Dr Phil Heyward

2024

Conference Contribution - Poster Presentation (not in published proceedings)

Crellin, S., Sheard, P., Glue, P., Heyward, P. M., & De Ridder, D. (2024, August-September). Novel therapeutic targets in the treatment of bipolar disorder. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Crellin, S., Sheard, P., Heyward, P., Glue, P., & de Ridder, D. (2024, August). Effect of bipolar disorder medications: Ex vivo and clinical results. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

Crellin, S., Glue, P., Sheard, P., Heyward, P. M., & De Ridder, D. (2024, August-September). EEG biomarkers and dysconnectivity in bipolar disorder. Verbal presentation at the Queenstown Research Week (QRW) Mental Health Meeting, Queenstown, New Zealand.

2023

Journal - Research Article

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B., & Tups, A. (2023). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Life Metabolism, 2(4), load026. doi: 10.1093/lifemeta/load026

Conference Contribution - Published proceedings: Abstract

Crellin, S., Sheard, P., Heyward, P. M., De Ridder, D., & Glue, P. (2023). Modulation of axonal action potential conduction with bipolar disorder therapeutics. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 48). Retrieved from https://www.awcbr.org

Conference Contribution - Verbal presentation and other Conference outputs

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Perry, N. B., & Tups, A. (2023, August-September). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Verbal presentation at the Queenstown Molecular Biology (QMB) Hypothalamic Neuroscience & Neuroendocrinology Australasia (HNNA) Satellite, Queenstown, New Zealand.

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., … Boer, G. A., Perry, N. B., & Tups, A. (2023, August). From mechanistic biomedical research on hypothalamic inflammation to a dietary supplement for glucose support. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Heyward, P. M., & Tups, A. (2023). Pharmaceutical combinations and methods for the treatment of diabetes and associated disorders. (11,738,001). United States.

2019

Journal - Research Article

Benzler, M., Benzler, J., Stoehr, S., Hempp, C., Rizwan, M. Z., Heyward, P., & Tups, A. (2019). "Insulin-like" effects of palmitate compromise insulin signalling in hypothalamic neurons. Journal of Comparative Physiology B, 189(3-4), 413-424. doi: 10.1007/s00360-019-01220-0

Conference Contribution - Published proceedings: Abstract

Williams, M. R., Hall, M. J., & Heyward, P. M. (2019). Levels of activity-dependent effects on Li⁺ on mitral cell activity. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 57). Retrieved from http://www.otago.ac.nz/awcbr

2018

Conference Contribution - Published proceedings: Abstract

Heyward, P. M., Williams, M. R., & Hall, M. J. (2018). Activity-dependent actions of Li⁺ in brain network connectivity. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 69). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr

2017

Conference Contribution - Published proceedings: Abstract

Kanthakumar, P., Hyland, B. I., & Heyward, P. (2017). Lithium may block the delay current (I_D) in olfactory projection neurons. Proceedings of the Society for Neuroscience 47th Annual Meeting. 375.02/D41. SfN. Retrieved from https://www.sfn.org/

Hall, M. J., Williams, M. R., & Heyward, P. M. (2017). Lithim promotes stereotyped responses to synaptic input: An in vitro olfactory bulb study. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 68). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Deeney, E. A., Power, E. M., Heyward, P. M., & Empson, R. M. (2017). Does voluntary exercise improve motor performance and/or cerebellar architecture in SCA1 moderately ataxic mice. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 50). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Kanthakumar, P., Hyland, B., & Heyward, P. (2017). Lithium may block the delay current (I_D) in olfactory projection neurons. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 38). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Heyward, P. M., Williams, M. R., Hall, M. J., & Kanthakumar, P. (2017). Lithium may enhance brain network coherence by acting on K⁺ channels. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. 35, (pp. 28). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

2014

Conference Contribution - Published proceedings: Abstract

Farley, L. T. A., & Heyward, P. M. (2014). Nitric oxide regulates spontaneous, electrically stimulated, and seizure-like activities in the mouse olfactory bulb in vitro. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 65). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

2012

Journal - Research Article

Igelström, K. M., & Heyward, P. M. (2012). Inhibition of hippocampal excitability by citalopram. Epilepsia, 53(11), 2034-2042. doi: 10.1111/j.1528-1167.2012.03660.x

Igelström, K. M., & Heyward, P. M. (2012). The antidepressant drug fluoxetine inhibits persistent sodium currents and seizure-like events. Epilepsy Research, 101(1-2), 174-181. doi: 10.1016/j.eplepsyres.2012.03.019

Conference Contribution - Published proceedings: Abstract

Farley, L. T. A., & Heyward, P. M. (2012). Nitric oxide in the olfactory bulb in vitro. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 47). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

