Contact Details
- Phone
- 64 3 378 6075
- toni.pitcher@nzbri.org
University Links
- Position
- Senior Research Fellow
- Department
- Department of Medicine (Christchurch)
- Qualifications
- BSc(Hons) PhD(Otago)
- Research summary
- Parkinson's disease
Research
I am involved in a number of projects relating to Parkinson’s and dementia. Within the Institute’s longitudinal Parkinson’s cohort, I co-ordinate the collection, storage, and use of biological samples (blood and urine). These samples are used in conjunction with collaborators (local, national, and international) to help further our understanding of biological pathways involved in the disease processes through the investigation of genetic and epigenetic factors, and the investigation of blood proteins levels as potential markers of the disease.I lead an epidemiology project, providing much needed information about the number of people in New Zealand living with Parkinson’s. We continue to use the national health datasets to further our understanding of the number of people with Parkinson’s dementia, mortality within this patient group, and regional variation in the numbers with the disease. I am also part of the International Parkinson and Movement Disorder Society’s Epidemiology Study Group.
Publications
Kim, J. J., Vitale, D., Otani, D. V., Lian, M. M., Heilbron, K., the 23andMe Research Team, … the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., Pitcher, T. L., … Mata, I. (2024). Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease. Nature Genetics, 56, 27-36. doi: 10.1038/s41588-023-01584-8 Journal - Research Article
Kerestes, R., Laansma, M. A., Owens-Walton, C., Perry, A., van Heese, E. M., Al-Bachari, S., Anderson, T. J., … Dalrymple-Alford, J. C., … Melzer, T. R., … Pitcher, T. L., … and the ENIGMA-Parkinson's Study. (2023). Cerebellar volume and disease staging in Parkinson's disease: An ENIGMA-PD study. Movement Disorders. Advance online publication. doi: 10.1002/mds.29611 Journal - Research Article
Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., … and the the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., & Pitcher, T. L. (2023). Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2) [Brief communication]. npj Parkinson's Disease, 9, 131. doi: 10.1038/s41531-023-00533-w Journal - Research Other
Lange, L. M., Avenali, M., Ellis, M., Illarionova, A., Keller Sarmiento, I. J., Tan, A.-H., … the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., & Pitcher, T. L. (2023). Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2) [Brief communication]. npj Parkinson's Disease, 9, 100. doi: 10.1038/s41531-023-00526-9 Journal - Research Other
Ganderton, J., Pitcher, T., Melzer, T., Philips, S., Harris, A., Dobson, R., Anderson, T., … Dalrymple-Alford, J. (2023). Reflex tears to target alpha-synuclein in Parkinson's disease. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 51). Retrieved from https://www.awcbr.org Conference Contribution - Published proceedings: Abstract
2024
Journal - Research Article
Kim, J. J., Vitale, D., Otani, D. V., Lian, M. M., Heilbron, K., the 23andMe Research Team, … the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., Pitcher, T. L., … Mata, I. (2024). Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease. Nature Genetics, 56, 27-36. doi: 10.1038/s41588-023-01584-8
2023
Journal - Research Article
Kerestes, R., Laansma, M. A., Owens-Walton, C., Perry, A., van Heese, E. M., Al-Bachari, S., Anderson, T. J., … Dalrymple-Alford, J. C., … Melzer, T. R., … Pitcher, T. L., … and the ENIGMA-Parkinson's Study. (2023). Cerebellar volume and disease staging in Parkinson's disease: An ENIGMA-PD study. Movement Disorders. Advance online publication. doi: 10.1002/mds.29611
MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Myall, D. J., Horne, K.-L., Shoorangiz, R., … Livingston, L., … Pascoe, M. J., Marshall, E. T., … Perry, S. E., Meissner, W. G., … Le Heron, C. J., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2023). The New Zealand Parkinson’s progression programme. Journal of the Royal Society of New Zealand, 53(4), 466-488. doi: 10.1080/03036758.2022.2111448
