Overview
Head of Department of Pathology and Molecular Medicine, Christchurch
Director, Carney Centre for Pharmacogenomics
Laboratory Director, Gene Structure and Function Laboratory
Email martin.kennedy@otago.ac.nz
Tel +64 3 244 1092
Research interests
Professor Martin Kennedy's main research interests are psychiatric genetics, pharmacogenomics, and the genetics of complex disease.
His current research largely focuses on pharmacogenomics, which aims to understand how drugs and genes interact with the goal of improving drug treatments and reducing adverse drug reactions. For example, analysis of genetic variation in genes such as those that encode drug metabolising liver enzymes like CYP2D6 and CYP2C19, is helping to determine genetic factors that impact on response to treatments for various diseases.
For a more comprehensive analysis of genetic factors impacting drug response or risks of adverse drug reactions, they are also applying Next Generation DNA sequencing methods including exome sequencing and other genomic approaches to explore drug response phenotypes.
In order to understand severe adverse drug reactions, his lab has developed a biobank for collecting biological samples of people who have suffered such reactions, called UDRUGS. This biobank is growing, and will enhance efforts to understand genetic factors that contribute to severe adverse drug reactions.
Other research interests include work with the Christchurch Health and Development Study looking at genetic contributions to a range of complex human traits, and a study focusing on the genetics of anorexia nervosa.
In addition, Martin's laboratory is examining the impact of G-quadruplex DNA structures and their relevance to genomic imprinting and other aspects of genome biology.
Education
Professor Kennedy obtained his BSc(Hons) at University of Canterbury, and his PhD in bacterial genetics at the University of Auckland, and carried out postdoctoral research in leukaemia genetics at the Laboratory of Molecular Biology, Cambridge (UK) before returning to University of Otago, Christchurch in 1991.
In the media
Professor Martin Kennedy was interviewed for Radio New Zealand's Our Changing World series in May 2013.
Useful information
Similar research opportunities
- Analysis of the pharmacogene CYP2D6 using nanopore DNA sequencing system
- Genetic and genomic analysis of diseases and their treatments
- Genomics of disease and drug responses
Affiliations
Orcid Identifier
Publications
Publications
Hitchman, L., Kerekere, T. W. A., Miller, A. L., Goodin, E., Koia, C., Watson, H., … Robertson, S. P., Wilcox, P., & Kennedy, M. A. (2026). Allelic diversity of the pharmacogenes CYP2D6 and CYP2C19 in Māori from Te Tairāwhiti, Aotearoa New Zealand. Frontiers in Genetics, 17, 1668409. doi: 10.3389/fgene.2026.1668409 Journal - Research Other
Strom, N. I., Verhulst, B., Bacanu, S.-A., Cheesman, R., Purves, K. L., Gedik, H., … Kennedy, M. A., Boden, J., … Horwood, J., … Hettema, J. M. (2026). Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Nature Genetics, 58(2), 275-288. doi: 10.1038/s41588-025-02485-8 Journal - Research Article
Schaumberg, K., Watson, H. J., Thornton, L. M., Kennedy, H. L., Ong, S. H., Roche, P., … Pettie, M. A., … Jordan, J., Kennedy, M. A., … Bulik, C. M. (2026). Assessment of maladaptive exercise history among individuals with eating disorders: Validation of a brief, self-report measure. European Eating Disorders Review. Advance online publication. doi: 10.1002/erv.70084 Journal - Research Article
Grotzinger, A. D., Werme, J., Peyrot, W. J., Frei, O., de Leeuw, C., Bicks, L. K., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Jordan, J., Kennedy, M. A., … Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, including Pearson, J. F., … Smoller, J. W. (2026). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649(8096), 406-415. doi: 10.1038/s41586-025-09820-3 Journal - Research Article
Pettie, M. A., Simcock, W., Whiskin, A., Clark, M. T. R., Kennedy, H., Kennedy, M., & Jordan, J. (2026). Māori experiences of eating disorders: A scoping review of how little we know. European Eating Disorders Review. Advance online publication. doi: 10.1002/erv.70076 Journal - Research Article
2026
Journal - Research Article
Strom, N. I., Verhulst, B., Bacanu, S.-A., Cheesman, R., Purves, K. L., Gedik, H., … Kennedy, M. A., Boden, J., … Horwood, J., … Hettema, J. M. (2026). Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Nature Genetics, 58(2), 275-288. doi: 10.1038/s41588-025-02485-8
Schaumberg, K., Watson, H. J., Thornton, L. M., Kennedy, H. L., Ong, S. H., Roche, P., … Pettie, M. A., … Jordan, J., Kennedy, M. A., … Bulik, C. M. (2026). Assessment of maladaptive exercise history among individuals with eating disorders: Validation of a brief, self-report measure. European Eating Disorders Review. Advance online publication. doi: 10.1002/erv.70084
Grotzinger, A. D., Werme, J., Peyrot, W. J., Frei, O., de Leeuw, C., Bicks, L. K., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Jordan, J., Kennedy, M. A., … Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, including Pearson, J. F., … Smoller, J. W. (2026). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649(8096), 406-415. doi: 10.1038/s41586-025-09820-3
Pettie, M. A., Simcock, W., Whiskin, A., Clark, M. T. R., Kennedy, H., Kennedy, M., & Jordan, J. (2026). Māori experiences of eating disorders: A scoping review of how little we know. European Eating Disorders Review. Advance online publication. doi: 10.1002/erv.70076
Journal - Research Other
Hitchman, L., Kerekere, T. W. A., Miller, A. L., Goodin, E., Koia, C., Watson, H., … Robertson, S. P., Wilcox, P., & Kennedy, M. A. (2026). Allelic diversity of the pharmacogenes CYP2D6 and CYP2C19 in Māori from Te Tairāwhiti, Aotearoa New Zealand. Frontiers in Genetics, 17, 1668409. doi: 10.3389/fgene.2026.1668409
2025
Journal - Research Article
van der Laan, C. M., Ip, H. F., Schipper, M., Hottenga, J.-J., St Pourcain, B., Zayats, T., … Miller, A., … Boden, J., Pearson, J., Horwood, J., Kennedy, M., Poulton, R., … Boomsma, D. I. (2025). Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57(10), 2427-2435. doi: 10.1038/s41588-025-02295-y
Watson, H. J., Schaumberg, K., Thornton, L. M., Kennedy, H. L., Ong, S. H., Roche, P., … Pettie, M. A., … Jordan, J., Kennedy, M. A., & Bulik, C. M. (2025). Maladaptive exercise in people with a lifetime history of eating disorders: A multicountry observational study. International Journal of Eating Disorders. Advance online publication. doi: 10.1002/eat.24563
Stevens, A. J., Kennedy, M. A., Doudney, K., Kidd, M. J. A., & Rucklidge, J. J. (2025). Potential link between copy number variation and abnormal genome wide DNA methylation profile in an individual with severe ADHD and a strong response to micronutrient treatment. Psychiatry Research Case Reports. Advance online publication. doi: 10.1016/j.psycr.2025.100254
Lawson, R., Watterson, R., Kennedy, M. A., Bulik, C. M., & Jordan, J. (2025). Time taken to reach treatment for eating disorders in New Zealand. Australasian Psychiatry, 3(3), 525-529. doi: 10.1177/10398562241298082
Walker, A., Karlsson, R., Szatkiewicz, J. P., Thornton, L. M., Yilmaz, Z., Leppä, V. M., … Jordan, J., Kennedy, M. A., … Wray, N. R. (2025). Genome-wide copy number variation association study in anorexia nervosa. Molecular Psychiatry, 30, 2009-2016. doi: 10.1038/s41380-024-02811-2
Journal - Research Other
Kennedy, M. A. (2025). The history and future of pharmacogenetics in Aotearoa/New Zealand. Journal of the Royal Society of New Zealand, 55(6), 2422-2439. doi: 10.1080/03036758.2024.2406824
Conference Contribution - Published proceedings: Abstract
Scott-Thomas, A., Chernysheva, E., Zawari, M., Miller, A., Chambers, S., Maze, M., Storer, M., & Kennedy, M. (2025). Detection of Legionella cell-free DNA in blood for the non-invasive diagnosis of Legionnaires' disease. Proceedings of the Infectious Diseases & Pandemic Preparedness Summit. (pp. 62). Retrieved from https://www.teniwha.com
Scott-Thomas, A., Chernysheva, E., Campbell, P., Miller, A., Chambers, S., Anderson, T., Douglas, N., & Kennedy, M. (2025). CRISPR-Cas12a detection of Mycobacterium leprae DNA in human samples for the diagnosis of leprosy. Proceedings of the Infectious Diseases & Pandemic Preparedness Summit. (pp. 61). Retrieved from https://www.teniwha.com
Scott-Thomas, A., Zawari, M., Chernysheva, E., Wolf, K., Anderson, T., Miller, A., Maze, M., Storer, M., Kennedy, M., Douglas, N., Faatoese, A., & Chambers, S. (2025). Microbial cell-free DNA: A non-invasive approach to diagnosing infectious diseases. Proceedings of the Infectious Diseases & Pandemic Preparedness Summit. (pp. 49). Retrieved from https://www.teniwha.com
Campbell, P., Naniseni, T., Miller, A., Rimon, E., Ioteba, N., Anderson, T., … Kennedy, M., Douglas, N., & Chambers, S. (2025). Improving the safety and effectiveness of leprosy treatment in Kiribati through enhanced molecular diagnostics. Proceedings of the Infectious Diseases & Pandemic Preparedness Summit. (pp. 31-32). Retrieved from https://www.teniwha.com
Myall, D. J., Sheat, C., Collins, M. F., Dalrymple-Alford, J., Simpson, M., Graham, O., Miller, A., Kennedy, M., Anderson, T. J., & Pitcher, T. L. (2025). Frequency of Parkinson's genetic risk variants in New Zealand. In A. Banstola (Ed.), Proceedings of the 41st International Australasian Winter Conference on Brain Research (AWCBR). 4.6, (pp. 43). Retrieved from https://www.awcbr.org
Hitchman, L. M., Magon, N. J., Miller, A. L., Sheen, C. R., Dunn, E., Bozonet, S. M., Pearson, J. F., … Faatoese, A., Merriman, T. R., Kettle, A. J., & Kennedy, M. A. (2025). CYP2D6*71 is a poor metaboliser allele common in Polynesian and Māori people and absent from Europeans. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
2024
Journal - Research Article
Berthold, N., Gaudieri, S., Hood, S., Tschochner, M., Miller, A. L., Jordan, J., … Kennedy, M. A. (2024). Nanopore sequencing as a novel method of characterising anorexia nervosa risk loci. BMC Genomics, 25, 1262. doi: 10.1186/s12864-024-11172-7
Stevens, A. J., Heiwari, T. M., Rich, F. J., Bradley, H. A., Gur, T. L., Galley, J. D., Kennedy, M. A., … Mulder, R. T., & Rucklidge, J. J. (2024). Randomised control trial indicates micronutrient supplementation may support a more robust maternal microbiome for women with antenatal depression during pregnancy. Clinical Nutrition, 3, 120-132. doi: 10.1016/j.clnu.2024.09.004
Conference Contribution - Published proceedings: Abstract
Pitcher, T. L., Collins, M. F., Sheat, C., Simpson, M., Douwes, J., Noyce, A., Kennedy, M., Anderson, T. J., & Myall, D. J. (2024). The New Zealand Parkinson’s Environment and Genes Study (NZPEGS). In K.-L. Horne (Ed.), Proceedings of the 40th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 29). Retrieved from https://www.awcbr.org
Kerekere, T. W. A., Hitchman, L., Miller, A. L., Goodin, E., Koia, C., Watson, H., Robertson, S. P., Wilcox, P., & Kennedy, M. A. (2024). Allelic diversity of pharmacogenes CYP2D6 and CPY2C19 in Māori from Te Tairāwhiti, Aotearoa New Zealand. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org
Kennedy-Smith, H., Pettie, M., Cleland, L., Miller, A., Hitchman, L., Thornton, L., Bulik, C., Kennedy, M., & Jordan, J. (2024). New Zealand's contribution to an international eating disorders GWAS: Eating Disorders Genetics Initiative (EDGI). Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org
Graham, O., Pitcher, T., Anderson, T., Kennedy, M., Myall, D., Collins, M., & Sheat, C. (2024). GBA1 variants as modifiers of Parkinson's disease (PD) in New Zealand Parkinson's environment and gene study (NZPEGS). Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org
Ayora, I., Graham, O., Miller, A., Bozonet, S., Helem, S., & Kennedy, M. (2024). Analysis of gene expression impacts of valproate on a human induced pluripotent stem cell line using long read RNA-sequencing. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org
Berthold, N., Gaudieri, S., Hood, S., Tschochner, M., Akkari, P. A., & Kennedy, M. (2024). Home base: Characterising structural genetic variation at the individual level in anorexia nervosa. European Neuropsychopharmacology, 87(Suppl. 1), (pp. 113-114). doi: 10.1016/j.euroneuro.2024.08.233
Other Research Output
Kennedy, M. (2024, June). CYP2D6: The gene we do and don't need. UOC Biomedical Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2023
Chapter in Book - Research
Kee, P. S., Karunanathie, H., Maggo, S. D. S., Kennedy, M. A., & Chua, E. W. (2023). Long-range polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods and protocols: Methods in molecular biology (Vol. 2967). (2nd ed.) (pp. 181-192). New York, NY: Humana. doi: 10.1007/978-1-0716-3358-8_15
Journal - Research Article
Morillon, M. B., Nørup, A., Singh, J. A., Dalbeth, N., Taylor, W. J., Kennedy, M. A., … Grainger, R., … Stamp, L. K., on behalf of the OMERACT Gout Working Group. (2023). Outcome reporting in randomized trials in gout: A systematic scoping review from the OMERACT gout working group assessing the uptake of the core outcome set. Seminars in Arthritis & Rheumatism, 60, 152191. doi: 10.1016/j.semarthrit.2023.152191
Kee, P. S., Maggo, S. D. S., Kennedy, M. A., & Chin, P. K. L. (2023). The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses [Brief research report]. Frontiers in Pharmacology, 14, 1080117. doi: 10.3389/fphar.2023.1080117
Cleland, L., Kennedy, H. L., Pettie, M. A., Kennedy, M. A., Bulik, C. M., & Jordan, J. (2023). Eating disorders, disordered eating, and body image research in New Zealand: A scoping review. Journal of Eating Disorders, 11(1), 7. doi: 10.1186/s40337-022-00728-1
Johnson, J. S., Cote, A. C., Dobbyn, A., Sloofman, L. G., Xu, J., Cotter, L., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J. M., Pearson, J. F., … Jordan, J., Kennedy, M., … Huckins, L. M. (2023). Mapping anorexia nervosa genes to clinical phenotypes. Psychological Medicine, 53, 2619-2633. doi: 10.1017/s0033291721004554
Journal - Research Other
Turner, A. J., Nofziger, C., Ramey, B. E., Ly, R. C., Bousman, C. A., Agúndez, J. A. G., … Kennedy, M. A., … Gaedigk, A. (2023). PharmVar tutorial on CYP2D6 structural variation testing and recommendations on reporting [Tutorial]. Clinical Pharmacology & Therapeutics, 114(6), 1220-1237. doi: 10.1002/cpt.3044
Prickett, T. C. R., Pearson, J. F., Troughton, R. W., Kennedy, M. A., & Espiner, E. A. (2023). The predictive value of A, B, and C-type natriuretic peptides in people at risk of heart disease: Protocol for a longitudinal observational study. JMIR Research Protocols, 12, e37011. doi: 10.2196/37011
Conference Contribution - Verbal presentation and other Conference outputs
Kerekere, T. W., Hitchman, L., Miller, A. L., Wilcox, P., Robertson, S., Watson, H., & Kennedy, M. A. (2023, August). Nanopore sequencing of the pharmacogene CYP2C19 in a Ngāti Porou Hauora cohort. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand.
