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Dr Kyoko Niimi

Contact Details

Honorary Senior Research Fellow
Department of Oral Sciences
DVM (Kyushu Dental) PhD (Otago)
Research summary
Molecular mycology, antifungal resistance, drug discovery


Dr Niimi's research interests are in molecular microbiology, particularly in mycology research and the development of drug efflux pump inhibitors. Her three main areas of research expertise are the molecular biology of human fungal pathogens Candida albicans and Candida glabrata, the mechanisms of antifungal drug resistance, and heterologous protein expression in baker's yeast Saccharomyces cerevisiae.


Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x Journal - Research Article

Niimi, K., Woods, M. A., Maki, K., Nakayama, H., Hatakenaka, K., Chibana, H., … Niimi, M., Cannon, R. D., & Monk, B. C. (2012). Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. Journal of Antimicrobial Chemotherapy, 67(7), 1666-1676. doi: 10.1093/jac/dks112 Journal - Research Article

Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., … Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/dkq073 Journal - Research Article

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., … Niimi, M., … Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/cmr.00051-08 Journal - Research Article

Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., & Cannon, R. D. (2006). Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility. Antimicrobial Agents & Chemotherapy, 50(4), 1148-1155. Journal - Research Article

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