Contact Details
- Phone
- +64 3 479 7329
- fiona.mcdonald@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Physiology
- Qualifications
- DPhil(Oxon)
- Research summary
- Epithelial sodium channel in blood pressure regulation and cancer
- Teaching
- PHSL 233 Epithelial signalling and polarity
- PHSL 343 Endocytosis in epithelia; trafficking pathways of the epithelial sodium channel; polycystic kidney disease
- PHSL 473 Kidney control of blood pressure
- Memberships
- Member of Kidney in Health and Disease Research Group
- New Zealand Association of Scientists
- NZ Biochemistry and Molecular Biology Society
- Physiological Society of NZ
- Dunedin Company of Physiologists
Research
The McDonald laboratory’s focus is on an ion channel, called ENaC, (epithelial sodium channel) that has diverse roles in the body including kidney control of blood pressure, and restraining breast cancer cell proliferation and migration. This channel operates in many tissues and cells of the body, particularly epithelia.
In the kidney ENaC rescues sodium from the urine and allows sodium to re-enter the blood in times of low blood pressure or salt depletion, promoting water retention and an increase in blood pressure. An increased salt load in the body is associated with high blood pressure conditions, and when a gene coding for ENaC is mutated in humans severe high or low blood pressure conditions develop.
We have identified and studied several proteins that associate with the sodium channel and control ENaC function, and hence blood pressure. We apply a wide range of techniques to study the channel: molecular biological methods, cell biological tools to visualise the cellular location of proteins, biochemical methods to detect the interaction of the channel with other proteins, and electrophysiological methods to gain insight into the effects of other proteins on current generated by the sodium channel.
ENaC is expressed in the mammary duct and is thought to assist in defining the components of milk during lactation. Further, ENaC levels appear to be important in breast cancer prognosis, therefore we are investigating how ENaC influences proliferation, migration and invasion in breast cancer cell lines, together with bioinformatic, transcriptome and exome analyses.
Publications
Kilworth, J. N. K., Munro, M. L., & McDonald, F. J. (2023, August). Investigating the functional interaction between the epithelial sodium channel and Ca2+ signalling in breast cancer. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Atta Manu, E., Munro, M., Ware, A., & McDonald, F. (2023, August). The mechanisms through which ENaC negatively modulates breast cancer proliferation and metastasis. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Logue, M. J. E., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2023, August). Retromer- and retriever-associated sorting nexin proteins regulate the trafficking of the Ca2+-activated K+ channel KCa2.3. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7 Journal - Research Article
Hamilton, K., Logue, M., Chueng, T., Pilmore, E., Devor, D., & McDonald, F. (2023). Retromer involvement in trafficking of the calcium-activated K channel, KCa3.1. Physiology, 38(Suppl. 1). doi: 10.1152/physiol.2023.38.S1.5733913 Conference Contribution - Published proceedings: Abstract
2023
Journal - Research Article
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7
Logue, M. J. E., Farquhar, R. E., Eckhoff-Björngard, Y., Cheung, T. T., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2023). The exocyst complex is required for the trafficking and delivery of KCa3.1 to the basolateral membrane of polarized epithelia. American Journal of Physiology: Cell Physiology, 324, C1249-C1262. doi: 10.1152/ajpcell.00374.2022
Conference Contribution - Published proceedings: Abstract
Hamilton, K., Logue, M., Chueng, T., Pilmore, E., Devor, D., & McDonald, F. (2023). Retromer involvement in trafficking of the calcium-activated K channel, KCa3.1. Physiology, 38(Suppl. 1). doi: 10.1152/physiol.2023.38.S1.5733913
McQueen, S., Ware, A., Cunliffe, H., & McDonald, F. (2023). Overexpression of the alpha subunit of the epithelial sodium channel in MDAMB231 breast cancer cells reduces cell migration and proliferation. Cancer Research, 83(Suppl. 5), P2-16-07. doi: 10.1158/1538-7445.SABCS22-P2-16-07
Conference Contribution - Poster Presentation (not in published proceedings)
