Principal Investigator
Research Professor
Email margreet.vissers@otago.ac.nz
Tel +64 3 244 1117
Research interests
Vitamin C and cancer
Most of my current research revolves around determining the biological functions of vitamin C (ascorbate), which is widely considered to be an important natural antioxidant. However, ascorbate is also an essential co-factor for a family of enzymes, the 2-oxoglutarate-dependent dioxygenases, which control many biological processes, ranging from the stress response to hypoxia, to the regulation of epigenetic enzymes. These processes are important in cancer and we are investigating the contribution of ascorbate to cancer growth as a result of its co-factor activity for these enzymes. We are planning clinical trials to determine the impact of ascorbate on the processes involved in cancer cell biology.
Vitamin C and immunity
The cofactor activities of ascorbate are likely to influence many biological processes that impact on health and disease, and our aim is to understand the extent of this involvement in the functioning of the immune system. My research has shown that ascorbate affects white blood cell function, and we have an interest in the role of ascorbate in acute inflammatory diseases such as pneumonia and sepsis.
Vitamin C and optimal health
We have investigated the comparative bioavailability of vitamin C from different sources (i.e. food-derived or synthetic) to organs and tissues in an animal model and human subjects. This research will help to inform the debate around the appropriate Nutrient Reference Value and Recommended Dietary Intake for vitamin C. Ascorbate acts as a cofactor for the enzymatic synthesis of mood and energy controlling hormones. We have investigated the association of vitamin C intake from an excellent food source (kiwifruit) with measures of subjective mood, including fatigue, and shown that a high vitamin C diet can improve mood and energy levels. This preliminary research will be followed up with a larger clinical study.
White blood cells and inflammation
My research interests also include the investigation of cellular responses to stress, in particular stress resulting from exposure to oxidants. I have extensive experience in working with inflammatory cells, particularly neutrophils, as a source of highly reactive oxidants. Neutrophils generate hypochlorous acid (HOCl), i.e. household bleach, which is known for its anti-microbial activity. HOCl also reacts with many biological targets, as we are investigating how it damages cells and tissues, and how it contributes to the many deleterious effects of chronic inflammatory diseases such as atherosclerosis. The oxidative stress-related processes we are most interested in are apoptosis (cell clearance from sites of inflammation), cell signalling (e.g. nuclear factor-kB; NFkB, and hypoxia-inducible factor 1a; HIF-1) and cytotoxicity (cell death).
Keywords: cancer, immunity, vitamin C (ascorbate), inflammation, atherosclerosis, oxidative stress, antioxidants.
In the media
Professor Margreet Vissers was featured in Radio New Zealand's The Science Of... Vitamin C in August 2017.
Affiliations
Inaugural Professorial Lectures
Publications
Praditi, C., Beverley-Stone, E., Reid, M., Burgess, E. R., Crake, R. L., Vissers, M. C. M., Royds, J. A., Slatter, T. L., Dachs, G. U., & Phillips, E. (2025). Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro. Frontiers in Oncology, 15, 1536549. doi: 10.3389/fonc.2025.1536549 Journal - Research Article
Smith-Díaz, C. C., Das, A. B., Jurkowski, T. P., Hore, T. A., & Vissers, M. C. M. (2025). Exploring the ascorbate requirement of the 2-oxoglutarate-dependent dioxygenases. Journal of Medicinal Chemistry, 68, 2219-2237. doi: 10.1021/acs.jmedchem.4c02342 Journal - Research Other
Burgess, E. R., Praditi, C., Phillips, E., Vissers, M. C. M., Robinson, B. A., Dachs, G. U., & Wiggins, G. A. R. (2024). Role of sodium-dependent vitamin C transporter-2 and ascorbate in regulating the hypoxic pathway in cultured glioblastoma cells. Journal of Cellular Biochemistry, e30658. Advance online publication. doi: 10.1002/jcb.30658 Journal - Research Article
Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017 Journal - Research Article
Coker, S. J., Berry, M. J., Vissers, M. C. M., & Dyson, R. M. (2024). Maternal vitamin C intake during pregnancy influences long-term offspring growth with timing- and sex-specific effects in guinea pigs. Nutrients, 16(3), 369. doi: 10.3390/nu16030369 Journal - Research Article
2025
Journal - Research Article
Praditi, C., Beverley-Stone, E., Reid, M., Burgess, E. R., Crake, R. L., Vissers, M. C. M., Royds, J. A., Slatter, T. L., Dachs, G. U., & Phillips, E. (2025). Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro. Frontiers in Oncology, 15, 1536549. doi: 10.3389/fonc.2025.1536549
Journal - Research Other
Smith-Díaz, C. C., Das, A. B., Jurkowski, T. P., Hore, T. A., & Vissers, M. C. M. (2025). Exploring the ascorbate requirement of the 2-oxoglutarate-dependent dioxygenases. Journal of Medicinal Chemistry, 68, 2219-2237. doi: 10.1021/acs.jmedchem.4c02342
2024
Journal - Research Article
Burgess, E. R., Praditi, C., Phillips, E., Vissers, M. C. M., Robinson, B. A., Dachs, G. U., & Wiggins, G. A. R. (2024). Role of sodium-dependent vitamin C transporter-2 and ascorbate in regulating the hypoxic pathway in cultured glioblastoma cells. Journal of Cellular Biochemistry, e30658. Advance online publication. doi: 10.1002/jcb.30658
Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017
Coker, S. J., Berry, M. J., Vissers, M. C. M., & Dyson, R. M. (2024). Maternal vitamin C intake during pregnancy influences long-term offspring growth with timing- and sex-specific effects in guinea pigs. Nutrients, 16(3), 369. doi: 10.3390/nu16030369
Fletcher, B. D., Haszard, J. J., Vissers, M. C. M., & Conner, T. S. (2024). Smartphone survey data reveals the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention in adults with low vitamin C. British Journal of Nutrition, 131(8), 1384-1396. doi: 10.1017/S0007114523002787
