Dr Matthias Fellner

2024

Journal - Research Article

Jo, J., Upadhyay, T., Woods, E. C., Park, K. W., Pedowitz, N. J., Jaworek-Korjakowska, J., … Fellner, M., & Bogyo, M. (2024). Development of oxadiazolone activity-based probes targeting FphE for specific detection of Staphylococcus aureus infections. Journal of the American Chemical Society. Advance online publication. doi: 10.1021/jacs.3c13974

2023

Journal - Research Article

Fellner, M., Walsh, A., Dela Ahator, S., Aftab, N., Sutherland, B., Tan, E. W., … Lentz, C. S. (2023). Biochemical and cellular characterization of the function of fluorophosphonate-binding hydrolase H (FphH) in Staphylococcus aureus support a role in bacterial stress response. ACS Infectious Diseases. Advance online publication. doi: 10.1021/acsinfecdis.3c00246

Conference Contribution - Published proceedings: Abstract

Tessadori, F., Duran, K., Knapp, K., Fellner, M., Makkers, J., Mace, P., Bicknell, L., & van Haaften, G. (2023). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. European Journal of Human Genetics, 31(Suppl. 1), (pp. 71-72). doi: 10.1038/s41431-023-01337-5

2022

Journal - Research Article

Tessadori, F., Duran, K., Knapp, K., Fellner, M., Deciphering Developmental Disorders Study, Smithson, S., … Robertson, S. P., … Mace, P. D., Bicknell, L. S., & van Haaften, G. (2022). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. American Journal of Human Genetics, 109, 750-758. doi: 10.1016/j.ajhg.2022.02.003

Journal - Research Other

Fellner, M. (2022). Newly discovered Staphylococcus aureus serine hydrolase probe and drug targets. ADMET & DMPK, 10(2), 107-114. doi: 10.5599/admet.1137

Other Research Output

Fellner, M. (2022, October). Development of molecular imaging and therapeutic agents for Staphylococcus aureus. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2021

Journal - Research Article

Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Willbanks, S. M., & Ledgerwood, E. C. (2021). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. Biochemical Journal, 478(3), 669-684. doi: 10.1042/bcj20200793

Chen, S., Lovell, S., Lee, S., Fellner, M., Mace, P. D., & Bogyo, M. (2021). Identification of highly selective covalent inhibitors by phage display. Nature Biotechnology, 39, 490-498. doi: 10.1038/s41587-020-0733-7

Conference Contribution - Published proceedings: Abstract

Fellner, M., Lentz, C., Bogyo, M., & Mace, P. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 261). Retrieved from https://www.faobmb2021.org

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. New Zealand Medical Journal, 134(1537), (pp. 114). Retrieved from https://www.nzma.org.nz/journal

2020

Journal - Research Article

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for the inhibitor and substrate specificity of the unique Fph serine hydrolases of Staphylococcus aureus. ACS Infectious Diseases, 6(10), 2771-2782. doi: 10.1021/acsinfecdis.0c00503

Desguin, B., Urdiain-Arraiza, J., Da Costa, M., Fellner, M., Hu, J., Hausinger, R. P., … Soumillion, P. (2020). Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases. Scientific Reports, 10, 18123. doi: 10.1038/s41598-020-74802-6

Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. Journal of Biological Chemistry, 295(24), 8272-8284. doi: 10.1074/jbc.RA120.013227

Fellner, M., Huizenga, K. G., Hausinger, R. P., & Hu, J. (2020). Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Scientific Reports, 10, 5830. doi: 10.1038/s41598-020-62847-6

Journal - Research Other

Reddington, C. J., Fellner, M., Burgess, A. E., & Mace, P. D. (2020). Molecular regulation of the polycomb repressive-deubiquitinase. International Journal of Molecular Sciences, 21(21), 1-15. doi: 10.3390/ijms21217837

Working Paper; Discussion Paper; Technical Report

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for active-site probes targeting Staphylococcus aureus serine hyrdolase virulence factors. bioRXiv. doi: 10.1101/2020.04.21.054437

Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Wilbanks, S. M., & Ledgerwood, E. C. (2020). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. bioRxiv. doi: 10.1101/2020.06.14.151373

Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and function. bioRxiv. doi: 10.1101/2020.02.25.964783

2019

Conference Contribution - Published proceedings: Abstract

Fellner, M., Lentz, C. S., Bogyo, M. S., & Mace, P. D. (2019). Using structural insight to design new drugs against Staphylococcus aureus serine hydrolases. Proceedings of the 16th Conference of the Asian Crystallographic Association. Retrieved from https://asca2019.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Foglizzo, M., Middleton, A. J., Burgess, A. E., Crowther, J. M., Dobson, R. C. J., … Day, C. L., & Mace, P. D. (2019, August-September). Structure of the polycomb repressive deubiquitinase complex. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Fellner, M., Hausinger, R. P., & Hu, J. (2018). A structural perspective on the PP-loop ATP pyrophosphatase family. Critical Reviews in Biochemistry & Molecular Biology, 53(6), 607-622. doi: 10.1080/10409238.2018.1516728

Fellner, M., Rankin, J. A., Desguin, B., Hu, J., & Hausinger, R. P. (2018). Analysis of the active site cysteine residue of the sacrificial sulfur insertase LarE from Lactobacillus plantarum. Biochemistry, 57(38), 5513-5523. doi: 10.1021/acs.biochem.8b00601

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Desguin, B., Rankin, J. A., Hausinger, R. P., & Hu, J. (2018, August). Lactate racemization: A story of so much more than just a nickel. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M., Desguin, B., Rankin, J., Hausinger, R., & Hu, J. (2018, December). Lactate racemization, a story of so much more than just a nickel. Verbal presentation at the Conference of the Asian Crystallographic Association (AsCA) and the Society of Crystallographers in Australia and New Zealand (SCANZ) (AsCA 2018/CRYSTAL 32), Auckland, New Zealand.