2011

Journal - Research Article

Igelström, K. M., Shirley, C. H., & Heyward, P. M. (2011). Low-magnesium medium induces epileptiform activity in mouse olfactory bulb slices. Journal of Neurophysiology, 106(5), 2593-2605. doi: 10.1152/jn.00601.2011

Conference Contribution - Published proceedings: Abstract

Igelstrom, K. M., & Heyward, P. M. (2011). Anticonvulsant effects and sodium channel inhibition by selective serotonin reuptake inhibitors. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 8.3. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

2010

Journal - Research Article

Heyward, P. M. (2010). A brain slice bath for physiology and compound microscopy, with dual-sided perifusion. Journal of Microscopy, 240(3), 207-215. doi: 10.1111/j.1365-2818.2010.03382.x

Butler-Munro, C., Coddington, E. J., Shirley, C. H., & Heyward, P. M. (2010). Lithium modulates cortical excitability in vitro. Brain Research, 1352, 50-60. doi: 10.1016/j.brainres.2010.07.021

Shirley, C. H., Coddington, E. J., & Heyward, P. M. (2010). All-or-none population bursts temporally constrain surround inhibition between mouse olfactory glomeruli. Brain Research Bulletin, 81(4-5), 406-415. doi: 10.1016/j.brainresbull.2009.10.022

Conference Contribution - Poster Presentation (not in published proceedings)

Igelstrom, K., & Heyward, P. (2010, September). Epileptiform activity in an olfactory brain circuit. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

2009

Conference Contribution - Published proceedings: Abstract

Heyward, P. (2009). Olfactory bulb output neuron activity in brain slices: Physiology or pathophysiology? Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Coddington, E. J., Shirley, C., Butler-Munro, C., & Heyward, P. M. (2009). Persistent sodium current (I_NaP) regulates excitability and synaptic integration in mitral cells. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Butler-Munro, C., Heyward, P. M., Shirley, C. H., & Coddington, E. (2009). Lithium blocks a transient outward current in output neurons of the olfactory bulb of the brain. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

2008

Chapter in Book - Research

Heinbockel, T., & Heyward, P. M. (2008). Glutamate synapses in olfactory neural circuits. In B. F. Paley & T. E. Warfield (Eds.), Amino acid receptor research. (pp. 391-425). New York: Nova Science.

Conference Contribution - Published proceedings: Abstract

Tantirigama, M., & Heyward, P. (2008). Excitation by GABA in the mouse olfactory bulb is not mediated by a bicarbonate efflux. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf

Igelstrom, K., & Heyward, P. (2008). Inhibitory action of taurine at GABA_A and glycine receptors in the main olfactory bulb of the brain. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf

Shirley, C. H., & Heyward, P. M. (2008). Centre-surround processing in the olfactory bulb is temporal, and intrinsic to the level of sensory input. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Coddington, E., & Heyward, P. (2008). Synaptic integration in mitral cells is regulated by a persistent sodium current (I_NAP-I_NaP). In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 31). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Butler-Munro, C., & Heyward, P. (2008). Lithium treatment in vitro has direct and adaptive effects on neuronal excitability. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 33). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

2007

Conference Contribution - Verbal presentation and other Conference outputs

Shirley, C. H., & Heyward, P. M. (2007, November). Centre-surround processing in olfactory bulb is temporal, and intrinsic to the level of sensory input. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2006

Conference Contribution - Verbal presentation and other Conference outputs

Butler-Munro, C., & Heyward, P. (2006, November-December). The electrophysiological effects of lithium on central neurons in vitro. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

2005

Journal - Research Article

Wachowiak, M., McGann, J. P., Heyward, P. M., Shao, Z., Puche, A. C., & Shipley, M. T. (2005). Inhibition of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx. Journal of Neurophysiology, 94, 2700-2712.

Conference Contribution - Poster Presentation (not in published proceedings)

Shirley, C. H., & Heyward, P. M. (2005, December). Olfactory bulb circuitry in odour coding. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

2004

Journal - Research Article

Puche, A. C., Heyward, P., & Shipley, M. T. (2004). Transmembrane dye labeling and immunohistochemical staining of electrophysiologically characterized single neurons. Journal of Neuroscience Methods, 137(2), 235-240.

Heinbockel, T., Heyward, P., Conquet, F., & Ennis, M. (2004). Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1. Journal of Neurophysiology, 92, 3085-3096.

Conference Contribution - Poster Presentation (not in published proceedings)

Heyward, P. M., Puche, A. C., Aungst, J. L., & Shipley, M. T. (2004, December). Centre-surround inhibition at the first stage of olfactory processing. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

2003

Journal - Research Article

Aungst, J. L., Heyward, P. M., Puche, A. C., Karnup, S. V., Hayar, A., Szabo, G., & Shipley, M. (2003). Centre-surround inhibition among olfactory bulb glomeruli. Nature, 426, 623-629.