2023
Journal - Research Article
Praditi, C., Bozonet, S. M., Dachs, G. U., & Vissers, M. C. M. (2023). Ascorbate uptake and retention by breast cancer cell lines and the intracellular distribution of sodium-dependent vitamin C transporter 2. Antioxidants, 12, 1929. doi: 10.3390/antiox12111929
Coker, S. J., Dyson, R. M., Smith-Díaz, C. C., Vissers, M. C. M., & Berry, M. J. (2023). Effects of low vitamin C intake on fertility parameters and pregnancy outcomes in guinea pigs. Nutrients, 15, 4107. doi: 10.3390/nu15194107
Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918
Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792
Conference Contribution - Published proceedings: Abstract
Praditi, C., Dachs, G., Bozonet, S., Pearson, J. A., Wiggins, G., & Vissers, M. (2023). The role of ascorbate in the activation of hypoxic response in breast cancer cell lines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Smith-Diaz, C., Magon, N. J., McKenzie, J. L., Hore, T., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2023). Transcriptomics and epigenomics analysis of SKM-1 leukaemia response to Vitamin C. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Vissers, M., & Smith Diaz, C. (2023). Considering the substrate requirements for the Fe-containing 2-oxoglutaratedependent dioxygenases and implications for their roles in development, metabolism and cancer. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
2022
Journal - Research Article
Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8
Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524
Journal - Research Other
Coker, S. J., Smith-Díaz, C. C., Dyson, R. M., Vissers, M. C. M., & Berry, M. J. (2022). The epigenetic role of vitamin C in neurodevelopment. International Journal of Molecular Sciences, 23, 1208. doi: 10.3390/ijms23031208
Vissers, M. C. M., & Pullar, J. M. (2022). Re-opening old wounds: Vitamin C and wound healing deserve a re-examination. American Journal of Clinical Nutrition, 115, 1-2. doi: 10.1093/ajcn/nqab300
Conference Contribution - Poster Presentation (not in published proceedings)
Vissers, M., Smith-Diaz, C., Coker, S., Dyson, R., Hore, T., & Berry, M. (2022, August-September). Low maternal vitamin C during pregnancy in guinea pigs results in persistent epigenetic dysregulation in the hippocampus of offspring together with an ADHD-related phenotype. Poster session presented at the 31st Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
2021
Journal - Research Article
Wohlrab, C., Vissers, M. C. M., Burgess, E. R., Nonis, M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2021). Limited association between ascorbate concentrations and vitamin C transporters in renal cell carcinoma cells and clinical samples. Cellular Physiology & Biochemistry, 55, 553-568. doi: 10.33594/000000435
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Frontiers in Oncology, 11, 709543. doi: 10.3389/fonc.2021.709543
Pearson, A. G., Pullar, J. M., Cook, J., Spencer, E. S., Vissers, M. C. M., Carr, A. C., & Hampton, M. B. (2021). Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration. Redox Biology, 43, 101980. doi: 10.1016/j.redox.2021.101980
Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021). Gene and protein expression is altered by ascorbate availability in murine macrophages cultured under tumour-like conditions. Antioxidants, 10(3), 430. doi: 10.3390/antiox10030430
Fletcher, B. D., Flett, J. A. M., Wickham, S.-R., Pullar, J. M., Vissers, M. C. M., & Conner, T. S. (2021). Initial evidence of variation by ethnicity in the relationship between vitamin C status and mental states in young adults. Nutrients, 13, 792. doi: 10.3390/nu13030792
Dachs, G. U., Gandhi, J., Wohlrab, C., Carr, A. C., Morrin, H. R., Pullar, J. M., Bayer, S. B., Eglinton, T. W., Robinson, B. A., & Vissers, M. C. M. (2021). Vitamin C administration by intravenous infusion increases tumor ascorbate content in patients with colon cancer: A clinical intervention study. Frontiers in Oncology, 10, 600715. doi: 10.3389/fonc.2020.600715
Journal - Research Other
Crake, R. L. I., Burgess, E. R., Royds, J. A., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2021). The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: A review of epigenetic reprogramming and hypoxic responses. Frontiers in Oncology, 11, 619300. doi: 10.3389/fonc.2021.619300
Das, A. B., Smith-Diaz, C. C., & Vissers, M. C. M. (2021). Emerging epigenetic therapeutics for myeloid leukemia: Modulating demethylase activity with ascorbate. Haematologica, 106(1), 14-25. doi: 10.3324/haematol.2020.259283
Conference Contribution - Published proceedings: Abstract
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org
Vissers, M. C., & Dachs, G. U. (2021). The 2-oxogiutarate-dependent dioxygenases: A new class of enzymes impacting cancer epigenetics and cancer cell metabolism. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 128). Retrieved from https://www.faobmb2021.org
Other Research Output
Vissers, M. (2021, August). What's in a name? The non-haem Fe(II) 2-oxoglutarate-dependent dioxygenases. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2020
Edited Book - Research
Chen, Q., & Vissers, M. C. M. (Eds.). (2020). Cancer and vitamin C. Boca Raton, FL: CRC Press, 174p.
Chen, Q., & Vissers, M. C. M. (Eds.). (2020). Vitamin C: New biochemical and functional insights. Boca Raton, FL: CRC Press, 256p.
Chapter in Book - Research
Pullar, J. M., & Vissers, M. C. M. (2020). Role of Vitamin C in chronic wound healing. In Q. Chen & M. C. M. Vissers (Eds.), Vitamin C: New biochemical and functional insights. (pp. 161-179). Boca Raton, FL: CRC Press.
Ang, A., Vissers, M. C. M., & Pullar, J. M. (2020). Vitamin C in immune cell function. In Q. Chen & M. C. M. Vissers (Eds.), Vitamin C: New biochemical and functional insights. (pp. 137-159). Boca Raton, FL: CRC Press.
Vissers, M. C. M., & Das, A. B. (2020). Ascorbate as an enzyme cofactor. In Q. Chen & M. C. M. Vissers (Eds.), Vitamin C: New biochemical and functional insights. (pp. 71-98). Boca Raton, FL: CRC Press.
