Profile

Contact Details

Phone: +64 3 364 0544
Email: gabi.dachs@otago.ac.nz

University Links

Position: Research Professor
Department: Department of Pathology and Molecular Medicine (Christchurch)
Qualifications: BSc PhD
Research summary: Cancer research

Research

Professor Gabi Dachs completed her undergraduate and PhD studies in Cape Town, South Africa, followed by postdoctoral work at the MRC Harwell in the United Kingdom.

Prior to joining the University of Otago in Christchurch, Professor Dachs worked as senior scientist at the Gray Cancer Institute in London, UK.

Professor Gabi Dachs is interested in why human tumours are difficult to treat, and in new ways of treating them. Current research interests at present include:

Can we dampen the activity of the global transcription factor HIF-1 using vitamin C? Can we reduce tumour growth in mice using vitamin C? Can we increase vitamin C in cancer cells using gene therapy?
Why do obese cancer patients often fare worse than non-obese patients? Can we identify the molecular factors associated with obesity in cancer? What effect do these obesity-related factors have on chemotherapy?
Which human enzymes are responsible for the activation of novel anticancer prodrugs (in collaboration with Auckland Cancer Society Research Centre)? Can this knowledge guide clinical use of these agents?
Can we improve gene directed enzyme prodrug therapy combinations to target solid tumours or their vasculature?

Publications

Tino, A. B., Sykes, P. H., Dachs, G. U., & Chitcholtan, K. (2026). Targeting phosphoinositide 3-kinase to reduce the progression of ovarian cancer cells in a 3D collagen model. Biomolecules, 16, 377. doi: 10.3390/biom16030377 Journal - Research Article

Tino, A. B., Dachs, G. U., Sykes, P. H., & Chitcholtan, K. (2025). Impact of tumor necrosis factor-alpha and lysophosphatidic acid on the behavior of ovarian cancer cells in a three-dimensional collagen hydrogel. Journal of Obstetrics & Gynaecology Research, 51, e70026. doi: 10.1111/jog.70026 Journal - Research Article

Brook, E. M., Helem, S. J., McDonald, C. C. M., Magon, N. J., Selwood, A. I., Harwood, D. T., … Hampton, M. B., & Dachs, G. U. (2025). Portimine A maintains bioactivity following exposure to liver microsomes and cell lysates: No evidence for significant metabolic inactivation. Medical Oncology, 42, 278. doi: 10.1007/s12032-025-02826-x Journal - Research Article

Praditi, C., Beverley-Stone, E., Reid, M., Burgess, E. R., Crake, R. L., Vissers, M. C. M., Royds, J. A., Slatter, T. L., Dachs, G. U., & Phillips, E. (2025). Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro. Frontiers in Oncology, 15, 1536549. doi: 10.3389/fonc.2025.1536549 Journal - Research Article

Burgess, E. R., Praditi, C., Phillips, E., Vissers, M. C. M., Robinson, B. A., Dachs, G. U., & Wiggins, G. A. R. (2025). Role of sodium-dependent vitamin C transporter-2 and ascorbate in regulating the hypoxic pathway in cultured glioblastoma cells. Journal of Cellular Biochemistry, 126, e30658. doi: 10.1002/jcb.30658 Journal - Research Article

2026

Journal - Research Article

2025

Journal - Research Article

2024

Journal - Research Article

Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017

2023

Journal - Research Article

Praditi, C., Bozonet, S. M., Dachs, G. U., & Vissers, M. C. M. (2023). Ascorbate uptake and retention by breast cancer cell lines and the intracellular distribution of sodium-dependent vitamin C transporter 2. Antioxidants, 12, 1929. doi: 10.3390/antiox12111929

de Vries, M., Stewart, T., Ireton, T., Keelan, K., Jordan, J., Robinson, B. A., & Dachs, G. U. (2023). Patients’ and carers’ priorities for cancer research in Aotearoa/New Zealand. PLoS ONE, 18(8), e0290321. doi: 10.1371/journal.pone.0290321

Conference Contribution - Published proceedings: Abstract

Praditi, C., Dachs, G., Bozonet, S., Pearson, J. A., Wiggins, G., & Vissers, M. (2023). The role of ascorbate in the activation of hypoxic response in breast cancer cell lines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. (2023, August). Ascorbate and the hypoxic pathway in glioblastoma. Verbal presentation at the New Zealand Aotearoa Neuro-Oncology Society (NANOS) Inaugural Annual Conference, Queenstown, New Zealand.