Bloomer, J., Pitcher, T., Mustapic, M., Eren, E., Yao, P. J., Vreones, M. P., … Dalrymple-Alford, J., Shoorangiz, R., Meissner, W. G., Anderson, T., & Kapogiannis, D. (2023). Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease. Brain, 146, 195-208. doi: 10.1093/brain/awac258
Journal - Research Other
Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., … and the the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., & Pitcher, T. L. (2023). Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2) [Brief communication]. npj Parkinson's Disease, 9, 131. doi: 10.1038/s41531-023-00533-w
Lange, L. M., Avenali, M., Ellis, M., Illarionova, A., Keller Sarmiento, I. J., Tan, A.-H., … the Global Parkinson's Genetic Program (GP2), including Anderson, T. J., & Pitcher, T. L. (2023). Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2) [Brief communication]. npj Parkinson's Disease, 9, 100. doi: 10.1038/s41531-023-00526-9
Guan, J., Li, F., Kang, D., Anderson, T., Pitcher, T., Dalrymple-Alford, J., … Singh-Mallah, G. (2023). Cyclic glycine-proline (cGP) normalises insulin-like growth factor-1 (IGF-1) function: Significance in the ageing brain and in age-related neurological conditions. Molecules, 28, 1021. doi: 10.3390/molecules28031021
Conference Contribution - Published proceedings: Abstract
Ganderton, J., Pitcher, T., Melzer, T., Philips, S., Harris, A., Dobson, R., Anderson, T., … Dalrymple-Alford, J. (2023). Reflex tears to target alpha-synuclein in Parkinson's disease. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 51). Retrieved from https://www.awcbr.org
Horne, K.-L., Harrison, S. J., Slater, N. M., Morris, L.-A., Myall, D. J., Melzer, T. R., Pitcher, T. L., Dalrymple-Alford, J. C., Anderson, T. J., & Le Heron, C. (2023). Understanding the development of anxiety over the disease course in Parkinson's disease. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 30). Retrieved from https://www.awcbr.org
Other Research Output
Pitcher, T. (2023, July). Parkinson's disease: who gets it and why. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2022
Journal - Research Article
Zhao, Y., van Heese, E., Laansma, M. A., Al-Bachari, S., Anderson, T., Assogna, F., … Dalrymple-Alford, J., … Melzer, T. R., … Pitcher, T., … Gutman, B. A. (2022). TV-L1 ordinal logistic regression reveals new morphometric patterns related to Parkinsonian symptom severity: An ENIGMA-PD study. Alzheimer's & Dementia, 18(Suppl. 6), e067037. doi: 10.1002/alz.067037
Conference Contribution - Published proceedings: Full paper
Zhao, Y., Laansma, M. A., van Heese, E. M., Owens-Walton, C., Parkes, L. M., Debove, I., … Anderson, T. J., … Melzer, T. R., Pitcher, T. L., … and for the ENIGMA consortium. (2022). Learning interpretable regularized ordinal models from 3D mesh data for neurodegenerative disease staging. In A. Abdulkadir, D. R. Bathula, N. C. Dvornek, M. Habes, S. Mostafa Kia, V. Kumar & T. Wolfers (Eds.), Machine Learning in Clinical Neuroimaging: Proceedings of the 5th International Workshop, held in conjunction with the 25th International Conference on Medical Imaging Computing and Computer Assisted Intervention (MICCAI): Lecture notes in computer science (Vol. 13596). (pp. 115-124). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-17899-3_12
Conference Contribution - Published proceedings: Abstract
Le Heron, C., MacAskill, M., Horne, K.-L., Livingston, L., Melzer, T., Myall, D., Pitcher, T., Dalrymple-Alford, J., Anderson, T., & Harrison, S. (2022). Temporal dynamics and longitudinal predictors of apathy in Parkinson's disease. Movement Disorders, 37(Suppl. 2), (pp. S630). doi: 10.1002/mds.29223
Nolan, D., Myall, D., Morgan, C., Shoorangiz, R., Livingston, L., Grenfell, S., Pitcher, T., MacAskill, M., Horne, K.-L., Le Heron, C., … Dalrymple-Alford, J., Anderson, T., & Melzer, T. (2022). MRI to investigate cerebrovascular changes in Parkinson's disease. Movement Disorders, 37(Suppl. 2), (pp. S87). doi: 10.1002/mds.29223
2021
Journal - Research Article
Le Heron, C., MacAskill, M., Mason, D., Dalrymple-Alford, J., Anderson, T., Pitcher, T., & Myall, D. (2021). A multi-step model of Parkinson's disease pathogenesis. Movement Disorders, 36(1), 2530-2538. doi: 10.1002/mds.28719