Vissers, M. C. M., Pullar, J. M., & Smirnoff, N. (2020). Chemistry and biochemistry of vitamin C in mammalian systems. In Q. Chen & M. C. M. Vissers (Eds.), Vitamin C: New biochemical and functional insights. (pp. 25-37). Boca Raton, FL: CRC Press.
Journal - Research Article
Conner, T. S., Fletcher, B. D., Haszard, J. J., Pullar, J. M., Spencer, E., Mainvil, L. A., & Vissers, M. C. M. (2020). KiwiC for vitality: Results of a placebo-controlled trial testing the effects of kiwifruit or vitamin C tablets on vitality in adults with low vitamin C levels. Nutrients, 12, 2898. doi: 10.3390/nu12092898
White, R., Nonis, M., Pearson, J. F., Burgess, E., Morrin, H. R., Pullar, J. M., Spencer, E., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2020). Low vitamin C status in patients with cancer is associated with patient and tumor characteristics. Nutrients, 12(8), 2338. doi: 10.3390/nu12082338
Pullar, J. M., Dunham, S., Dachs, G. U., Vissers, M. C. M., & Carr, A. C. (2020). Erythrocyte ascorbate is a potential indicator of steady-state plasma ascorbate concentrations in healthy non-fasting individuals. Nutrients, 12(2), 418. doi: 10.3390/nu12020418
Journal - Research Other
Pullar, J. M., & Vissers, M. C. M. (2020). Re: "Micronutrient status of diabetic patients with food ulcers" by Pena et al. Advances in Wound Care, 10(1), 49-50. doi: 10.1089/wound.2020.1184
2019
Journal - Research Article
Talla, U., Bozonet, S. M., Parker, H. A., Hampton, M. B., & Vissers, M. C. M. (2019). Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils. Journal of Leukocyte Biology, 106, 1367-1379. doi: 10.1002/jlb.4a0319-079rr
Tang, J. S., Bozonet, S. M., McKenzie, J. L., Anderson, R. F., Melton, L. D., & Vissers, M. C. M. (2019). Physiological concentrations of blueberry-derived phenolic acids reduce monocyte adhesion to human endothelial cells. Molecular Nutrition & Food Research, 63, 1900478. doi: 10.1002/mnfr.201900478
Wohlrab, C., Kuiper, C., Vissers, M. C. M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2019). Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells. Hypoxia, 7, 17-31. doi: 10.2147/hp.S201643
Campbell, E. J., Dachs, G. U., Morrin, H. R., Davey, V., Robinson, B. A., & Vissers, M. C. M. (2019). Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels. BMC Cancer, 19, 307. doi: 10.1186/s12885-019-5503-x
Journal - Research Other
Das, A. B., Kakadia, P. M., Wojcik, D., Pemberton, L., Browett, P. J., Bohlander, S. K., & Vissers, M. C. M. (2019). Clinical remission following ascorbate treatment in a case of acute myeloid leukemia with mutations in TET2 and WT1. Blood Cancer Journal, 9, 82. doi: 10.1038/s41408-019-0242-4
Conference Contribution - Published proceedings: Abstract
Carr, A., Vissers, M., & Cook, J. (2019). Pharmacologic vitamin C improves fatigue and quality of life in cancer patients. Proceedings, 5(1), 3 (6.1). doi: 10.3390/proceedings2019005003
Dachs, G., & Vissers, M. (2019). Regulation of transcription factors by ascorbate. Proceedings, 5(1), 3 (3.2). doi: 10.3390/proceedings2019005003
Vissers, M. C. M. (2019). Overview of vitamin C: New horizons for nutrition and in the clinic. Proceedings, 5(1), 3 (2.1). doi: 10.3390/proceedings2019005003
Das, A. B., Kakadia, P. M., Wojcik, D., Pemberton, L., Browett, P. J., Bohlander, S. K., & Vissers, M. C. M. (2019). Ascorbate targets acute myeloid leukaemia subclones with mutations that affect TET2 activity. Proceedings, 5(1), 3 (6.6). doi: 10.3390/proceedings2019005003
Conference Contribution - Verbal presentation and other Conference outputs
Das, A. B., Hampton, M. B., & Vissers, M. C. M. (2019, August-September). Creodes and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Edited Book - Research
Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p.
Chapter in Book - Research
Vissers, M. C. M., Pullar, J. M., & Peskin, A. V. (2018). Myeloperoxidase-derived oxidants hypochlorous acid and chloramines: Microbicidal marvels and inflammatory mischief makers. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 305-326). Boca Raton, FL: CRC Press.
Journal - Research Article
Wohlrab, C., Vissers, M. C. M., Phillips, E., Morrin, H., Robinson, B. A., & Dachs, G. U. (2018). The association between ascorbate and the hypoxia-inducible factors in human renal cell carcinoma requires a functional von Hippel-Lindau protein. Frontiers in Oncology, 8, 574. doi: 10.3389/fonc.2018.00574
Pullar, J. M., Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2018). High vitamin C status is associated with elevated mood in male tertiary students. Antioxidants, 7(7), 91. doi: 10.3390/antiox7070091
Tang, J. S., Vissers, M. C. M., Anderson, R. F., Sreebhavan, S., Bozonet, S. M., Scheepens, A., & Melton, L. D. (2018). Bioavailable blueberry-derived phenolic acids at physiological concentrations enhance Nrf2-regulated antioxidant responses in human vascular endothelial cells. Molecular Nutrition & Food Research, 62(5), 1700647. doi: 10.1002/mnfr.201700647
Journal - Research Other
Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018). Vitamin C and immune cell function in inflammation and cancer. Biochemical Society Transactions, 46, 1147-1159. doi: 10.1042/bst20180169
Vissers, M. C. M., & Das, A. B. (2018). Potential mechanisms of action for vitamin C in cancer: Reviewing the evidence. Frontiers in Physiology, 9, 809. doi: 10.3389/fphys.2018.00809
Conference Contribution - Published proceedings: Abstract
Wohlrab, C., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2018). Vitamin C transporters in renal cell carcinoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Das, A., Morison, I., Bohlander, S., & Vissers, M. (2018). The potential use of ascorbate as an epigenetic therapeutic in acute myeloid leukaemia. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Vissers, M. C. M., Das, A., & Dachs, G. U. (2018). The 2-oxoglutarate-dependent dioxygenases and their role in cancer development, growth and metastasis. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Wohlrab, C., Kuiper, C., Vissers, M. C. M., Phillips, E., Robinson, B., & Dachs, G. U. (2018). Ascorbate modulates the hypoxic pathway by increasing activity of HIF hydroxylases. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Conference Contribution - Poster Presentation (not in published proceedings)
Campbell, E., Dachs, G. U., Morrin, H. R., Davey, V., Robinson, B. A., & Vissers, M. C. M. (2018, August). The regulation of the tumour hypoxic response by ascorbate and association with clinicopathological factors and patient outcome in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Das, A. B., Kakadia, P. M., Morison, I. M., Bohlander, S. K., & Vissers, M. C. M. (2018, August). The potential use of ascorbate as an epigenetic therapeutic in acute myeloid leukaemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Das, A., Morison, I., Kennedy, M., & Vissers, M. (2018, April). The potential use of ascorbate as an epigenetic therapeutic in acute myeloid leukaemia by enhancing 2-oxoglutarate dependent dioxygenase activity. Poster session presented at the Keystone Symposium: Therapeutic Targeting of Hypoxia-Sensitive Pathways, Oxford, UK.