Heyward, P. M., & Shipley, M. (2003). A device for automated control of pipette internal pressure for patch-clamp recording. Journal of Neuroscience Methods, 123, 109-115.

Conference Contribution - Published proceedings: Abstract

Aungst, J. L., Heyward, P. M., & Shipley, M. T. (2003). Evidence for dendritic localization of I_H in granule cells of mouse main olfactory bulb. Proceedings of the 33rd Annual Meeting of Society for Neuroscience. [Abstract]

Puche, A. C., Aungst, J. L., Heyward, P. M., Erdelyi, F., Szabo, G., Karnup, S. V., & Shipley, M. T. (2003). Neural basis for interglomerular circuits in the main olfactory bulb. Proceedings of the 25th Annual Meeting of the Association for Chemoreception Sciences. [Abstract]

Aungst, J. L., Heyward, P. M., Hayar, A. M., & Shipley, M. T. (2003). I_H modulation of granule cell function in the mouse main olfactory bulb. Proceedings of the 25th Annual Meeting of the Association for Chemoreception Sciences. [Abstract]

2002

Conference Contribution - Published proceedings: Abstract

Wachowiak, M., Heyward, P., Puche, A., & Shipley, M. T. (2002). Regulation of receptor neuron input to the mouse olfactory bulb mediated by suppression of presynaptic calcium influx. Proceedings of the Society for Neuroscience 32nd Annual Meeting. Washington, DC: SfN. [Abstract]

Wachowiak, M., Heyward, P. M., Puche, A. C., & Shipley, M. T. (2002). Regulation of receptor neuron input to the mouse olfactory bulb mediated by suppression of presynaptic calcium influx. Chemical Senses. 27, (pp. A89). [Abstract]

Heyward, P. M., Izhikevich, E. M., & Shipley, M. T. (2002). Modeling bistability and resonance in the membrane dynamics of mitral cells. Chemical Senses. 27, (pp. A64). [Abstract]

Puche, A. C., Heyward, P. M., & Shipley, M. T. (2002). Ultra-long-lasting depolarizations in response to olfactory nerve input in developing mitral cells. Chemical Senses. 27, (pp. A63). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Heyward, P., & Izhikevich, E. M. (2002, March). Bistability and resonance in dynamics of mitral neurons in olfactory bulb. Poster session presented at the Life Sciences Conference, Boston, MA, USA.

2001

Journal - Research Article

Heyward, P., Ennis, M., Keller, A., & Shipley, M. T. (2001). Membrane bistability in olfactory bulb mitral cells. Journal of Neuroscience, 21(14), 5311-5320.

Hayar, A., Heyward, P. M., Heinbockel, T., Shipley, M. T., & Ennis, M. (2001). Direct excitation of mitral cells via activation of α1-noradrenergic receptors in rat olfactory bulb slices. Journal of Neurophysiology, 86, 2173-2182.

Conference Contribution - Published proceedings: Abstract

Heinbockel, T., Hayar, A., Heyward, P., Shipley, M., & Ennis, M. (2001). Modulation of neural signaling by metabotropic glutamate receptros in rat olfactory bulb slices. In N. Elsner & G. W. Kreutzberg (Eds.), Göttingen Neurobiology Report. 2, (pp. 450). [Abstract]

Heyward, P., Puche, A., & Shipley, M. (2001). Electrophysiology of main olfactory bulb mitral cells during postnatal development: Ultra-long-lasting depolarizations in response to olfactory nerve input. Proceedings of the Society for Neuroscience's 31st Annual Meeting. Washington, DC: SfN. [Abstract]

Heinbockel, T., Hayar, A., Heyward, P. M., Shipley, M. T., & Ennis, M. (2001). Neural activity is modulated by metabotropic glutamate receptors in rat olfactory bulb slices. Chemical Senses. 26, (pp. 1065). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Heinbockel, T., Hayar, A., Heyward, P. M., Shipley, M. T., & Ennis, M. (2001, February). Modulation of neural signaling by metabotropic glutamate receptros in rat olfactory bulb slices. Poster session presented at the Colloquia of the National Academy of Sciences, Washington, DC, USA.

2000

Conference Contribution - Published proceedings: Abstract

Heyward, P. M., Ennis, M., & Shipley, M. T. (2000). A persistent sodium current generates up-state plateau potentials and active subthreshold responses to olfactory nerve input in mitral cells of the main olfactory bulb. Chemical Senses. 25, (pp. 642). [Abstract]

Heyward, P. M., & Shipley, M. T. (2000). Mitral cell intrinsic membrane properties amplify responses to olfactory nerve synaptic input. Proceedings of the Society for Neuroscience's 30th Annual Meeting. Washington, DC: SfN. [Abstract]