Kilworth, J. N. K., Munro, M. L., & McDonald, F. J. (2023, August). Investigating the functional interaction between the epithelial sodium channel and Ca2+ signalling in breast cancer. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Atta Manu, E., Munro, M., Ware, A., & McDonald, F. (2023, August). The mechanisms through which ENaC negatively modulates breast cancer proliferation and metastasis. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Logue, M. J. E., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2023, August). Retromer- and retriever-associated sorting nexin proteins regulate the trafficking of the Ca2+-activated K+ channel KCa2.3. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2022
Journal - Research Article
Farquhar, R. E., Cheung, T. T., Logue, M. J. E., McDonald, F. J., Devor, D. C., & Hamilton, K. L. (2022). Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium. Frontiers in Physiology, 13, 905834. doi: 10.3389/fphys.2022.905834
Paudel, P., van Hout, I., Bunton, R. W., Parry, D. J., Coffey, S., McDonald, F. J., & Fronius, M. (2022). Epithelial sodium channel δ subunit is expressed in human arteries and has potential association with hypertension. Hypertension, 79(7), 1385-1394. doi: 10.1161/hypertensionaha.122.18924
Conference Contribution - Published proceedings: Abstract
McQueen, S. R. A., Cunliffe, H. E., & McDonald, F. J. (2022). Alpha-ENaC overexpression in MDAMB231 breast cancer cells reduces cell migration and proliferation. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Conference Contribution - Poster Presentation (not in published proceedings)
Ware, A. W., Cheung, T. T., McQueen, S. R. A., Chin, W. Q., Cunliffe, H. E., & McDonald, F. J. (2022, August-September). The role of the epithelial sodium channel (ENaC) in breast cancer. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chin, W. Q., Ware, A., McDonald, F., & Fronius, M. (2022, August-September). Epithelial-mesenchymal plasticity and breast cancer: A role for the epithelial sodium channel? Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kularathna, B. A. S. A., McDonald, F. J., & Ware, A. W. (2022, August-September). The role of ENaC in breast cancer migration: An implication towards cancer metastasis. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Loke, J. J., McDonald, F. J., & Ware, A. W. (2022, August-September). EMP-associated signalling genes regulated by ENaC in breast cancer. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F. J., Harris, J. J., Slatter, T. L., Cunliffe, H. E., & Ware, A. W. (2022, August). Epithelial sodium channel regulates breast cancer cell proliferation. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Logue, M. J. E., Cheung, T. T., Devor, C. E., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2022, August-September). The differential role of retromer in the trafficking of the Ca2+-activated K+ channels KCa2.3 and KCa3.1. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
McQueen, S. R. A., Cunliffe, H. E., & McDonald, F. J. (2022, August-September). Alpha-ENaC overexpression in MDAMB231 breast cancer cells reduces cell migration and proliferation. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2021
Journal - Research Article
Ware, A. W., Harris, J. J., Slatter, T. L., Cunliffe, H. E., & McDonald, F. J. (2021). The epithelial sodium channel has a role in breast cancer cell proliferation. Breast Cancer Research & Treatment, 187, 31-43. doi: 10.1007/s10549-021-06133-7
Journal - Research Other
Paudel, P., McDonald, F. J., & Fronius, M. (2021). The δ subunit of epithelial sodium channel in humans: A potential player in vascular physiology. American Journal of Physiology: Heart & Circulatory Physiology, 320, H487-H493. doi: 10.1152/ajpheart.00800.2020
Conference Contribution - Published proceedings: Abstract
Logue, M., Cheung, T., Devor, C., Devor, D., McDonald, F., & Hamilton, K. (2021). The Role of Retromer in the Trafficking of the Ca2+- activated K+ channels KCa2.3 and KCa3.1. FASEB Journal, 35(Suppl. 1). doi: 10.1096/fasebj.2021.35.S1.04094
McQueen, S., Ware, A., Cunliffe, H., & McDonald, F. (2021). The influence of the epithelial sodium channel in breast cancer cells. FASEB Journal, 35(Suppl. 1). doi: 10.1096/fasebj.2021.35.S1.05028
Paudel, P., McDonald, F., & Fronius, M. (2021). Vascular ENaC in human arteries and its role in hypertension. FASEB Journal, 35(Suppl. 1). doi: 10.1096/fasebj.2021.35.S1.02625
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F. J. (2021, November). Epithelial sodium channel regulates breast cancer cell proliferation. Verbal presentation at the New Zealand Breast Cancer Symposium (NZBCS), [Online].