2017

Chapter in Book - Research

Fellner, M., Rankin, J. A., Hu, J., & Hausinger, R. P. (2017). Lactate racemase. In R. A. Scott (Ed.), Encyclopedia of inorganic and bioinorganic chemistry. John Wiley & Sons. doi: 10.1002/9781119951438.eibc2508

Journal - Research Article

Zhang, T., Liu, J., Fellner, M., Zhang, C., Sui, D., & Hu, J. (2017). Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway. Science Advances, 3(8), e1700344. doi: 10.1126/sciadv.1700344

Fellner, M., Desguin, B., Hausinger, R. P., & Hu, J. (2017). Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. PNAS, 114(34), 9074-9079. doi: 10.1073/pnas.1704967114

Martinez, S., Fellner, M., Herr, C. Q., Ritchie, A., Hu, J., & Hausinger, R. P. (2017). Structures and mechanisms of the non-heme Fe(II)- and 2-oxoglutarate-dependent ethylene-forming enzyme: Substrate binding creates a twist. Journal of the American Chemical Society, 139(34), 11980-11988. doi: 10.1021/jacs.7b06186

2016

Journal - Research Article

Tchesnokov, E. P., Faponle, A. S., Davies, C. G., Quesne, M. G., Turner, R., Fellner, M., Souness, R. J., Wilbanks, S. M., … Jameson, G. N. L. (2016). An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase. Chemical Communications, 52, 8814-8817. doi: 10.1039/c6cc03904a

Fellner, M., Siakkou, E., Faponle, A. S., Tchesnokov, E. P., de Visser, S. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Influence of cysteine 164 on active site structure in rat cysteine dioxygenase. Journal of Biological Inorganic Chemistry, 21, 501-510. doi: 10.1007/s00775-016-1360-0

Fellner, M., Aloi, S., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Substrate and pH-dependent kinetic profile of 3-mercaptopropionate dioxygenase from Pseudomonas aeruginosa. Biochemistry, 55(9), 1362-1371. doi: 10.1021/acs.biochem.5b01203

2015

Journal - Research Article

Tchesnokov, E. P., Fellner, M., Siakkou, E., Kleffmann, T., Martin, L. W., Aloi, S., Lamont, I. L., Wilbanks, S. M., & Jameson, G. N. L. (2015). The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase. Journal of Biological Chemistry, 290(40), 24424-24437. doi: 10.1074/jbc.M114.635672

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Tchesnokov, E. P., Souness, R. J., Wilbanks, S. M., & Jameson, G. N. L. (2015, August-September). Crystallographic analysis of an unusual posttranslation modification, a cysteine-tyrosine crosslink, in thiol dioxygenases. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Davies, C. G., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). The Cys-Tyr crosslink of cysteine dioxygenase changes the optimal pH of the reaction without structural change. Biochemistry, 53(50), 7961-7968. doi: 10.1021/bi501277a

Fellner, M., Doughty, L. M., Jameson, G. N. L., & Wilbanks, S. M. (2014). A chromogenic assay of substrate depletion by thiol dioxygenases. Analytical Biochemistry, 459, 56-60. doi: 10.1016/j.ab.2014.05.008

Conference Contribution - Published proceedings: Abstract

Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). Implications of cysteine-tyrosine crosslink in cysteine dioxygenase. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 74). Retrieved from http://www.crystal29.com/

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014, September). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M. (2014, June-July). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Verbal presentation at the New Zealand Structural Biology Meeting, Hanmer Springs, New Zealand.

Fellner, M. (2014, July). A chromogenic assay of substrate depletion by thiol diosygenases. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.

Tchesnokov, E. P., Turner, R., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2014, November-December). Rapid single turnover dioxygenation by substrate-bound cysteine dioxygenase. Invited presentation at the 7th Asian Biological Inorganic Chemistry Conference, Gold Coast, Australia.

2013

Conference Contribution - Published proceedings: Abstract

Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Proceedings of the 246th American Chemical Society (ACS) National Meeting & Exposition. ACS. Retrieved from http://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html

Conference Contribution - Poster Presentation (not in published proceedings)

Tchesnokov, E. P., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Mechanism of thiol dioxygenation: Dioxygen binding in the absence of thiols. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Doughty, L. M., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Modification of cysteine dioxygenase in the search for reactive intermediates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Fellner, M., Gruber, L., & Steiner, I. (2012). Migrationspotenzial von Kaffeefilter-Papieren. Deutsche Lebensmittel-Rundschau, 108(6), 305-312.

Conference Contribution - Published proceedings: Abstract

Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012). Cysteine dioxygenase unfaithful: And why we are excited about that. Proceedings of the Oxygen Theme Meeting. (pp. 31). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012, November). Cysteine dioxygenase unfaithful: And why we are excited about that. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.