Professor Ping Liu

Deane, A. R., Jing, Y., Shoorangiz, R., Liu, P., & Ward, R. D. (2023). Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. Behavioral Neuroscience, 137(1), 67-77. doi: 10.1037/bne0000540

Journal - Research Article

Highet, B., Wiseman, J. A., Mein, H., Parker, R., Ryan, B., Turner, C. P., Jing, Y., … Liu, P., … Faull, R. L. M., … Curtis, M. A. (2023). PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization. Journal of Alzheimer's Disease. Advance online publication. doi: 10.3233/jad-220986

Journal - Research Article

Ahmed, S., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2022). Partial endothelial nitric oxide synthase deficiency exacerbates cognitive deficit and amyloid pathology in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. International Journal of Molecular Sciences, 23(13), 7316. doi: 10.3390/ijms23137316

Journal - Research Article

Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011

Journal - Research Article

Ahmad, F., & Liu, P. (2021). A time-efficient fluorescence spectroscopy-based assay for evaluating actin polymerization status in rodent and human brain tissues. Journal of Visualized Experiments, 172, e62268. doi: 10.3791/62268

Journal - Research Article

Ahmad, F., Jing, Y., Lladó, A., & Liu, P. (2021). Chemical stimulation of rodent and human cortical synaptosomes: Implications in neurodegeneration. Cells, 10(5), 1174. doi: 10.3390/cells10051174

Journal - Research Article

Ahmad, F., Mein, H., Jing, Y., Zhang, H., & Liu, P. (2021). Behavioural functions and cerebral blood flow in a P301S tauopathy mouse model: A time-course study. International Journal of Molecular Sciences, 22, 9727. doi: 10.3390/ijms22189727

Journal - Research Article

Zhang, J., Jing, Y., Zhang, H., & Liu, P. (2021). Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats. Amino Acids, 53, 1441-1454. doi: 10.1007/s00726-021-03040-5

Journal - Research Article

Du, Z.-P., Feng, S., Li, Y.-L., Li, R., Lv, J., Ren, W.-Q., … Liu, P., & Wang, Q.-N. (2020). Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells. Toxicology & Applied Pharmacology, 394, 114960. doi: 10.1016/j.taap.2020.114960

Journal - Research Article

Neale, J. P. H., Pearson, J. T., Thomas, K. N., Tsuchimochi, H., Hosoda, H., Kojima, M., … Jones, G. T., Denny, A. P., Daniels, L. J., Chandrasekera, D., Liu, P., van Rij, A. M., Katare, R., & Schwenke, D. O. (2020). Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; Clinical relevance to peripheral artery disease. Scientific Reports, 10, 13651. doi: 10.1038/s41598-020-70391-6

Journal - Research Article

Vemula, P. K., Jing, Y., Cicolini, J., Zhang, H., Mockett, B. G., Abraham, W. C., & Liu, P. (2020). Altered brain arginine metabolism with age in the APP_swe/PSEN1_dE9 mouse model of Alzheimer's disease. Neurochemistry International, 140, 104798. doi: 10.1016/j.neuint.2020.104798

Journal - Research Article

Zhu, Y.-d., Liang, C.-m., Hu, Y.-b., Li, Z.-j., Wang, S.-f., Xiang, H.-Y., … Liu, P., & Tao, F.-B. (2020). Repeated measures of prenatal thallium exposure and placental inflammatory cytokine mRNA expression: The Ma'anshan birth cohort (MABC) study. Chemosphere, 246, 125721. doi: 10.1016/j.chemosphere.2019.125721

Journal - Research Article

Bergin, D. H., Jing, Y., Williams, G., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2019). Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate. Scientific Reports, 9, 12669. doi: 10.1038/s41598-019-49078-0

Journal - Research Article

Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2019). Altered neurovascular coupling and brain arginine metabolism in endothelial nitric oxide synthase deficient mice. Nitric Oxide, 87, 60-72. doi: 10.1016/j.niox.2019.03.006

Journal - Research Article

Vemula, P., Jing, Y., Zhang, H., Hunt, Jr, J. B., Sandusky-Beltran, L. A., Lee, D. C., & Liu, P. (2019). Altered brain arginine metabolism in a mouse model of tauopathy. Amino Acids, 51, 513-528. doi: 10.1007/s00726-018-02687-x