Other Research Output
McDonald, F. (2021, March). Unravelling control pathways for sodium channels: Implications for blood pressure. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2020
Journal - Research Article
Cheung, T. T., Geda, A. C., Ware, A. W., Rasulov, S. R., Tenci, P., Hamilton, K. L., & McDonald, F. J. (2020). Retromer is involved in epithelial Na+ channel trafficking. American Journal of Physiology: Renal Physiology, 319, F895-F907. doi: 10.1152/ajprenal.00198.2019
Journal - Research Other
McDonald, F. J. (2020). Explosion in the complexity of membrane protein recycling. American Journal of Physiology: Cell Physiology, 320, C483-C494. doi: 10.1152/ajpcell.00171.2020
Ware, A. W., Rasulov, S. R., Cheung, T. T., Lott, J. S., & McDonald, F. J. (2020). Membrane trafficking pathways regulating the epithelial sodium channel, ENaC. American Journal of Physiology: Renal Physiology, 318, F1-F13. doi: 10.1152/ajprenal.00277.2019
Conference Contribution - Published proceedings: Abstract
Paudel, P., McDonald, F., & Fronius, M. (2020). Epithelial Na+ channel (ENaC) in human arteries: An emerging player in hypertension. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03713
Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2020). Sorting nexins 1, 2, 3 and 17 regulate epithelial sodium channel trafficking. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.07065
2019
Journal - Research Article
Cheung, T. T., Ismail, N. A. S., Moir, R., Arora, N., McDonald, F. J., & Condliffe, S. B. (2019). Annexin II light chain p11 interacts with ENaC to increase functional activity at the membrane. Frontiers in Physiology, 10, 7. doi: 10.3389/fphys.2019.00007
Conference Contribution - Published proceedings: Abstract
Hamilton, K. L., Farquhar, R. E., Eckhoff-Björngard, Y., Cheung, T., & McDonald, F. J. (2019). Interactions between SNARE and exocyst complex proteins with KCa3. 1 in the tethering and fusion of KCa3. 1-containing vesicles to the basolateral membrane of epithelial cells. FASEB Journal, 33(Suppl. 1), 824.16. doi: 10.1096/fasebj.2019.33.1_supplement.824.16
Conference Contribution - Poster Presentation (not in published proceedings)
Walters, C., Hamilton, K. L., & McDonald, F. J. (2019, September). The effect of Rab7 on the trafficking of the epithelial sodium channel. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2018
Journal - Research Article
Healy, M. D., Hospenthal, M. K., Hall, R. J., Chandra, M., Chilton, M., Tillu, V., … McDonald, F. J., … Ghai, R. (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLIFE, 7, e35898. doi: 10.7554/eLife.35898
Ware, A. W., Cheung, T. T., Rasulov, S., Burstein, E., & McDonald, F. J. (2018). Epithelial Na+ Channel: Reciprocal control by COMMD10 and Nedd4-2. Frontiers in Physiology, 9, 793. doi: 10.3389/fphys.2018.00793
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017
Conference Contribution - Published proceedings: Full paper
Denny, P., McDonald, F., Empson, R., Kelly, P., & Petersen, A. (2018). Empirical support for a causal relationship between gamification and learning outcomes. Proceedings of the CHI Conference on Human Factors in Computing Systems. 311. New York, NY: ACM. doi: 10.1145/3173574.3173885
Conference Contribution - Published proceedings: Abstract
Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018). Recycling of the epithelial sodium channel requires SNX1 and SNX2. New Zealand Medical Journal, 131(1470), (pp. 110). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Paudel, P., Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018, August). Epithelial sodium channel in human arteries: An emerging player for blood pressure regulation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ware, A. W., McQueen, S., Cunliffe, H., Fronius, M., & McDonald, F. J. (2018, August). Epithelial sodium channel, ENaC, as a potential therapeutic target for breast cancer. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
McDonald, F. J., Cheung, T. T., Ismail, N. A. S., Moir, R., Arora, N., & Condliffe, S. B. (2018, August). Annexin II light chain p11 interacts with ENaC to increase functional activity at the membrane. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2018, August). Characterising the role of vascular ENaC for blood pressure regulation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018, August). Endosomal SNX proteins are required for recycling of the epithelial sodium channel. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Conference Contribution - Published proceedings: Abstract