Other Research Output

Dachs, G. (2023, May). Scatterlings: Cancer research across continents and time. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture].

2022

Journal - Research Article

Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8

Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524

2021

Journal - Research Article

Abbattista, M. R., Ashoorzadeh, A., Guise, C. P., Mowday, A. M., Mittra, R., Silva, S., … Dachs, G. U., … Patterson, A. V. (2021). Restoring tumour selectivity of the bioreductive prodrug pr-104 by developing an analogue resistant to aerobic metabolism by human aldo-keto reductase 1c3. Pharmaceuticals, 14(12). doi: 10.3390/ph14121231

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Wohlrab, C., Vissers, M. C. M., Burgess, E. R., Nonis, M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2021). Limited association between ascorbate concentrations and vitamin C transporters in renal cell carcinoma cells and clinical samples. Cellular Physiology & Biochemistry, 55, 553-568. doi: 10.33594/000000435

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021). Gene and protein expression is altered by ascorbate availability in murine macrophages cultured under tumour-like conditions. Antioxidants, 10(3), 430. doi: 10.3390/antiox10030430

Dachs, G. U., Gandhi, J., Wohlrab, C., Carr, A. C., Morrin, H. R., Pullar, J. M., Bayer, S. B., Eglinton, T. W., Robinson, B. A., & Vissers, M. C. M. (2021). Vitamin C administration by intravenous infusion increases tumor ascorbate content in patients with colon cancer: A clinical intervention study. Frontiers in Oncology, 10, 600715. doi: 10.3389/fonc.2020.600715

Journal - Research Other

Crake, R. L. I., Burgess, E. R., Royds, J. A., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2021). The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: A review of epigenetic reprogramming and hypoxic responses. Frontiers in Oncology, 11, 619300. doi: 10.3389/fonc.2021.619300

Buss, L. A., Dachs, G. U., Goddard, L., Ang, A. D., Robinson, B. A., Currie, M. J., & Hock, B. (2021). Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies? Immunology Letters, 234, 13-15. doi: 10.1016/j.imlet.2021.04.003

Conference Contribution - Published proceedings: Abstract

Vissers, M. C., & Dachs, G. U. (2021). The 2-oxogiutarate-dependent dioxygenases: A new class of enzymes impacting cancer epigenetics and cancer cell metabolism. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 128). Retrieved from https://www.faobmb2021.org

Other Research Output

Dachs, G. (2021, September). Mate Pukupuku: He aha ō whakaaro? Cancer: What do you think is important for us to research? UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2020

Chapter in Book - Research

Buss, L. A., & Dachs, G. U. (2020). Effects of exercise on the tumour microenvironment. In A. Birbrair (Ed.), Tumor microenvironment: Recent advances. (pp. 31-51). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-35727-6_3

Journal - Research Article

White, R., Nonis, M., Pearson, J. F., Burgess, E., Morrin, H. R., Pullar, J. M., Spencer, E., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2020). Low vitamin C status in patients with cancer is associated with patient and tumor characteristics. Nutrients, 12(8), 2338. doi: 10.3390/nu12082338

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Pullar, J. M., Dunham, S., Dachs, G. U., Vissers, M. C. M., & Carr, A. C. (2020). Erythrocyte ascorbate is a potential indicator of steady-state plasma ascorbate concentrations in healthy non-fasting individuals. Nutrients, 12(2), 418. doi: 10.3390/nu12020418

2019

Journal - Research Article

Wohlrab, C., Kuiper, C., Vissers, M. C. M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2019). Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells. Hypoxia, 7, 17-31. doi: 10.2147/hp.S201643

Campbell, E. J., Dachs, G. U., Morrin, H. R., Davey, V., Robinson, B. A., & Vissers, M. C. M. (2019). Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels. BMC Cancer, 19, 307. doi: 10.1186/s12885-019-5503-x