Berthold, N., Akkari, P. A., & Kennedy, M. (2023, August). Finding new ways forward: Nanopore sequencing as a novel method of characterizing anorexia nervosa associated genetics. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand.
2022
Journal - Research Article
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Frontiers in Genetics, 13, 1016416. doi: 10.3389/fgene.2022.1016416
Xu, J., Johnson, J. S., Signer, R., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Birgegård, A., Jordan, J., Kennedy, M. A., … Bulik, C. M., & Huckins, L. M. (2022). Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: A phenome-wide and polygenic risk study. Lancet Digital Health, 4, e604-e614. doi: 10.1016/S2589-7500(22)00099-1
Noble, A. J., Pearson, J. F., Noble, A. D., Boden, J. M., Horwood, L. J., Kennedy, M. A., & Osborne, A. J. (2022). DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence. Reproduction, Fertility & Development, 34(7), 540-548. doi: 10.1071/rd21108
Surgenor, L. J., Dhakal, S., Watterson, R., Lim, B., Kennedy, M., Bulik, C., … Jordan, J. (2022). Psychosocial and financial impacts for carers of those with eating disorders in New Zealand. Journal of Eating Disorders, 10, 37. doi: 10.1186/s40337-022-00565-2
Karunanathie, H., Kee, P. S., Ng, S. F., Kennedy, M. A., & Chua, E. W. (2022). PCR enhancers: Types, mechanisms, and applications in long-range PCR. Biochimie, 197, 130-143. doi: 10.1016/j.biochi.2022.02.009
Watson, H. J., Thornton, L. M., Yilmaz, Z., Baker, J. H., Coleman, J. R. I., Adan, R. A. H., … Boden, J. M., … Horwood, L. J., … Jordan, J., Kennedy, M., … Bulik, C. M. (2022). Common genetic variation and age at onset of anorexia nervosa. Biological Psychiatry: Global Open Science, 2, 368-378. doi: 10.1016/j.bpsgos.2021.09.001
Journal - Research Other
Kee, P. S., Maggo, S. D. S., Kennedy, M. A., Barclay, M. L., Miller, A. L., Lehnert, K., … Chin, P. K. L. (2022). Omeprazole treatment failure in gastroesophageal reflux disease and genetic variation at the CYP2C locus [Brief research report]. Frontiers in Genetics, 13, 869160. doi: 10.3389/fgene.2022.869160
MacDermod, C., Pettie, M. A., Carrino, E. A., Cruz Garcia, S., Padalecki, S., Finch, J. E., … Kennedy, H. L., … Kennedy, M. A., Cleland, L., Jordan, J., … Bulik, C. M. (2022). Recommendations to encourage participation of individuals from diverse backgrounds in psychiatric genetic studies. American Journal of Medical Genetics Part B, 189B, 163-173. doi: 10.1002/ajmg.b.32906
Kennedy, H. L., Dinkler, L., Kennedy, M. A., Bulik, C. M., & Jordan, J. (2022). How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID). Journal of Eating Disorders, 10, 53. doi: 10.1186/s40337-022-00578-x
Stevens, A. J., de Jong, L., & Kennedy, M. A. (2022). The dynamic regulation of G-quadruplex DNA structures by cytosine methylation. International Journal of Molecular Sciences, 23, 2407. doi: 10.3390/ijms23052407
Conference Contribution - Published proceedings: Abstract
Sidari, M., Mitchell, B., Conde, L. C., Maguire, S., Kennedy, M., Jordan, J., … Martin, N. (2022). Using multi-polygenic risk score analyses to predict anorexia nervosa case status. European Neuropsychopharmacology, 63, (pp. e125). doi: 10.1016/j.euroneuro.2022.07.233
Conference Contribution - Poster Presentation (not in published proceedings)
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022, August-September). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Poster session presented at the 31st Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Liau, Y., Maggo, S., Lehnert, K., Doogue, M. P., Scull, A., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2022, August-September). Genomic analysis of angiotensin converting enzyme inhibitor-induced angioedema. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Kee, P. S., Maggo, S., Kennedy, M. A., Barclay, M. L., Miller, A., Lehnert, K., … Faull, R. L. M., … Chin, P. K. L. (2022, August-September). Omeprazole treatment failure in gastro-oesophageal reflux disease and genetic variation at the CYP2C locus. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
2021
Journal - Research Article
Morillon, M. B., Christensen, R., Singh, J. A., Dalbeth, N., Saag, K., Taylor, W. J., … Kennedy, M. A., … Grainger, R., … Stamp, L. K., for the OMERACT Gout Working Group. (2021). Serum urate as a proposed surrogate outcome measure in gout trials: From the OMERACT Working Group. Seminars in Arthritis & Rheumatism, 51, 1378-1385. doi: 10.1016/j.semarthrit.2021.11.004
Ip, H. F., van der Laan, C. M., Krapohl, E. M. L., Brikell, I., Sánchez-Mora, C., Nolte, I. M., … Miller, A., … Boden, J., Pearson, J., Horwood, L. J., Kennedy, M., Poulton, R., … Boomsma, D. I. (2021). Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry, 11, 413. doi: 10.1038/s41398-021-01480-x
Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6
Nabais, M. F., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., … Anderson, T. J., … Kennedy, M., … Pearson, J., Pitcher, T. L., … McRae, A. F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22(1), 90. doi: 10.1186/s13059-021-02275-5
Sinha, P., Cree, S. L., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2021). Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms. Pharmacogenomics Journal, 21, 359-375. doi: 10.1038/s41397-021-00215-x
Noble, A. J., Pearson, J. F., Boden, J. M., Horwood, L. J., Gemmell, N. J., Kennedy, M. A., & Osborne, A. J. (2021). A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing. PeerJ, 9, e10762. doi: 10.7717/peerj.10762
Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M. A., … Agrawal, A. (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, 26, e12880. doi: 10.1111/adb.12880
Journal - Research Other
Bulik, C. M., Thornton, L. M., Parker, R., Kennedy, H., Baker, J. H., MacDermod, C., … Cleland, L., Miller, A. L., … Jordan, J., Kennedy, M. A., & Martin, N. G. (2021). The Eating Disorders Genetics Initiative (EDGI): Study protocol. BMC Psychiatry, 21(1), 234. doi: 10.1186/s12888-021-03212-3
Conference Contribution - Published proceedings: Abstract
Noble, A. J., Pearson, J. F., Kennedy, M. A., Boden, J. M., Horwood, L. J., & Osborne, A. J. (2021). Does DNA methylation link the association between maternal tobacco use during pregnancy and altered offspring neurodevelopment. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 292). Retrieved from https://www.faobmb2021.org
Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Other Research Output
Kennedy, M. (2021, October). EDGing towards understanding the genetics of eating disorders. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2020
Journal - Research Article
Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., … Melzer, T. R., … Pearson, J. F., Pitcher, T. L., … Anderson, T. J., … Kennedy, M. A., … Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)–Genetics working group. (2020). The genetic architecture of the human cerebral cortex. Science, 367, 1340. doi: 10.1126/science.aay6690
Johnson, E. C., Demontis, D., Thorgeirsson, T. E., Walters, R. K., Polimanti, R., Hatoum, A. S., … Boden, J., … Pearson, J. F., … Horwood, J., … Kennedy, M. A., … Agrawal, A. (2020). A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry, 7, 1032-1045. doi: 10.1016/S2215-0366(20)30339-4
Cree, S. L., Chua, E. W., Crowther, J., Dobson, R. C. J., & Kennedy, M. A. (2020). G-quadruplex structures bind to EZ-Tn5 transposase. Biochimie, 177, 190-197. doi: 10.1016/j.biochi.2020.07.022
Schierding, W., Farrow, S., Fadason, T., Graham, O. E. E., Pitcher, T. L., Qubisi, S., … Anderson, T. J., Kennedy, M. A., … O'Sullivan, J. M. (2020). Common variants coregulate expression of GBA and modifier genes to delay Parkinson's disease onset. Movement Disorders, 35(8), 1346-1356. doi: 10.1002/mds.28144
Bulik, C., Kennedy, M., & Wade, T. (2020). ANGI: Anorexia Nervosa Genetics Initiative. Twin Research & Human Genetics, 23, 135-136. doi: 10.1017/thg.2020.24
Bryois, J., Skene, N. G., Folmann Hansen, T., Kogelman, L. J. A., Watson, H. J., Liu, Z., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J., … Jordan, J., … Kennedy, M., … Pearson, J., … Sullivan, P. F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52, 482-493. doi: 10.1038/s41588-020-0610-9
Osborne, A. J., Pearson, J. F., Noble, A. J., Gemmell, N. J., Horwood, L. J., Boden, J. M., … Kennedy, M. A. (2020). Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. Translational Psychiatry, 10, 114. doi: 10.1038/s41398-020-0800-3
Vallerga, C. L., Zhang, F., Fowdar, J., McRae, A. F., Qi, T., Nabais, M. F., … Kennedy, M., … Gratten, J. (2020). Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease. Nature Communications, 11, 1238. doi: 10.1038/s41467-020-15065-7
Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761
Searchfield, G. D., Poppe, T. N. E. R., Durai, M., Jensen, M., Kennedy, M. A., Maggo, S., Miller, A. L., … Russell, B. R., … Wise, K. (2020). A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity. International Journal of Neuroscience, 130(7), 671-682. doi: 10.1080/00207454.2019.1702544
Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022
Heft, I. E., Mostovoy, Y., Levy-Sakin, M., Ma, W., Stevens, A. J., Pastor, S., … Kennedy, M. A., … Sikela, J. M. (2020). The driver of extreme human-specific Olduvai repeat expansion remains highly active in the human genome. Genetics, 214, 179-191. doi: 10.1534/genetics.119.302782
Journal - Research Other
Kee, P. S., Chin, P. K. L., Kennedy, M. A., & Maggo, S. D. S. (2020). Pharmacogenetics of statin-induced myotoxicity. Frontiers in Genetics, 11, 575678. doi: 10.3389/fgene.2020.575678
Adehin, A., Kennedy, M. A., Soyinka, J. O., Alatise, O. I., Olasehinde, O., & Bolaji, O. O. (2020). Breast cancer and tamoxifen: A Nigerian perspective to effective personalised therapy. Breast Cancer, 12, 123-130. doi: 10.2147/BCTT.S266314
Nofziger, C., Turner, A. J., Sangkuhl, K., Whirl-Carrillo, M., Agúndez, J. A. G., Black, J. L., … Kennedy, M. A., … Gaedigk, A. (2020). PharmVar GeneFocus: CYP2D6. Clinical Pharmacology & Therapeutics, 107(1), 154-170. doi: 10.1002/cpt.1643
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Jordan, J., Miller, A. L., Cleland, L., Kennedy, H. L., & Bulik, C. (2020). The genetics of eating disorders: What do we know and where are we going? Proceedings of the Genetics Otago (GO) Zoom Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/
Noble, A., Pearson, J., Boden, J., Horwood, J., Kennedy, M., & Osborne, A. (2020). Understanding the interaction between maternal tobacco use during pregnancy and adult offspring with conduct disorder. New Zealand Medical Journal, 133(1524), (pp. 144). Retrieved from https://www.nzma.org.nz/journal
2019
Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Maggo, S. D. S., Sycamore, K. L. V., Miller, A. L., & Kennedy, M. A. (2019). The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand. Frontiers in Psychiatry, 10, 690. doi: 10.3389/fpsyt.2019.00690
Liau, Y., Cree, S. L., Maggo, S., Miller, A. L., Pearson, J. F., Gladding, P. A., & Kennedy, M. A. (2019). A multiplex pharmacogenetics assay using the MinION nanopore sequencing device. Pharmacogenetics & Genomics, 29(9), 207-215. doi: 10.1097/fpc.0000000000000385