Journal - Research Article

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2019). Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 73, e22072. doi: 10.1002/syn.22072

Journal - Research Article

Bergin, D. H., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2018). Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Translational Psychiatry, 8, 108. doi: 10.1038/s41398-018-0149-z

Journal - Research Article

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia Research, 192, 431-441. doi: 10.1016/j.schres.2017.05.016

Journal - Research Article

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 72(1), e22011. doi: 10.1002/syn.22011

Journal - Research Article

Knox, L. T., Jing, Y., Bawazier-Edgecombe, J., Collie, N. D., Zhang, H., & Liu, P. (2017). Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. Pharmacology Biochemistry & Behavior, 153, 45-59. doi: 10.1016/j.pbb.2016.12.006

Journal - Research Article

Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033

Journal - Research Article

Mazlan, M., Hamizah, H. S., Taridi, N. M., Jing, Y., Liu, P., Zhang, H., … Damanhuri, H. A. (2017). Effects of aging and tocotrienol-rich fraction supplementation on brain arginine metabolism in rats. Oxidative Medicine & Cellular Longevity, 2017, 6019796. doi: 10.1155/2017/6019796

Journal - Research Article

Jing, Y., Liu, P., & Leitch, B. (2016). Region-specific changes in presynaptic agmatine and glutamate levels in the aged rat brain. Neuroscience, 312, 10-18. doi: 10.1016/j.neuroscience.2015.11.002

Journal - Research Article

Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Altered brain arginine metabolism in schizophrenia. Translational Psychiatry, 6, e871. doi: 10.1038/tp.2016.144

Journal - Research Article

Bergin, D. H., Jing, Y., Zhang, H., & Liu, P. (2015). A single intracerebroventricular Aβ_25-35 infusion leads to prolonged alterations in arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 298, 367-379. doi: 10.1016/j.neuroscience.2015.04.034

Journal - Research Article

Knox, L. T., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2014). Effects of acute phencyclidine administration on arginine metabolism in the hippocampus and prefrontal cortex in rats. Neuropharmacology, 81, 195-205. doi: 10.1016/j.neuropharm.2014.02.004

Journal - Research Article

Liu, P., Fleete, M. S., Jing, Y., Collie, N. D., Curtis, M. A., Waldvogel, H. J., … Abraham, W. C., & Zhang, H. (2014). Altered arginine metabolism in Alzheimer’s disease brains. Neurobiology of Aging, 35(9), 1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013

Journal - Research Article

Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2013). Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord. Neuroscience, 252, 98-108. doi: 10.1016/j.neuroscience.2013.08.002

Journal - Research Article

Jing, Y., Zhang, H., Wolff, A. R., Bilkey, D. K., & Liu, P. (2013). Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring. Schizophrenia Research, 148(1-3), 151-156. doi: 10.1016/j.schres.2013.06.001

Journal - Research Article

Rushaidhi, M., Jing, Y., Zhang, H., & Liu, P. (2013). Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study. Neuropharmacology, 65, 200-205. doi: 10.1016/j.neuropharm.2012.10.007

Journal - Research Article

Rushaidhi, M., Zhang, H., & Liu, P. (2013). Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience, 234, 116-124. doi: 10.1016/j.neuroscience.2013.01.004

Journal - Research Article

Smith, P. F., Ganesh, S., & Liu, P. (2013). A comparison of random forest regression and multiple linear regression for prediction in neuroscience. Journal of Neuroscience Methods, 220(1). doi: 10.1016/j.jneumeth.2013.08.024

Journal - Research Article

Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2012). Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats. Neuroscience, 226, 178-196. doi: 10.1016/j.neuroscience.2012.09.013

Journal - Research Article

Gupta, N., Zhang, H., & Liu, P. (2012). Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. Pharmacology Biochemistry & Behavior, 100(3), 464-473. doi: 10.1016/j.pbb.2011.10.011

Journal - Research Article

Rushaidhi, M., Collie, N. D., Zhang, H., & Liu, P. (2012). Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218(30), 206-215. doi: 10.1016/j.neuroscience.2012.05.015

Journal - Research Article

Rushaidhi, M., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2012). Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels. Neuroscience, 209, 21-31. doi: 10.1016/j.neuroscience.2012.02.021

Journal - Research Article

Knox, L. T., Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2011). Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61(8), 1452-1462. doi: 10.1016/j.neuropharm.2011.08.042