Conference Contribution - Published proceedings: Abstract

Ang, A., Currie, M., & Dachs, G. (2019). Effect of ascorbate on tumour-associated macrophage phenotype ex vivo. Proceedings, 5(1), 3 (6.7). doi: 10.3390/proceedings2019005003

Dachs, G., & Vissers, M. (2019). Regulation of transcription factors by ascorbate. Proceedings, 5(1), 3 (3.2). doi: 10.3390/proceedings2019005003

2018

Journal - Research Article

Wohlrab, C., Vissers, M. C. M., Phillips, E., Morrin, H., Robinson, B. A., & Dachs, G. U. (2018). The association between ascorbate and the hypoxia-inducible factors in human renal cell carcinoma requires a functional von Hippel-Lindau protein. Frontiers in Oncology, 8, 574. doi: 10.3389/fonc.2018.00574

Buss, L. A., Mandani, A., Phillips, E., Scott, N. J. A., Currie, M. J., & Dachs, G. U. (2018). Characterisation of a mouse model of breast cancer with metabolic syndrome. In Vivo, 32(5), 1071-1080. doi: 10.21873/invivo.11348

Buss, L. A., & Dachs, G. U. (2018). The role of exercise and hyperlipidaemia in breast cancer progression. Exercise Immunology Review, 24, 8-23.

Buss, L. A., & Dachs, G. U. (2018). Voluntary exercise slows breast tumor establishment and reduces tumor hypoxia in ApoE^-/- mice. Journal of Applied Physiology, 124(4), 938-949. doi: 10.1152/japplphysiol.00738.2017

Conference Contribution - Published proceedings: Abstract

Wohlrab, C., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2018). Vitamin C transporters in renal cell carcinoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Vissers, M. C. M., Das, A., & Dachs, G. U. (2018). The 2-oxoglutarate-dependent dioxygenases and their role in cancer development, growth and metastasis. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Tino, A., Dachs, G., Sykes, P., Evans, J., & Chitcholtan, K. (2018). Ovarian cancer cell lines grown in a three dimensional collagen model respond differentially to lysophosphatidic acid and tumour necrosis factor-alpha. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018). Exercise reduces hypoxia and increases perfusion in tumours from mice with melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Ang, A., Currie, M., & Dachs, G. (2018). Effect of ascorbate on tumour associated macrophage phenotype ex vivo. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Wohlrab, C., Kuiper, C., Vissers, M. C. M., Phillips, E., Robinson, B., & Dachs, G. U. (2018). Ascorbate modulates the hypoxic pathway by increasing activity of HIF hydroxylases. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Campbell, E., Dachs, G. U., Morrin, H. R., Davey, V., Robinson, B. A., & Vissers, M. C. M. (2018, August). The regulation of the tumour hypoxic response by ascorbate and association with clinicopathological factors and patient outcome in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). Post-tumour-implantation exercise does not alter tumour growth rate in mice with subcutaneous B16-F10 melanoma. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. U., & Vissers, M. C. (2018, August). The role of ascorbate in modifying the hypoxic response in cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). T-cell distribution in melanoma from exercising mice. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Ang, A., Currie, M., & Dachs, G. (2018, August). Effect of ascorbate on tumour associated macrophage phenotype ex vivo. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

2017

Journal - Research Article

Wohlrab, C., Phillips, E., & Dachs, G. U. (2017). Vitamin C transporters in cancer: Current understanding and gaps in knowledge. Frontiers in Oncology, 7, 74. doi: 10.3389/fonc.2017.00074

Robinson, B., Currie, M., Phillips, E., Dachs, G., Strother, M., Morrin, H., Davey, V., & Frampton, C. (2017). Body mass index (BMI): Association with clinicopathological factors and outcome of women with newly diagnosed breast cancer in New Zealand. New Zealand Medical Journal, 130(1451), 46-56. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Buss, L. A., & Dachs, G. U. (2017, July). Effects of exercise and hyperlipidaemia on the breast tumour microenvironment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Ang, A., Currie, M., & Dachs, G. (2017, July). Does ascorbate affect the interaction between tumour and immune cells? Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Campbell, E. J., Vissers, M. C. M., Wohlrab, C., Hicks, K. O., Strother, R. M., Bozonet, S. M., Robinson, B. A., & Dachs, G. U. (2016). Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radical Biology & Medicine, 99, 451-462. doi: 10.1016/j.freeradbiomed.2016.08.027

