Associate Professor Chris Baldi

Contact Details
University Links
- Position
- Research Associate Professor
- Department
- Department of Medicine (Dunedin)
- Qualifications
- MSc PhD FACSM
- Research summary
- Diabetes and cardiovascular dysfunction
Research
My general area of research is to examine the causes and prevention of cardiovascular dysfunction in patients with diabetes (type 1 and 2). Interests include:
- Exercise intolerance in diabetes
- Myocardial and pulmonary dysfunction in diabetes
- Paediatric diabetes research
Publications
Clifford, K., Woodfield, J. C., Tait, W., Campbell, H. A., & Baldi, J. C. (2023). Association of preoperative high-intensity interval training with cardiorespiratory fitness and postoperative outcomes among adults undergoing major surgery: A systematic review and meta-analysis. JAMA Network Open, 6(6), e2320527. doi: 10.1001/jamanetworkopen.2023.20527
Ng, Y. H., Lamberts, R. R., Jones, P. P., Sammut, I. A., Diffee, G. M., Wilkins, G. T., & Baldi, J. C. (2022). Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Scientific Reports, 12(1), 16904. doi: 10.1038/s41598-022-20520-0
Greenman, A. C., Diffee, G. M., Power, A. S., Wilkins, G. T., Gold, O. M. S., Erickson, J. R., & Baldi, J. C. (2022). Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats. Journal of Applied Physiology, 132, 1350-1360. doi: 10.1152/japplphysiol.00785.2021
Woodfield, J. C., Clifford, K., Wilson, G. A., Munro, F., & Baldi, J. C. (2022). Short-term high-intensity interval training improves fitness before surgery: A randomised clinical trial. Scandinavian Journal of Medicine & Science in Sports, 32, 856-865. doi: 10.1111/sms.14130
Chiavaroli, V., Hopkins, S. A., Biggs, J. B., Rodrigues, R. O., Seneviratne, S. N., Baldi, J. C., … Derraik, J. G. B. (2021). The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years. Scientific Reports, 11, 20865. doi: 10.1038/s41598-021-99869-7
Clifford, K., Woodfield, J. C., Tait, W., Campbell, H. A., & Baldi, J. C. (2023). Association of preoperative high-intensity interval training with cardiorespiratory fitness and postoperative outcomes among adults undergoing major surgery: A systematic review and meta-analysis. JAMA Network Open, 6(6), e2320527. doi: 10.1001/jamanetworkopen.2023.20527
Journal - Research Article
Greenman, A. C., Diffee, G. M., Power, A. S., Wilkins, G. T., Gold, O. M. S., Erickson, J. R., & Baldi, J. C. (2022). Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats. Journal of Applied Physiology, 132, 1350-1360. doi: 10.1152/japplphysiol.00785.2021
Journal - Research Article
Ng, Y. H., Lamberts, R. R., Jones, P. P., Sammut, I. A., Diffee, G. M., Wilkins, G. T., & Baldi, J. C. (2022). Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Scientific Reports, 12(1), 16904. doi: 10.1038/s41598-022-20520-0
Journal - Research Article
Woodfield, J. C., Clifford, K., Wilson, G. A., Munro, F., & Baldi, J. C. (2022). Short-term high-intensity interval training improves fitness before surgery: A randomised clinical trial. Scandinavian Journal of Medicine & Science in Sports, 32, 856-865. doi: 10.1111/sms.14130
Journal - Research Article
Bell, R. A., Baldi, J. C., & Jones, L. M. (2021). Additional cardiovascular fitness when progressing from moderate- to high-intensity exercise training in previously trained breast cancer survivors. Supportive Care in Cancer, 29, 6645-6650. doi: 10.1007/s00520-021-06259-w
Journal - Research Article
Chiavaroli, V., Hopkins, S. A., Biggs, J. B., Rodrigues, R. O., Seneviratne, S. N., Baldi, J. C., … Derraik, J. G. B. (2021). The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years. Scientific Reports, 11, 20865. doi: 10.1038/s41598-021-99869-7
Journal - Research Article
Greenman, A. C., Diffee, G. M., Power, A. S., Wilkins, G. T., Gold, O. M. S., Erickson, J. R., & Baldi, J. C. (2021). Increased myofilament calcium sensitivity is associated with decreased cardiac troponin I phosphorylation in the diabetic rat heart. Experimental Physiology, 106, 2235-2247. doi: 10.1113/ep089730
Journal - Research Article
Jones, L. M., Wilson, R., Stoner, L., & Baldi, J. C. (2021). Arterial stiffness as a cardiovascular risk factor in prostate cancer survivors: A case-control study. Journal of Science in Sport & Exercise, 3(2), 171-178. doi: 10.1007/s42978-019-00036-2
Journal - Research Article