Liau, Y., Maggo, S., Miller, A. L., Pearson, J. F., Kennedy, M. A., & Cree, S. L. (2019). Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications. Pharmacogenomics, 20(14), 1033-1047. doi: 10.2217/pgs-2019-0080
Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., … Kennedy, M., Pitcher, T., Pearson, J., … Anderson, T., … Visscher, P. M. (2019). Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine, 11(1), 54. doi: 10.1186/s13073-019-0667-1
Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y
Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., … Roberts, M., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M., … Bulik, C. M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51, 1207-1214. doi: 10.1038/s41588-019-0439-2
Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9, 10128. doi: 10.1038/s41598-019-46146-3
Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, including Jordan, J., Kennedy, M. A., … Substance Use Disorder Working Group of the PGC, including Horwood, L. J., Pearson, J. F., … Polderman, T. J. C. (2019). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, 49(7), 1166-1173. doi: 10.1017/S0033291718002039
Reynolds, R. H., Botía, J., Nalls, M. A., International Parkinson's Disease Genomics Consortium (IPDGC), including System Genomics of Parkinson's Disease (SGPD), Anderson, T., … Kennedy, M., Pearson, J., … Ryten, M. (2019). Moving beyond neurons: The role of cell type-specific gene regulation in Parkinson's disease heritability. npj Parkinson's Disease, 5, 6. doi: 10.1038/s41531-019-0076-6
Watson, G. M., Chan, C. W., Belluscio, L., Doudney, K., Lacey, C. J., Kennedy, M. A., & Bridgman, P. (2019). Comparing the variants of takotsubo syndrome: An observational study of the ECG and structural changes from a New Zealand tertiary hospital. BMJ Open, 9(5), e025253. doi: 10.1136/bmjopen-2018-025253
Balasubramanian, D., Pearson, J. F., & Kennedy, M. A. (2019). Gene expression effects of lithium and valproic acid in a serotonergic cell line. Physiological Genomics, 51, 43-50. doi: 10.1152/physiolgenomics.00069.2018
Richards, A., Horwood, J., Boden, J., Kennedy, M., Sellers, R., Riglin, L., … Harold, G. T. (2019). Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study. British Journal of Psychiatry, 214, 96-102. doi: 10.1192/bjp.2018.227
Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476
Rucklidge, J. J., Eggleston, M. J. F., Darling, K., Stevens, A., Kennedy, M., & Frampton, C. M. (2019). Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 89, 181-192. doi: 10.1016/j.pnpbp.2018.09.007
Adehin, A., Adeagbo, B. A., Kennedy, M. A., Bolaji, O. O., Olugbade, T. A., Bolarinwa, R. A., & Durosinmi, M. A. (2019). Inter-individual variation in imatinib disposition: Any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in Nigerian CML patients? Leukemia & Lymphoma, 60(1), 216-221. doi: 10.1080/10428194.2018.1466291
Journal - Research Other
Maggo, S., Kennedy, M. A., Barczyk, Z. A., Miller, A. L., Rucklidge, J. J., Mulder, R. T., & Foulds, J. A. (2019). Common CYP2D6, CYP2C9, and CYP2C19 gene variants, health anxiety, and neuroticism are not associated with self-reported antidepressant side effects [Brief report]. Frontiers in Genetics, 10, 1199. doi: 10.3389/fgene.2019.01199
Chua, E. W., Harger, S. P., & Kennedy, M. A. (2019). Metoclopramide-induced acute dystonic reactions may be associated with the CYP2D6 poor metabolizer status and pregnancy-related hormonal changes. Frontiers in Pharmacology, 10, 931. doi: 10.3389/fphar.2019.00931
Liau, Y., Chua, I., Kennedy, M. A., & Maggo, S. (2019). Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema. Clinical & Experimental Allergy, 49, 142-154. doi: 10.1111/cea.13326
Conference Contribution - Published proceedings: Abstract
Osborne, A., Pearson, J., Noble, A., Gemmell, N., Horwood, J., Boden, J., Hore, T., … Kennedy, M. (2019). Genome-wide DNA methylation analysis in the Christchurch Health and Development Study reveals potential for epigenetic effects of cannabis use on pathways involved neurodevelopment and neuronal signalling. Proceedings of the 16th Asian Conference on Transcription. (pp. 55). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02
Doudney, K., Lacey, C. J., Bridgman, P. G., Mulder, R. T., Zarifeh, J. J., Kimber, B., Cadzow, M., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2019). Rare copy number variants involving cardiac function and development genes detected in earthquake induced takotsubo cardiomyopathy patients. European Journal of Human Genetics, 27(Suppl. 1), (pp. 160). doi: 10.1038/s41431-019-0407-4
Liu, W., Liau, Y., Maggo, S., Doogue, M., & Kennedy, M. (2019). Exploring combinatorial genetic contributions to a serious adverse drug reaction. Proceedings of the MapNet Meeting. (pp. 28). Retrieved from http://mapnet2019.nz/
Maggo, S., Kennedy, M., Barczyk, Z., Miller, A., Rucklidge, J., Mulder, R., & Foulds, J. (2019). Pharmacogenetic variants and psychological factors do not explain self-reported antidepressant side effects. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 66). Retrieved from https://www.asceptasm.com
Sinha, P., Cree, S., Balasubramanian, D., Pearson, J., & Kennedy, M. (2019). Gene expression effects of valproic acid in a serotonergic cell line. European Neuropsychopharmacology, 29(Suppl. 4), (pp. S1248-S1249). doi: 10.1016/j.euroneuro.2018.08.331
Osborne, A., Pearson, J., Gemmell, N., Boden, J., Horwood, J., & Kennedy, M. (2019). Methylome impacts of cannabis use in the Christchurch Health and Development Study. European Neuropsychopharmacology, 29(Suppl. 3), (pp. S851). doi: 10.1016/j.euroneuro.2017.08.125
Conference Contribution - Verbal presentation and other Conference outputs
Pearson, J., Osborne, A., Noble, A., Kennedy, M., Horwood, J., & Boden, J. (2019, August-September). Epigenetic impact of cannabis use in the Christchurch Health and Development Study. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Noble, A., Pearson, J., Boden, J., Horwood, J., Kennedy, M., & Osborne, A. (2019, August-September). Understanding the relationship between maternal tobacco smoking and offspring conduct disorder: Are metastable epialleles present? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kennedy, M. (2019, October). Genetics as a key to understanding and improved treatment of mental disorders. Verbal presentation at the Otago Spotlight Series: Mental Health Research, Wellington, New Zealand.
Working Paper; Discussion Paper; Technical Report
Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M. A., … Agrawal, A. (2019). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. bioRxiv. doi: 10.1101/741512
Osborne, A. J., Pearson, J. F., Noble, A. J., Gemmell, N. J., Horwood, L. J., Boden, J. M., … Kennedy, M. A. (2019). Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. bioRxiv. Retrieved from https://www.biorxiv.org/content/10.1101/829598v2.supplementary-material
2018
Journal - Research Article
Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., … Kennedy, M. A., … Pearson, J. F., … Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience, 21(12), 1656-1669. doi: 10.1038/s41593-018-0275-1
Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2018). Genetic polymorphism of CYP2C9 and VKORC1 in the Nigerian population: Significance for warfarin therapy in the population. Polish Annals of Medicine, 25(2), 180-183. doi: 10.29089/2017.17.00041
Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., … Horwood, L. J., Boden, J. M., Pearson, J. F., … Jordan, J., Kennedy, M. A., … Bulik, C. M. (2018). The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials, 74, 61-69. doi: 10.1016/j.cct.2018.09.015
Stevens, A. J., Rucklidge, J. J., Darling, K. A., Eggleston, M. J. F., Pearson, J. F., & Kennedy, M. A. (2018). Methylomic changes in response to micronutrient supplementation and MTHFR genotype. Epigenomics, 10(9), 1201-1214. doi: 10.2217/epi-2018-0029
Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., … Kennedy, M. A., … Gearry, R. B., … Barclay, M. (2018). Nonsynonymous polymorphism in guanine monophosphate synthetase is a risk factor for unfavorable thiopurine metabolite ratios in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 24(12), 2606-2612. doi: 10.1093/ibd/izy163
Lacey, C. J., Doudney, K., Bridgman, P. G., George, P. M., Mulder, R. T., Zarifeh, J. J., Kimber, B., Cadzow, M. J., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2018). Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. Scientific Reports, 8, 7548. doi: 10.1038/s41598-018-25827-5
Ton, K. N. T., Cree, S. L., Gronert-Sum, S. J., Merriman, T. R., Stamp, L. K., & Kennedy, M. A. (2018). Multiplexed nanopore sequencing of HLA-B locus in Māori and Pacific Island samples. Frontiers in Genetics, 9, 152. doi: 10.3389/fgene.2018.00152
Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2018). Epigenetics, nutrition and mental health: Is there a relationship? [Review]. Nutritional Neuroscience, 21(9), 602-613. doi: 10.1080/1028415x.2017.1331524
Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., … Horwood, J., … Fergusson, D. M., … Kennedy, M., … Bierut, L. J. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23, 133-142. doi: 10.1038/mp.2017.44
Journal - Research Other
Kennedy, M. A. (2018). A genome project for Māori and Pasifika: Charting a path to equity in genomic medicine for Aotearoa. New Zealand Medical Journal, 131(1480), 8-10. Retrieved from https://www.nzma.org.nz/journal
Gurney, J. K., Stanley, J., McGlynn, K., Richiardi, L., Shaw, C., Edwards, R., Merriman, T. R., Robson, B., … McLeod, M., Kennedy, M. A., & Sarfati, D. (2018). Testicular Cancer in New Zealand (TCNZ) study: Protocol for a national case-control study. BMJ Open, 8, e025212. doi: 10.1136/bmjopen-2018-025212
Conference Contribution - Published proceedings: Abstract
Maggo, S., Liau, Y., Doogue, M., & Kennedy, M. (2018). Understanding drug reactions using genome sequencing (UDRUGS) study: A New Zealand initiative to investigate the genetics of ADRs. Basic & Clinical Pharmacology & Toxicology, 123(Suppl. 1), (pp. 3). doi: 10.1111/bcpt.13020
Conference Contribution - Poster Presentation (not in published proceedings)
Das, A., Morison, I., Kennedy, M., & Vissers, M. (2018, April). The potential use of ascorbate as an epigenetic therapeutic in acute myeloid leukaemia by enhancing 2-oxoglutarate dependent dioxygenase activity. Poster session presented at the Keystone Symposium: Therapeutic Targeting of Hypoxia-Sensitive Pathways, Oxford, UK.
Conference Contribution - Verbal presentation and other Conference outputs
Sinha, P., Cree, S., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2018, August). Gene expression effects of sodium valproate in a serotonergic cell line. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
King, M., Kennedy, M., Rhodes, S., & Brown, A. (2018, June). Opening the doors on animal research. Panel discussion at the Australian and New Zealand Laboratory Animal Association (ANZLAA) New Zealand Branch Winter Meeting, Christchurch, New Zealand.
2017
Chapter in Book - Research
Chua, E. W., Maggo, S., & Kennedy, M. A. (2017). Long fragment polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods in molecular biology (Vol. 1620). (pp. 65-74). New York, NY: Springer. doi: 10.1007/978-1-4939-7060-5_3
Journal - Research Article
Whitefield, J., & Kennedy, M. (2017). Above the threshold. Junctures, 2017(18), 9-18.
Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Jordan, J., Kennedy, M., … Bulik, C. M. (2017). Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. American Journal of Psychiatry, 174(9), 850-858. doi: 10.1176/appi.ajp.2017.16121402
Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2017). Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population. Drug Metabolism & Personalized Therapy, 32(1), 39-47. doi: 10.1515/dmpt-2016-0041
Adehin, A., Bolaji, O. O., & Kennedy, M. A. (2017). Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population. Drug Metabolism & Pharmacokinetics, 32(3), 189-191. doi: 10.1016/j.dmpk.2016.09.001
Adehin, A., Bolaji, O. O., Kennedy, M. A., & Adeagbo, B. A. (2017). Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population. Polish Annals of Medicine, 24(2), 144-147. doi: 10.1016/j.poamed.2016.06.007
Stevens, A. J., & Kennedy, M. A. (2017). Methylated cytosine maintains G-quadruplex structures during polymerase chain reaction and contributes to allelic dropout. Biochemistry, 56(29), 3691-3698. doi: 10.1021/acs.biochem.7b00480
Kirk, K. M., Martin, F. C., Mao, A., Parker, R., Maguire, S., Thornton, L. M., … Jordan, J., Kennedy, M. A., … Martin, N. G. (2017). The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm. Australian & New Zealand Journal of Psychiatry, 51(6), 583-594. doi: 10.1177/0004867417700731
Shchepetkina, A. A., Hock, B. D., Miller, A., Kennedy, M. A., & Gieseg, S. P. (2017). Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. International Journal of Biochemistry & Cell Biology, 87, 27-33. doi: 10.1016/j.biocel.2017.03.017
Bagshaw, A. T. M., Horwood, L. J., Fergusson, D. M., Gemmell, N. J., & Kennedy, M. A. (2017). Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. BMC Medical Genetics, 18, 12. doi: 10.1186/s12881-017-0374-y
Stevens, A. J., Taylor, M. G., Pearce, F. G., & Kennedy, M. A. (2017). Allelic dropout during polymerase chain reaction due to G-quadruplex structures and DNA methylation is widespread at imprinted human loci. Genes Genomes Genetics, 7(3), 1019-1025. doi: 10.1534/g3.116.038687
Stevens, A. J., & Kennedy, M. A. (2017). Structural analysis of G-quadruplex formation at the human MEST promoter. PLoS ONE, 12(1), e0169433. doi: 10.1371/journal.pone.0169433
Appleby, S., Pearson, J. F., Aitchison, A., Spittlehouse, J. K., Joyce, P. R., & Kennedy, M. A. (2017). Mean telomere length is not associated with current health status in a 50-year-old population sample. American Journal of Human Biology, 29(1), e22906. doi: 10.1002/ajhb.22906
Conference Contribution - Published proceedings: Abstract
Osborne, A., Pearson, J., Hore, T., Horwood, J., Macartney-Coxson, D., Gemmell, N., & Kennedy, M. (2017). Identifying methylome changes in response to heavy, long-term cannabis use, in a large longitudinal cohort. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 519. Retrieved from http://gen2017.w.events4you.currinda.com
Cree, S., Maggo, S., Slow, S., Ton, K., de Jong, L., Anderson, T., Pearson, J., Miller, A., Walker, L., Murdoch, D., & Kennedy, M. (2017). Long read nanopore sequencing in the laboratory. Proceedings of the MapNet Conference. Retrieved from http://scienceevents.co.nz/mapnet/
Kennedy, M. A., Maggo, S. D. S., Foulds, J., Luty, S., Chua, E. W., Cree, S., Ton, K., Liau, Y., Miller, A. L., Chin, P., … Doogue, M. (2017). DNA banking and genetic analysis of adverse drug reactions in the New Zealand healthcare setting. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 2123. Retrieved from http://www.ashg.org/2017meeting/
Conference Contribution - Poster Presentation (not in published proceedings)
Das, A., Morison, I., Kennedy, M., & Vissers, M. (2017, October). The potential use of ascorbate as an epigenetic drug in acute myeloid leukaemia. Poster session presented at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. A., Cree, S. L., Miller, A. L., Pearson, J., Maggo, S., Liau, Y., Ton, K., de Jong, L., & Walker, L. C. (2017, September). The MinION nanopore sequencer: Toy or tool? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Liau, Y., Cree, S. M., Maggo, S., Miller, A. L., Pearson, J., & Kennedy, M. A. (2017, September). A nanopore sequencing-based multiplex assay for pharmacogenetics of clopidogrel and warfarin. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Osborne, A. J., Pearson, J. F., Horwood, J., Hore, T., Macartney-Coxson, D., Gemmell, N. J., & Kennedy, M. A. (2017, September). Cannabis use and epigenetics: EPIC insights into the human methylome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Working Paper; Discussion Paper; Technical Report
Lacey, C. J., Doudney, K., Bridgman, P. G., George, P. M., Mulder, R. T., Zarifeh, J. A., Kimber, B., Cadzow, M. J., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2017). Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. bioRxiv. doi: 10.1101/144675
2016
Journal - Research Article
Cree, S. L., Fredericks, R., Miller, A., Pearce, F. G., Filichev, V., Fee, C., & Kennedy, M. A. (2016). DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters, 590(17), 2870-2883. doi: 10.1002/1873-3468.12331
Stevens, A. J., Kennedy, H. L., & Kennedy, M. A. (2016). Fluorescence methods for probing G-quadruplex structure in single- and double-stranded DNA. Biochemistry, 55(26), 3714-3725. doi: 10.1021/acs.biochem.6b00327
Osborne, A. J., Negro, S. S., Chilvers, B. L., Robertson, B. C., Kennedy, M. A., & Gemmell, N. J. (2016). Genetic evidence of a population bottleneck and inbreeding in the endangered New Zealand sea lion, Phocarctos hookeri. Journal of Heredity, 107(5), 392-402. doi: 10.1093/jhered/esw015
Chua, E. W., Cree, S. L., Ton, K. N. T., Lehnert, K., Shepherd, P., Helsby, N., & Kennedy, M. A. (2016). Cross-comparison of exome analysis, next-generation sequencing of amplicons, and the iPLEX® ADME PGx Panel for pharmacogenomic profiling. Frontiers in Pharmacology, 7, 1. doi: 10.3389/fphar.2016.00001
Maggo, S. D. S., Savage, R. L., & Kennedy, M. A. (2016). Impact of new genomic technologies on understanding adverse drug reactions. Clinical Pharmacokinetics, 55(4), 419-436. doi: 10.1007/s40262-015-0324-9
Journal - Research Other
Stevens, A. J., Appleby, S., & Kennedy, M. A. (2016). Many commercial hot-start polymerases demonstrate activity prior to thermal activation. Biotechniques, 61(6), 293-296. doi: 10.2144/000114481
Foulds, J. A., Maggo, S. D. S., & Kennedy, M. A. (2016). Personalised prescribing in psychiatry: Has pharmacogenomics delivered on its promise? Australian & New Zealand Journal of Psychiatry, 50(6), 509-510. doi: 10.1177/0004867416640099
Bridgman, P. G., Finsterer, J., Lacey, C., Kimber, B., Parkin, P. J., Miller, A. L., & Kennedy, M. A. (2016). CTG-repeat expansions in the DMPK gene do not cause takotsubo syndrome [Short communication]. International Journal of Cardiology, 203, 107-108. doi: 10.1016/j.ijcard.2015.10.112
Conference Contribution - Published proceedings: Abstract
Maggo, S., Young, J., Lehnert, K., George, P., & Kennedy, M. A. (2016). Statin induced myalgia, is there a genetic link? Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 334. Retrieved from http://www.asceptasm.com/
Maggo, S. D. S., Young, J., Lehnert, K., George, P., & Kennedy, M. A. (2016). Understanding adverse drug reactions using genome sequencing (UDRUGS): A focus on statin induced myalgia. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 44). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/
Conference Contribution - Poster Presentation (not in published proceedings)
Stevens, A., Appleby, S., & Kennedy, M. (2016, August-September). Many commercial hot-start polymerases demonstrate activity prior to thermal activation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Morris, R. W., Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., … Horwood, J., Fergusson, D. M., Kennedy, M. A., … Sattar, N. (2015). Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis: The CARTA consortium. BMJ Open, 5(8), e008808. doi: 10.1136/bmjopen-2015-008808
Adkins, D. E., Clark, S. L., Copeland, W. E., Kennedy, M., Conway, K., Angold, A., … Fergusson, D. M., Horwood, L. J., … Costello, E. J. (2015). Genome-wide meta-analysis of longitudinal alcohol consumption across youth and early adulthood. Twin Research & Human Genetics, 18(4), 335-347. doi: 10.1017/thg.2015.36
Balasubramanain, D., Deng, A. X., Doudney, K., Hampton, M. B., & Kennedy, M. A. (2015). Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology, 99, 79-88. doi: 10.1016/j.neuropharm.2015.06.018
Osborne, A. J., Pearson, J., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2015). Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease. PLoS ONE, 10(4), e0122703. doi: 10.1371/journal.pone.0122703
Chua, E. W., Cree, S., Barclay, M. L., Doudney, K., Lehnert, K., Aitchison, A., & Kennedy, M. A. (2015). Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers. Pharmacogenomics Journal, 15, 414-421. doi: 10.1038/tpj.2015.9
Osborne, A. J., Pearson, J., Negro, S. S., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2015). Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics. Molecular Ecology, 24, 1419-1432. doi: 10.1111/mec.13128
Foulds, J. A., Ton, K., Kennedy, M. A., Adamson, S. J., Mulder, R. T., & Sellman, J. D. (2015). OPRM1 genotype and naltrexone response in depressed alcohol-dependent patients. Pharmacogenetics & Genomics, 25(5), 270-273. doi: 10.1097/fpc.0000000000000128
Larsen, P. D., Johnston, L. R., Holley, A., La Flamme, A., Smyth, L., Chua, E. W., Kennedy, M. A., & Harding, S. A. (2015). Prevalence and significance of CYP2C19*2 and CYP2C19*17 alleles in a New Zealand acute coronary syndrome population. Internal Medicine Journal, 45(5), 537-545. doi: 10.1111/imj.12698
Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208
Davis, J. M., Searles, V. B., Anderson, N., Keeney, J., Raznahan, A., Horwood, L. J., Fergusson, D. M., Kennedy, M. A., … Sikela, J. M. (2015). DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores. Human Genetics, 134(1), 67-75. doi: 10.1007/s00439-014-1489-2
Journal - Research Other
Chua, E.-W., Miller, A. L., & Kennedy, M. A. (2015). Choice of PCR microtube can impact on the success of long-range PCRs. Analytical Biochemistry, 477, 115-117. doi: 10.1016/j.ab.2015.02.023
Conference Contribution - Poster Presentation (not in published proceedings)
Ton, K. N. T., Macmil, S., Rand, C., Stanton, J.-A., & Kennedy, M. A. (2015, August-September). A next generation sequencing PGx panel for predicting adverse drug reaction and unusual response. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Sinha, P., Balasubramanain, D., Pearson, J. F., & Kennedy, M. A. (2015, August-September). RNA-Seq analysis of gene expression changes caused by mood stabilizer drugs in a serotonergic cell line. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Jodczyk, S., Cree, S., & Kennedy, M. A. (2015, August-September). Trialling the MinION™ nanopore DNA sequencer for direct measurement of human telomere length. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Stevens, A., & Kennedy, M. (2015, August-September). CpG Methylation increases G-quadruplex re-association during PCR and influences genotyping of the imprinted MEST gene promoter. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kennedy, M., Jordan, J., Martin, N., Wade, T., Montgomery, G., & Bulik, C. (2015, August). The Anorexia Nervosa Genetics Initiative (ANGI): Australia and New Zealand join forces. Poster session presented at the 13th Australia & New Zealand Academy for Eating Disorders (ANZAED) Annual Conference, Surfers Paradise, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M., Doudney, K., Bickley, V., Bridgman, P., Cameron, V., Cadzow, M., Black, M., Merriman, T., … Miller, A., Zarifeh, J., Kimber, B., George, P., & Lacey, C. (2015, August-September). Genomes, earthquakes and broken hearts. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Cree, S. L., Miller, A. L., Chua, E. W., Maggo, S., & Kennedy, M. A. (2015, August). Long-read nanopore Sequencing for the detection of genetic polymorphisms in the CYP2D6 gene. Verbal presentation at the 7th Annual New Zealand Next Generation Sequencing (NGS) Conference, Palmerston North, New Zealand.