Campbell, E. J., Vissers, M. C. M., & Dachs, G. U. (2016). Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo^-/- mice. Hypoxia, 4, 41-52. doi: 10.2147/HP.S103088

Bonifert, G., Folkes, L., Gmeiner, C., Dachs, G., & Spadiut, O. (2016). Recombinant horseradish peroxidase variants for targeted cancer treatment. Cancer Medicine, 5(6), 1194-1203. doi: 10.1002/cam4.668

Conference Contribution - Published proceedings: Abstract

Campbell, E., Vissers, M., Wohlrab, C., Hicks, K., Strother, M., Robinson, B., Bozonet, S., & Dachs, G. (2016). High-dose ascorbate administration increases tumor ascorbate levels and decreases hypoxia-inducible factor-1 activity and tumor growth in mice. Free Radical Biology & Medicine, 100(Suppl.), (pp. S132). doi: 10.1016/j.freeradbiomed.2016.10.346

Vissers, M. C. M., Campbell, E. J., Kuiper, C., Carr, A. C., Wohlrab, C., Bozonet, S. M., Morrin, H., Robinson, B. A., & Dachs, G. U. (2016). Ascorbate as an anti-cancer therapy? Investigations into feasibility and potential mechanism of action. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

2015

Journal - Research Article

Dachs, G. U., Phillips, E., Phung, Y., Dyer, A., Willis, J. A., Currie, M. J., & Robinson, B. A. (2015). Tumour growth in mice resistant to diet-induced obesity. Journal of Molecular Biochemistry, 4(2), 42-49.

Campbell, E. J., Vissers, M. C. M., Bozonet, S., Dyer, A., Robinson, B. A., & Dachs, G. U. (2015). Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo^−/− mice. Cancer Medicine, 4(2), 303-314. doi: 10.1002/cam4.349

Conference Contribution - Poster Presentation (not in published proceedings)

Ernst, C., Phillips, E., Morrin, H., Vissers, M., Robinson, B., & Dachs, G. (2015, October). The role of ascorbate in controlling hypoxia factors in renal cell carcinoma. Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

2014

Journal - Research Article

Campbell, E. J., & Dachs, G. U. (2014). Current limitations of murine models in oncology for ascorbate research. Frontiers in Oncology, 4, 282. doi: 10.3389/fonc.2014.00282

Kanthou, C., Dachs, G. U., Lefley, D. V., Steele, A. J., Coralli-Foxon, C., Harris, S., … Tozer, G. M. (2014). Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics. PLoS ONE, 9(8), e104015. doi: 10.1371/journal.pone.0104015

Wang, J., Guise, C. P., Dachs, G. U., Phung, Y., Hsu, A. H.-L., Lambie, N. K., … Wilson, W. R. (2014). Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5. Biochemical Pharmacology, 91(4), 436-446. doi: 10.1016/j.bcp.2014.08.003

Vissers, M. C. M., Kuiper, C., & Dachs, G. U. (2014). Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer. Biochemical Society Transactions, 42(4), 945-951. doi: 10.1042/bst20140118

Flett, T., Campbell, E. J., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2014). Gulonolactone addition to human hepatocellular carcinoma cells with gene transfer of gulonolactone oxidase restores ascorbate biosynthesis and reduces hypoxia inducible factor 1. Biomedicines, 2(1), 98-109. doi: 10.3390/biomedicines2010098

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2014). Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radical Biology & Medicine, 69, 308-317. doi: 10.1016/j.freeradbiomed.2014.01.033

Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2014). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer. Frontiers in Oncology, 4, 10. doi: 10.3389/fonc.2014.00010

Volkova, E., Robinson, B. A., Willis, J., Currie, M. J., & Dachs, G. U. (2014). Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells. Oncology Letters, 7(2), 311-320. doi: 10.3892/ol.2013.1710