Ng, Y. H., Okolo, C. A., Erickson, J. R., Baldi, J. C., & Jones, P. P. (2021). Protein O-GlcNAcylation in the heart. Acta Physiologica, 233, e13696. doi: 10.1111/apha.13696
Journal - Research Article
Jones, L. M., Stoner, L., Baldi, J. C., & McLaren, B. (2020). Circuit resistance training and cardiovascular health in breast cancer survivors. European Journal of Cancer Care, 29, e13231. doi: 10.1111/ecc.13231
Journal - Research Article
Jones, L. M., Stoner, L., Brown, C., Baldi, J. C., & McLaren, B. (2019). Cardiorespiratory fitness predicts cardiovascular health in breast cancer survivors, independent of body composition, age and time post-treatment completion. Breast Cancer, 26, 729-737. doi: 10.1007/s12282-019-00975-2
Journal - Research Article
Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise, 51(6), 1099-1105. doi: 10.1249/mss.0000000000001897
Journal - Research Article
Chiavaroli, V., Hopkins, S. A., Derraik, J. G. B., Biggs, J. B., Rodrigues, R. O., Brennan, C. H., … Baldi, J. C., … Hofman, P. L. (2018). Exercise in pregnancy: 1-year and 7-year follow-ups of mothers and offspring after a randomized controlled trial. Scientific Reports, 8(1), 12915. doi: 10.1038/s41598-018-30925-5
Journal - Research Article
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Journal - Research Article
Gusso, S., Pinto, T., Baldi, J. C., Derraik, J. G. B., Cutfield, W. S., Hornung, T., & Hofman, P. L. (2017). Exercise training improves but does not normalize left ventricular systolic and diastolic function in adolescents with type 1 diabetes. Diabetes Care, 40(9), 1264-1272. doi: 10.2337/dc16-2347
Journal - Research Article
Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1
Journal - Research Article
Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184
Journal - Research Article
Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248
Journal - Research Article
Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9
Journal - Research Article
Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053
Journal - Research Article
Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204
Journal - Research Article
Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955
Journal - Research Article
Baldi, J. C., Dacey, M. J., Lee, M. J., & Coast, J. R. (2014). Prior maximal exercise decreases pulmonary diffusing capacity during subsequent exercise. International Journal of Sports Medicine, 35(12), 982-986. doi: 10.1055/s-0034-1372635
Journal - Research Article
Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6
Journal - Research Article
Hoye, N. A., Baldi, J. C., Putt, T. L., Schollum, J. B., Wilkins, G. T., & Walker, R. J. (2014). Endovascular renal denervation: A novel sympatholytic with relevance to chronic kidney disease. Clinical Kidney Journal, 7(1), 3-10. doi: 10.1093/ckj/sft130
Journal - Research Article
Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72
Journal - Research Article
Pinto, T. E., Gusso, S., Hofman, P. L., Derraik, J. G. B., Hornung, T. S., Cutfield, W. S., & Baldi, J. C. (2014). Systolic and diastolic abnormalities reduce the cardiac response to exercise in adolescents with type 2 diabetes. Diabetes Care, 37(5), 1439-1446. doi: 10.2337/dc13-2031
Journal - Research Article
Jones, L. M., Stoner, L., Brown, C., Baldi, C., & McLaren, B. (2013). Cardiovascular disease among breast cancer survivors: The call for a clinical vascular health toolbox. Breast Cancer Research & Treatment, 142(3), 645-653. doi: 10.1007/s10549-013-2766-9
Journal - Research Article
Carrick-Ranson, G., Doughty, R. N., Whalley, G. A., Walsh, H. J., Gamble, G. D., & Baldi, J. C. (2012). The larger exercise stroke volume in endurance-trained men does not result from increased left ventricular early or late inflow or tissue velocities. Acta Physiologica, 205(4), 520-531. doi: 10.1111/j.1748-1716.2012.02430.x
Journal - Research Article
Gusso, S., Pinto, T. E., Baldi, J. C., Robinson, E., Cutfield, W. S., & Hofman, P. L. (2012). Diastolic function is reduced in adolescents with type 1 diabetes in response to exercise. Diabetes Care, 35(10), 2089-2094. doi: 10.2337/dc11-2331
Journal - Research Article
Wimer, G. S., & Baldi, J. C. (2012). Limb-specific training affects exercise hyperemia but not sympathetic vasoconstriction. European Journal of Applied Physiology, 112(11), 3819-3828.