Journal - Research Article

Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2011). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Synapse, 65(2), 146-153. doi: 10.1002/syn.20828

Journal - Research Article

Liu, P., Jing, Y., Collie, N. D., Campbell, S. A., & Zhang, H. (2011). Pre-aggregated Aβ_25-35 alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 193, 269-282. doi: 10.1016/j.neuroscience.2011.07.054

Journal - Research Article

Seo, S., Liu, P., & Leitch, B. (2011). Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience, 129, 28-36. doi: 10.1016/j.neuroscience.2011.07.007

Journal - Research Article

Bergin, D. H., & Liu, P. (2010). Agmatine protects against β-amyloid_25-35-induced memory impairments in the rat. Neuroscience, 169, 794-811. doi: 10.1016/j.neuroscience.2010.05.004

Journal - Research Article

Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019

Journal - Research Article

Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075

Journal - Research Article

Liu, P., & Bergin, D. H. (2009). Differential effects of i.c.v. mcroinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience, 159(3), 951-961. doi: 10.1016/j.neuroscience.2009.01.039

Journal - Research Article

Liu, P., & Collie, N. D. (2009). Behavioral effects of agmatine in naive rats are task- and delay-dependent. Neuroscience, 163(1), 82-96. doi: 10.1016/j.neuroscience.2009.05.061

Journal - Research Article

Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029

Journal - Research Article

Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in L-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561

Journal - Research Article

Nerad, L., Liu, P., & Bilkey, D. K. (2009). Bilateral NMDA lesions centered on the postrhinal cortex have minimal effects on hippocampal place cell firing. Hippocampus, 19(3), 221-227. doi: 10.1002/hipo.20517

Journal - Research Article

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448

Journal - Research Article

Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18, 1094-1098. doi: 10.1002/hipo.20482

Journal - Research Article

Liu, P., Gupta, N., Jing, Y., & Zhang, H. (2008). Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience, 155, 789-796. doi: 10.1016/j.neuroscience.2008.06.033

Journal - Research Article

Liu, P., Rushaidhi, M., Collie, N. D., Leong, M.-T. T., & Zhang, H. (2008). Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behavioral Neuroscience, 122(3), 557-569. doi: 10.1037/0735-7044.122.3.557

Journal - Research Article

Liu, P., Smith, P. F., & Darlington, C. L. (2008). Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Synapse, 62, 834-841. doi: 10.1002/syn.20563

Journal - Research Article

Lindsay, L., Liu, P., Gliddon, C., Zheng, Y., Smith, P. F., & Darlington, C. L. (2005). Cytosolic glucocorticoid receptor expression in the rat vestibular nucleus and hippocampus following unilateral vestibular deafferentation. Experimental Brain Research, 162, 309-314. doi: 10.1007/s00221-004-2168-7

Journal - Research Article

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2005). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Hippocampus, 15, 642-655.

Journal - Research Article

Smith, P. F., Horii, A., Russell, N., Bilkey, D. K., Zheng, Y., Liu, P., Kerr, D. S., & Darlington, C. L. (2005). The effects of vestibular lesions on hippocampal function in rats. Progress in Neurobiology, 75, 391-405.

Journal - Research Article

Ashton, J. C., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation. Brain Research, 1021, 264-271.

Journal - Research Article

Liu, P., Gliddon, C. M., Lindsay, L., Darlington, C. L., & Smith, P. F. (2004). Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: A link to deficits in object recognition? Journal of Vestibular Research, 14, 411-417.

Journal - Research Article

Liu, P., Jarrard, L. E., & Bilkey, D. K. (2004). Excitotoxic lesions of the pre- and parasubiculum disrupt the place fields of hippocampal pyramidal cells. Hippocampus, 14(1), 107-116.

Journal - Research Article

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex. Neurobiology of Aging, 25(4), 547-552.

Journal - Research Article

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Potential involvement of NOS and arginase in age-related behavioural impairments. Experimental Gerontology, 39(8), 1207-1222.

Journal - Research Article

Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: Regional variations and age-related changes. Brain Research, 979(1-2), 235-239.

Journal - Research Article

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: Regional variations and age-related changes. Hippocampus, 13, 859-867.

Journal - Research Article

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Neuroscience, 119(3), 679-687.