Laansma, M. A., Bright, J. K., Al-Bachari, S., Anderson, T. J., Ard, T., Assogna, F., … Dalrymple-Alford, J., … Melzer, T. R., … Pitcher, T. L., … and the ENIGMA-Parkinson's Study. (2021). International multicenter analysis of brain structure across clinical stages of Parkinson's disease. Movement Disorders, 36(11), 2583-2594. doi: 10.1002/mds.28706
Blakemore, R. L., Pascoe, M. J., Horne, K.-L., Livingston, L., Young, B. N., Elias, B., … Pitcher, T. L., Dalrymple-Alford, J. C., Le Heron, C. J., Anderson, T. J., & MacAskill, M. R. (2021). Higher perceived stress and exacerbated motor symptoms in Parkinson's disease during the COVID-19 lockdown in New Zealand. New Zealand Medical Journal, 134(1538), 44-51. Retrieved from https://www.nzma.org.nz/journal
Nabais, M. F., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., … Anderson, T. J., … Kennedy, M., … Pearson, J., Pitcher, T. L., … McRae, A. F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22(1), 90. doi: 10.1186/s13059-021-02275-5
Horne, K.-L., MacAskill, M. R., Myall, D. J., Livingston, L., Grenfell, S., Pascoe, M. J., … Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., & Dalrymple-Alford, J. C. (2021). Neuropsychiatric symptoms are associated with dementia in Parkinson's disease but not predictive of it. Movement Disorders Clinical Practice, 8(3), 390-399. doi: 10.1002/mdc3.13151
Conference Contribution - Published proceedings: Abstract
Pike, C., Myall, D., MacAskill, M., Anderson, T., & Pitcher, T. (2021). Investigating patterns of cholinesterase inhibitor utilisation in New Zealanders with Parkinson's disease: A nationwide study using linked administrative data. Proceedings of the 6th Pharmacoepidemiology Research Network Symposium. (pp. 19-20). Retrieved from https://www.otago.ac.nz/pharmacoepidemiology
Horne, K.-L., MacAskill, M. R., Myall, D. J., Livingston, L., Grenfell, S., Pascoe, M. J., … Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Dalrymple-Alford, J. C., & Anderson, T. J. (2021). Hallucinations in Parkinson's disease: Are they predictive of dementia? New Zealand Medical Journal, 134(1539), (pp. 88-89). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Spencer, E. S., Pitcher, T., Veron, G., Hannam, T., MacAskill, M., Anderson, T., Dalrymple-Alford, J., & Carr, A. C. (2020). Positive association of ascorbate and inverse association of urate with cognitive function in people with Parkinson’s disease. Antioxidants, 9(10), 1-13. doi: 10.3390/antiox9100906
Hofer, E., Roshchupkin, G. V., Adams, H. H. H., Knol, M. J., Lin, H., Li, S., … ENIGMA consortium, including Pitcher, T. L., Melzer, T. R., Anderson, T. J., … Seshadri, S. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications, 11, 4796. doi: 10.1038/s41467-020-18367-y
MacAskill, M. R., Myall, D. J., Shoorangiz, R., Anderson, T. J., & Pitcher, T. L. (2020). Childbirth and delayed parkinson's onset: A reproducible nonbiological artifact of societal change. Movement Disorders, 35(7), 1268-1271. doi: 10.1002/mds.28135
Fan, D., Pitcher, T., Dalrymple-Alford, J., MacAskill, M., Anderson, T., & Guan, J. (2020). Changes of plasma cGP/IGF-1 molar ratio with age is associated with cognitive status of Parkinson disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 12(1), e12025. doi: 10.1002/dad2.12025
Schierding, W., Farrow, S., Fadason, T., Graham, O. E. E., Pitcher, T. L., Qubisi, S., … Anderson, T. J., Kennedy, M. A., … O'Sullivan, J. M. (2020). Common variants coregulate expression of GBA and modifier genes to delay Parkinson's disease onset. Movement Disorders, 35(8), 1346-1356. doi: 10.1002/mds.28144
Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022
Journal - Research Other
Alamri, Y., Pitcher, T., & Anderson, T. J. (2020). Variations in the patterns of prevalence and therapy in Australasian Parkinson’s disease patients of different ethnicities. BMJ Neurology Open, 2(1), e000033. doi: 10.1136/bmjno-2019-000033
Conference Contribution - Poster Presentation (not in published proceedings)
Laansma, M., Bright, J., Gutman, B., Rummel, C., Wiest, R., Debove, I., … Pitcher, T., Melzer, T., … Van der Werf, Y. (2020, June-July). Mega-analysis shows brain structure abnormalities related to disease severity in Parkinson's disease. Poster session presented at the Organization for Human Brain Mapping (OHBM) 26th Annual Meeting, [Online].