Journal - Research Article
Hopkins, S. A., Baldi, J. C., Cutfield, W. S., McCowan, L., & Hofman, P. L. (2011). Effects of exercise training on maternal hormonal changes in pregnancy. Clinical Endocrinology, 74(4), 495-500. doi: 10.1111/j.1365-2265.2010.03964.x
Journal - Research Article
Wheatley, C. M., Baldi, J. C., Cassuto, N. A., Foxx-Lupo, W. T., & Snyder, E. M. (2011). Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes: Alveolar-capillary membrane conductance in type 1 diabetes. European Journal of Applied Physiology, 111(3), 567-578. doi: 10.1007/s00421-010-1663-8
Journal - Research Article
Baldi, J. C., & Hofman, P. L. (2010). Does careful glycemic control improve aerobic capacity in subjects with type 1 diabetes? Exercise & Sport Sciences Reviews, 38(4), 161-167. doi: 10.1097/JES.0b013e3181f4501e
Journal - Research Article
Baldi, J. C., Cassuto, N. A., Foxx-Lupo, W. T., Wheatley, C. M., & Snyder, E. M. (2010). Glycemic status affects cardiopulmonary exercise response in athletes with type 1 diabetes. Medicine & Science in Sports & Exercise, 42(8), 1454-1459. doi: 10.1249/MSS.0b013e3181d1fdb3
Journal - Research Article
Hopkins, S. A., Baldi, J. C., Cutfield, W. S., McCowan, L., & Hofman, P. L. (2010). Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity. Journal of Clinical Endocrinology & Metabolism, 95(5), 2080-2088. doi: 10.1210/jc.2009-2255
Journal - Research Article
Lalande, S., Hofman, P., & Baldi, J. C. (2010). Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes. Acta Physiologica, 199(1), 23-30. doi: 10.1111/j.1748-1716.2010.02081.x
Journal - Research Article
Whalley, G. A., Gusso, S., Hofman, P., Cutfield, W., Poppe, K. K., Doughty, R. N., & Baldi, J. C. (2009). Structural and functional cardiac abnormalities in adolescent girls with poorly controlled type 2 diabetes. Diabetes Care, 32(5), 883-888. doi: 10.2337/dc08-2005
Journal - Research Article
Gusso, S., Hofman, P., Lalande, S., Cutfield, W., Robinson, E., & Baldi, J. C. (2008). Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus. Diabetologia, 51(7), 1317-1320. doi: 10.1007/s00125-008-1012-1
Journal - Research Article
Lalande, S., Gusso, S., Hofman, P. L., & Baldi, J. C. (2008). Reduced leg blood flow during submaximal exercise in type 2 diabetes. Medicine & Science in Sports & Exercise, 48(4), 612-617. doi: 10.1249/MSS.0b013e318161aa99
Journal - Research Article
Baldi, J. C., Lalande, S., Carrick-Ranson, G., & Johnson, B. D. (2007). Postural differences in hemodynamics and diastolic function in healthy older men. European Journal of Applied Physiology, 99(6), 651-657. doi: 10.1007/s00421-006-0384-5
Journal - Research Article
Hammett, C. J. K., Prapavessis, H., Baldi, J. C., Ameratunga, R., Schoenbeck, U., Varo, N., … Stewart, R. A. H. (2007). Variation in blood levels of inflammatory markers related and unrelated to smoking cessation in women. Preventive Cardiology, 10(2), 68-75. doi: 10.1111/j.1520-037X.2007.05957.x
