., & Bhatia, M. (2007). Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. Journal of Immunology, 179, 4153-4160.

Zhi, L., Ang, A. D., Zhang, H., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway. Journal of Leukocyte Biology, 81, 1322-1332. doi: 10.1189/jlb.1006599

Bhatia, M., & Hegde, A. (2007). Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regulatory Peptides, 138(1), 40-48. doi: 10.1016/j.regpep.2006.08.006

Zhang, H., Zhi, L., Moochhala, S. M., Moore, P. K., & Bhatia, M. (2007). Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. Journal of Leukocyte Biology, 82, 894-905. doi: 10.1189/jlb.0407237

Zhang, H., Zhi, L., Moochhala, S., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-κB. American Journal of Physiology: Lung Cellular & Molecular Physiology, 292, L960-L971. doi: 10.1152/ajplung.00388.2006

Sun, J., Ramnath, R. D., & Bhatia, M. (2007). Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. American Journal of Physiology: Cell Physiology, 293, C696-C704. doi: 10.1152/ajpcell.00060.2007

Sun, J., & Bhatia, M. (2007). Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G143-G153. doi: 10.1152/ajpgi.00271.2006

Sidhapuriwala, J., Li, L., Sparatore, A., Bhatia, M., & Moore, P. K. (2007). Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. European Journal of Pharmacology, 569, 149-154. doi: 10.1016/j.ejphar.2007.05.003

Liew, H. C., Khoo, H. E., Moore, P. K., Bhatia, M., Lu, J., & Moochhala, S. M. (2007). Synergism between hydrogen sulfide (H₂S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom. Life Sciences, 80(18), 1664-1668. doi: 10.1016/j.lfs.2007.01.058

Lau, H. Y., & Bhatia, M. (2007). Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1283-G1292. doi: 10.1152/ajpgi.00429.2006

Hegde, A., Zhang, H., Moochhala, S., & Bhatia, M. (2007). Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Journal of Leukocyte Biology, 82, 678-685. doi: 10.1189/jlb.0407217

He, M., Horuk, R., Moochhala, S. M., & Bhatia, M. (2007). Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1173-G1180. doi: 10.1152/ajpgi.00420.2006

He, M., Lau, H. Y., Ng, S. W., & Bhatia, M. (2007). Chemokines in acute inflammation: Regulation, function and therapeutic strategies. International Journal of Integrative Biology, 1(1), 18-27.

Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2007). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology, 170(5), 1521-1534. doi: 10.2353/ajpath.2007.061149

2006

Journal - Research Article

Cao, Y., Adhikari, S., Ang, A. D., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G95-G101. doi: 10.1152/ajpgi.00520.2005

Cao, Y., Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. American Journal of Physiology: Cell Physiology, 291, 503-510. doi: 10.1152/ajpcell.00547.2005

Lau, H. Y., & Bhatia, M. (2006). The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Journal of Pathology, 208, 364-371. doi: 10.1002/path.1899

Li, L., Bhatia, M., & Moore, P. K. (2006). Hydrogen sulphide: A novel mediator of inflammation? Current Opinion in Pharmacology, 6(2), 125-129. doi: 10.1016/j.coph.2005.10.007

Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., & et al (2006). Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (mangrove catsnake) with bird-specific activity. Journal of Biological Chemistry, 281(39), 29030-29041. doi: 10.1074/jbcM605850200

Puneet, P., Hegde, A., Ng, S. W., Lau, H. Y., Lu, J., Moochhala, S. M., & Bhatia, M. (2006). Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. Journal of Immunology, 176, 3813-3820.

Ramnath, R. D., Weing, S., He, M., Sun, J., Zhang, H., Bawa, M. S., & Bhatia, M. (2006). Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases. Journal of Organ Dysfunction, 2(2), 80-92. doi: 10.1080/17471060500435662

Ramnath, R. D., & Bhatia, M. (2006). Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-κB. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G1113-G1119. doi: 10.1152/ajpgi.00177.2006

Whiteman, M., Li, L., Kostetski, I., Chu, S. H., Siau, J. L., Bhatia, M., & Moore, P. K. (2006). Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochemical & Biophysical Research Communications, 343(1), 303-310. doi: 10.1016/j.bbrc.2006.02.154

Zhang, H., Zhi, L., Moore, P. K., & Bhatia, M. (2006). Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. American Journal of Physiology: Lung Cellular & Molecular Physiology, 290, L1193-L1201. doi: 10.1152/ajplung.00489.2005

Ali, M. Y., Ping, C. Y., Mok, Y.-Y., Ling, L., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Regulation of vascular nitric oxide in vitro and in vivo: A new role for endogenous hydrogen sulphide? British Journal of Pharmacology, 149(6), 625-634. doi: 10.1038/sj.bjp.0706906

Anuar, F., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation Research, 55(11), 498-503. doi: 10.1007/s00011-006-5150-y

Anuar, F., Whiteman, M., Siau, J. L., Kwong, S. E., Bhatia, M., & Moore, P. K. (2006). Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British Journal of Pharmacology, 147(8), 966-974. doi: 10.1038/sj.bjp.0706696