Working Paper; Discussion Paper; Technical Report
MacAskill, M. R., Myall, D. J., Pitcher, T. L., Watanabe, M., & Anderson, T. J. (2020). “Pervasive ocular tremor of Parkinson’s” is not pervasive, ocular, or uniquely Parkinsonian. OSF Preprints. doi: 10.31219/osf.io/s8rwt
2019
Journal - Research Article
Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., … Kennedy, M., Pitcher, T., Pearson, J., … Anderson, T., … Visscher, P. M. (2019). Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine, 11(1), 54. doi: 10.1186/s13073-019-0667-1
Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., Dalrymple-Alford, J. C., & Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology, 10, 391. doi: 10.3389/fneur.2019.00391
Conference Contribution - Published proceedings: Abstract
Pitcher, T., Myall, D., Dalrymple-Alford, J., MacAskill, M., & Anderson, T. (2019). Number of people with Parkinson's dementia in New Zealand. Movement Disorders, 34(Suppl. 2), (pp. S756). doi: 10.1002/mds.27795
Stark, M., Melzer, T., Myall, D., Keenan, R., Pitcher, T., Horne, K.-L., Livingston, L., MacAskill, M., Dalrymple-Alford, J., & Anderson, T. (2019). Amyloid load and cognitive decline in Parkinson's disease: Preliminary longitudinal findings. Movement Disorders, 34(Suppl. 2), (pp. S831). doi: 10.1002/mds.27795
Horne, K.-L., Shoorangiz, R., Livingston, L., Grenfell, S., Almuqbel, M., Young, B., … MacAskill, M., Myall, D., Pitcher, T., Anderson, T., Dalrymple-Alford, J., & Melzer, T. (2019). Association of MRI-derived estimated brain age and cognitive ability in Parkinson's disease. Movement Disorders, 34(Suppl. 2), (pp. S796). doi: 10.1002/mds.27795
2018
Journal - Research Article
Pitcher, T. L., Myall, D. J., Pearson, J. F., Lacey, C. J., Dalrymple-Alford, J. C., Anderson, T. J., & MacAskill, M. R. (2018). Parkinson's disease across ethnicities: A nationwide study in New Zealand. Movement Disorders, 33(9), 1440-1448. doi: 10.1002/mds.27389
Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., … Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders, 225, 91-96. doi: 10.1016/j.jad.2017.07.049
Conference Contribution - Published proceedings: Abstract
Melzer, T., Myall, D., Livingston, L., Almuqbel, M., MacAskill, M., Pitcher, T., Horne, K., Grenfell, S., … Keenan, R., Dalrymple-Alford, J., & Anderson, T. (2018). Longitudinal MRI to predict cognitive impairment in Parkinson's disease. Movement Disorders, 33(Suppl. 2), (pp. S701). doi: 10.1002/mds.116
Melzer, T., Stark, M., Myall, D., Keenan, R., Livingston, L., Almuqbel, M., MacAskill, M., Pitcher, T., Horne, K., Grenfell, S., … Dalrymple-Alford, J., & Anderson, T. (2018). Amyloid PET and cognition in Parkinson's disease. Movement Disorders, 33(Suppl. 2), (pp. S698). doi: 10.1002/mds.116
MacAskill, M., Myall, D., Pitcher, T., Melzer, T., Dalrymple-Alford, J., & Anderson, T. (2018). Does having more children really delay Parkinson's age of onset in women? Movement Disorders, 33(Suppl. 2), (pp. S356). doi: 10.1002/mds.116
Livingstone, M., Elias, B., Goh, J., Peterson, E., Goulden, M., Myall, D., Melzer, T., Pitcher, T., Livingston, L., Horne, K., … Wilkinson, M., MacAskill, M., … Mulligan, H., Anderson, T., Hale, L., … Dalrymple-Alford, J. (2018). Theory of mind in Parkinson's disease: A longitudinal follow-up. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 55). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Elias, B., Livingstone, M., Irish, M., Nicolson, M., Peterson, E., Goulden, M., … Myall, D., Melzer, T., Pitcher, T., Livingston, L., Grenfell, S., … Wilkinson, M., Horne, K., MacAskill, M., … Mulligan, H., Anderson, T., Hale, L., & Dalrymple-Alford, J. (2018). Autobiographical memory in Parkinson's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 45). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Conference Contribution - Verbal presentation and other Conference outputs
Myall, D., Anderson, T., Pearson, J., Dalrymple-Alford, J., MacAskill, M., & Pitcher, T. (2018, November). Do commonly used drugs reduce the risk of Parkinson's. Verbal presentation at the 4th Pharmacoepidemiology Research Network Symposium, Dunedin, New Zealand.
