Professor Pete Jones

2023

Journal - Research Article

Okolo, C. A., Khaing, E.-P., Mereacre, V., Wallace, R. S., Munro, M. L., Erickson, J. R., & Jones, P. P. (2023). Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation. Cardiovascular Diabetology, 22, 276. doi: 10.1186/s12933-023-02010-3

Aitken-Buck, H. M., Khaing, E. P., Lamberts, R. R., & Jones, P. P. (2023). Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling. Journal of Cellular & Molecular Medicine. Advance online publication. doi: 10.1111/jcmm.17949

Parveen, S., Cheah, P. H. S., Worthington, L. P. I., Smither, R. A., Munro, M. L., Bussey, C. T., Lamberts, R. R., & Jones, P. P. (2023). Depressed HCN4 function in the type 2 diabetic sinoatrial node. Molecular & Cellular Biochemistry, 478, 1825-1833. doi: 10.1007/s11010-022-04635-6

Conference Contribution - Verbal presentation and other Conference outputs

Chan, J. A., Ohline, S. M., Munro, M. L., & Jones, P. P. (2023, August). Ryanodine type II receptor clustering in Alzheimer's disease. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sibbles, E., Jones, P., & Munro, M. (2023, August). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2023, August). Determining the functional effect of phosphorylated calsequestrin II in heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Ng, Y. H., Lamberts, R. R., Jones, P. P., Sammut, I. A., Diffee, G. M., Wilkins, G. T., & Baldi, J. C. (2022). Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Scientific Reports, 12(1), 16904. doi: 10.1038/s41598-022-20520-0

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APP_swe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876

Satthenapalli, R., Lee, S., Bellae Papannarao, J., Hore, T. A., Chakraborty, A., Jones, P. P., Lamberts, R. R., & Katare, R. (2022). Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage. Stem Cell Research & Therapy, 13(1), 185. doi: 10.1186/s13287-022-02845-9

Gonano, L. A., Aitken-Buck, H. M., Chakraborty, A. D., Worthington, L. P. I., Cully, T. R., Lamberts, R. R., … Jones, P. P. (2022). Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G. Current Research in Physiology, 5, 171-178. doi: 10.1016/j.crphys.2022.03.004

Journal - Research Other

Sibbles, E. T., Waddell, H. M. M., Mereacre, V., Jones, P. P., & Munro, M. L. (2022). The function and regulation of calsequestrin-2: Implications in calcium-mediated arrhythmias. Biophysical Reviews, 14, 329-352. doi: 10.1007/s12551-021-00914-6

Conference Contribution - Published proceedings: Abstract

Chan, J. A., & Jones, P. P. (2022). The effect of benzothiazepine S107, a preventative Ca²⁺ leak drug, on ryanodine type II receptor (RyR2) calcium leak. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 58). Retrieved from https://www.queenstownresearchweek.org

Silva, R., Ohline, S., Munro, M., & Jones, P. (2022). Role of ryanodine receptor clustering in Alzheimer's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.queenstownresearchweek.org

Aitken-Buck, H., Krause, J., Coffey, S., Zeller, T., Jones, P., & Lamberts, R. (2022). Identification of acylcarnitine dysregulation in atrial fibrillation and the role of circulating acylcarnitines in arrhythmogenesis. Heart, Lung & Circulation, 31(Suppl. 3), (pp. S312). doi: 10.1016/j.hlc.2022.06.541

Conference Contribution - Poster Presentation (not in published proceedings)

de Jonge, W., Van Hout, I., Leleai, M., Gosling, A., Parry, D., Coffey, S., Jones, P. P., Schwenke, D. O., Matisoo-Smith, L., Coppell, K., & Lamberts, R. R. (2022, August-September). Representation of Māori and Pacific Island patients in cardiac research requiring tissue collection in the Southern District Health Board region in Aotearoa. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Khaing, E. P., Okolo, C. A., Erickson, J. R., & Jones, P. P. (2022, August-September). Regulation of RyR2 by O-GlcNAcylation. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Watanabe, E., Deb, A., & Jones, P. P. (2022, August-September). The development of a super-resolution fluorescence microscope for investigating protein distribution in human tissue. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Pirker, T., & Jones, P. P. (2022, August-September). CK2 phosphorylation of RyR2 in heart failure patients. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Jones, P. (2022, August). Role of calcium in arrhythmias. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Aitken-Buck, H. M., Waddell, H. M. M., Babakr, A. A., Moore, M. K., Berkahn, E. F., van Hout, I., Fomison-Nurse, I. C., Moharram, M., … Coffey, S., Jones, P. P., & Lamberts, R. R. (2022, August). Linking epicardial fat to cardio-metabolic disease: Evidence from basic research. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022, August-September). Altered membrance properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APP_swe/PS1dE9 model of Alzheimer's disease. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hintz, M., Mereacre, V., & Jones, P. (2022, August-September). CK2-mediated hyperphosphorylation of RyR2: Can it protect against cardiac arrhythmia? Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sibbles, E., Jones, P., & Munro, M. (2022, August-September). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Mereacre, V., & Jones, P. (2022, August-September). Phosphorylation of RyR2 by CK2 is anti-arrhythmic. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2021