Journal - Research Other

Dachs, G. U., Munn, D. G., Carr, A. C., Vissers, M. C. M., & Robinson, B. A. (2014). Consumption of vitamin C is below recommended daily intake in many cancer patients and healthy volunteers in Christchurch. New Zealand Medical Journal, 127(1390). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Kuiper, C., Dachs, G., Currie, M., Pearson, J., Munn, D., & Vissers, M. (2014). Tumor ascorbate content is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Flett, T., Campbell, E., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2014). Does gene transfer of gulono-lactone oxidase into human hepatocellular carcinoma cells restore ascorbate biosynthesis? Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Campbell, E. J., Bozonet, S. M., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014). Restoring physiological levels of ascorbate alleviates HIF-1 activation and reduces tumour growth in Gulo^-/- mice. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Conference Contribution - Poster Presentation (not in published proceedings)

Campbell, E. J., Bozonet, S., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014, August). Pharmacokinetic and anti-cancer properties of high dose vitamin C in tumour bearing Gulo^-/- mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. (2014, July). Vitamin C is dispensable for oxygen sensing? Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.

Campbell, E., Kuiper, C., Vissers, M. C. M., & Dachs, G. (2014, August). Vitamin C is not dispensible for oxygen sensing. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2013

Journal - Research Article

Currie, M. J., Beardsley, B. E., Harris, G. C., Gunningham, S. P., Dachs, G. U., Dijkstra, B., Morrin, H. R., Wells, J. E., & Robinson, B. A. (2013). Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: Relationships with markers of tumor hypoxia and microvascularity. Human Pathology, 44(3), 402-411. doi: 10.1016/j.humpath.2012.06.004

Conference Contribution - Published proceedings: Abstract

Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2013). The impact of physiological levels of vitamin C on tumour growth and HIF-1 activation in the Gulo ^-/- mouse. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2013, August). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2013, August). The effect of dietary ascorbate levels on tumour growth and HIF-1 activation in the Gulo^-/- mouse. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Vissers, M. C. M., Kuiper, C., Dachs, G. U., Campbell, E., Pujary, U.-R., Bozonet, S. M., Pullar, J. M., & Carr, A. C. (2013, August). The role of vitamin C in managing metabolic stress and its impact in tumour biology and inflammation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Dachs, G. (2013, February). Diet and cancer. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand.

2012

Journal - Research Article

Guise, C. P., Abbattista, M. R., Tipparaju, S. R., Lambie, N. K., Su, J., Li, D., … Dachs, G. U., & Patterson, A. V. (2012). Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia. Molecular Pharmacology, 81(1), 31-40. doi: 10.1124/mol.111.073759

Hunt, M. A., Li, D., Hay, M. P., Currie, M. J., Robinson, B. A., Patterson, A. V., & Dachs, G. U. (2012). Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro. Journal of Gene Medicine, 14(1), 62-74. doi: 10.1002/jgm.1635

Conference Contribution - Published proceedings: Abstract

Dachs, G., Kuiper, C., Currie, M. J., & Vissers, M. C. M. (2012). Impact of ascorbate levels on hypoxia inducible factor-1 activity in cancer cells in culture and in endometrial tumours. Mutagenesis, 27(1), (pp. 114). doi: 10.1093/mutage/ger068

Conference Contribution - Poster Presentation (not in published proceedings)

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, September). Intracellular ascorbate and HIF-1 inhibition in cancer cells. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2012, September). The impact of physiological levels of vitamin C on tumour growth in gulo-/- mice. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Campbell, E. J., Dyer, A., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2012, August). The impact of physiological levels of vitamin C on tumour growth in Gulo-/-mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, August). Intracellular ascorbate and modification of the tumour response to the microenvironment. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

MacKenzie, K. A., Miller, A. P., Hock, B. D., Gardner, J., Simcock, J. W., Roake, J. A., Dachs, G. U., Robinson, B. A., & Currie, M. J. (2011). Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients. Histopathology, 58(6), 875-885. doi: 10.1111/j.1365-2559.2011.03845.x

Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2011). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, 104, 51-59. doi: 10.1038/sj.bjc.6606005