Maggo, S. D. S., Foulds, J., Luty, S. E., Miller, A. L., Kennedy, H., Doogue, M., & Kennedy, M. A. (2015, September). Understanding adverse drug reactions using genome sequencing (UDRUGS): Recent cases on SSRIs and SNRIs. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2014
Journal - Research Article
Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., … Horwood, J., Fergusson, D. M., Kennedy, M. A., … Sattar, N. (2014). Stratification by smoking status reveals a direct association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics, 10(12), e1004799. doi: 10.1371/journal.pgen.1004799
Stevens, A. J., Stuffrein-Roberts, S., Cree, S. L., Gibb, A., Miller, A. L., Doudney, K., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2014). G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter. PLoS ONE, 9(12), e113955. doi: 10.1371/journal.pone.0113955
Taylor, A. E., Fluharty, M. E., Bjømgaard, J. H., Gabrielsen, M. E., Skorpen, F., Marioni, R. E., … Horwood, L. J., … Kennedy, M. A., … Munafò, M. R. (2014). Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: The CARTA consortium. BMJ Open, 4(10), e006141. doi: 10.1136/bmjopen-2014-006141
Cree, S. L., & Kennedy, M. A. (2014). Relevance of G-quadruplex structures to pharmacogenetics. Frontiers in Pharmacology, 5, 160. doi: 10.3389/fphar.2014.00160
Lacey, C., Mulder, R., Bridgman, P., Kimber, B., Zarifeh, J., Kennedy, M., & Cameron, V. (2014). Broken heart syndrome: Is it a psychosomatic disorder? Journal of Psychosomatic Research, 77(2), 158-160. doi: 10.1016/j.jpsychores.2014.05.003
Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014). No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS ONE, 9(5), e97102. doi: 10.1371/journal.pone.0097102
Joyce, P. R., Stephenson, J., Kennedy, M., Mulder, R. T., & McHugh, P. C. (2014). The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder. Frontiers in Genetics, 4, 313. doi: 10.3389/fgene.2013.00313
Conference Contribution - Published proceedings: Abstract
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). No association between telomere length and exposure to life course stress or adversity in two longitudinal New Zealand cohorts. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 1325M. Retrieved from http://www.ashg.org/
Peterson, R. E., Maes, H. H., Eaves, L. J., Silberg, J. L., Adkins, D. E., Clark, S. L., … Kennedy, M., Fergusson, D. M., Horwood, L. J., … Conway, K. (2014). Polygenicity analysis of smoking behavior in adolescence. Proceedings of the Society for Research on Nicotine and Tobacco (SRNT) 20th Annual Meeting. (pp. 163-164). SRNT. Retrieved from http://www.srnt.org/conferences/past/index.cfm
Maes, H. H., Peterson, R. E., Eaves, L. J., Silberg, J. L., Adkins, D. E., Clark, S. L., … Kennedy, M., Fergusson, D. M., Horwood, L. J., … Costello, E. J. (2014). A genome-wide meta-analytic study of smoking behavior in adolescents. Proceedings of the Society for Research on Nicotine and Tobacco (SRNT) 20th Annual Meeting. (pp. 159). SRNT. Retrieved from http://www.srnt.org/conferences/past/index.cfm
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). Association between telomere length and life stress in two New Zealand cohorts. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Jodczyk, S., Pearson, J., Fergusson, D., Horwood, J., Spittlehouse, J., Joyce, P., Hampton, M., & Kennedy, M. (2014, September). No association between telomere length and exposure to life course stress in two longitudinal New Zealand cohorts. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. (2014, November). Genomic tools for analysis of adverse drug reactions. Verbal presentation at the 10th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Kennedy, M. (2014, August). G-quadruplex structures and allelic drop-out during PCR of the imprinted MEST gene promoter. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Chapter in Book - Other
Kennedy, M., Joyce, P., & Begg, E. (2013). Carney Centre for Pharmacogenomics. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 100-104). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Chua, E. W., Foulds, J., Miller, A. L., & Kennedy, M. A. (2013). Novel CYP2D6 and CYP2C19 variants identified in a patient with adverse reactions towards venlafaxine monotherapy and dual therapy with nortriptyline and fluoxetine. Pharmacogenetics & Genomics, 23(9), 494-497. doi: 10.1097/FPC.0b013e328363688d
Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal
Trent, R. J., Cheong, P. L., Chua, E. W., & Kennedy, M. A. (2013). Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care. Pathology, 45(4), 357-370. doi: 10.1097/PAT.0b013e328360b66e
Costello, E. J., Eaves, L., Sullivan, P., Kennedy, M., Conway, K., Adkins, D. E., … van den Oord, E. (2013). Genes, environments, and developmental research: Methods for a multi-site study of early substance abuse. Twin Research & Human Genetics, 16(2), 505-515. doi: 10.1017/thg.2013.6
Osborne, A. J., Zavodna, M., Chilvers, B. L., Robertson, B. C., Negro, S. S., Kennedy, M. A., & Gemmell, N. J. (2013). Extensive variation at MHC DRBin the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection. Heredity, 111, 44-56. doi: 10.1038/hdy.2013.18
Appell, M. L., Berg, J., Duley, J., Evans, W. E., Kennedy, M. A., Lennard, L., … Coulthard, S. A. (2013). Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenetics & Genomics, 23, 242-248. doi: 10.1097/FPC.0b013e32835f1cc0
Bagshaw, A. T. M., Horwood, L. J., Liu, Y., Fergusson, D. M., Sullivan, P. F., & Kennedy, M. A. (2013). No effect of genome-wide copy number variation on measures of intelligence in a New Zealand birth cohort. PLoS ONE, 8(1), e55208. doi: 10.1371/journal.pone.0055208
Journal - Research Other
Pearson, J. F., Fergusson, D. M., Horwood, L. J., Miller, A. L., Sullivan, P. F., Youfang, L. E., & Kennedy, M. A. (2013). Increased risk of major depression by childhood abuse is not modified by CNR1 genotype. American Journal of Medical Genetics Part B, 162(2), 224-226. doi: 10.1002/ajmg.b.32124
Conference Contribution - Published proceedings: Abstract
Stevens, A. J., Stuffrein-Roberts, S., Macmil, S., Gibb, A., Doudney, K., Miller, A. L., Bagshaw, A., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2013). Allelic-dropout during PCR of the imprinted MEST promoter caused by interaction between G-quadruplex structures and DNA methylation. Proceedings of the 4th International Meeting on G-quadruplex Nucleic Acids: From Structure to Chemistry and Biology. 83. Retrieved from http://www.g4meeting2013.com/
Macmil, S. L., Fredericks, R., Miller, A., Fee, C., Filichev, V. V., & Kennedy, M. A. (2013). Structure based function: Investigating the role of G-quadruplex structures in de novo DNA methylation. Proceedings of the 4th International Meeting on G-quadruplex Nucleic Acids: From Structure to Chemistry and Biology. 79. Retrieved from http://www.g4meeting2013.com/
Kennedy, M. (2013). Just when will genetics revolutionise medicine: Part 1. Proceedings of the George Abbott Symposium. Retrieved from http://www.otago.ac.nz/george-abbott
Johnston, L., Smyth, L., Kennedy, M., Holley, A., Sasse, A., La Flamme, A., Larsen, P., & Harding, S. (2013). High on treatment platelet reactivity is associated with a higher risk of MACE in ACS patients: Diabetes and loss of function genotype the driving forces. Heart, Lung & Circulation, 22(7), (pp. 561). doi: 10.1016/j.hlc.2013.04.035
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. (2013, September). Understanding the genome to improve medicine. Verbal presentation at the Inaugural Genetics Week, Auckland, New Zealand.
Kennedy, M. A., Chua, E. W., Macmil, S., Foulds, J., Barclay, M., Savage, R., … Miller, A. (2013, August). Genomic medicine and adverse drug reactions. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Chua, E. W., Macmil, S., Foulds, J., Barclay, M., Savage, R., Helsby, N. A., Miller, A., & Kennedy, M. A. (2013, August). Understanding adverse Drug Reactions or responses Using Genomic Sequencing (UDRUGS). Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
Buffery, P. J., Barclay, M. L., Doogue, M. P., Moore, G. A., & Kennedy, M. A. (2013, August). Codeine, breastfeeding and infant narcosis: A cautionary case. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
Kennedy, M. (2013, February). Drugs and the genome. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand.
Other Research Output
Kennedy, M. (2013, February). DNA and disease: Following a common thread, University of Otago Christchurch Health Lecture Series. Christchurch, New Zealand. [Public Seminar].
2012
Journal - Research Article
Chua, E. W., & Kennedy, M. A. (2012). Current state and future prospects of direct-to-consumer pharmacogenetics. Frontiers in Pharmacology, 3, 152. doi: 10.3389/fphar.2012.00152
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A., & Kennedy, M. A. (2012). Moderating role of the MAOA genotype in antisocial behaviour. British Journal of Psychiatry, 200(2), 116-123. doi: 10.1192/bjp.bp.111.093328
Journal - Research Other
Kennedy, M. A., Joyce, P. R., & Begg, E. J. (2012). Institutional Profile: The Carney Centre for Pharmacogenomics: A New Zealand focus for personalized medicine research [News & Views]. Pharmacogenomics, 13(8), 865-868. doi: 10.2217/pgs.12.55
Conference Contribution - Published proceedings: Abstract
Osborne, A. J., Brauning, R., Schultz, J. K., Kennedy, M. A., Slate, J., & Gemmell, N. J. (2012). Development of a predicted physical map of microsatellite locus positions for pinnipeds, with wider applicability to the Carnivora. Proceedings of the Centre for Reproduction and Genomics 4th Annual Research Colloquium. (pp. 13). Retrieved from http://www.otago.ac.nz/crg/news/colloquium/
Conference Contribution - Poster Presentation (not in published proceedings)
Achram, H., Shaw, I. C., & Kennedy, M. (2012, September). DNA methylation as a potential biomarker of phthalate exposure. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Jodczyk, S., Miller, A., Fergusson, D., Horwood, J., & Kennedy, M. (2012, March). Association between nicotine and alcohol dependence and short mean telomere length in a longitudinal birth cohort study. Poster session presented at the Human Genome Meeting (HUGO): Genetics and Genomics in Personalised Medicine, Sydney, Australia.
Stevens, A., Stuffrein-Roberts, S., Miller, A., Gibb, A., Doudney, K., Bagshaw, A., Aitchison, A., Eccles, M., … Kennedy, M. (2012, August). G-quadruplex DNA structures, genomic imprinting and allelic drop-out in PCR. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Balasubramanain, D., Hampton, M., & Kennedy, M. (2012, November). Effect of valproate on SPR gene expression in a serotonergic cell line. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Chua, E. W., Foulds, J., Miller, A. L., & Kennedy, M. A. (2012, November). Novel CYP2D6 mutation in a patient with poor response to venlafaxine. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Kennedy, M. A., Chua, E. W., Barclay, M. L., & Savage, R. (2012, November). Growing a New Zealand biobank (UDRUGS) to allow genetic analysis of rare, serious adverse drug reactions and unusual drug responses. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Kennedy, M. (2012, September). Genomes and drugs: How do we make them work together? Verbal presentation at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Stevens, A. J., Stuffrein-Roberts, S., Miller, A. L., Gibb, A., Doudney, K., Bagshaw, A., Aitchison, A., Eccles, M. R., … Kennedy, M. A. (2012, August). G-quadruplex DNA structures, genomic imprinting and allelic drop-out in PCR. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. British Journal of Psychiatry, 198, 457-463. doi: 10.1192/bjp.bp.110.086991
Osborne, A. J., Brauning, R., Schultz, J. K., Kennedy, M. A., Slate, J., & Gemmell, N. J. (2011). Development of a predicted physical map of microsatellite locus positions for pinnipeds, with wider applicability to the Carnivora. Molecular Ecology Resources, 11(3), 503-513. doi: 10.1111/j.1755-0998.2010.02962.x
Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. British Journal of Psychiatry, 198, 129-135. doi: 10.1192/bjp.bp.110.085993
Maggo, S. D. S., Kennedy, M. A., & Clark, D. W. J. (2011). Clinical implications of pharmacogenetic variation on the effects of statins. Drug Safety, 34(1), 1-19. doi: 10.2165/11584380-000000000-00000
McHugh, P. C., Joyce, P. R., Deng, X., & Kennedy, M. A. (2011). A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. Pharmacogenomics Journal, 11(3), 207-213. doi: 10.1038/tpj.2010.23
Conference Contribution - Published proceedings: Abstract
Harley, J. A., Kennedy, M. A., Doudney, K., Allington, M., Pearson, J., Black, M., & Joyce, P. R. (2011). Antidepressants cause specific changes in the rat peripheral blood transcriptome. Biological Psychiatry. 69(9, Suppl. 1), (pp. 89S). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. (2011, March). Genomics and sport: Facts and fairytales. Verbal presentation at the Future of Fairness Symposium, Dunedin, New Zealand.
2010
Journal - Research Article
Stamp, L. K., Chapman, P. T., O'Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics & Genomics, 20(6), 367-376. doi: 10.1097/FPC.0b013e3283398a71
Joyce, P. R., Light, K. J., Rowe, S. L., Cloninger, C. R., & Kennedy, M. A. (2010). Self-mutilation and suicide attempts: Relationships to bipolar disorder, borderline personality disorder, temperament and character. Australian & New Zealand Journal of Psychiatry, 44(3), 250-257. doi: 10.3109/00048670903487159
Glubb, D. M., McHugh, P. C., Deng, X., Joyce, P. R., & Kennedy, M. A. (2010). Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. Pharmacogenomics Journal, 10, 126-133. doi: 10.1038/tpj.2009.33
McHugh, P. C., Rogers, G. R., Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2010). Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. Journal of Psychopharmacology, 24(8), 1243-1251. doi: 10.1177/0269881109102786
Harley, J., Roberts, R., Joyce, P., Mulder, R., Luty, S., Frampton, C., & Kennedy, M. (2010). Orosomucoid influences the response to antidepressants in major depressive disorder. Journal of Psychopharmacology, 24(4), 531-535. doi: 10.1177/0269881109105101
Conference Contribution - Published proceedings: Abstract
Harley, J. A., Doudney, K., Allington, M. A., McNoe, L., Pearson, J., Black, M., Joyce, P. R., & Kennedy, M. A. (2010). Antidepressant specific changes in rat whole blood gene expression identified by gene-chip analysis. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/
Kennedy, M. (2010). Pharmacogenetics and pain. Proceedings of the Australian and New Zealand College of Anaesthetists (ANZCA) Annual Scientific Meeting. Retrieved from http://www.conference.co.nz/index.cfm/anzca10
Conference Contribution - Poster Presentation (not in published proceedings)
Marshall, A. J., Negro, S. S., Robertson, B. C., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2010, September). Can human health research hold the key to New Zealand sea lion survival? Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. (2010, February). Probing psychiatric drug action by analysis of gene expression. Verbal presentation at the 9th Annual MicroArray Workshop, Dunedin, New Zealand.
Kennedy, M. (2010, March). Novel genetic variants that impact on Thiopurine drug responses. Verbal presentation at the NZBIO Conference: Advancing a bio-based economy, Auckland, New Zealand.