Reynolds, J., Oranje, J. M., Spronken-Smith, R. A., & McDonald, F. J. (2017). The challenges of leading large scale curriculum change from a student-centred framework. Proceedings of the Talking Teaching Conference. Retrieved from https://akoacademy.ac.nz/programme
Ware, A. W., & McDonald, F. J. (2017). COMMD10: A novel regulator of ENaC endocytosis. New Zealand Medical Journal, 130(1460), (pp. 97). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
Daniels, L. J., Lamberts, R. R., McDonald, F., Pereira, L., Bers, D. M., & Erickson, J. R. (2017, September). The role of calcium calmodulin dependent protein kinase II in type 2 diabetic cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2017, September). Hypertension is associated with increased ENaC expression in the arteries of Cyp1a1-Ren2 rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2016
Conference Contribution - Published proceedings: Abstract
Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016). The flow detection role of the vascular epithelial sodium channel (ENaC) in an experimental model of hypertension: The novel target for spironolactone therapy? Journal of Hypertension, 34(Suppl. 2), (pp. e103). [Abstract]
McDonald, F., & Bahn, A. (2016). New technologies in teaching and learning. Proceedings of the First Year Biology Educators' Colloquium (FYBC). (pp. 7). Retrieved from http://www.otago.ac.nz/fybec/programme-and-speakers/index.html
Ware, A., Burstein, E., & McDonald, F. (2016). COMMD10: A novel regulator of ENaC trafficking? FASEB Journal, 30(Suppl. 1), 1223.8. doi: 10.1096/fj.1530-6860
Conference Contribution - Poster Presentation (not in published proceedings)
Cheung, T. T., Geda, A., Pilmore, E., Hamilton, K. L., & McDonald, F. J. (2016, December). How is epithelial ion transport maintained? Implications for hypertension. Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Mugloo, S., Leader, C., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2016, August). Characterising ENaC expression in vasculature. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I., Walker, R., McDonald, F., & Fronius, M. (2016, December). Epithelial Sodium Channel (ENaC): An emerging regulator of vascular physiology. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016, December). Role of ENaC in the dysfunction of resistance arteries in hypertension with/without the confounding factor of myocardial infarction. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Jennings, M., Ashley, Z., Leader, C., McDonald, F., Sammut, I., Walker, R., & Fronius, M. (2016, December). The ultrastructure of mesenteric arteries in a hypertensive rat model. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
McDonald, F. J., Cheung, T. T., Geda, A., Pilmore, E., & Hamilton, K. L. (2016, December). Recycling of epithelial ion channels by Retromer with implications for water and salt homeostasis. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Ware, A. W., & McDonald, F. J. (2016, December). COMMD10: A novel regulator of ENaC endocytosis and recycling. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Daniels, L. J., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2016, August-September). The effects of CaMKII inhibition on post-rest behavior and spontaneous contractions in isolated Zucker diabetic fatty rat cardiac muscle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Daniels, L. J., Lamberts, R. R., McDonald, F. J., & Erickson, J. R. (2016, August). CaMKII inhibition restores contractile performance in cardiac muscle from a rat model of type 2 diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3
Taura, M., Kudo, E., Kariya, R., Goto, H., Matsuda, K., Hattori, S., … McDonald, F., … Okada, S. (2015). COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. Journal of Virology, 89(5), 2643-2658. doi: 10.1128/jvi.03105-14
Conference Contribution - Poster Presentation (not in published proceedings)
Ware, A. W., Burstein, E., & McDonald, F. J. (2015, August-September). COMMD10: A novel regulator of the protein trafficking pathway? Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2014
Conference Contribution - Published proceedings: Abstract
Malahay, I., Cheung, T., Bright, L., & McDonald, F. (2014). COMMD10 is important for zymogen granule formation in AR42J pancreatic acinar cells. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F. (2014, August). Multiple COMMD proteins alter the trafficking of the epithelial sodium channel, ENaC. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Journal - Research Article