Journal - Research Article
Lalande, S., & Baldi, J. C. (2007). Left ventricular mass in elite Olympic weight lifters. American Journal of Cardiology, 100(7), 1177-1180. doi: 10.1016/j.amjcard.2007.05.036
Journal - Research Article
Prapavessis, H., Cameron, L., Baldi, J. C., Robinson, S., Borrie, K., Harper, T., & Grove, J. R. (2007). The effects of exercise and nicotine replacement therapy on smoking rates in women. Addictive Behaviors, 32(7), 1416-1432. doi: 10.1016/j.addbeh.2006.10.005
Journal - Research Article
Baldi, J. C., Aoina, J. L., Whalley, G. A., Carrick-Ranson, G., Walsh, H., O'Shaughnessy, H., … Doughty, R. N. (2006). The effect of type 2 diabetes on diastolic function. Medicine & Science in Sports & Exercise, 38(8), 1384-1388. doi: 10.1249/01.mss.0000228954.90591.95
Journal - Research Article
Hammett, C. J. K., Prapavessis, H., Baldi, J. C., Varo, N., Schoenbeck, U., Ameratunga, R., … Stewart, R. A. H. (2006). Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal, 151(2), 367 e7-367 e16. doi: 10.1016/j.ahj.2005.08.009
Journal - Research Article
Whalley, G. A., Doughty, R. N., Gamble, G. D., Oxenham, H. C., Walsh, H. J., Reid, I. R., & Baldi, J. C. (2004). Association of fat-free mass and training status with left ventricular size and mass in endurance-trained athletes. JACC, 44(4), 892-896. doi: 10.1016/j.jacc.2004.04.051
Journal - Research Article
Baldi, J. C., McFarlane, K., Oxenham, H. C., Whalley, G. A., Walsh, H. J., & Doughty, R. N. (2003). Left ventricular diastolic filling and systolic function of young and older trained and untrained men. Journal of Applied Physiology, 95, 2570-2575. doi: 10.1152/japplphysiol.00441.2003
Journal - Research Article
Woodfield, J. C., Baldi, J. C., & Clifford, K. (2019). What is the minimal dose of HIIT required to achieve pre-operative benefit. Scandinavian Journal of Medicine & Science in Sports, 29, 1841. doi: 10.1111/sms.13538
Journal - Research Other
Woodfield, J., Zacharias, M., Wilson, G., Munro, F., Thomas, K., Gray, A., & Baldi, J. (2018). Protocol, and practical challenges, for a randomised controlled trial comparing the impact of high intensity interval training against standard care before major abdominal surgery: Study protocol for a randomised controlled trial. Trials, 19(1), 331. doi: 10.1186/s13063-018-2701-9
Journal - Research Other
Baldi, J. C., Manning, P. J., Hofman, P. L., & Walker, R. J. (2013). Comment on: TODAY Study Group. Effects of Metformin, Metformin plus Rosiglitazone, and Metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY. Diabetes Care 2013;36:1749-1757 [Comment]. Diabetes Care, 36, e223. doi: 10.2337/dc13-1426
Journal - Research Other
Whalley, G. A., Doughty, R. N., & Baldi, J. C. (2005). Detection of pathologic or physiologic left ventricular remodeling in athletes: Reply. JACC, 45(10), 1731. doi: 10.1016/j.jacc.2005.02.048
Journal - Research Other