2009
Journal - Research Article
Petermann, I., Huebner, C., Browning, B. L., Gearry, R. B., Barclay, M. L., Kennedy, M., Roberts, R., … Han, D. Y., & Ferguson, L. R. (2009). Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Human Immunology, 70, 440-446. doi: 10.1016/j.humimm.2009.03.002
Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x
McHugh, P. C., Joyce, P. R., & Kennedy, M. A. (2009). Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. Pharmacogenetics & Genomics, 19(5), 330-337. doi: 10.1097/FPC.0b013e328328f82c
Joyce, P. R., McHugh, P. C., Light, K. J., Rowe, S., Miller, A. L., & Kennedy, M. A. (2009). Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. Biological Psychiatry, 66(8), 717-721. doi: 10.1016/j.biopsych.2009.03.005
Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2009). Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. Neuroscience Letters, 460, 185-190. doi: 10.1016/j.neulet.2009.05.065
Journal - Research Other
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Barclay, M. L., Kennedy, M. A., Frampton, C. M. A., & Roberts, R. L. (2009). Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to longterm therapy with methotrexate response in rheumatoid arthritis [Letter]. Annals of the Rheumatic Diseases, 68(1), 154-155. doi: 10.1136/ard.2008.089383
Conference Contribution - Published proceedings: Abstract
Harley, J. A., Doudney, K., Allington, M., Pearson, J., Black, M., Joyce, P. R., & Kennedy, M. A. (2009). Blood mRNA changes induced by antidepressants. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Bagshaw, A. T., Joyce, P. R., & Kennedy, M. A. (2009). Does copy number variation influence personality? Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 574). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf
Doudney, K., Harley, J. A., Deng, X. Y., Allington, M., Waldvogel, H. J., Faull, R. L. M., Joyce, P. R., & Kennedy, M. A. (2009). Brain and peripheral gene expression changes in rats after two weeks of exposure to antidepressant drugs. Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 626). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf
Kennedy, M. A., Deng, X. Y., Doudney, K., McHugh, P. C., & Joyce, P. R. (2009). Exploring gene regulation by antidepressant drugs. Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 633). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf
Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2 is associated with adipose metabolism in bipolar patients with valproate induced weight gain. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Roberts, R. L., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., Kennedy, M. A., Barclay, M. L., & Stamp, L. K. (2009). Genetic polymorphisms in the folate pathway predict red blood cell folate concentrations but not methotrexate response in rheumatoid arthritis. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Deng, S., McHugh, P. C., Doudney, K., Joyce, P. R., & Kennedy, M. A. (2009). Gene regulation by drugs used to treat mood disorders. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Johnstone, A. C., Kennedy, M. A., Lea, R. A., & Fitzmaurice, P. S. (2009). The effect of exposure to benzylpiperazine or methamphetamine on gene expression. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf
Stamp, L., O'Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., Barclay, M., Kennedy, M., & Roberts, R. (2009). Functional polymorphisms within the folate pathway predict red blood cell folate concentrations but are not associated with methotrexate response in RA. Arthritis & Rheumatism, 60(Suppl. 10), (pp. S150). doi: 10.1002/art.27423
Harley, J. A., Doudney, K., Allington, M., Pearson, J., Black, M., Joyce, P. R., & Kennedy, M. A. (2009). Blood mRNA changes induced by antidepressants: Future biomarkers to tailor depression treatment? Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Xu, J. B., Mitchell, N. L., Kennedy, M. A., & Palmer, D. N. (2009). Allelic variation in exon1 of CLN5 is not disease associated. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Doudney, K., Harley, J. A., Deng, X. Y., Allington, M., Waldvogel, H. J., Faull, R. L. M., Joyce, P. R., & Kennedy, M. A. (2009). Gene expression changes in rat brain following antidepressant drug treatment. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Marshall, A. J., Negro, S. S., Robertson, B. C., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2009). Assessing genomic variability in species of high conservation priority. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Deng, X., McHugh, P. C., Doudney, K., Joyce, P. R., & Kennedy, M. A. (2009). Gene regulation by drugs used to treat mood disorders. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Johnstone, A., Brennan, K., Schenk, S., Kennedy, M., Fitzmaurice, P., & Lea, R. (2009, September). Neurogenomics of drugs of abuse: Methamphetamine and benzylpiperazine. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.
Deng, X. S., McHugh, P. C., Doudney, K., Joyce, P. R., & Kennedy, M. A. (2009, September). Gene regulation by drugs used to treat mood disorders. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Roberts, R. L., O'Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., Kennedy, M. A., Barclay, M. L., & Stamp, L. K. (2009, September). Genetic polymorphisms in the folate pathway are predictive of red blood cell folate concentrations but not methotrexate response in rheumatoid arthritis patients. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Film/Video/CD Rom
Fraser, R., Joyce, P., Sellman, D., & Kennedy, M. (2009). The Body, the Research, the Professor: Mental Health [Episode 4] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
2008
Journal - Research Article
Clark, D. W. J., Ashton, J. A., Zhou, L., Wallace, A. K., & Kennedy, M. A. (2008). Pharmacogenetic investigation using a pharmacovigilance database. PharmacoVigilance Review, 2(3), 9-13.
Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C. W., George, P. M., Burt, M., … Barclay, M. L., & Kennedy, M. A. (2008). Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenetics & Genomics, 18(5), 434-438.
Porter, R. J., Mulder, R. T., Joyce, P. R., Miller, A. L., & Kennedy, M. (2008). Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. Journal of Affective Disorders, 109(1-2), 209-212. doi: 10.1016/j.jad.2007.11.010
McHugh, P. C., Rogers, G. R., Loudon, B., Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2008). Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine. Journal of Neuroscience Research, 86(2), 306-316.
Stuffrein-Roberts, S., Joyce, P. R., & Kennedy, M. A. (2008). Role of epigenetics in mental disorders. Australian & New Zealand Journal of Psychiatry, 42(2), 97-107.
Littlejohn, M. D., Palmer, B. R., Richards, A. M., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Cameron, V. A., & Kennedy, M. A. (2008). Ile164 variant of β2-adrenoceptor does not influence outcome in heart failure but may interact with β blocker treatment. European Journal of Heart Failure, 10(1), 55-59. doi: 10.1016/j.ejheart.2007.10.011
Lea, R. A., Roberts, R. L., Green, M. R., Kennedy, M. A., & Chambers, G. K. (2008). Allele frequency differences of cytochrome P450 polymorphisms in a sample of New Zealand Māori. New Zealand Medical Journal, 121(1272). Retrieved from http://journal.nzma.org.nz/journal/121-1272/3002/content.pdf
Bentley, R. W., Keenan, J. I., Gearry, R. B., Kennedy, M. A., Barclay, M. L., & Roberts, R. L. (2008). Incidence of Mycobacterium avium subspecies paratuberculosis in a population-based cohort of patients with Crohn's disease and control subjects. American Journal of Gastroenterology, 103(5), 1168-1172. doi: 10.1111/j.1572-0241.2007.01742.x
McHugh, P. C., Rogers, G. R., Glubb, D. M., Allington, M. D., Hughes, M., Joyce, P. R., & Kennedy, M. A. (2008). Downregulation of Ccnd1 and Hes6 in rat hippocampus after chronic exposure to the antidepressant paroxetine. Acta Neuropsychiatrica, 20(6), 307-313. doi: 10.1111/j.1601-5215.2008.00334.x
Roberts, R. L., Gearry, R. B., Kennedy, M. A., & Barclay, M. L. (2008). Beyond TPMT: Genetic influences on thiopurine drug responses in inflammatory bowel disease. Personalized Medicine, 5(3), 233-248. doi: 10.2217/17410541.5.3.233
Roberts, R. L., Hollis-Moffatt, J. E., Gearry, R. B., Kennedy, M. A., Barclay, M. L., & Merriman, T. R. (2008). Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes & Immunity, 9(6), 561-565. doi: 10.1038/gene.2008.49
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Boden, J. M., Miller, A., Horwood, L. J., & Fergusson, D. M. (2008). Is the CHRNA3-CHRNA5 genomic region really a susceptibility locus for nicotine addiction? Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Frampton, C. M., Skelton, L., Littlejohn, M. D., Kennedy, M. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2008). Cardiovascular pharmacogenetics: Taking the opportunities. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Gearry, R. B., Roberts, R. L., Kennedy, M. A., Zhang, M., & Barclay, M. L. (2008). Thiopurine metabolites, intermediate steps on the way to complete thiopurine pharmacogenetics. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Deng, X., McHugh, P. C., Doudney, K., Joyce, P. R., & Kennedy, M. A. (2008). Gene regulation by antidepressant drugs. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Glubb, D., Joyce, P., McHugh, P., Deng, S., & Kennedy, M. A. (2008). In vitro expression analysis and association study provide evidence for adrenomedullin involvement in response to the antidepressant paroxetine. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Kennedy, M. A., Bland, M. V., Roberts, R. L., McHugh, P. C., Light, K. J., Miller, A. L., & Joyce, P. R. (2008). The GATA2 transcription factor gene: Promotor haplotypes and preliminary association with neuropsychiatric phenotypes. Proceedings of the American Society of Human Genetics 58th Annual Meeting. (pp. 362). ASHG. Retrieved from http://www.ashg.org/2008meeting/pdf/abstractbook1.pdf
Harley, J. A., Doudney, K., Joyce, P. R., & Kennedy, M. A. (2008). Search for the black bile: Biomarkers of antidepressant exposure. Proceedings of the 8th Annual Australasian Microarray and Associated Technologies (AMATA) Conference. Retrieved from http://www.amata.org.au/index.php/resources/2008-conference-abstracts
Conference Contribution - Verbal presentation and other Conference outputs
Gearry, R. B., Roberts, R. L., Kennedy, M. A., Zhang, M., & Barclay, M. L. (2008, October). Thiopurine metabolites, intermediate steps on the way to complete thiopurine pharmacogenetics. Verbal presentation at the 4th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
2007
Journal - Research Article
Beaglehole, B., Luty, S. E., Mulder, R. T., Kennedy, M. A., & Joyce, P. R. (2007). Low red cell folate levels are associated with poor response to nortriptyline in major depression. Acta Neuropsychiatrica, 19, 204-207.
Johnstone, A. C., Lea, R. A., Brennan, K. A., Schenk, S., Kennedy, M. A., & Fitzmaurice, P. S. (2007). Benzylpiperazine: A drug of abuse? [Review]. Journal of Psychopharmacology, 21, 888-894. doi: 10.1177/0269881107077260
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology, 102, 2754-2761.
Joyce, P. R., Light, K. J., Rowe, S. L., & Kennedy, M. A. (2007). Bipolar disorder not otherwise specified: Comparison with bipolar disorder I/II and major depression. Australian & New Zealand Journal of Psychiatry, 41, 843-849.
Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance. Pharmacogenomics Journal, 7(5), 312-317.
Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Carter, J. D., Frampton, C. M. A., Miller, A. L., & Kennedy, M. A. (2007). An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behavioral & Brain Functions, 3(3). Retrieved from http://www.behavioralandbrainfunctions.com/content/3/1/3
Gearry, R. B., Roberts, R. L., Burt, M. J., Frampton, C. M. A., Chapman, B. A., Collett, J. A., Shirley, P., Allington, M. D. E., Kennedy, M. A., & Barclay, M. L. (2007). Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort. Inflammatory Bowel Diseases, 13(10), 1220-1227.
Journal - Research Other
Kennedy, M. A. (2007). Pharmacogenomics: Single genes, whole genomes and global networks [Conference scene]. Personalized Medicine, 4(1), 87-94.
Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the editor]. Molecular Psychiatry, 12, 899-900.
Conference Contribution - Published proceedings: Abstract
Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C., George, P. M., Burt, M., Kennedy, M. A., & Barclay, M. L. (2007). Trinucleotide repeat variants in inflammatory bowel disease patients exhibiting ultra-high thiopurine S-methyltransferase activity. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Barclay, M., Roberts, R., Gearry, R., & Kennedy, M. (2007). Inflammatory bowel disease pharmacogenetics. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Harley, J. A., Joyce, P. R., & Kennedy, M. A. (2007). The search for the black bile: Peripheral biomarkers in depression. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
McHugh, P. C., Joyce, P. R., & Kennedy, M. A. (2007). Sepiapterin reductase (SPR): A novel candidate gene for antidepressant response and affective disorders? Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Glubb, D., Rogers, G., Joyce, P. R., & Kennedy, M. A. (2007). Antidepressant pharmacogenomics of a serotonergic cell line. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Joyce, P., Light, K., Rowe, S., & Kennedy, M. (2007). Self mutilation and suicide attempts, temperament and character, in borderline personality disorder and bipolar disorder. Proceedings of the Australasian Society for Bipolar Disorders Conference. Retrieved from http://www.asbd2007.com/
Joyce, P., Light, K., Rowe, S., & Kennedy, M. (2007). Bipolar disorder NOS: A comparison with bipolar disorder I/II and major depression. Proceedings of the Australasian Society for Bipolar Disorders Conference. Retrieved from http://www.asbd2007.com/
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. New Zealand Medical Journal, 120(1266). Retrieved from http://journal.nzma.org.nz/journal/120-1266/2848/content.pdf
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q & ATG16L1 T300A are associated with Crohn's disease in a population-based New Zealand Caucasian cohort. Gut. 56(Suppl. III), (pp. A19). [Abstract]
Bentley, R. W., Gearry, R. B., Keenan, J. I., Aitken, J. M., Kennedy, M. A., Barclay, M. L., & Roberts, R. L. (2007). Relative incidence of Mycobacterium avium subsp. paratuberculosis in a population-based cohort of Crohn's disease patients. Gut. 56(Suppl. III), (pp. A127). [Abstract]
Bentley, R. W., Roberts, R. L., Gearry, R. B., Merriman, T. R., Kennedy, M. A., & Barclay, M. L. (2007). The GLI1 gene as a risk factor for ulcerative colitis. Journal of Gastroenterology & Hepatology, 22(Suppl. 3), (pp. A321). doi: 10.1111/j.1440-1746.2007.05172.x
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q & ATG16L1 T300A are associated with Crohn's disease in a population-based Caucasian cohort. Journal of Gastroenterology & Hepatology, 22(Suppl. 3), (pp. A305). doi: 10.1111/j.1440-1746.2007.05172.x
Bentley, R. W., Roberts, R. L., Gearry, R. B., Merriman, T. R., Kennedy, M. A., & Barclay, M. L. (2007). The GLI1 gene as a risk factor for ulcerative colitis GLI1. Proceedings of the American Society of Human Genetics 57th Annual Meeting. Retrieved from http://www.ashg.org/genetics/ashg/annmeet/2007/call/postersessionlisting.shtml
Gearry, R., Nolan, R., Roberts, R., Barclay, M., Kennedy, M. A., Patterson, A., … Nolan, D. (2007). HLA, TPMT and ITPA genotypes and susceptibility to azathioprine hypersensitivity reactions (HSR) in inflammatory bowel disease (IBD) patients. Journal of Gastroenterology & Hepatology, 22(Suppl. 3), (pp. A304). doi: 10.1111/j.1440-1746.2007.05172.x
Bentley, R. W., Gearry, R. B., Keenan, J. I., Aitken, J. M., Kennedy, M. A., Barclay, M. L., & Roberts, R. L. (2007). Relative incidence of Mycobacterium avium subsp. paratuberculosis in a population-based cohort of Crohn's disease patients. Journal of Gastroenterology and Hepatology. 22(Suppl. 3), (pp. A317). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C. W., George, P. M., Burt, M., Kennedy, M. A., & Barclay, M. L. (2007, October). Promoter insertion in an inflammatory bowel disease patient exhibiting ultra-high thiopurine S-methyltransferase activity. Verbal presentation at the Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference, Cold Spring Harbor, New York.