Bhatia, M., Zhi, L., Zhang, H., Ng, S.-W., & Moore, P. (2006). Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. American Journal of Physiology: Lung Cellular & Molecular Physiology, 291, L896-L904. doi: 10.1152/ajplung.00053.2006

Bhatia, M., Li, L., & Moore, P. K. (2006). The role of hydrogen sulfide in lung inflammation. Drug Discovery Today: Disease Mechanisms, 3(1), 71-75. doi: 10.1016/j.ddmec.2006.02.010

Conference Contribution - Published proceedings: Abstract

Ramnath, R., & Bhatia, M. (2006). Treatment with substance P and caerulein induces chemokine synthesis in pancreatic acinar cells. FEBS Journal, 273(Suppl. 1), (pp. 82-83). doi: 10.1111/j.1742-4658.2006.05277.x

He, M., Horuk, R., & Bhatia, M. (2006). Protective role of BX471, a non-peptide CCR1 antagonist, in acute pancreatitis and sepsis. FEBS Journal, 273(Suppl. 1), (pp. 286). doi: 10.1111/j.1742-4658.2006.05277.x

Lau, H. Y., & Bhatia, M. (2006). Effect of CP96 345 treatment on the expression of adhesion molecules in acute pancreatitis. FEBS Journal, 273(Suppl. 1), (pp. 285-286). doi: 10.1111/j.1742-4658.2006.05277.x

Zhang, H. L., Zhi, L., Moore, P. K., & Bhatia, M. (2006). The role of hydrogen sulfide in cecal ligation and puncture induced sepsis in the mouse. FEBS Journal, 273(Suppl. 1), (pp. 284). doi: 10.1111/j.1742-4658.2006.05277.x

Sun, J., & Bhatia, M. (2006). Blockade of neurokinin 1 receptor attenuates CC and CXC chemokine production in acute pancreatitis. FEBS Journal, 273(Suppl. 1), (pp. 284). doi: 10.1111/j.1742-4658.2006.05277.x

Cao, Y., Adhikari, S., Moore, P. K., & Bhatia, M. (2006). Pro-apoptotic effect of the hydrogen sulfide (h₂s) in isolated pancreatic acinar cells. FEBS Journal, 273(Suppl. 1), (pp. 111). doi: 10.1111/j.1742-4658.2006.05277.x

Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). The role of nitric oxide in caerulein-induced acute pancreatitis in mice. Pancreatology. 6(6), (pp. 556). doi: 10.1159/000096550

Adhikari, S., Cao, Y., Ang, A. D., Clement, M. V., Wallig, M., & Bhatia, M. (2006). Mechanism of pancreatic acinar cell apoptosis induced by crambene. FEBS Journal, 273(Suppl. 1), (pp. 47). doi: 10.1111/j.1742-4658.2006.05276.x

Bhatia, M., Puneet, P., & Moochhala, S. (2006). Pre-protachykinin-A gene products play a critical role in the pathogenesis of sepsis. FEBS Journal, 273(Suppl. 1), (pp. 67). doi: 10.1111/j.1742-4658.2006.05277.x

Sun, J., & Bhatia, M. (2006). Blockade of neurokinin-1 receptor attentuates CC and CXC chemokine production in acute pancreatitis and associated lung injury. Pancreatology. 6(4), (pp. 344). doi: 10.1159/000093601

He, M., Horuk, R., & Bhatia, M. (2006). Treatment with BX471, a non-peptide CCR1 antagonist, protect mice against acute pancreatitis-associated lung injury by modulating neutrophils recruitment. Pancreatology. 6(4), (pp. 349). doi: 10.1159/000093601

Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Treatment with a neutralizing anti-IL-10 reverses crambene mediated protection against acute pancreatitis. Pancreatology. 6(4), (pp. 350). doi: 10.1159/000093601

Bhatia, M., & Hegde, A. (2006). Treatment with the CXCR2 antagonist antileukinate protects mice against acute pancreatitis and associated lung injury. Pancreatology. 6(4), (pp. 351). doi: 10.1159/000093601

Ramnath, R. D., & Bhatia, M. (2006). Treatment with caerulein and substance P induces chemokine synthesis on pancreatic acinar cells. Pancreatology. 6(4), (pp. 376). doi: 10.1159/000093601

Lau, H. Y., & Bhatia, M. (2006). Neurokinin-1 receptor antagonist treatment alters the expression of adhesion molecules in acute pancreatitis. Pancreatology. 6(4), (pp. 378). doi: 10.1159/000093601

Whiteman, M., Ali, M., Li, L., Cheong, Y. P., Mok, Y.-Y. P., Kostetski, I., … Bhatia, M., & Moore, P. K. (2006). Hydrogen sulfide regulates the availability of nitric oxide through the formation of a novel nitrosothiol: Implications for cardiovascular function and human disease. Nitric Oxide. 14, (pp. A40). doi: 10.1016/j.niox.2006.04.136