Conference Contribution - Published proceedings: Abstract

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2011). Low ascorbate levels are associated with high hypoxia-inducible factor-1 activity and a more aggressive tumor phenotype in endometrial cancer. Clinical and Experimental Metastasis. 28(2), (pp. 175). doi: 10.1007/s10585-010-9361-9

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2011). Optimal intracellular ascorbate concentrations suppress hypoxia-inducible factor-la and its transcriptional activity differentially in cancer and normal cells. Clinical & Experimental Metastasis. 28(2), (pp. 231-232). doi: 10.1007/s10585-010-9361-9

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. (2011, May). Developing an obese mouse model of colorectal cancer. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

Dachs, G. (2011, May). Response to chemotherapy is modulated by insulin, insulin-like growth factor-1 and glucose concentration in colorectal cells in culture. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

2010

Journal - Research Article

Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., … Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Māori breast cancer patients. BMC Cancer, 10, 543. doi: 10.1186/1471-2407-10-543

Hunt, M. A., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2010). Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. Journal of Biomolecular Techniques, 21, 66-72.

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263

Tupper, J., Stratford, M. R., Hill, S., Tozer, G. M., & Dachs, G. U. (2010). In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer. Cancer Gene Therapy, 17(6), 420-428. doi: 10.1038/cgt.2009.86

Guise, C. P., Abbattista, M. R., Singleton, R. S., Holford, S. D., Connolly, J., Dachs, G. U., Fox, S. B., Pollock, R., Harvey, J., Guilford, P., … Patterson, A. V. (2010). The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Research, 70(4), 1573-1584. doi: 10.1158/0008-5472.CAN-09-3237

Conference Contribution - Published proceedings: Abstract

Guise, C. P., Tipparaju, S. R., Abbattista, M. R., Dachs, G. U., Su, J., Foehrenbacher, A. B., … Patterson, A. V. (2010). Identification of human oxidoreductases involved in the hypoxia-dependent activation of bioreductive prodrugs. Proceedings of the American Association for Cancer Research (AACR) 101st Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. (2010, August-September). Comparison of enzyme prodrug gene therapy combinations in coated spheroids and in vitro models of vascular networks. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2009

Journal - Research Article

Dachs, G. U., Hunt, M. A., Syddall, S., Singleton, D. C., & Patterson, A. V. (2009). Bystander or no bystander for gene directed enzyme prodrug therapy. Molecules, 14(11), 4517-4545. doi: 10.3390/molecules14114517

Conference Contribution - Published proceedings: Abstract

Dachs, G. U., Hunt, M., Patterson, A. V., Ackerley, D., Currie, M. J., & Robinson, B. A. (2009). Vascular targeted gene therapy of cancer. Journal of Vascular Research, 46(Suppl. 2), (pp. 18). doi: 10.1159/000230992

Volkova, E., Willis, J., Robinson, B., Dachs, G., & Currie, M. (2009). Obesity and tumour angiogenesis in colon cancer. Journal of Vascular Research, 46(Suppl. 2), (pp. 17). doi: 10.1159/000230992

Hunt, M., Keown, D., Patterson, A., Currie, M., Robinson, B., & Dachs, G. (2009). Novel prodrugs for enzyme prodrug gene therapy against tumor endothelium. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Volkova, E., Willis, J. A., Gunningham, S. P., Hanrahan, V., Pearson, J., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2009). Role of obesity in colon tumor angiogenesis and cancer progression. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S172-S173). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Hunt, M. A., Keown, D. A., Patterson, A. V., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2009, September). Novel prodrugs for enzyme prodrug gene therapy against tumour endothelium. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Dachs, G. (2009, August). Vascular targeted gene therapy of cancer. Verbal presentation at the 14th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Queenstown, New Zealand.