Barclay, M. L., Roberts, R. L., Gearry, R. B., Zhang, M., & Kennedy, M. A. (2007, August). Novel gene mutations for enzymes in the thiopurine metabolic pathway in patients with inflammatory bowel disease and severe azathioprine resistance. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Stamp, L. K., O'Donnell, J. L., Chapman, P. T., Frampton, C., Barclay, M. L., Kennedy, M., & Roberts, R. L. (2007, August-September). HLA-G 14BP polymorphism is not associated with response to methotrexate in rheumatoid arthritis. Verbal presentation at the New Zealand Rheumatology Association Conference, Dunedin, New Zealand.
Bentley, R. W., Roberts, R. L., Gearry, R. B., Keenan, J. I., Kennedy, M. A., & Barclay, M. L. (2007, November). Relative incidence of Mycobacterium avium subsp. paratuberculosis in a New Zealand population-based cohort of patients with Crohn's disease. Verbal presentation at the New Zealand Society of Gastroenterology & NZNO Gastroenterology Nurses Section Annual Scientific Meeting combined with the RACP and IMSANZ, Christchurch, New Zealand.
Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C. W., George, P. M., Burt, M., Kennedy, M. A., & Barclay, M. L. (2007, September). Trinucleotide repeat variants in inflammatory bowel disease patients exhibiting ultra-high thiopurine S-methyltransferase activity. Verbal presentation at the 3rd Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007, November). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. Verbal presentation at the New Zealand Society of Gastroenterology & NZNO Gastroenterology Nurses Section Annual Scientific Meeting combined with the RACP and IMSANZ, Christchurch, New Zealand.
Barclay, M., Roberts, R., Gearry, R., & Kennedy, M. (2007, September). Inflammatory bowel disease pharmacogenetics. Verbal presentation at the 3rd Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Intellectual Property
Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). Method of identifying individuals at risk of thiopurine drug resistance and intolerance. International (PCT) Patent Application (PCT/NZ2007/000329).
Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). Method of identifying individuals at risk of thiopurine drug resistance and intolerance. United States Patent Application (60/935367).
Other Research Output
Kennedy, M. A. (2007, December). Pharmacogenetics in the era of personal genomes. Festschrift in honour of Associate Professor David Clark: An international symposium on New Zealand's crucial role in monitoring/improving the safety of Medicine. Dunedin, New Zealand. [Public Seminar].
2006
Journal - Research Article
Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Frampton, C. M. A., Joyce, L. R. M., Miller, A. L., & Kennedy, M. A. (2006). Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. American Journal of Medical Genetics Part B, 141B(4), 409-413. doi: 10.1002/ajmg.b.30308
Joyce, P. R., McKenzie, J. M., Mulder, R. T., Luty, S. E., Sullivan, P. F., Miller, A. L., & Kennedy, M. A. (2006). Genetic, developmental and personality correlates of self-mutilation in depressed patients. Australian & New Zealand Journal of Psychiatry, 40, 225-229.
Joyce, P. R., McHugh, P. C., McKenzie, J. M., Sullivan, P. F., Mulder, R. T., Luty, S. E., Carter, J. D., Frampton, C. M. A., … Miller, A. L., & Kennedy, M. A. (2006). A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychological Medicine, 36, 807-813. doi: 10.1017/s0033291706007288
Roberts, R. L., & Kennedy, M. A. (2006). Rapid detection of common cytochrome P450 2D6 alleles in Caucasians. Clinica Chimica Acta, 366, 348-351.
Journal - Research Other
Stamp, L., Roberts, R., Kennedy, M., Barclay, M., O'Donnell, J., & Chapman, P. (2006). The use of low dose methotrexate in rheumatoid arthritis: Are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomedicine & Pharmacotherapy, 60, 678-687.
Gearry, R. B., Lea, R. A., Roberts, R. L., Chambers, G. K., Barclay, M. L., & Kennedy, M. A. (2006). CARD15 allele frequency differences in New Zealand Maori: Ancestry specific susceptibility to Crohn's disease in New Zealand? [Letter]. Gut, 55, 580. doi: 10.1136/gut.2005.085464
Conference Contribution - Published proceedings: Abstract
Bland, M., Joyce, P., & Kennedy, M. (2006). Genetic variation of 5-HT transcription factors in affective disorders. Proceedings of the 11th International Congress of Human Genetics. Retrieved from http://www.ichg2006.com/abstract/777.htm
Gearry, R. B., Roberts, R. R., Richardson, A., Frampton, C. M. A., Kennedy, M. A., & Barclay, M. L. (2006). The prevalence and genetic determinants of inflammatory bowel disease (IBD) in Canterbury. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
Kennedy, M. A., McHugh, P. C., Rogers, G. R., Glubb, D. M., Allington, M., & Joyce, P. R. (2006). Gene and protein expression changes induced by chronic exposure to the antidepressant paroxetine. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
Kennedy, M. A., Roberts, R. R., Gearry, R. B., Barclay, M. L., Taylor, D. R., Begg, E. J., Clark, D. W. J., & Joyce, P. R. (2006). Pharmacogenetics and genomics ″Down Under″: Focus on asthma, inflammatory bowel disease, and major depression. Proceedings of the Pharmacogenomics Meeting. (pp. 11). NY: Cold Spring Harbor Laboratory. [Abstract]
Gearry, R. B., Roberts, R. L., Frampton, C. M., Burt, M. J., Collett, J. A., Chapman, B. A., Allington, M. D., Kennedy, M. A., & Barclay, M. L. (2006). From Vienna to Montreal: The impact of changes in IBD classification on CARD15 genotype-phenotype relationships in a population-based cohort. Gastroenterology. 130(4, Suppl. 2), (pp. A-586). [Abstract]
Gearry, R. B., Roberts, R. L., Frampton, C. M., Burt, M. J., Collett, J. A., Chapman, B. A., Allington, M. D., Kennedy, M. A., & Barclay, M. L. (2006). From Vienna to Montreal: The impact of changes in IBD classification on CARD15 genotype-phenotype relationships in a population-based cohort. Journal of Gastroenterology & Hepatology, 21(Suppl. 4), (pp. A271). doi: 10.1111/j.1440-1746.2006.04687.x
Fitches, A., Clark, D., Joyce, P. R., Kennedy, M. A., Wells, J. E., & Olds, R. J. (2006). Association of alleles at GSK3b-50 with bipolar disorder age of onset. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. (7), 141B, (pp. 746). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Roberts, R. L., Gearry, R. B., Kennedy, M. A., & Barclay, M. L. (2006, November-December). Mutations in the guanosine 5'-monophosphate synthetase (GMPS) gene are associated with thiopurine resistance. Poster session presented at the Medical Sciences Congress, Rotorua, New Zealand.
2005
Journal - Research Article
Taylor, D. R., Epton, M. J., Kennedy, M. A., Smith, A. D., Iles, S., Miller, A. L., Littlejohn, M. D., Cowan, J. O., Hewitt, T., Swanney, M. P., Brassett, K. P., & Herbison, G. P. (2005). Bronchodilator response in relation to β2-adrenoceptor haplotype in patients with asthma. American Journal of Respiratory & Critical Care Medicine, 172(6), 700-703.
Joyce, P. R., Porter, R. J., Mulder, R. T., Luty, S. E., McKenzie, J. M., Miller, A. L., & Kennedy, M. A. (2005). Reversed diurnal variation in depression: Associations with a differential antidepressant response, tryptophan: Large neutral amino acid ratio and serotonin transporter polymorphisms. Psychological Medicine, 35, 511-517.
Conference Contribution - Published proceedings: Abstract
Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2005). Interim CARD15 genotype results from a population-based study of Inflammatory Bowel Disease. European Journal of Human Genetics, 13(Suppl. 1), (pp. 304). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Bland, M. V., Joyce, P. R., McHugh, P. C., & Kennedy, M. A. (2005, August). Polymorphism analysis of novel serotonergic candidate genes in depression. Poster session presented at the 23rd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Kennedy, M. A., McHugh, P. C., Glubb, D. M., Rogers, G. R., & Joyce, P. R. (2005, October). Molecular changes induced by chronic exposure to the antidepressant paroxetine in a neuronal cell culture system. Poster session presented at the American Society of Human Genetics 55th Annual Meeting, Salt Lake City, UT, USA.
Bland, M. V., Joyce, P. R., McHugh, P. C., & Kennedy, M. A. (2005, August). Polymorphism analysis of novel serotonergic candidate genes in depression. Poster session presented at the 15th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Glubb, D., McHugh, P., Rogers, G., Allington, M., Cameron, V., Joyce, P., & Kennedy, M. (2005, August). Validating gene expression changes caused by exposure of neuron cultures and rat brain to the antidepressant paroxetine (Aropax). Poster session presented at the 15th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Glubb, D. M., McHugh, P. C., Rogers, G. R., Joyce, P. R., & Kennedy, M. A. (2005, August). Molecular approaches for understanding antidepressant function. Poster session presented at the 23rd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Barclay, M. L., Roberts, R. L., Gearry, R. B., & Kennedy, M. A. (2005, September). Interim CARD15 genotype results from a population-based study of inflammatory bowel disease in New Zealand. Poster session presented at the World Congress of Gastroenterology, Montréal, Canada.
Conference Contribution - Verbal presentation and other Conference outputs
Gearry, R., Roberts, R., Richardson, A., Frampton, C., Kennedy, M., & Barclay, M. (2005, November). The epidemiology and genetic determinants of inflammatory bowel disease (IBD) in Canterbury. Verbal presentation at the New Zealand Society of Gastroenterology & NZNO Gastroenterology Nurses Section Annual Scientific Meeting, Hamilton, New Zealand.
2004
Chapter in Book - Research
Kennedy, M. A., Rogers, G. R., & Joyce, P. R. (2004). Pharmacogenetics of antidepressants and mood stabilisers. In P. R. Joyce & P. B. Mitchell (Eds.), Mood disorders: Recognition and treatment. (pp. 223-237). Sydney, Australia: The University of New South Wales Press Ltd.
Journal - Research Article
Gearry, R. B., Roberts, R. L., Barclay, M. L., & Kennedy, M. A. (2004). Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics, 14(11), 779-781.
Roberts, R. L., Barclay, M. L., Gearry, R. B., & Kennedy, M. A. (2004). A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations. Clinica Chimica Acta, 341(1-2), 49-53.
Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2004). Rapid detection of common CARD15 variants in patients with inflammatory bowel disease. Molecular Diagnosis, 8(2), 101-105. doi: 10.1007/BF03260052
Roberts, R. L., Luty, S. E., Mulder, R. T., Joyce, P. R., & Kennedy, M. A. (2004). Association between cytochrome P450 2D6 genotype and harm avoidance. American Journal of Medical Genetics Part B, 127B, 90-93. Wiley-Liss Inc.
Roberts, R. L., Mulder, R. T., Joyce, P. R., Luty, S. E., & Kennedy, M. A. (2004). No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline. Human Psychopharmacology, 19(1), 17-23.
Clark, D. W. J., Donnelly, E., Coulter, D. M., Roberts, R. L., & Kennedy, M. A. (2004). Linking pharmacovigilance with pharmacogenetics. Drug Safety, 27(15), 1171-1184.
Rogers, G., Joyce, P., Mulder, R., Sellman, D., Miller, A., Allington, M., Olds, R., Wells, E., & Kennedy, M. (2004). Association of a duplicated repeat polymorphism in the 5′-untranslated region of the DRD4 gene with novelty seeking. American Journal of Medical Genetics Part B, 126B, 95-98.
Conference Contribution - Published proceedings: Abstract
Clark, D. W. J., & Kennedy, M. A. (2004). Potential for linking pharmacogenetic investigations with pharmacovigilance databases. Proceedings of the Winter Conference on Pharmacogenomics. (pp. 40). New York: Cold Spring Harbor Laboratory. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Roberts, R. L., Potter, H., Harraway, J., Pike, L., George, P. M., & Kennedy, M. A. (2004, April). Characterisation of a length polymorphism in intron 5 of the thiopurine S-methyltransferase (TPMT) gene. Poster session presented at the Human Genome Meeting, Berlin.
2003
Journal - Research Article
Joyce, P. R., Rogers, G. R., Miller, A., Mulder, R. T., Luty, S. E., & Kennedy, M. A. (2003). Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Research, 119, 1-10.
Gearry, R. B., Barclay, M. L., Burt, M. J., Collett, J. A., Chapman, B. A., Roberts, R., & Kennedy, M. A. (2003). Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 18, 395-400.
Sundram, S., Joyce, P. R., & Kennedy, M. A. (2003). Schizophrenia and bipolar affective disorder: Perspectives for the development of therapeutics. Current Molecular Medicine, 3, 393-407.
