Dr Aaron Jeffs

2026

Journal - Research Article

Sarkar, D., Gyanwali, G. C., Patel, J., Shevchuk, P., Jeffs, A., Woolley, A. G., Wang, S., Sardari, M., Bhandarkar, A., Siddiqui, H., Ratajska, M., Sarwar, M., … Drummond, C. J., McKinney, C., Antony, J., McCormick, S. P., Braithwaite, A., & Mehta, S. (2026). TP53 mutation at codon 179 metabolically reprograms cancer cells to promote invasion. Cancer Gene Therapy. Advance online publication. doi: 10.1038/s41417-026-01045-4

Wang, S., Shafaei Pishabad, Z., Sarkar, D., Arun Bhandarkar, A., Sarwar, M., Jeffs, A., Reid, G., Braithwaite, A., & Mehta, S. (2026). YBX1 expression marks proliferative tumour states with context-dependent genomic instability: A pan-cancer analysis. International Journal of Molecular Sciences, 27(10), 4340. doi: 10.3390/ijms27104340

2025

Journal - Research Article

Bhandarkar, A. A., Kelly-Foleni, N. E., Sarkar, D., Jeffs, A., Slatter, T., Braithwaite, A., & Mehta, S. (2025). TP53 splice mutations have tumour-independent effects on genomic stability and prognosis: An in silico study. International Journal of Molecular Sciences, 26, 12080. doi: 10.3390/ijms262412080

Conference Contribution - Published proceedings: Abstract

Bhandarkar, A. A., Sarkar, D., Jeffs, A., Kelly-Foleni, N. E., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Role of the TP53 splice mutations in cancer progression. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Shafaei Pishabad, Z., Sarkar, D., Jeffs, A., Samaratunga, H., Rhodes, J., Costello, R., Highton, A., Wright, D., Pattison, S., Kemp, R., Delahunt, B., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Development of a prognostic tool for identifying high-risk prostate cancer patients. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2017

Journal - Research Article

Zellmer, J., & Jeffs, A. (2017). ACCess mATTers: Trio. Junctures, (18), 22-27.

2016

Journal - Research Article

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

2014

Journal - Research Article

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Morris, J. N., Crawford, T. S., Jeffs, A., Stockwell, P. A., Eaton-Rye, J. J., & Summerfield, T. C. (2014). Whole genome re-sequencing of two ‘wild-type’ strains of the model cyanobacterium Synechocystis sp. PCC 6803. New Zealand Journal of Botany, 52(1), 36-47. doi: 10.1080/0028825X.2013.846267

2013

Journal - Research Article

Eccles, M. R., He, S., Ahn, A., Slobbe, L. J., Jeffs, A. R., Yoon, H.-S., & Baguley, B. C. (2013). MITF and PAX3 play distinct roles in melanoma cell migration: Outline of a “genetic switch” theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma. Frontiers in Oncology, 3, 229. doi: 10.3389/fonc.2013.00229

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

2012

Journal - Research Article

Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054

Conference Contribution - Published proceedings: Abstract

Anagnostopoulou, A., Walker, R., Jeffs, A., Scherer, A., Bedford, J., Leader, J., … Marti, H.-P. (2012). A subset of metzincins and related genes constitutes a marker of solid organ fibrosis across species. Nephrology Dialysis Transplantation, 27(Suppl. 2), (pp. 44). doi: 10.1093/ndt/gfs198

Marti, H. P., Jeffs, A., Scherer, A., Leader, J., Bedford, J., Davis, G., … Walker, R. (2012). Solid organ fibrosis: Evidence for a common pathway across species! Nephrology, 17(Suppl. 2), (pp. 57). doi: 10.1111/j.1440-1797.2012.01632.x

Conference Contribution - Verbal presentation and other Conference outputs

Campbell, H. G., Rubio, C., Slatter, T. L., Jeffs, A. R., Baird, M., & Braithwaite, A. W. (2012, August). The p53 isoform, Δ133p53 binds to and inhibits the p53 family members, p63 and p73. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Algie, M., Jeffs, A., Woolley, A., Kleffmann, T., & Braithwaite, A. (2012, August). Identification of binding partners of the oncoprotein Y-box binding protein (YBX1) in breast cancer cell-line. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Braithwaite, A. W., Baird, M. A., Campbell, H. G., Hung, N. A., Jeffs, A. R., Print, C. G., & Slatter, T. L. (2012, August). Isoforms of the p53 tumour suppressor, inflammation, and cancer. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851

