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Contact Details

Email
sean.coffey@otago.ac.nz
Position
Senior Lecturer
Department
Department of Medicine (Dunedin)
Qualifications
MB BS FRACP Phd
Research summary
Cardiovascular medicine
Clinical
  • Clinical cardiology
  • Cardiovascular imaging – echocardiography, cardiac CT, and cardiac MRI

Research

I am interested in many aspects of cardiovascular medicine, especially valvular heart disease, but also ischaemic heart disease, cardiomyopathies, and atrial fibrillation.

To tackle these, I, along with collaborators, use basic science techniques in molecular biology and genomics, population based approaches, and advanced phenotyping techniques using echocardiography, cardiac CT, and cardiac MRI. We have started running clinical trials in-house, with the aim of developing therapies for testing in wider clinical settings.

Current research projects

The PressUre reduction in Mild-to-moderate Aortic Stenosis (PUMAS) study

Publications

Pons, A., Whalley, G., Wyber, R., Bridgman, P., Stewart, R., Adamson, P., … Coffey, S. (2026). Fatigue is a key contributor to quality of life in heart valve disease and after valve replacement/repair: A qualitative study. Heart, Lung & Circulation. Advance online publication. doi: 10.1016/j.hlc.2025.11.008 Journal - Research Article

Pons, A., Sneddon, K., Whalley, G., Jenkinson, C., Morley, D., & Coffey, S. (2026). The semantic differential questionnaire format warrants consideration for use in healthcare settings. Quality of Life Research, 35(4), 94. doi: 10.1007/s11136-026-04198-9 Journal - Research Article

Choudhury, Z. Z., Dey, S., Wang, H., Coffey, S., Chakraborti, T., & McCane, B. (2026). Cross-modal image generation with uncertainty quantification from echocardiogram to MRI. Methods, 247, 1-11. doi: 10.1016/j.ymeth.2025.12.012 Journal - Research Article

Shuen, M., Lamberts, R. R., Coffey, S., & Sheard, P. W. (2026). A role for long-lived nuclear envelope proteins in cardiac ageing. Mechanisms of Ageing & Development, 229, 112145. doi: 10.1016/j.mad.2025.112145 Journal - Research Article

Jones, G. T., Williams, M. J. A., Khashram, M., Fitzgerald, S., Lyons, O. T. A., Griffin, C. L., Lesche, S., Krysa, J., & Coffey, S. (2026). A DNA methylation marker, cg05575921 (AHRR), outperforms self-reported smoking exposure for its association with cardiovascular disease prevalence. Nicotine & Tobacco Research, 28(3), 422-428. doi: 10.1093/ntr/ntaf165 Journal - Research Article

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