Journal - Research Article

Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021

Ng, Y. H., Okolo, C. A., Erickson, J. R., Baldi, J. C., & Jones, P. P. (2021). Protein O-GlcNAcylation in the heart. Acta Physiologica, 233, e13696. doi: 10.1111/apha.13696

Zhong, X., Guo, W., Wei, J., Tang, Y., Liu, Y., Zhang, J. Z., … Jones, P. P., … Wayne Chen, S. R. (2021). Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Bioscience Reports, 41, BSR20210209. doi: 10.1042/bsr20210209

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044

Conference Contribution - Published proceedings: Abstract

Mereacre, V., & Jones, P. (2021). Phosphorylation of RyR2 by CK2 is anti-arrhythmic. New Zealand Medical Journal, 134(1547), (pp. 138-139). Retrieved from https://www.nzma.org.nz/journal

Aitken-Buck, H. M., van Hout, I., Krause, J., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Arrhythmogenic and inotropic effects of long-chain acylcarnitines in the human heart. New Zealand Medical Journal, 134(1537), (pp. 111-112). Retrieved from https://www.nzma.org.nz/journal

2020

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, E540-E547. doi: 10.1152/ajpendo.00202.2020

Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal

McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd₂ (hextrz)₄]⁴⁺ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Journal - Research Other

Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856

Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569

Conference Contribution - Published proceedings: Abstract

Moharram, M., van Hout, I., Jones, P., Lamberts, R., Whalley, G., Williams, M., & Coffey, S. (2020). Speckle tracking strain analysis for the detection of changes in left ventricular function in patients with hypertension. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2020.05.048

Frisk, M., Le, C., Hou, Y., Røe, Å., Dahl, C., Shen, X., … Jones, P., & Louch, W. (2020). T-tubule disruption is a prominent feature of HFrEF but not HFpEF. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 26). doi: 10.1016/j.yjmcc.2019.11.060

Gonano, L. A., Chakraborty, A. D., Aitken-Buck, H., Vila Petroff, M., & Jones, P. P. (2020). Phosphorylation of cardiac ryanodine receptors by protein kinase G: Evaluation of its impact on store overload-induced calcium release. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 49). doi: 10.1016/j.yjmcc.2019.11.117

Hou, Y., Laasmaa, M., Li, J., Manfra, O., Shen, X., Jones, P. P., … Louch, W. E. (2020). Correlating calcium sparks and ryanodine receptor localization in live cardiomyocytes. Biophysical Journal, 118(3, Suppl. 1), (pp. 567a). doi: 10.1016/j.bpj.2019.11.3088

2019

Journal - Research Article

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003

Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Conference Contribution - Published proceedings: Abstract

Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101

Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276

Parveen, S., Lamberts, R., & Jones, P. (2019). Clock changes in the type 2 diabetic sinoatrial node. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S206). doi: 10.1016/j.hlc.2019.06.169

Conference Contribution - Poster Presentation (not in published proceedings)

Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Aitken-Buck, H. M., van Hout, I., Davis, P. J., Coffey, S., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2019, September). Long-chain acylcarnitines as acute modulators of human atrial muscle function. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Article

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Journal - Research Other

Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773

Conference Contribution - Published proceedings: Abstract

Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β₁-but not β₃-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283

Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., Jayasinghe, I. D., Crossman, D. J., Baddeley, D., Soeller, C., & Jones, P. P. (2018, August). Super resolved calcium channel organisation in the heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Okolo, C. A., McLay, J. C., McLachlan, J. J., Munro, M., Tanner, C., Chakraborty, A. D., Erickson, J. R., & Jones, P. P. (2018, August). Regulation of RyR2 by O-linked glycosylation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Journal - Research Article

Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799

Journal - Research Other

Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca²⁺. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805

Conference Contribution - Published proceedings: Abstract

Chakraborty, A., Gonano, L., McLay, J., Dulhunty, A., & Jones, P. (2017). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 11). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Jones, P., Chakraborty, A., Gonano, L. A., & Dulhunty, A. (2017). Arrhythmogenic ATP-based kinase inhibitors directly increase the activity of RyR2. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S158). doi: 10.1016/j.hlc.2017.06.262

Conference Contribution - Poster Presentation (not in published proceedings)

Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chakraborty, A. D., Gonano, L. A., Mclay, J. C., Dulhunty, A., & Jones, P. P. (2017, September). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2016

Journal - Research Article

Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca²⁺ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528

Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036

Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca²⁺ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Conference Contribution - Poster Presentation (not in published proceedings)

Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca²⁺ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Okolo, C. A., McLachlan, J. J., McLay, J. C., Erickson, J. R., & Jones, P. P. (2016, August-September). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Okolo, C. A., McLachlan, J. J., McLay, J., Erickson, J. R., & Jones, P. P. (2016, August). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Chakraborty, A., McLay, J., & Jones, P. (2016, August). Regulation of RyR2 by protein kinase CK2. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August). Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca++ waves in cardiac myocytes. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Chakraborty, A. D., McLay, J., & Jones, P. (2016, August-September). Regulation of RyR2 by protein kinase CK2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Jones, P. (2016, August-September). FKBPs facilitate the termination of spontaneous Ca²⁺ release in wild type RyR2 but not CPVT mutant RyR2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August-September). RyR2 dysfunction and digitalis toxicity. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

McLachlan, J., & Jones, P. (2016, August). Development of RyR2-based redox sensor for H₂O₂ quantification in cardiac dyad microdomain. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

2015

Journal - Research Article

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Mi, T., Xiao, Z., Guo, W., Tang, Y., Hiess, F., Xiao, J., … Zhang, J. Z., … Jones, P. P., & Chen, S. R. W. (2015). Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor. Biochemical Journal, 467(1), 177-190. doi: 10.1042/BJ20141263

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Liu, Y., Sun, B., Xiao, Z., Wang, R., Guo, W., Zhang, J. Z., … Jones, P. P., … Chen, S. R. W. (2015). Roles of the NH₂-terminal domains of cardiac ryanodine receptor in Ca²⁺ release activation and termination. Journal of Biological Chemistry, 290(12), 7736-7746. doi: 10.1074/jbc.M114.618827

Conference Contribution - Published proceedings: Full paper

Zhang, J. Z., Waddell, H. M. M., & Jones, P. P. (2015). Regulation of RyR2 by sarcoplasmic reticulum Ca²⁺. Clinical & Experimental Pharmacology & Physiology, 42(6), (pp. 720-726). doi: 10.1111/1440-1681.12364

Conference Contribution - Published proceedings: Abstract

Lamberts, R. R., Hughes, G., Bussey, C. T., Saxena, P., Galvin, I. F., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., on behalf of HeartOtago. (2015). Left ventricular calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 312-313). doi: 10.1093/eurheartj/ehv399

2014

Journal - Research Article

Zhang, J. Z., McLay, J. C., & Jones, P. P. (2014). The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca²⁺ release due to an impaired ability to buffer store Ca²⁺. Journal of Molecular & Cellular Cardiology, 74, 22-31. doi: 10.1016/j.yjmcc.2014.04.019

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Chen, W., Wang, R., Chen, B., Zhong, X., Kong, H., Bai, Y., … Jones, P. P., … Chen, S. R. W. (2014). The ryanodine receptor store-sensing gate controls Ca²⁺ waves and Ca²⁺-triggered arrhythmias. Nature Medicine, 20(2), 184-192. doi: 10.1038/nm.3440

Conference Contribution - Published proceedings: Abstract

Zhang, J. Z., McLay, J., & Jones, P. P. (2014). Regulation of cardiac ryanodine receptor by histidine rich Ca²⁺ binding protein. Proceedings of the Medical Sciences Congress (MedSci). (pp. 17). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Jones, P. P., Bai, Y., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. (2014). Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Proceedings of the Medical Sciences Congress (MedSci). (pp. 7). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Conference Contribution - Verbal presentation and other Conference outputs

Jones, P. (2014, November). Role of RyR2 in arrhythmia. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