Conference Contribution - Published proceedings: Abstract

Eccles, M., Print, C., Jeffs, A., He, S., Slobbe, L., & Baguley, B. (2011). Plasticity of melanoma cell differentiation state and switching of migratory potential. Proceedings of the Inaugural International Cancer Symposium. Retrieved from http://www.wnmeds.ac.nz/cancersymposium/programme.html

2010

Conference Contribution - Verbal presentation and other Conference outputs

Jeffs, A. (2010, August-September). GLIPR1 levels correlate with invasive potential in melanoma cells. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2009

Journal - Research Article

Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., … Print, C. G., … Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461

Jenkins, Z. A., van Kogelenberg, M., Morgan, T., Jeffs, A., Fukuzawa, R., Pearl, E., … Robertson, S. P. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics, 41(1), 95-100. doi: 10.1038/ng.270

Conference Contribution - Published proceedings: Abstract

van Kogelenberg, M., Jenkins, Z. A., Morgan, T., Holman, S., Jeffs, A., Fukuzawa, R., … Reeve, A. E., Robertson, S. P., the OSCS Study Group. (2009). Germline mutations in the tumour suppressor WTX cause a sclerosing bone dysplasia but do not predispose to Wilms tumour. Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 734). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf

Tyndall, J. D. A., Awasthi, A., Jeffs, A., & Wilbanks, S. M. (2009). GLIPR1 is differentially expressed in melanoma cells and correlates with invasive potential. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

He, S., Li, C. G., Jeffs, A., Glover, A., Yoon, H.-S., Baguley, B., & Eccles, M. R. (2009). Induction of cell death or differentiation by silencing of PAX3 is independent of MITF expression. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Conference Contribution - Verbal presentation and other Conference outputs

Awasthi, A., Tyndall, J. D. A., Jeffs, A., & Wilbanks, S. M. (2009, February). Glioma pathogenesis related protein: A survival factor for gliomas and melanomas. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

2008

Journal - Professional & Other Non-Research Articles

Robson, E. J. D., Jeffs, A. R., & Eccles, M. R. (2008). Off-target response to decoy oligodeoxynucleotide treatment. Nature Precedings. doi: 10.1038/npre.2008.2281.1

Conference Contribution - Published proceedings: Abstract

Jeffs, A., Glover, M., He, S., Baguley, B., & Eccles, M. (2008). Gene expression signatures of invasion and survival in melanoma. Proceedings of the 8th Annual Australasian Microarray and Associated Technologies (AMATA) Conference. Retrieved from http://www.amata.org.au/index.php/resources/2008-conference-abstracts

Eccles, M., He, S., Jeffs, A., Li, C., Glover, A., Ineson, J., … Yoon, H.-S., & Baguley, B. (2008). PAX3 and MITF oppositely regulate a melanogenesis nodal point in melanoma cell lines. Proceedings of the American Society of Human Genetics 58th Annual Meeting. (pp. 264). ASHG. Retrieved from http://www.ashg.org/2008meeting/pdf/abstractbook1.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

He, S., Li, C. G., Jeffs, A., Glover, A., Yoon, H.-S., Baguley, B., & Eccles, M. R. (2008, August-September). PAX3 and MITF oppositely regulate cell differentiation and independently confer cell survival. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Jeffs, A., Glover, A., He, S., Woolley, A., Eccles, M., & Baguley, B. (2008, August-September). Gene expression signatures of invasion in melanoma. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Awasthi, A., Wilbanks, S. M., Jeffs, A., & Tyndall, J. D. A. (2008, November-December). Is glioma pathogenesis related protein a survival factor for gliomas? Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Jeffs, A., Glover, A., He, S., Eccles, M., & Baguley, B. (2008, August). Gene expression signatures of invasion in melanoma. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

He, S., Jeffs, A., Li, C., Glover, A., Ineson, J., Suh, B.-J., … Yoon, H.-S., … Eccles, M. R. (2008, August). PAX3, MITF and melanoma. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

2007

Conference Contribution - Published proceedings: Abstract

Stayner, C., Ellis, L., Jeffs, A., McGlashan, S. R., Poole, C. A., Jensen, C. G., & Eccles, M. R. (2007). Development of immortalized fibroblast and epithelial cell lines from Pkd1/Pax2 mutant mice. Proceedings of the ISN-Nature Genetics Forefronts Symposium on Nephrogenetics: From Development to Physiology. Retrieved from http://dir.isn-online.org/ISN/forefronts/pages/abstractview.cfm?id=3&page=0

Conference Contribution - Poster Presentation (not in published proceedings)

Li, C., Jeffs, A., He, S., Woolley, A., & Eccles, M. (2007, May). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, May). The role of PAX3 in malignant melanoma. Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, August). The role of PAX3 in malignant melanoma. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Eccles, M. R., He, S., Ineson, J., Yoon, H.-S., Li, C. G., Jeffs, A., … Baguley, B. (2007, October). Apoptosis induced in human melanoma cells with a PAX3 antisense oligonucleotide is associated with down-regulation of BCL2 and CDK2. Poster session presented at the American Society of Human Genetics 57th Annual Meeting, San Diego, USA.

