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Contact Details

Phone
+64 3 479 7690
Email
p.cooper@otago.ac.nz
Position
Professor of Oral Biology
Department
Department of Oral Sciences
Qualifications
BSc(Hons) (Leeds) PhD (Birmingham) PGCILTHE (Birmingham)
Research summary
Tissue engineering, pulp biology, periodontal inflammation, photobiomodulation
Teaching
Oral Biology
Memberships
IADR, PBRG

Research

My research is within the field of oral and dental tissue inflammation and repair. Current areas of research interest include:

1. Dentine-Pulp complex biology
Paul has led projects studying the molecular changes which occur in the dentine-pulp complex as a result of disease, dental injury and repair, and in its response to dental materials. PhD projects he has supervised have characterised dental pulp stem cells (DPSC) responses with the aim of developing novel treatment technologies.

2. Molecular and Cellular aspects of Periodontal Disease
Paul has led studies characterising oral epithelial or neutrophil responses to periodontal bacteria. In collaboration his work has shown that elevated systemic levels of IFNs are associated with the disease. Subsequently this has led to further studies on the roles of Neutrophil Extracellular Traps (NETs), auto-immunity/-inflammation, DNAse deficiency, epigenetics and efferocytosis in periodontitis and its comorbidities.

3. Low Level Light/Laser Therapy (LLLT) / photobiomodulation / phototherapy
Recent studies indicate the utility of phototherapies in promoting oral and dental tissue health as well as for disinfection. Different light delivery approaches are being explored to identify delivery parameters which modulate dentine-pulp complex, gingival and immune cell responses relevant to tissue health.

4. Assessment of toothpaste cleaning
Industry funded studies have utilised profilometry, gloss analyses, stain models and SEM to investigate mechanistic actions of dental dentifrices for oral hygiene.

Additional details

Professor Cooper has published over 140 research papers and authored 10 book chapters. He has delivered over 40 invited lectures globally. He has supervised over 40 PhD students and received over NZ$10-million (equivalent) in research funding.

In 2010, Paul was awarded the IADR Distinguished Scientist Young Investigator Award and he is currently the vice-president of the Pulp Biology and Regeneration Group of IADR.

Paul serves on the editorial boards of the Journal of Dental Research, Journal of Endodontics and Journal of Periodontal Research.

Paul completed his postgraduate certificate in learning and teaching in higher education (PGCILTHE) in 2003 and is a Fellow of the Higher Education Academy.

Publications

Chen, A. M.-C., Ekambaram, M., Li, K. C., Cooper, P. R., & Mei, M. L. (2024). A scoping review of the influence of clinical contaminants on bond strength in direct adhesive restorative procedures. Journal of Dentistry, 145, 104985. doi: 10.1016/j.jdent.2024.104985 Journal - Research Other

Al-Maswary, A. A., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2024). Low-intensity pulsed ultrasound induces proliferation of human neural stem cells. Clinical & Translational Discovery, 4, e259. doi: 10.1002/ctd2.259 Journal - Research Article

Lundy, F. T., Friedlander, L. T., & Cooper, P. R. (2024). Biological basis for vital pulp treatment. In H. F. Duncan & I. A. El-Karim (Eds.), Vital pulp treatment. (pp. 20-46). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781119930419.ch2 Chapter in Book - Research

Hussein, H. R., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2024). E-cadherin and TAC in GCF accurately discriminate periodontal health and disease. Oral Diseases. Advance online publication. doi: 10.1111/odi.14862 Journal - Research Article

Khurshid, Z., Adanir, N., Ratnayake, J., Dias, G., & Cooper, P. R. (2023). Demineralized dentin matrix for bone regeneration in dentistry: A critical update. Saudi Dental Journal. Advance online publication. doi: 10.1016/j.sdentj.2023.11.028 Journal - Research Other

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