Joyce, P. R., Mulder, R. T., Luty, S. E., McKenzie, J. M., Miller, A., Rogers, G. R., & Kennedy, M. A. (2003). Age-dependent antidepressant pharmacogenomics: Polymorphisms of the serotonin transporter and G protein β3 subunit as predictors of response to fluoxetine and nortriptyline. International Journal of Neuropsychopharmacology, 6, 339-346.
Barclay, M. L., Sawyers, S. M., Begg, E. J., Zhang, M., Roberts, R., Kennedy, M. A., & Elliott, J. M. (2003). Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics, 13(10), 627-632.
Conference Contribution - Published proceedings: Abstract
Clark, D. W., Coulter, D. M., & Kennedy, M. A. (2003). Development of pharmacogenetic investigations in the New Zealand Intensive Medicines Monitoring Programme (IMMP). Pharmacoepidemiology and Drug Safety. 12(Suppl. 2), (pp. S215-S216). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
McHugh, P., Rogers, G. R., Allington, M., Cameron, V. A., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2003, July). Model systems for exploring antidepressant pharmacogenomics. Poster session presented at the XIX International Congress of Genetics: Genomes, the linkage to life, Victoria, Australia.
2002
Journal - Research Article
Stedman, C. A. M., Begg, E. J., Kennedy, M. A., Roberts, R., & Wilkinson, T. J. (2002). Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia. Human Psychopharmacology, 17(4), 187-190.
Kennedy, M. A., & Taylor, D. R. (2002). Beta-adrenergic receptor polymorphisms and drug responses in asthmatics. Pharmacogenomics, 3, 173-184.
Wood, J. G., Joyce, P. R., Miller, A., Mulder, R. T., & Kennedy, M. A. (2002). A polymorphism in the dopamine β-hydroxylase gene is associated with "paranoid ideation" in patients with major depression. Biological Psychiatry, 51, 365-369.
Ferguson, G., Heinemann, J., & Kennedy, M. A. (2002). Gene transfer between Salmonella enterica Serovar Typhimuirium inside epithelial cells. Journal of Bacteriology, 184, 2235-2242.
Littlejohn, M. D., Taylor, D. R., Miller, A. L., & Kennedy, M. A. (2002). Determination of β2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay. Human Mutation, 20(6), 479. doi: 10.1002/humu.9091
Roberts, R. L., Joyce, P. R., Mulder, R. T., Begg, E. J., & Kennedy, M. A. (2002). A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics Journal, 2(3), 191-196. doi: 10.1038/sj.tpj.6500099
Roberts, R., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2002). How the pharmacogenetics of cytochrome P450 enzymes may affect prescribing. New Zealand Medical Journal, 115(1150), 137-140.
Conference Contribution - Published proceedings: Abstract
Robertson, R. L., Joyce, P. R., Mulder, R. T., Begg, E. J., & Kennedy, M. A. (2002). P-Glycoprotein polymorphisms and nortriptyline-induced hypotension. Proceedings of the ASCEPT Annual Meeting. [Abstract]
McHugh, P., Rogers, G., Allington, M., Cameron, A. V., Edgar, P., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2002). Pharmacogenomics of antidepressant drug responses. American Journal of Medical Genetics abstracts for the Xth World Congress of Psychiatric Genetics. 114(7), (pp. 881). Brussels, Belgium. [Abstract]
Allington, M., Rogers, G. R., McHugh, P. C., Cameron, V. A., Edgar, P., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2002). Exploring differential gene expression in the brain following chronic antidepressant treatment. Proceedings of the 12th Annual Queenstown Molecular Biology Meeting. (pp. T2). Queenstown: Queenstown Molecular Biology Meeting, Inc. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Barclay, M. L., Gearry, R. B., Burt, M. J., Collett, J. A., Roberts, R. L., & Kennedy, M. A. (2002, November). Azathioprine and 6-mercaptopurine adverse effects and TPMT genotype in patients with inflammatory bowel disease. Verbal presentation at the Annual Meeting of the New Zealand Society of Gastroenterology, Auckland, New Zealand.
Kennedy, M. A. (2002, September). Genetic engineering in medicine: The first 30 years [Invited]. Verbal presentation at the National Conference of the New Zealand Dietetic Association, Palmerston North, New Zealand.
Kennedy, M. A. (2002, November). Coping with compliance [Invited]. Verbal presentation at the Microbes and Molecules Conference, Christchurch, New Zealand.
Kennedy, M. A. (2002, August). Drugd and DNA: An ABC of pharmacogenetics [Invited]. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Christchurch, New Zealand.
Barclay, M. L., Gearry, R. B., Burt, M. J., Collett, J. A., Roberts, R. L., & Kennedy, M. A. (2002, August). Azathioprine and 6-mercaptopurine adverse effects and TPMT genotype in patients with inflammatory bowel disease. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Meeting, Christchurch, New Zealand.
McHugh, P., Rogers, G., Allington, M., Cameron, A. V., Edgar, P., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2002, October). Pharmacogenomics of antidepressant drug responses. Verbal presentation at the Pharmacogenomics: The promise and reality of individualized treatment, Paris, France.
2001
Journal - Research Article
Martin, J. H., Begg, E. J., Kennedy, M. A., Roberts, R., & Barclay, M. L. (2001). Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration? British Journal of Clinical Pharmacology, 51, 627-630.
Taylor, D. R. R., & Kennedy, M. A. (2001). Genetic variation of the β2-adrenoceptor: functional and clinical importance in bronchial asthma. American Journal of PharmacoGenomics, 1(3), 165-174.
Kennedy, M. A. (2001). What does the human genome project mean for medicine? New Zealand Medical Journal, 114, 190-192.
Conference Contribution - Published proceedings: Full paper
Barclay, M. L., Sawyers, S. M., Begg, E. J., Roberts, R. L., Kennedy, M. A., & Elliott, J. M. (2001). Correlation of CYP450 2D6 genotype withperhexiline phenotypic metaboliser status. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 9, (pp. 111). [Full Paper]
Conference Contribution - Verbal presentation and other Conference outputs
Hopkins, R., & Kennedy, M. A. (2001, August). Variation within the promoter of the murine serotonin transporter gene. Verbal presentation at the 11th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Kennedy, M. A., & Taylor, D. R. (2001). Pharmacogenetics of asthma: Role of the andrenoceptor. Verbal presentation at the Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand, Christchurch, New Zealand.
Littlejohn, M. D., Miller, A., Taylor, R., & Kennedy, M. A. (2001). Rapid determination of 2-adrenergic receptor haplotypes using a multiplex polymerase chain reaction. Verbal presentation at the 11th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Kennedy, M. A. (2001, October). A common P-glycoprotein polymorphism is associated with nortriptyline induced postural hypotension in patients treated for major depression. Verbal presentation at the 9th World Congress on Psychiatric Genetics, St Louis, USA.
2000
Chapter in Book - Research
Kennedy, M. A. (2000). Mendelian Genetic Disorders. In The Encyclopedia of Life Sciences. London: Nature Publishing Group.
Journal - Research Article
Martin, J. H., Begg, E. J., Kennedy, M. A., Roberts, R. L., & Barclay, M. L. (2000). Cytochrome P450 2C9 genotype does not predict incidence of gastric bleeding with non steroidal anti-inflammatory drugs. Proceedings of ASCEPT, 7(April), 57.
Roberts, R., Sullivan, P., Joyce, P. R., & Kennedy, M. A. (2000). Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction. Human Mutation, 16, 77-85.
Conference Contribution - Published proceedings: Abstract
Rogers, G. R., Miller, A., Damak, S., & Kennedy, M. A. (2000). A mouse model of adrenoleukodystrophy: Analysis of cytokine gene expression in the brain. An oral presentation. Bulletin of the Human Genetics Society of Australasia. 13(2). NSW, Australia: SHS, Northwest Business Park. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M. A. (2000, July). Pharmacogenetics: What? How? Why? [Invited speaker]. Verbal presentation at the New Zealand Biotechnology Association Annual Meeting, Auckland.
Kennedy, M. A. (2000, November). Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction. Verbal presentation at the Thirt International Workshop on Advances Genomics, Japan.
Rogers, G., Allington, M., McHugh, P., Cameron, V., Edgar, P., Begg, E., Joyce, P., & Kennedy, M. (2000, July). Exploring differential gene expression in the brain following chronic antidepressant treatment. Verbal presentation at the Australian Microarray Meeting
Kennedy, M. A. (2000, June). A mouse model of X-linked adrenoleukodystrophy [Invited speaker]. Verbal presentation at the Australian New Zealand Society for Cell and Developmental Biology Inc.: Use of Genetically Modified Animals in Cell aqnd Developmental Biology, Dunedin.
Kennedy, M. A. (2000, September). Basic biological concepts needed for genetic epidemiology. Verbal presentation at the Workshop on Genetic Epidemiology: Australasian Epidemiology Association, Wellington.
1999
Journal - Research Article
Hanrahan, V., George, P. M., & Kennedy, M. A. (1999). Instability characteristics of trinucleotide (CAG) repeat tracts in Escherichia coli. Journal of Biochemistry, Molecular Biology & Biophysics, 3, 117-125.
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Damak, S., Miller, A. P., Cameron, A. V., Rogers, G. R., Day, W. A., … Fleming, J. S., … Love, D. R. (1999). A Mouse Model of Adrenoleukodystrophy. Proceedings of the Human Genome Meeting. Brisbane, Australia: Human Genome Organisation (HUGO). [Abstract]
Hanrahan, V., & Kennedy, M. A. (1999). Structure and expression of the human homeobox gene HLX1. 14th Symposium of the Federation of Asian and Oceanic Biochemists and Molecular Biologists. [Abstract]
Neville, L., Cameron, A. V., & Kennedy, M. A. (1999). Gene trapping in mouse embryonic stem cells. 9th Queenstown Molecular Biology Meeting. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Neville, L., Cameron, A. V., & Kennedy, M. A. (1999, March). Gene trapping in mouse embryonic stem cells. Verbal presentation at the Human Genome Meeting, Brisbane, Australia.
Roberts, R. L., Joyce, P. R., Sullivan, P. F., & Kennedy, M. A. (1999, December). Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplez polymerase chain reaction. Verbal presentation at the FAOMB Meeting on Gene Diversity and Bioinformatics, Dunedin, New Zealand.
Littlejohn, M. D., Taylor, D. R., Miller, A. L., & Kennedy, M. A. (1999, April). Determination of 2-adrenergic receptor haplotypes by a multiplexed polymerase chain reaction assay. Verbal presentation at the Human Genome Meeting, Shanghai, China.
1998
Journal - Research Article
Sullivan, P. F., Fifield, W. J., Kennedy, M. A., Mulder, R. T., Sellman, J. D., & Joyce, P. R. (1998). No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. American Journal of Psychiatry, 155, 98-101.
Conference Contribution - Verbal presentation and other Conference outputs
Kennedy, M., Miller, A., Rogers, G. R., Damak, S., Sharp, P., Carey, W. A., & Love, D. R. (1998). Mouse model of adrenoleukodysrophy. Verbal presentation at the 8th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
1997
Journal - Research Article
Dodd, A., Rowland, S., Hawkes, L. J., Kennedy, M. A., & Love, D. R. (1997). Mutations in the adrenoleukodystrophy gene. Human Mutation, 9(6), 500-511.
Sullivan, P. F., Fifield, W. J., Kennedy, M. A., Mulder, R. T., Sellman, J. D., & Joyce, P. R. (1997). Novelty seeking and a dopamine transporter gene polymorphism (DAT1). Biological Psychiatry, 42(11), 1070-1072.
1996
Chapter in Book - Research
Kennedy, M. A. (1996). Internet resources for human and mouse molecular genetics. In S. R. Swindell, R. Miller & G. S. A. Myers (Eds.), Internet for the Molecular Biologist. (pp. 123-149). Norfolk: Horizon Scientific Press.
Journal - Research Article
Kennedy, M. A., Rowland, S., Miller, A., Morris, C. M., Neville, L., Dodd, A., … Love, D. R. (1996). Structure and location of the murine adrenoleukodystrophy gene. Genomics, 32(3), 395-400.
Cameron, V. A., Aitken, G. D., Ellmers, L. J., Kennedy, M. A., & Espiner, E. A. (1996). The sites of gene expression of atrial, brain and C-type natriuretic peptides in mouse fetal development: Temporal changes in embryos and placenta. Endocrinology, 137(3), 817-824. doi: 10.1210/endo.137.3.8603590
Rowland, S., Dodd, A., Roche, A. L., Manilal, S., Kennedy, M. A., Becroft, D. M. O., … Love, D. R. (1996). DNA-based diagnostics for adrenoleukodystrophy in a large New Zealand family. New Zealand Medical Journal, 109, 312-315.
Morris, C., Jeffs, A., Smith, T., McDonald, M., Board, P., Kennedy, M., & Fitzgerald, P. (1996). BCR gene recombines with genomically distinct sites on band 11q13 in complex BCR-ABL translocations of chronic myeloid leukemia. Oncogene, 12(3), 677-685.
1995
Journal - Research Article
Neville, L., Cochrane, J., Fitzgerald, P. H., & Kennedy, M. A. (1995). Fragile X mental retardation syndrome: DNA diagnosis and carrier detection in New Zealand families. New Zealand Medical Journal, 108, 404-406.
1993
Journal - Research Article
Sowerby, S. J., Kennedy, M. A., Fitzgerald, P. H., & Morris, C. M. (1993). DNA sequence analysis of the major breakpoint cluster region of the BCR gene rearranged in Philadelphia-positive human leukemias. Oncogene, 8(6), 1679-1683.