Starokadomskyy, P., Gluck, N., Li, H., Chen, B., Wallis, M., Maine, G. N., … McDonald, F. J., … Burstein, E. (2013). CCDC22 deficiency in humans blunts activation of proinflammatory NF-κβ signaling. Journal of Clinical Investigation, 123(5), 2244-2256. doi: 10.1172/JCI66466
Liu, Y. F., Swart, M., Ke, Y., Ly, K., & McDonald, F. J. (2013). Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. American Journal of Physiology: Renal Physiology, 305(1), F80-F89. doi: 10.1152/ajprenal.00158.2013
Bobby, R., Medini, K., Neudecker, P., Verne Lee, T., Brimble, M. A., McDonald, F. J., … Dingley, A. J. (2013). Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif. Biochimica et Biophysica Acta: Proteins & Proteomics, 1834(8), 1632-1641. doi: 10.1016/j.bbapap.2013.04.031
Ly, K., McIntosh, C. J., Biasio, W., Liu, Y., Ke, Y., Olson, D. R., … McDonald, F. J. (2013). Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8. Journal of Cellular Physiology, 228, 2190-2201. doi: 10.1002/jcp.24390
Journal - Research Other
McDonald, F. J. (2013). COMMD1 and ion transport proteins: What is the COMMection? Focus on "COMMD1 interacts with the COOH terminus of NKCC! in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination". American Journal of Physiology: Cell Physiology, 305(2), C129-C130. doi: 10.1152/ajpcell.00128.2013
Conference Contribution - Published proceedings: Abstract
McDonald, F., Reynolds, J., Spronken-Smith, R., & Bixley, A. (2013). A longitudinal study of deep, surface and strategic approaches to learning. In J. McDonald, S.-K. Loke, A. McLean & M. Rajoo (Eds.), Proceedings of the Spotlight on Teaching and Learning Colloquium. (pp. 22). Dunedin, New Zealand: HEDC, University of Otago. [Abstract]
2011
Journal - Research Article
Chang, T., Ke, Y., Ly, K., & McDonald, F. J. (2011). COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination. Biochemical & Biophysical Research Communications, 411(3), 506-511. doi: 10.1016/j.bbrc.2011.06.149
Conference Contribution - Published proceedings: Abstract
McDonald Cowles, F., Liu, Y., Hospenthal, M., Swart, M., Ke, Y., & Lott, S. (2011). Three COMMD family proteins are located in collecting duct cells and regulate ENaC. Proceedings of the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels: Molecular Mechanisms and Pathophysiology. (pp. 26). Retrieved from http://the-aps.org/mm/Conferences/APS-Conferences/2011-Conferences/ENaC
2010
Journal - Research Article
Wiemuth, D., Lott, J. S., Ly, K., Ke, Y., Teesdale-Spittle, P., Snyder, P. M., & McDonald, F. J. (2010). Interaction of Serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS ONE, 5(8), e12163. doi: 10.1371/journal.pone.0012163
Ke, Y., Butt, A. G., Swart, M., Liu, Y.-f., & McDonald, F. J. (2010). COMMD1 down-regulates the epithelial sodium channel through Nedd4-2. American Journal of Physiology: Renal Physiology, 298, F1445-F1456. doi: 10.1152/ajprenal.00257.2009
Walker, R., Spronken-Smith, R., Bond, C., McDonald, F., Reynolds, J., & McMartin, A. (2010). The impact of curriculum change on health sciences first year students' approaches to learning. Instructional Science, 38(6), 707-722. doi: 10.1007/s11251-009-9092-y
Conference Contribution - Published proceedings: Abstract
Liu, Y., Swart, M., & McDonald, F. J. (2010). Interaction of COMMD family proteins with the epithelial sodium channel. FASEB Journal, 24, 611.13. [Abstract]
McDonald, F. J., Swart, M., & Ke, Y. (2010). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. FASEB Journal, 24, 611.13. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F. J., Swart, M., & Ke, Y. (2010, August-September). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2009
Conference Contribution - Published proceedings: Abstract
Liu, H.-J., Ke, Y., & McDonald, F. (2009). Investigation of the stabilising effect of COMMD1 on SGK1. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf
Glass, L., & McDonald, F. (2009). COMMD2 interacts with the epithelial sodium channel ENaC. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf
McDonald, F. J., Swart, M., & Ke, Y. (2009). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Swart, M., Liu, Y., Ke, Y., & McDonald, F. J. (2009). Cellular localisation of the COMMD1 and 3 proteins. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Liu, H., Ke, Y., & McDonald, F. J. (2009). Investigation of the stabilising effect of COMMD1 on SGK1. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
2008
Journal - Research Article
Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.