Conference Contribution - Verbal presentation and other Conference outputs
Dachs, G. U., & Vissers, M. C. (2018, August). The role of ascorbate in modifying the hypoxic response in cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Journal - Research Article
Mitsuya, K., Parker, A. N., Liu, L., Ruan, J., Vissers, M. C. M., & Myatt, L. (2017). Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation. PLoS ONE, 12(10), e0186115. doi: 10.1371/journal.pone.0186115
Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The roles of vitamin C in skin health. Nutrients, 9(8), 866. doi: 10.3390/nu9080866
Pearson, J. F., Pullar, J. M., Wilson, R., Spittlehouse, J. K., Vissers, M. C. M., Skidmore, P. M. L., Willis, J., Cameron, V. A., & Carr, A. C. (2017). Vitamin C status correlates with markers of metabolic and cognitive health in 50-year-olds: Findings of the CHALICE Cohort Study. Nutrients, 9(8), 831. doi: 10.3390/nu9080831
Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327
Conner, T. S., Brookie, K. L., Carr, A. C., Mainvil, L. A., & Vissers, M. C. M. (2017). Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial. PLoS ONE, 12(2), e0171206. doi: 10.1371/journal.pone.0171206
Brookie, K. L., Mainvil, L. A., Carr, A. C., Vissers, M. C. M., & Conner, T. S. (2017). The development and effectiveness of an ecological momentary intervention to increase daily fruit and vegetable consumption in low-consuming young adults. Appetite, 108, 32-41. doi: 10.1016/j.appet.2016.09.015
Conference Contribution - Published proceedings: Abstract
Vissers, M. C. M. (2017). Vitamin C-dependent regulation of the hypoxic response in cancer [Invited]. Antioxidants, 6(4), 94. doi: 10.3390/antiox6040094
Conference Contribution - Poster Presentation (not in published proceedings)
Das, A., Morison, I., Kennedy, M., & Vissers, M. (2017, October). The potential use of ascorbate as an epigenetic drug in acute myeloid leukaemia. Poster session presented at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
Bozonet, S., Hampton, M., & Vissers, M. (2017, September). Hypothiocyanous acid protects endothelial cells from hypochlorous acid-mediated death. Poster session presented at the European Cell Death Organisation (ECDO)25gth Conference: Cell Death and Immunity in Disease: From Molecules to Translational Medicine, Leuven, Belgium.
Conference Contribution - Verbal presentation and other Conference outputs
Talla, U. R., Parker, H., Bozonet, S., Hampton, M., & Vissers, M. (2017, July). An altered cell death pathway for neutrophils in a hypoxic environment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Carr, A., Vissers, M., & Shaw, G. (2017, July). Can vitamin C aid immune function in sepsis? Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
2016
Journal - Research Article
Campbell, E. J., Vissers, M. C. M., Wohlrab, C., Hicks, K. O., Strother, R. M., Bozonet, S. M., Robinson, B. A., & Dachs, G. U. (2016). Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radical Biology & Medicine, 99, 451-462. doi: 10.1016/j.freeradbiomed.2016.08.027
Carr, A. C., Pullar, J. M., Bozonet, S. M., & Vissers, M. C. M. (2016). Marginal ascorbate status (Hypovitaminosis C) results in an attenuated response to vitamin C supplementation. Nutrients, 8(6), 341. doi: 10.3390/nu8060341
Campbell, E. J., Vissers, M. C. M., & Dachs, G. U. (2016). Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice. Hypoxia, 4, 41-52. doi: 10.2147/HP.S103088
Conference Contribution - Published proceedings: Abstract
Brookie, K., Mainvil, L., Carr, A., Vissers, M., & Conner, T. (2016). The effect of fruit and vegetable consumption on psychological wellbeing in young adults. European Health Psychology Society (EHPS) and the British Psychology Society Division of Health Psychology (DHP) Annual Conference. (pp. 499). Retrieved from http://ehps2016.org
Campbell, E., Vissers, M., Wohlrab, C., Hicks, K., Strother, M., Robinson, B., Bozonet, S., & Dachs, G. (2016). High-dose ascorbate administration increases tumor ascorbate levels and decreases hypoxia-inducible factor-1 activity and tumor growth in mice. Free Radical Biology & Medicine, 100(Suppl.), (pp. S132). doi: 10.1016/j.freeradbiomed.2016.10.346
Talla, U. R., Bozonet, S., Parker, H., Hampton, M., & Vissers, M. (2016). Inhibition of neutrophil apoptosis and initiation of an autophagy-like process in hypoxia and effects on neutrophil function. Free Radical Biology & Medicine, 100(Suppl.), (pp. S63). doi: 10.1016/j.freeradbiomed.2016.10.166
Vissers, M. C. M., Campbell, E. J., Kuiper, C., Carr, A. C., Wohlrab, C., Bozonet, S. M., Morrin, H., Robinson, B. A., & Dachs, G. U. (2016). Ascorbate as an anti-cancer therapy? Investigations into feasibility and potential mechanism of action. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
2015
Journal - Research Article
Bozonet, S. M., Carr, A. C., Pullar, J. M., & Vissers, M. C. M. (2015). Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients, 7(4), 2574-2588. doi: 10.3390/nu7042574
Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422
Campbell, E. J., Vissers, M. C. M., Bozonet, S., Dyer, A., Robinson, B. A., & Dachs, G. U. (2015). Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo−/− mice. Cancer Medicine, 4(2), 303-314. doi: 10.1002/cam4.349
Journal - Research Other
Carr, A. C., Vissers, M. C. M., & Cook, J. S. (2015). Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis. Case Reports in Clinical Pathology, 2(2), 57-61. doi: 10.5430/crcp.v2n2p57