Ellis, L., Shields, J., Jeffs, A., Eccles, M., & Stayner, C. (2007, August). Development of immortalised epithelial cell lines from Pkd1/Pax2 mutant mice. Poster session presented at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

He, S., Ineson, J., Li, C. G., Jeffs, A., Marshall, E., Baguley, B., Yoon, H.-S., & Eccles, M. R. (2007, August). PAX3 is expressed in melanocytes, nevi and melanomas, and is associated with BCL-2 and CDK2-mediated cell survival. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Li, C., Jeffs, A., He, S., Marshall, E., Baguley, B., Braithwaite, A., & Eccles, M. (2007, August). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, September). Expression profiling, characterisation, and the role of PAX3 in the NZM panel of metastatic melanoma cell lines. Verbal presentation at the Joint Meeting of the 10th Annual Microarray and Gene Expression Data Society (MGED) Meeting and the 7th Annual Australasian Microarray and Associated Technologies (AMATA) Conference, Brisbane, Australia.

2006

Journal - Research Article

Dziarmaga, A., Hueber, P.-A., Iglesias, D., Hache, N., Jeffs, A., Gendron, N., … Eccles, M., & Goodyer, P. (2006). Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. American Journal of Physiology: Renal Physiology, 291, F913-F920. doi: 10.1152/ajprenal.00004.2006

2002

Journal - Research Article

Futschik, M., Jeffs, A., Pattison, S., Kasabov, N., Sullivan, M., Merrie, A., & Reeve, A. (2002). Gene expression profiling of metastatic and nonmetastatic colorectal cancer cell lines. Genome Letters, 1(1), 26-34. doi: 10.1166/gl.2002.005

2001

Journal - Research Article

Jeffs, A. R., Wells, E., & Morris, C. M. (2001). Nonrandom distribution of interspersed repeat elements in the BCR and ABL1 genes and its relation to breakpoint cluster regions. Genes Chromosomes & Cancer, 32(2), 144-154. doi: 10.1002/gcc.1176

Conference Contribution - Published proceedings: Abstract

Jeffs, A., Pattison, S., Xu, J., & Reeve, A. (2001). Microarray analysis of colorectal cancer cell lines. Nature Genetics, 27, (pp. 62). doi: 10.1038/87138

2000

Conference Contribution - Poster Presentation (not in published proceedings)

Walker, L. C., Smith, T. L., Jeffs, A. R., Rodley, P. D., & Morris, C. M. (2000). Detailed analysis of a complex t(7;9;22) in a patient with chronic myeloid leukaemia (CML). Poster session presented at the Genome Diversity and Bioinformatics Conference, Dunedin.

1999

Journal - Research Article

Benjes, S. M., Millow, L. J., Jeffs, A. R., Sowerby, S. J., Reeve, A. E., & Morris, C. M. (1999). 3' BCR recombines with IGL locus in BCR-ABL-positive Philadelphia-negative chronic myeloid leukaemia. Genes Chromosomes & Cancer, 26(4), 366-371.

Conference Contribution - Poster Presentation (not in published proceedings)

Morris, C., Benjes, S., Gagic, M., Gough, S., Jeffs, A., McDonald, M., Taylor, J. E., Walker, L., & Spearing, R. (1999). Leukaemia research at the Cytogenetics & Molecular Oncology Unit. Poster session presented at the Inaugural New Zealand Cancer Society Conference, Christchurch, New Zealand.

1998

Journal - Research Article

Jeffs, A. R., Benjes, S. M., Smith, T. L., Sowerby, S. J., & Morris, C. M. (1998). The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia. Human Molecular Genetics, 7, 767-776.

1996

Journal - Research Article

Morris, C., Jeffs, A., Smith, T., McDonald, M., Board, P., Kennedy, M., & Fitzgerald, P. (1996). BCR gene recombines with genomically distinct sites on band 11q13 in complex BCR-ABL translocations of chronic myeloid leukemia. Oncogene, 12(3), 677-685.