Journal - Research Article

Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Long-term changes in hippocampal N-methyl-D-aspartate receptor subunits following unilateral vestibular damage in rat. Neuroscience, 117, 965-970.

Journal - Research Article

Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Nitric oxide synthase and arginase expression in the vestibular nucleus and hippocampus following unilateral vestibular deafferentation in the rat. Brain Research, 966, 19-25.

Journal - Research Article

Liu, P., Zheng, Y., Smith, P. F., & Bilkey, D. K. (2003). Changes in NOS protein expression and activity in the rat hippocampus, entorhinal and postrhinal cortices after unilateral electrolytic perirhinal cortex lesions. Hippocampus, 13, 561-571.

Journal - Research Article

King, J., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. NeuroReport, 13(12), 1541-1545.

Journal - Research Article

Liu, P., & Bilkey, D. (2002). The effects of NMDA lesions centered on the postrhinal cortex on spatial memory tasks in the rat. Behavioral Neuroscience, 116, 860-873.

Journal - Research Article

Liu, P., & Bilkey, D. (2001). The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks. Behavioral Neuroscience, 115(1), 94-111.

Journal - Research Article

Liu, P., Jarrard, L. E., & Bilkey, D. (2001). Excitotoxic lesions of the pre- and parasubiculum disrupt object recognition and spatial memory processes. Behavioral Neuroscience, 115(1), 112-124.

Journal - Research Article

Zironi, I., Iacovelli, P., Aicardi, G., Liu, P., & Bilkey, D. K. (2001). Prefrontal cortex lesions augment the location-related firing properties of area TE/perirhinal cortex neurons in a working memory task. Cerebral Cortex, 11, 1093-1100.

Journal - Research Article

Bilkey, D., & Liu, P. (2000). The effects of separate and combined perirhinal and prefrontal cortex lesions on spatial memory tasks in the rat. Psychobiology, 28(1), 12-20.

Journal - Research Article

Liu, P., & Bilkey, D. (1999). The effects of excitotoxic lesions centered on the perirhinal cortex in two versions of the radial arm maze task. Behavioral Neuroscience, 113(4), 672-682.

Journal - Research Article

Liu, P., & Bilkey, D. (1998). Excitotoxic lesions centered on perirhinal cortex produce delay-dependent deficits in a test of spatial memory. Behavioral Neuroscience, 112(2), 512-524.

Journal - Research Article

Liu, P., & Bilkey, D. (1998). Lesions of perirhinal cortex produce spatial memory deficits in the radial maze. Hippocampus, 8(2), 114-121.

Journal - Research Article

Liu, P., & Bilkey, D. (1998). Perirhinal cortex contributions to performance in the water maze. Behavioral Neuroscience, 112(2), 304-315.

Journal - Research Article

Liu, P., & Bilkey, D. K. (1997). Current source density analysis of the potential evoked in hippocampus by perirhinal cortex stimulation. Hippocampus, 7(4), 389-396.

Journal - Research Article

Liu, P., & Bilkey, D. K. (1997). Parallel involvement of perirhinal and lateral entorhinal cortex in the polysynaptic activation of hippocampus by olfactory inputs. Hippocampus, 7(3), 296-306.

Journal - Research Article

Liu, P., & Bilkey, D. (1996). Long-term potentration the perirhinal-hippocampus pathway is NMDA dependent. NeuroReport, 7, 1241-1244.

Journal - Research Article

Liu, P., & Bilkey, D. (1996). The direct connection between perirhinal cortex and hippocampus is a major constituent of the lateral perforant path. Hippocampus, 6, 125-134.

Journal - Research Article

Ahmad, F., & Liu, P. (2020). (Ascorb)ing Pb neurotoxicity in the developing brain. Antioxidants, 9, 1311. doi: 10.3390/antiox9121311

Journal - Research Other

Ahmad, F., & Liu, P. (2020). Synaptosome as a tool in Alzheimer’s disease research. Brain Research, 1746, 147009. doi: 10.1016/j.brainres.2020.147009

Journal - Research Other

Piletz, J. E., Aricioglu, F., Cheng, J.-T., Fairbanks, C. A., Gilad, V. H., Haenisch, B., … Liu, P., … Gilad, G. M. (2013). Agmatine: Clinical applications after 100 years in translation. Drug Discovery Today, 18(17-18), 880-893. doi: 10.1016/j.drudis.2013.05.017

Journal - Research Other