Conference Contribution - Published proceedings: Abstract
Carr, A., Pullar, J., Bozonet, S., & Vissers, M. (2015). Marginal ascorbate status (hypovitaminosis C) results in an attenuated response to supplementation. Proceedings of the Nutrition Society of Australia, 39, (pp. 71). Sydney, Australia: Nutrition Society of Australia. [Abstract]
Brookie, K., Carr, A., Vissers, M., & Conner, T. (2015). Can an apple a day keep the psychologist away? The role of fruit and vegetable consumption in psychological well-being of young adults. Proceedings of the Psycolloquy Seminar. (pp. 12). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from http://www.otago.ac.nz/psychology/research/otago059081.html
Conference Contribution - Poster Presentation (not in published proceedings)
Ernst, C., Phillips, E., Morrin, H., Vissers, M., Robinson, B., & Dachs, G. (2015, October). The role of ascorbate in controlling hypoxia factors in renal cell carcinoma. Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.
2014
Journal - Research Article
Kuiper, C., & Vissers, M. C. M. (2014). Ascorbate as a cofactor for Fe-and 2-oxoglutarate dependent dioxygenases: Physiological activity in tumour growth and progression. Frontiers in Oncology, 4, 359. doi: 10.3389/fonc.2014.00359
Kuiper, C., Vissers, M. C. M., & Hicks, K. O. (2014). Pharmacokinetic modelling of ascorbate diffusion through normal and tumour tissue. Free Radical Biology & Medicine, 77, 340-352. doi: 10.1016/j.freeradbiomed.2014.09.023
Carr, A. C., Vissers, M. C. M., & Cook, J. S. (2014). The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Frontiers in Oncology, 4, 283. doi: 10.3389/fonc.2014.00283
Vissers, M. C. M., Kuiper, C., & Dachs, G. U. (2014). Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer. Biochemical Society Transactions, 42(4), 945-951. doi: 10.1042/bst20140118
Flett, T., Campbell, E. J., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2014). Gulonolactone addition to human hepatocellular carcinoma cells with gene transfer of gulonolactone oxidase restores ascorbate biosynthesis and reduces hypoxia inducible factor 1. Biomedicines, 2(1), 98-109. doi: 10.3390/biomedicines2010098
Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2014). Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radical Biology & Medicine, 69, 308-317. doi: 10.1016/j.freeradbiomed.2014.01.033
Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2014). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer. Frontiers in Oncology, 4, 10. doi: 10.3389/fonc.2014.00010
Journal - Research Other
Carr, A. C., Vissers, M. C. M., & Cook, J. (2014). Parenteral vitamin C for palliative care of terminal cancer patients. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal
Dachs, G. U., Munn, D. G., Carr, A. C., Vissers, M. C. M., & Robinson, B. A. (2014). Consumption of vitamin C is below recommended daily intake in many cancer patients and healthy volunteers in Christchurch. New Zealand Medical Journal, 127(1390). Retrieved from http://www.nzma.org.nz/journal
Carr, A. C., Vissers, M. C. M., & Cook, J. (2014). Relief from cancer chemotherapy side effects with pharmacologic vitamin C. New Zealand Medical Journal, 127(1388). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Kuiper, C., Dachs, G., Currie, M., Pearson, J., Munn, D., & Vissers, M. (2014). Tumor ascorbate content is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Flett, T., Campbell, E., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2014). Does gene transfer of gulono-lactone oxidase into human hepatocellular carcinoma cells restore ascorbate biosynthesis? Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Campbell, E. J., Bozonet, S. M., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014). Restoring physiological levels of ascorbate alleviates HIF-1 activation and reduces tumour growth in Gulo-/- mice. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Conference Contribution - Poster Presentation (not in published proceedings)
Campbell, E. J., Bozonet, S., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014, August). Pharmacokinetic and anti-cancer properties of high dose vitamin C in tumour bearing Gulo-/- mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Vissers, M. (2014, November). Vitamin C for cancer: New mechanisms controlling gene expression. Verbal presentation at the 10th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Vissers, M. (2014, July). Cell metabolism and control of the 2-oxoglutarate-dependent dioxygenases. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.
Hicks, K. O., Hay, M. P., McManaway, S. P., Pruijn, F. B., Kuiper, C., Vissers, M. C. M., … Wilson, W. R. (2014, August). The tumour microenvironment in vitro and in silico. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Vissers, M. C. M., & Kuiper, C. (2014, August). Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Campbell, E., Kuiper, C., Vissers, M. C. M., & Dachs, G. (2014, August). Vitamin C is not dispensible for oxygen sensing. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Vissers, M. (2014, August). Metabolic sensing by the 2-oxyglutarate-dependent dioxygenase demethylases and potential effects on epigenetics. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Vissers, M. (2014, May). Vitamin C and quality of life. Verbal presentation at the Australasian Integrative Medicine Association (AIMA) Conference, Auckland, New Zealand.