2008

Journal - Research Article

Dachs, G. U., Currie, M. J., Mckenzie, F., Jeffreys, M., Cox, B., Foliaki, S., … Robinson, B. A. (2008). Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people. Lancet Oncology, 9(5), 473-484. doi: 10.1016/S1470-2045(08)70127-X

Conference Contribution - Published proceedings: Abstract

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2008). Cancer Society Tissue Bank (CSTB) New Zealand: The increasing importance of supplementary sample banking for breast cancer research. Cell Preservation Technology, 6(2), (pp. 157). doi: 10.1089/cpt.2008.9998

Kano, M., Volkova, E., Harris, G. C., Morrin, H. R., Cheale, M., Frampton, C., Wells, E., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2008). A comparison of patient, tumour and circulating factors in breast cancer patients of different ethnicities in New Zealand. Proceedings of the American Association for Cancer Research (AACR) 99th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Dachs, G. U., Hunt, M., & Patterson, A. V. (2008). Activation of paracetamol by horseradish peroxidase and cytochrome P450 1A2 in human endothelial cells and cancer cell lines. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Vissers, M., Suzuki, S., Scott-Thomas, A., Gunningham, S., & Dachs, G. (2008). The effect of intracellular ascorbate on HIF-1 mediated gene expression and the phenotype of tumour cells. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Hunt, M. A., Dachs, G. U., Currie, M. J., Patterson, A. V., & Robinson, B. A. (2008). Vessel directed enzyme-prodrug therapy for cancer. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

2007

Journal - Research Article

Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007). Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radical Biology & Medicine, 42, 765-772.

Gunningham, S. P., Currie, M. J., Morrin, H. R., Tan, E. Y., Turley, H., Dachs, G. U., Watson, A. I., Frampton, C., Robinson, B. A., & Fox, S. B. (2007). The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is asociated with P-selectin expression in breast cancers. Journal of Pathology, 212, 335-344.

Conference Contribution - Published proceedings: Abstract

Gunningham, S., Currie, M., Hanrahan, V., Dachs, G., Morrin, H., Frampton, C., Robinson, B., & Fox, S. (2007). The short mRNA isoform of vascular endothelial growth factor receptor-3 (VEGFR-3) is down-regulated by estrogen and progesterone in breast cancer. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2006

Journal - Research Article

Dachs, G. U., Steele, A. J., Coralli, C., Kanthou, C., Brooks, A. C., Gunningham, S. P., Currie, M. J., Watson, A. I., Robinson, B. A., & Tozer, G. M. (2006). Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-I and gene expression. BMC Cancer, 6, 280. doi: 10.1186/1471-2407-6-280

Conference Contribution - Published proceedings: Abstract

Currie, M. J., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Dachs, G. U., Frampton, C., Fox, S. B., & Robinson, B. A. (2006). Increased Ang1 and Tie2 gene expression is associated with survival in colorectal cancer patients. Proceedings of the American Association for Cancer Research (AACR) 97th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Vissers, M., Gunningham, S., Morrison, M., Dachs, G., & Currie, M. (2006). Modulation of hypoxia-inducible factor 1-α in cultured primary cells by intracellular ascorbate: An important function for vitamin C. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Morrin, H. R., Gunningham, S. P., Currie, M. J., Dachs, G. U., Fox, S. B., & Robinson, B. A. (2006). The Christchurch Tissue Bank: A biorepository for cancer research. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Dachs, G. U., Watson, A. I., Currie, M. J., Gunningham, S. P., Tupper, J., & Robinson, B. A. (2006). Using gene therapy to activate paracetemol for anti-vascular treatment of cancer. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

2005

Journal - Research Article

Dachs, G. U., Tupper, J., & Tozer, G. M. (2005). From bench to bedside for gene-directed enzyme prodrug therapy of cancer. Anti-Cancer Drugs, 16, 349-359.

Williams, K. J., Telfer, B. A., Xenaki, D., Sheridan, M. R., Desbaillets, I., Peters, H. J. W., … Dachs, G. U., … Stratford, I. J. (2005). Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiotherapy & Oncology, 75, 89-98. doi: 10.1016/j.radonc.2005.01.009

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2005). The Christchurch Tissue Bank to support cancer research. New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1735/content.pdf

Conference Contribution - Published proceedings: Abstract

Gunningham, S. P., Currie, M. J., Morrin, H. R., Dachs, G. U., Scott, P. A. E., Frampton, C. M., Robinson, B. A., & Fox, S. B. (2005). The angiogenic factor thymidine phosphorylase upregulates the cell adhesion factor p-selectin in human endothelial cells. Proceedings of the American Association for Cancer Research (AACR) 96th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2004