Journal - Professional & Other Non-Research Articles
McDonald, F. J. (2008). A new SGK1 knockout mouse. American Journal of Physiology: Renal Physiology, 294(6), F1296-F1297. doi: 10.1152/ajprenal.90245.2008
Conference Contribution - Published proceedings: Abstract
Walker, R., McMartin, A., McDonald, F., Reynolds, J., Spronken-Smith, R., & Bond, C. (2008). Approaches to learning in first year health science. Proceedings of the Higher Education Research and Development Society of Australasia 31st Annual International Conference. HERDSA. Retrieved from http://conference.herdsa.org.au/2008/program.cfm
Walker, R., Bond, C., Spronken-Smith, R., McDonald, F., Reynolds, J., & McMartin, A. (2008). Student learning experiences in first year health science: Change in curriculum, change in approach? In C. Bond & R. Spronken-Smith (Eds.), Proceedings of the Spotlight on Teaching at Otago Conference. (pp. 43). Dunedin, New Zealand: HEDC, University of Otago. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Liu, Y., & McDonald, F. (2008, August-September). Interaction of COMMD family proteins with the epithelial sodium channel. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.
McDonald, F., Chang, T., Ke, Y., & Ly, K. (2008, August-September). δENaC ubiquitination and regulation by COMMD1. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.
Ke, Y., & McDonald, F. (2008, August-September). Mechanism by which COMMD1 down-regulates human epithelial sodium channel activity. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.
2007
Journal - Research Article
Wiemuth, D., Ke, Y., Rohlfs, M., & McDonald, F. J. (2007). Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochemical Journal, 405, 147-155.
Conference Contribution - Published proceedings: Abstract
Chang, T., & McDonald, F. J. (2007). COMMD1 downregulates δ epithelial sodium channel (δENaC) through trafficking and ubiquitination. FASEB Journal, 21(6), lb465, (pp. LB99). [Abstract]
Ke, Y., Chang, T., & McDonald, F. (2007). Mechanisms by which the copper metabolism gene MURR1 domain 1 (COMMD1) protein down-regulates human epithelial sodium channel activity. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2740/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Ke, Y., Chang, T., & McDonald, F. (2007, October). Mechanisms by which COMMD1 down-regulates human epithelial sodium channel activity. Poster session presented at the 6th International Symposium on ″Aldosterone and ENaC: From gene to disease″, Zermatt, Switzerland.
Liu, Y.-F., Swart, M., & McDonald, F. J. (2007, November). Interaction of COMMD family proteins with the epithelial sodium channel. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F. J., & Ke, Y. (2007, November). Mechanisms by which COMMD1 down-regulates human epithelial sodium channel activity. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Ly, K., & McDonald, F. J. (2007, November). Ubiquitination of delta epithelial sodium channel (δENaC). Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
McDonald, F. J., Chang, T., Ke, Y., & Ly, K. (2007, October). δ-ENaC ubiquitination and regulation by COMMD1. Verbal presentation at the 6th International Symposium on ″Aldosterone and ENaC: From gene to disease″, Zermatt, Switzerland.
2006
Journal - Research Article
Bromhead, C., Miller, J. H., & McDonald, F. J. (2006). Regulation of T-cadherin by hormones, glucocorticoid and EGF. Gene, 374, 58-67.
Conference Contribution - Published proceedings: Abstract
Ke, Y., Chang, T., & McDonald, F. (2006). Murr1, a novel regulator of epithelial sodium channel activity. Proceedings of the Australian Society for Biochemistry and Molecular Biology (ComBio). Retrieved from http://www.asbmb.org.au/combio2006/abstracts/edited/KE-20060623115838.rtf
Chang, T., & McDonald, F. J. (2006). Murr1/COMMD1 colocalises with delta epithelial sodium channel (δENaC) and regulates its ubiquitination. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
McDonald, F. J., Lott, J. S., Rohlfs, M., & Wiemuth, D. (2006, August-September). Epithelial sodium channel (ENaC) interaction with Nedd4-2, SGK and ubiquitin. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.
Fleming, R. I., McDonald, F. J., & Lott, J. S. (2006, August-September). How structural biology affects your blood pressure: Understanding epithelial sodium channel regulation. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.
Crook, A., McDonald, F. J., & Lott, J. S. (2006, August-September). COMMD proteins: A unique family structurally and functionally related to MURR1. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
McDonald, F., Chang, T., Ke, Y., Ly, K., Swart, M., & Wiemuth, D. (2006, November-December). Hypertension and the kidney. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.
Ly, K., & McDonald, F. (2006, November-December). Investigation of delta Epithelial Sodium Channel (δENaC) ubiquitination. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.