2013
Chapter in Book - Research
Vissers, M. C. M., Carr, A. C., Pullar, J. M., & Bozonet, S. M. (2013). The bioavailability of vitamin C from kiwifruit. In M. Boland & P. J. Moughan (Eds.), Nutritional benefits of kiwifruit. (pp. 125-147). Waltham, MA: Academic Press. doi: 10.1016/b978-0-12-394294-4.00007-9
Journal - Research Article
Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2013). A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C. Nutrients, 5(11), 4451-4461. doi: 10.3390/nu5114451
Carr, A. C., & Vissers, M. C. M. (2013). Synthetic or food-derived vitamin C—are they equally bioavailable? Nutrients, 5(11), 4284-4304. doi: 10.3390/nu5114284
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C. Nutrients, 5(9), 3684-3695. doi: 10.3390/nu5093684
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013). Mood improvement in young adult males following supplementation with gold kiwifruit, a high-vitamin C food. Journal of Nutritional Science, 2, e24. doi: 10.1017/jns.2013.12
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. American Journal of Clinical Nutrition, 97, 800-807. doi: 10.3945/ajcn.112.053207
Journal - Research Other
Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2013). Vitamin C supplementation and kidney stone risk. New Zealand Medical Journal, 126(1384). Retrieved from http://www.nzma.org.nz/journal
Carr, A. C., Pullar, J. M., & Vissers, M. C. M. (2013). Beating the blues: The association between fruit and vegetable intake and improved mood. New Zealand Medical Journal, 126(1384). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013). Mood and vitality improvement in young adult males following supplementation with gold kiwifruit, a high vitamin C food. Australasian Medical Journal, 6(11), (pp. 667). [Abstract]
Carr, A. C., Pullar, J. M., Bozonet, S. M., Moran, S., & Vissers, M. C. M. (2013). Bioavailability of vitamin C from a common food source (kiwifruit) in young adult males. Australasian Medical Journal, 6(11), (pp. 658). [Abstract]
Schon, B. S., Hooper, G., Vissers, M., & Woodfield, T. B. F. (2013). Assembling modular components to engineer articular cartilage. Proceedings of the Tissue Engineering and Regenerative Medicine International Society European Chapter Meeting (TERMIS-EU). (pp. 266). Retrieved from http://www.termis.org/eu2013/
Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2013). The impact of physiological levels of vitamin C on tumour growth and HIF-1 activation in the Gulo -/- mouse. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2013, August). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Carr, A. C., Vissers, M. C. M., & Cook, J. (2013, August). Pharmacologic vitamin C improves fatigue and quality of life in cancer patients: Two case reports. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013, August). Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013, August). Mood improvement and reduced fatigue in young adult males following supplementation with kiwifruit, a high vitamin C food. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Pujary, U. R., Hampton, M., Parker, H., & Vissers, M. (2013, August). Effect of hypoxia on neutrophil survival and function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2013, August). The effect of dietary ascorbate levels on tumour growth and HIF-1 activation in the Gulo-/- mouse. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Vissers, M. C. M., Kuiper, C., Dachs, G. U., Campbell, E., Pujary, U.-R., Bozonet, S. M., Pullar, J. M., & Carr, A. C. (2013, August). The role of vitamin C in managing metabolic stress and its impact in tumour biology and inflammation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2012
Journal - Research Article
Carr, A. C., Pullar, J. M., Moran, S., & Vissers, M. C. M. (2012). Bioavailability of vitamin C from kiwifruit in non-smoking males: Determination of ‘healthy’ and ‘optimal’ intakes. Journal of Nutritional Science, 1, e14. doi: 10.1017/jns.2012.15
Stacey, M. M., Vissers, M. C., & Winterbourn, C. C. (2012). Oxidation of 2-Cys peroxiredoxins in human endothelial cells by hydrogen peroxide, hypochlorous acid and chloramines. Antioxidants & Redox Signaling, 17(3), 411-421. doi: 10.1089/ars.2011.4348
Journal - Research Other
Carr, A. C., Vissers, M. C. M., Lewis, J., & Elder, P. (2012). Multiple nutrient insufficiencies: Hypovitaminosis D and C in young adult New Zealand males. New Zealand Medical Journal, 125(1364). Retrieved from http://www.nzma.org.nz/journal
Carr, A. C., & Vissers, M. C. M. (2012). Good nutrition matters: Hypovitaminosis C associated with depressed mood and poor wound healing. New Zealand Medical Journal, 125(1362). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Pujary, U. R., Hampton, M., Winterbourn, C., & Vissers, M. (2012). Hypoxia extends neutrophil survival but does not necessarily retain cell function. Proceedings of the Oxygen Theme Meeting. (pp. 35). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Dachs, G., Kuiper, C., Currie, M. J., & Vissers, M. C. M. (2012). Impact of ascorbate levels on hypoxia inducible factor-1 activity in cancer cells in culture and in endometrial tumours. Mutagenesis, 27(1), (pp. 114). doi: 10.1093/mutage/ger068
Conference Contribution - Poster Presentation (not in published proceedings)
Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, September). Intracellular ascorbate and HIF-1 inhibition in cancer cells. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2012, September). The impact of physiological levels of vitamin C on tumour growth in gulo-/- mice. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2012, August). The impact of physiological levels of vitamin C on tumour growth in Gulo-/-mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Vissers, M. (2012, August). Understanding the biochemistry of vitamin C: From enzyme co-factor to antioxidant and back again. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, August). Intracellular ascorbate and modification of the tumour response to the microenvironment. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Parker, A., Cuddihy, S. L., Son, T. G., Vissers, M. C. M., & Winterbourn, C. C. (2011). Roles of superoxide and myeloperoxidase in ascorbate oxidation in stimulated neutrophils and H2O2-treated HL60 cells. Free Radical Biology & Medicine, 51(7), 1399-1405. doi: 10.1016/j.freeradbiomed.2011.06.029
Vissers, M. C. M., Bozonet, S. M., Pearson, J. F., & Braithwaite, L. J. (2011). Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: Tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit). American Journal of Clinical Nutrition, 93, 292-301. doi: 10.3945/ajcn.110.004853