Journal - Research Article

Cemazar, M., Wilson, I., Dachs, G. U., Tozer, G. M., & Sersa, G. (2004). Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy: Spatial and time dependent distribution. BMC Cancer, 4(81). Retrieved from http://www.biomedcentral.com/1471-2407/4/81

Dachs, G. U., Greco, O., & Tozer, G. M. (2004). Targeting cancer with gene therapy using hypoxia as a stimulus. Methods in Molecular Medicine, 90, 371-387.

Tupper, J., Greco, O., Tozer, G. M., & Dachs, G. U. (2004). Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a three-dimensional tumor model. Cancer Gene Therapy, 11(7), 508-513.

Tupper, J., Tozer, G. M., & Dachs, G. U. (2004). Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol. British Journal of Cancer, 90(9), 1858-1862.

Conference Contribution - Poster Presentation (not in published proceedings)

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2004, June). The Christchurch tissue bank: An investment in cancer research. Poster session presented at the New Zealand Society of Oncology Conference, Christchurch, New Zealand.

2003

Journal - Research Article

Greco, O., Marples, B., Dachs, G., Williams, K. J., Patterson, A. V., Scott, S. D., & Hsieh, J. T. (2003). Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Urologic Oncology, 21(4), 314.

2002

Journal - Research Article

Greco, O., Marples, B., Dachs, G. U., Williams, K. J., Patterson, A. V., & Scott, S. D. (2002). Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Human Gene Therapy, 9, 1403-1411.

Folkes, L. K., Greco, O., Dachs, G. U., Stratford, M. R. L., & Wardman, P. (2002). 5-fluoroindole-3-acetic acid: A prodrug activated by a peroxidase with potential for use in targeted cancer therapy. Biochemical Pharmacology, 63, 265-272.

Greco, O., Tozer, G. M., & Dachs, G. U. (2002). Oxic and anoxic enhancement of radiation-mediated toxicity by horseradish peroxidase/indole-3-acetic acid gene therapy. International Journal of Radiation Biology, 78(3), 173-181.

Cemazar, M., Sersa, G., Wilson, J., Tozer, G. M., Hart, S. L., Grosel, A., & Dachs, G. U. (2002). Effective gene transfer to solid tumors using different nonviral gene delivery techniques: Electroporation, liposomes, and integrin-targeted vector. Cancer Gene Therapy, 9, 399-406.

Greco, O., Dachs, G. U., Tozer, G. M., & Kanthou, C. (2002). Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy. Journal of Cellular Biochemistry, 87, 221-232.

2001

Journal - Research Article

Greco, O., Rossiter, S., Kanthou, C., Folkes, L. K., Wardman, P., Tozer, G. M., & Dachs, G. U. (2001). Horseradish peroxidase-mediated gene therapy: Choice of prodrugs in oxic and anoxic tumor conditions. Molecular Cancer Therapeutics, 1, 151-160.

Greco, O., & Dachs, G. U. (2001). Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives. Journal of Cellular Physiology, 187, 22-36.

Coralli, C., Cemazar, M., Kanthou, C., Tozer, G. M., & Dachs, G. U. (2001). Limitations of the reporter green fluorescent protein under simulated tumor conditions. Cancer Research, 61, 4784-4790.

2000

Journal - Research Article

Dachs, G. U., & Tozer, G. M. (2000). Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation. European Journal of Cancer, 36, 1649-1660.

Dachs, G. U., Coralli, C., Hart, S. L., & Tozer, G. M. (2000). Gene delivery to hypoxic cells in vitro. British Journal of Cancer, 83(5), 662-667.

Greco, O., Patterson, A. V., & Dachs, G. U. (2000). Can gene therapy overcome the problem of hypoxia in radiotherapy? Journal of Radiation Research, 41, 201-212.

Greco, O., Folkes, L. K., Wardman, P., Tozer, G. M., & Dachs, G. U. (2000). Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish peroxidase/indole-3-acetic acid. Cancer Gene Therapy, 7(11), 1414-1420.