Swart, M., Crook, A., Lott, S., & McDonald, F. (2006, November-December). Interaction of COMMD family members with δENAC. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.
2005
Journal - Research Article
Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.
Conference Contribution - Published proceedings: Abstract
McDonald, F. J., & Wiemuth, D. (2005). Interactions of SGK, the epithelial sodium channel (ENaC), and ubiquitin ligases Nedd4 and Nedd4-2. Proceedings of the Medical Sciences Congress. (pp. 42). [Abstract]
Wiemuth, D., & McDonald, F. J. (2005). Interactions between the serum- and glucocorticoid regulated kinase (SGK), the epithelial sodium channel (ENaC) and the ubiquitin ligases Nedd4 and Nedd4-2. FEBS Journal, 272(Suppl.1), (pp. 162). doi: 10.1111/j.1742-4658.2005.4739_4.x
Chang, T., & McDonald, F. J. (2005). Interaction of delta epithelial sodium channel and its modulator Murr1. Proceedings of the ComBio Conference. (pp. 41). [Abstract]
Ke, Y., Chang, T., & McDonald, F. (2005). Murr1, a novel regulator of epithelial sodium channel activity. Proceedings of the Medical Sciences Congress. (pp. 71-72). [Abstract]
Chang, T., & McDonald, F. J. (2005). The study of delta epithelial sodium channel (δENaC) and its modulator Murr1/COMMD1. Proceedings of the Medical Sciences Congress. (pp. 68-69). [Abstract]
2004
Journal - Research Article
Biasio, W., Chang, T., McIntosh, C. J., & McDonald, F. J. (2004). Identification of Murr1 as a regulator of the human δ epithelial sodium channel. Journal of Biological Chemistry, 279(7), 5429-5434.
Kivell, B. M., Day, D. J., McDonald, F. J., & Miller, J. H. (2004). Mu and delta opioid receptor immunoreactivity and mu receptor regulation in brainstem cells cultured from late fetal and early postnatal rats. Developmental Brain Research, 149, 9-19.
Kivell, B. M., Day, D. J., McDonald, F. J., & Miller, J. H. (2004). Developmental expression of μ and δ opioid receptors in the rat brainstem: Evidence for a postnatal switch in μ isoform expression. Developmental Brain Research, 148, 185-196.
Conference Contribution - Published proceedings: Abstract
Wiemuth, D., & McDonald, F. J. (2004). The serum- and glucocorticoid regulated kinase (SGK) binds to different WW-domains of the ubiquitin ligases Nedd4 and Nedd4-2. Proceedings of the 14th Annual Queenstown Molecular Biology Meeting. (13). [Abstract]
Chang, T., Biasio, W., & McDonald, F. J. (2004). Interaction between the delta subunit of epithelial sodium channel (δENaC) and a copper-toxicosis related protein Murr1. Proceedings of the Medical Sciences Congress: Celebrating New Zealand Health Research. (A28), (pp. 36). [Abstract]
Chang, T., Biasio, W., & McDonald, F. J. (2004). Interaction between the delta subunit of epithelial sodium channel (δENaC) and a copper-toxicosis related protein Murr1. Proceedings of the 14th Annual Queenstown Molecular Biology Meeting. (104). [Abstract]
2003
Journal - Research Article
Morrison, P. S., Dobbie, G., & McDonald, F. J. (2003). Research collaboration among university scientists. Higher Education Research & Development, 22(3), 275-296.
2002
Journal - Research Article
Lott, J. S., Coddington-Lawson, S. J., Teesdale-Spittle, P. H., & McDonald, F. J. (2002). A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochemical Journal, 361, 481-488.
McDonald, F. J. (2002). Regulation of the epithelial sodium channel by the ubiquitin pathway: implications for hypertension. New Zealand BioScience, 11(3), 8-10.