Conference Contribution - Published proceedings: Abstract
Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2011). Low ascorbate levels are associated with high hypoxia-inducible factor-1 activity and a more aggressive tumor phenotype in endometrial cancer. Clinical and Experimental Metastasis. 28(2), (pp. 175). doi: 10.1007/s10585-010-9361-9
Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2011). Optimal intracellular ascorbate concentrations suppress hypoxia-inducible factor-la and its transcriptional activity differentially in cancer and normal cells. Clinical & Experimental Metastasis. 28(2), (pp. 231-232). doi: 10.1007/s10585-010-9361-9
Conference Contribution - Verbal presentation and other Conference outputs
Vissers, M. (2011, May). The vital role of ascorbate as an enzyme co-factor and implications for its role in cancer treatment and prevention. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
2010
Journal - Research Article
Bozonet, S. M., Scott-Thomas, A. J., Nagy, P., & Vissers, M. C. M. (2010). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation in endothelial cells. Free Radical Biology & Medicine, 49(6), 1054-1063. doi: 10.1016/j.freeradbiomed.2010.06.028
Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263
Conference Contribution - Published proceedings: Abstract
Stacey, M. M., Vissers, M., & Winterbourn, C. (2010). Oxidation versus hyperoxidation of peroxiredoxins in human endothelial cells exposed to inflammatory oxidants. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/journal/123-1324/4402/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Bozonet, S. M., Scott-Thomas, A., Nagy, P., & Vissers, M. C. M. (2010, November-December). Hypothiocyanous acid is a selective inhibitor of caspase activation and apoptosis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Vissers, M. C. M., Bozonet, S. M., & Kuiper, C. (2010, November-December). The vital role of ascorbate as an enzyme co-factor and implications for its role in health and nutrition. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
2009
Journal - Research Article
Stacey, M. M., Peskin, A. V., Vissers, M. C., & Winterbourn, C. C. (2009). Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2. Free Radical Biology & Medicine, 47(10), 1468-1476. doi: 10.1016/j.freeradbiomed.2009.08.022
Conference Contribution - Published proceedings: Abstract
Vissers, M., & Bozonet, S. (2009). Oxidative stress in the blood vessel wall and the development of atherosclerosis. Journal of Vascular Research, 46(Suppl. 2), (pp. 11). doi: 10.1159/000230992
Stacey, M. M., Vissers, M. C. M., & Winterbourn, C. C. (2009). Characterization of peroxiredoxin oxidation mediated by inflammatory oxidants in human endothelial cells. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Dann, J., Evans, J., Sykes, P., Vissers, M., & Mason, D. (2009). Food compounds in the regulation of angiogenic factors in endometrial cancer. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Stacey, M., Vissers, M., & Winterbourn, C. (2009). Characterization of peroxiredoxin oxidation mediated by inflammatory oxidants in human endothelial cells. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S82). [Abstract]
Bozonet, S. M., Scott-Thomas, A., Nagy, P., & Vissers, M. (2009). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S55). [Abstract]
Vissers, M., & Kuiper, C. (2009). Vitamin C and the regulation of HIF-1: Impact on cell survival in inflammation and cancer. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S9). [Abstract]
Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S172-S173). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Vissers, M. (2009, August). Oxidative stress in the blood vessel wall and the development of atherosclerosis. Verbal presentation at the 14th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Queenstown, New Zealand.
Vissers, M. (2009, December). Inhibition of apoptosis and caspase 3 activation in endothelial cells by hypothiocyanous acid. Verbal presentation at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.
Vissers, M., & Kuiper, C. (2009, November). Vitamin C and the regulation of HIF-1: Impact on cell survival in inflammation and cancer. Plenary presentation at the Society for Free Radical Biology and Medicine (SFRBM) 16th Annual Meeting, San Francisco, CA, USA.
Film/Video/CD Rom
Fraser, R., Chambers, S., Fellows, A., Brennan, S., Vissers, M., Fu, R., & Scott-Thomas, A. (2009). The Body, the Research, the Professor: Respiratory Research and Cystic Fibrosis [Episode 5] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
2008
Journal - Research Article
Cuddihy, S. L., Parker, A., Harwood, D. T., Vissers, M. C. M., & Winterbourn, C. C. (2008). Ascorbate interacts with reduced glutathione to scavenge phenoxyl radicals in HL60 cells. Free Radical Biology & Medicine, 44(8), 1637-1644. doi: 10.1016/j.freeradbiomed.2008.01.021
Conference Contribution - Published proceedings: Abstract
Stacey, M. M., Winterbourn, C. C., & Vissers, M. C. (2008). Prx II provides protection against neutrophil-derived oxidants in human erythrocytes. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Wilkie, R., Vissers, M. C. M., & Hampton, M. B. (2008). A functional NADPH oxidase promotes neutrophil apoptosis by a caspase-independent mechanism. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Vissers, M., Suzuki, S., Scott-Thomas, A., Gunningham, S., & Dachs, G. (2008). The effect of intracellular ascorbate on HIF-1 mediated gene expression and the phenotype of tumour cells. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
2007
Journal - Research Article
Vissers, M. C. M., & Wilkie, R. P. (2007). Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1α. Journal of Leukocyte Biology, 81, 1236-1244. doi: 10.1189/jlb.0806541
Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007). Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radical Biology & Medicine, 42, 765-772.
Wilkie, R. P., Vissers, M. C. M., Dragunow, M., & Hampton, M. B. (2007). A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection & Immunity, 75(7), 3256-3263.
2006
Journal - Research Article
Gokhalé, P., Patel, T., Morrison, M. J., & Vissers, M. C. M. (2006). The effect of intracellular ascorbate on the susceptibility of HL60 and Jurkat cells to chemotherapy agents. Apoptosis, 11, 1737-1746.
Midwinter, R. G., Cheah, F.-C., Moskovitz, J., Vissers, M. C., & Winterbourn, C. C. (2006). IκB is a sensitive target for oxidation by cell-permeable chloramines: Inhibition of NF-κB activity by glycine chloramine through methionine oxidation. Biochemical Journal, 396, 71-78.