2013

Journal - Research Article

Liu, Y., Kimlicka, L., Heiss, F., Tian, X., Wang, R., Zhang, L., Jones, P. P., … Chen, S. R. W. (2013). The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca²⁺ release and destabilizes the N-terminal domains. Biochemical Journal, 454(1), 123-131. doi: 10.1042/BJ20130594

Bai, Y., Jones, P. P., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. W. (2013). Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research, 113, 517-526. doi: 10.1161/circresaha.113.301678

Conference Contribution - Published proceedings: Abstract

Diong, C., Gray, E., Jones, P., & Schwenke, D. (2013). Increased sympathetic activity in obesity may protect against pulmonary hypertension. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal

Lamberts, R., Lingam, S., Wang, S., Saxena, P., Galvin, I., Bunton, R., Williams, M., Coffey, S., Baldi, J., & Jones, P. (2013). Impaired functional relaxation despite upregulated calcium handling proteins in human diabetic myocardium. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S57). doi: 10.1016/j.hlc.2013.05.137

Zhang, J., McLay, J., & Jones, P. (2013). Histidine-rich Ca²⁺ binding protein inhibits the propensity for store overload-induced Ca²⁺ release (SOICR). Heart, Lung & Circulation, 22(Suuppl. 1), (pp. S78). doi: 10.1016/j.hlc.2013.05.186

Conference Contribution - Poster Presentation (not in published proceedings)

Waddell, H. M. M., McLay, J. C., & Jones, P. P. (2013, August). Oxidation of the cardiac ryanodine receptor reduces the threshold for spontaneous calcium release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hoeksema, K. J., McLay, J. C., & Jones, P. P. (2013, August). Assessing the efficacy of a new class of anti-arrhythmics in human atrial samples. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Lingam, S. J., Wang, S. H. Y., Saxena, P., Galvin, I. F., Bunton, R. W., Williams, M. J. A., Coffey, S., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2013, August). Relaxation in human diabetic myocardium. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Diong, C. T., Gray, E. A., Jones, P., & Schwenke, D. O. (2013, August). Can sympathetic hyperexcitation in obesity protect against pulmonary hypertension? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Conference Contribution - Published proceedings: Abstract

Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Protein expression of SERCA2a and PLB in diabetes. Proceedings of the Oxygen Theme Meeting. (pp. 34). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca²⁺ release. Proceedings of the Oxygen Theme Meeting. (pp. 30). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Lingam, S., Saxena, P., Coffey, S., Williams, M., Baldi, J., Lamberts, R., & Jones, P. (2012). Improved atrial relaxation in human type 2 diabetes mellitus. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Deo, M., McLay, J., & Jones, P. (2012). Triadin decreases the propensity for Store Overload Induced Calcium Release (SOICR). New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Deo, M., Wu, E., McLay, J., & Jones, P. P. (2012). Proteins associated with the cardiac ryanodine receptor alter the threshold for store overload-induced calcium release. Heart, Lung & Circulation, 21(12), (pp. 860). doi: 10.1016/j.hlc.2012.08.023

Jones, P. P. (2012). From dyes to proteins, imaging subcellular calcium events. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Lingam, S. J., Saxena, P., Coffey, S., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Hastened relaxation in a non-failing diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 67). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca²⁺ release. Proceedings of the Medical Sciences Congress (MedSci). (pp. 66). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Jones, P., Bai, Y., Vallmitjana, A., Wang, R., Clark, R., Zhou, Q., … Chen, S. (2012). Disrupting Ca²⁺ waves, but not Ca²⁺ leak, protects against cardiac arrhythmia. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S78). doi: 10.1016/j.hlc.2012.05.198

Conference Contribution - Poster Presentation (not in published proceedings)

Deo, M., McLay, J., & Jones, P. P. (2012, September). Luminal regulation of the RYR2 by triadin reduces the propensity for store overload induced calcium release. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Zhang, J., McLay, J., & Jones, P. P. (2012, September). Histidine-rich CA2+ binding protein (HRC) attenuates the propensity for store overload-induced CA2+ release (SOICR). Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012, September). Improved atrial relaxation in human type 2 diabetes mellitus. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Jones, P. P. (2012, August). From dyes to proteins: Imaging subcellular calcium events. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Beca, S., Helliwell, P. B., Simpson, J. A., Zhao, D., Farman, G. P., Jones, P. P., … Backx, P. H. (2011). Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca²⁺ release and cardiac contractility, independently of L-Type Ca²⁺ current. Circulation Research, 109(9), 1024-1030. doi: 10.1161/CIRCRESAHA.111.250464

Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011). Carvedilol and its new analogs suppress arrhythmogenic store overload—induced Ca²⁺ release. Nature Medicine, 17, 1003-1009. doi: 10.1038/nm.2406

Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P. P., … Chen, S. R. W. (2011). Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14), 12202-12212. doi: 10.1074/jbc.M110.194316

Conference Contribution - Poster Presentation (not in published proceedings)

Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011, August). Unique action of carvedilol and its novel analogues: Suppression of store-overload-induced Ca2⁺ release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Jones, P. (2011, September). Regulation of RyR2 and its implications in arrhythmia. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2010

Journal - Research Article

Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., … Gollob, M. H. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666

Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. A., Anfinogenova, Y., El-Yazbi, A., … Jones, P. P., … Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca²⁺ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300

Conference Contribution - Published proceedings: Abstract

Mufti, R., Welsh, S. B., El-Rahman, R. A., Jones, P., Chen, W., & Welsh, D. (2010). The role of IP3 receptors in generating calcium waves and cerebral myogenic tone. FASEB Journal, 24(Meeting Abstracts), 1033.3. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Chen, S. R. W., Wang, R., Clark, R. B., Zhou, Q., & Jones, P. P. (2010, November-December). Increased calcium leak alone is not sufficient to cause arrhythmia. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2009

Journal - Research Other

Jones, P. P., & Braun, A. P. (2009). Store operated Ca²⁺ entry (SOCE) [Commentary]. Channels, 3(1), 1-2. doi: 10.4161/chan.3.1.7983

Conference Contribution - Published proceedings: Abstract

Chen, S. R. W., Chen, W., Tian, X., Wang, R., Kong, H., O'Mara, M. L., Jones, P. P., … Tieleman, D. P. (2009). Molecular basis of luminal Ca2+ gating of the cardiac ryanodine receptor. Biophysical Journal. 96(3, Suppl. 1), (pp. 551a). doi: 10.1016/j.bpj.2008.12.2984

2008

Journal - Research Article

Jones, P. P., Meng, X., Xiao, B., Cai, S., Bolstad, J., Wagenknecht, T., … Chen, S. R. W. (2008). Localization of PKA phosphorylation site, Ser²⁰³⁰, in the three-dimensional structure of cardiac ryanodine receptor. Biochemical Journal, 410, 261-270. doi: 10.1042/BJ20071257

Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008). Caffeine induces Ca²⁺ release by reducing the threshold for luminal Ca²⁺ activation of the ryanodine receptor. Biochemical Journal, 414, 441-452. doi: 10.1042/BJ20080489

Jones, P. P., Jiang, D., Bolstad, J., Hunt, D. J., Zhang, L., Demaurex, N., & Chen, S. R. W. (2008). Endoplasmic reticulum Ca²⁺ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca²⁺ release. Biochemical Journal, 412, 171-178. doi: 10.1042/BJ20071287

Jiang, D., Chen, W., Xiao, J., Wang, R., Kong, H., & Jones, P. P. (2008). Reduced threshold for luminal Ca²⁺ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. Journal of Biological Chemistry, 283(30), 20813-20820. doi: 10.1074/jbc.M801944200

2007

Journal - Research Article

Xiao, J., Tian, X., Jones, P. P., Bolstad, J., Kong, H., Wang, R., … Chen, S. R. W. (2007). Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Journal of Biological Chemistry, 282(48), 34828-34838. doi: 10.1074/jbc.M707423200

Xiao, B., Tian, X., Xie, W., Jones, P. P., Cai, S., Wang, X., … Chen, S. R. W. (2007). Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store overload-induced Ca²⁺ release. Journal of Biological Chemistry, 282(41), 30256-30264. doi: 10.1074/jbc.M703510200

Hunt, D. J., Jones, P. P., Wang, R., Chen, W., Bolstad, J., Chen, K., … Chen, S. R. W. (2007). K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochemical Journal, 404, 431-438. doi: 10.1042/BJ20070135

2006

Journal - Research Article

Jones, P. P., Bazzazi, H., Kargacin, G. J., & Colyer, J. (2006). Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca²⁺ transient. Biophysical Journal, 91, 433-443. doi: 10.1529/biophysj.106.083931