McDonald, F. J., Western, A. H., McNeil, J. D., Thomas, B. C., Olson, D., & Snyder, P. (2002). Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na+ channel. American Journal of Physiology: Renal Physiology, 283, 431-436. doi: 10.1152/ajprenal.00080.2002
Conference Contribution - Published proceedings: Abstract
McIntosh, J., Page, R., Miller, J., Snyder, P., & McDonald, F. J. (2002). Nedd8, a potential regulator of the human epithelial sodium channel. Non-traditional functions of ubiquitin and ubiquitin-like proteins. Colorado Springs. 91, (pp. 33). [Abstract]
Biasio, W., Strauss, M., & McDonald, F. J. (2002). Identification of proteins binding to the {delta} subunit of the human epithelial sodium channel. European Journal of Biochemistry Supplement. 269, (pp. 60-61). Oxford: Blackwell Publishing. [Abstract]
2001
Journal - Research Article
Snyder, P. M., Olson, D. R., McDonald, F. J., & Bucher, D. B. (2001). Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4. Journal of Biological Chemistry, 276(30), 28321-28326.
Kivell, B. M., McDonald, F. J., & Miller, J. H. (2001). Method for serum-free culture of late fetal and early postnatal rat brainstem neurons. Brain Research Protocols, 6(3), 91-99. doi: 10.1016/S1385-299X(00)00037-4
Journal - Professional & Other Non-Research Articles
Rohlfs, M., McIntosh, C. J., & McDonald, F. J. (2001). Regulation of the epithelial sodium channel by ubiquitination and endocytosis. 40th Annual Report of the Wellington Research Foundation Inc., 8-9.
McDonald, F. J. (2001). From molecule to malady: a report on the XXXIV International Congress of Physiological Sciences held in Christchurch during 26-31 August, 2001. New Zealand Science Review, 58(3), 78.
Conference Contribution - Published proceedings: Abstract
McDonald, F. J., Coddington-Lawson, S. J., Teesdale-Spittle, P. H., & Lott, J. S. (2001). Binding of the human Nedd4 WW domains to the human epithelial sodium channel. Proceedings of the Physiological Society of New Zealand. 20, (pp. 71). [Abstract]
Day, D., Kivell, B. M., McDonald, F. J., & Miller, J. H. (2001). Mu and delta opioid receptor immunocytochemistry in SH-SY5Y cells and cells cultured from the rat brainstem. Proceedings of the Physiological Society of New Zealand. 20, (pp. 43). [Abstract]
Bromhead, C., Grebe, S. K., Miller, J. H., Bethwaite, P. B., Tie, A. M., Teague, C. A., & McDonald, F. J. (2001). T-cadherin expression is regulated in EGF, estradiol and dexamethasone in human osteosarcoma cells. Molecular Biology of the Cell (special supplement). 12(November), (pp. 480a). [Abstract]
2000
Journal - Research Article
Kivell, B. M., McDonald, F. J., & Miller, J. H. (2000). Serum-free culture of rat post-natal and fetal brainstem neurons. Developmental Brain Research, 120, 199-210.
Farr, T. J., Coddington-Lawson, S. J., Snyder, P. M., & McDonald, F. J. (2000). Human Nedd4 interacts with the human epthithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochemical Journal, 345, 503-509.
Conference Contribution - Published proceedings: Abstract
Kivell, B. M., McDonald, F. J., & Miller, J. H. (2000). Immunocytochemistry of mu opioid receptors in cells cultured from the rat brainstem. Proceedings of the Physiological Society of New Zealand. 19. [Abstract]
1999
Journal - Research Article
McDonald, F. J., Yang, B., Hrstka, R. F., Drummond, H. A., Tarr, D. E., McCray, P. B., … Williamson, R. A. (1999). Disruption of the β subunit of the epithelial Na+ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. PNAS, 96(4), 1727-1731.
Conference Contribution - Published proceedings: Abstract
Kivell, B. M., Miller, J. H., & McDonald, F. J. (1999). Serum-free culture of rat postnatal and fetal brainstem neurons. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]
Coddington-Lawson, S. J., & McDonald, F. J. (1999). Identification of Nedd4 binding proteins by MALDI-TOF mass spectrometry. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]
McDonald, F. J., Coddington-Lawson, S. J., Snyder, P., & Lott, J. S. (1999). Interaction and regulation of the human epithelial sodium channel by E3 ubiquitin-protein ligases. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]
1997
Journal - Research Article
McDonald, F. J. (1997). Salt intake and high blood pressure. New Zealand Science Review, 54(3-4), 47-52.
Conference Contribution - Published proceedings: Abstract
McDonald, F. J., Farr, T. J., Coddington, S. J., & Welsh, M. J. (1997). Binding proteins of the epithelial sodium channel. The Physiologist. 40(5). [Abstract]