Conference Contribution - Published proceedings: Abstract
Vissers, M., Gunningham, S., Morrison, M., Dachs, G., & Currie, M. (2006). Modulation of hypoxia-inducible factor 1-α in cultured primary cells by intracellular ascorbate: An important function for vitamin C. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf
Vissers, M. C. M. (2006). Vitamin C is essential for neutrophil apoptosis: Implications for the resolution of inflammation and death by scurvy. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
Wilkie, R., Vissers, M., & Hampton, M. (2006). Role of NADPH oxidase: Derived oxidants in neutrophil apoptosis. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
2005
Journal - Research Article
Cheah, F. C., Winterbourn, C. C., Darlow, B. A., Mocatta, T. J., & Vissers, M. C. M. (2005). Nuclear factor κB activation in pulmonary leukocytes from infants with hyaline membrane disease: Associations with chorioamnionitis and Ureaplasma urealyticum colonization. Pediatric Research, 57(5), 616-623. doi: 10.1203/01.PDR.0000156209.37627.82
Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-KB activation. Journal of Leukocyte Biology, 77, 432-437.
2004
Journal - Research Article
Midwinter, R. G., Peskin, A. V., Vissers, M. C. M., & Winterbourn, C. C. (2004). Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor. Journal of Biological Chemistry, 279(31), 32205-32211.
Conference Contribution - Published proceedings: Full paper
Vissers, M. C. M., & Hampton, M. B. (2004). The role of oxidants and vitamin C on neutrophil apoptosis and clearance. Biochemical Society Transactions. 32(3), (pp. 499-501). [Full Paper]
Conference Contribution - Published proceedings: Abstract
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. M. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Proceedings of the Perinatal Society of Australia and New Zealand: 8th Annual Congress. (pp. P133). Sydney, Australia: PSANZ. [Abstract]
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Pediatric Research. 56(3), (pp. 474). [Abstract]
2003
Conference Contribution - Published proceedings: Abstract
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hunter, L. A., Mogridge, N., & Vissers, M. C. M. (2003). Nuclear factor-kappa B activation is expressed in tracheal aspriate cells of premature infants born with evidence of histologic chorioamnionitis. Proceedings of the 7th Annual Congress of the Perinatal Society of Australia and New Zealand. [Abstract]
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Mocatta, T. J., Mogridge, N., & Vissers, M. C. (2003). Nuclear factor-κB activation is expressed in tracheal aspirate cells of premature infants born with evidence of histologic chorioamnionitis. Pediatric Research. 53. [Abstract]
Cheah, F. C., Winterbourn, C. C., Darlow, B. A., Mocatta, T. J., Harwood, D. T., & Vissers, M. C. (2003). NF-Kappa B activation in pulmonary neutrophils was associated with elevated TNF-alpha levels in tracheal aspirates of infants with HMD. American Journal of Respiratory and Critical Care Medicine. 167. [Abstract]
2002
Journal - Research Article
Pullar, J., Winterbourn, C. C., & Vissers, M. C. M. (2002). The effect of hypochlorous acid on the expression of adhesion molecules and activation of NF-κ in cultured human endothelial cells. Antioxidants & Redox Signaling, 4(1), 5-15.
Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781.
Conference Contribution - Published proceedings: Full paper
Cheah, F. C., Mocatta, T., Winterbourn, C. C., Darlow, B. A., & Vissers, M. C. (2002). NF-kappa B activation in pulmonary inflammatory cells is associated with TNF-alpha elevation in tracheal aspirates from infants with respiratory distress syndrome. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch. [Full Paper]
2001
Journal - Research Article
Vissers, M. C. M., Carr, A. C., & Winterbourn, C. C. (2001). Fatty acid chlorohydrins and bromohydrins are cytotoxic to human endothelial cells. Redox Report, 6, 49-55. doi: 10.1179/135100001101536030
Vissers, M. C. M., Lee, W. G., & Hampton, M. B. (2001). Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants. Journal of Biological Chemistry, 276(50), 46835-46840. doi: 10.1074/jbc.M107664200
Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001). Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide. Journal of Biological Chemistry, 276(25), 22120-22125. doi: 10.1074/jbc.M102088200
Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001). Hypochlorous acid stimulation of the MAP-kinase pathway enhances cell survival. Archives of Biochemistry & Biophysics, 394(1), 13-20. doi: 10.1006/abbi.2001.2530
2000
Journal - Research Article
Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2000). Living with a killer: The effects of hypochlorous acid on mammalian cells. IUBMB Life, 50, 259-266.
Journal - Research Other
Winterbourn, C. C., Vissers, M. C., & Kettle, A. J. (2000). Myeloperoxidase. Current Opinion in Hematology, 7, 53-58. [Review].
1999
Journal - Research Article
Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999). Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochemical Journal, 344, 443-449.
Pullar, J. M., Winterbourn, C. C., & Vissers, M. C. M. (1999). Loss of GSH and thiol enzymes in endothelial cellls exposed to sublethal concentrations of hypochlorous acid. American Journal of Physiology: Heart & Circulatory Physiology, 277, H1505-H1512.
1998
Journal - Research Article
Vissers, M. C. M., Carr, A. C., & Chapman, A. L. P. (1998). A comparison of human red cell lysis by hypochlorous and hypobromous acid: insights into the mechanism of lysis. Biochemical Journal, 330, 131-138. doi: 10.1042/bj3300131
1997
Journal - Research Article
Vissers, M. C. M., & Thomas, C. (1997). Hypochlorous acid disrupts the adhesive properties of subendothelial matrix. Free Radical Biology & Medicine, 23(3), 401-411. doi: 10.1016/S0891-5849(96)00619-3
Carr, A. C., Vissers, M. C., Domigan, N. M., & Winterbourn, C. C. (1997). Modification of red cell membrane lipids by hypochlorus acid and haemolysis by preformed lipid chlorohydrins. Redox Report, 3, 263-271.