2017
Journal - Research Article
Myall, D. J., Pitcher, T. L., Pearson, J. F., Dalrymple-Alford, J. C., Anderson, T. J., & MacAskill, M. R. (2017). Parkinson's in the oldest old: Impact on estimates of future disease burden. Parkinsonism & Related Disorders, 42, 78-84. doi: 10.1016/j.parkreldis.2017.06.018
Jones, A. J., Kuijer, R. G., Livingston, L., Myall, D., Horne, K., MacAskill, M., Pitcher, T., … Anderson, T. J., & Dalrymple-Alford, J. C. (2017). Caregiver burden is increased in Parkinson's disease with mild cognitive impairment (PD-MCI). Translational Neurodegeneration, 6, 17. doi: 10.1186/s40035-017-0085-5
Conference Contribution - Published proceedings: Abstract
Horne, K.-L., Myall, D., MacAskill, M., Livingston, L., Grenfell, S., Melzer, T., Pitcher, T., Anderson, T., & Dalrymple-Alford, J. (2017). Patient-reported hallucinations and the probability of progression to dementia in Parkinson’s disease. Movement Disorders, 32(Suppl. 2), (pp. S373). doi: 10.1002/mds.27086
Livingstone, M., Elias, B., Goh, J., Peterson, E., Wilkinson, M., Goulden, M., … Melzer, T., Pitcher, T., Livingston, L., Horne, K., … MacAskill, M., … Mulligan, H., Cutfield, N., Anderson, T., Hale, L., & Dalrymple-Alford, J. (2017). Maintaining independence in Parkinson's disease: Cognitive effects of a combined cognitive and physical exercise intervention. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 62). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Peterson, E., Goh, J., Wilkinson, M., Livingstone, M., Elias, B., Goulden, M., Myall, D., Melzer, T., Pitcher, T., Livingston, L., Horne, K., Grenfell, S., … MacAskill, M., … Mulligan, H., Cutfield, N., Anderson, T., Hale, L., & Dalrymple-Alford, J. (2017). Motor outcomes in Parkinson's disease patients: An RCT of physical exercise and cognitive enrichment. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 62). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Elias, B., Goh, J., Peterson, E., Livingstone, M., Goulden, M., Myall, D., Melzer, T., Pitcher, T., Livingston, L., Horne, K., Grenfell, S., … Wilkinson, M., MacAskill, M., … Mulligan, H., Cutfield, N., Anderson, T., Hale, L., & Dalrymple-Alford, J. (2017). Theory of mind in Parkinson's disease: Improvement after physical and cognitive exercise. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 61). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Horne, K.-L., Myall, D. J., MacAskill, M. R., Livingston, L., Grenfell, S. F., Melzer, T. R., Pitcher, T. L., Anderson, T. J., & Dalrymple-Alford, J. C. (2017). Patient-reported hallucinations are associated with future progression to dementia in Parkinson's disease, but cognition is more informative. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. 35, (pp. 40). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Guan, J., Fan, D., Pitcher, T., Dalrymple-Alford, J., Anderson, T., & Alamri, Y. (2017). A novel biomarker for IGF-1 function: The application in aging and neurological conditions. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 29). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
2016
Journal - Research Article
Wood, K.-L., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., … Anderson, T. J., & Dalrymple-Alford, J. C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson's disease: A 4-year longitudinal study. npj Parkinson's Disease, 2, 15027. doi: 10.1038/npjparkd.2015.27
Almuqbel, M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Wood, K.-L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson’s disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. doi: 10.1016/j.parkreldis.2015.11.008
Conference Contribution - Published proceedings: Abstract
Myall, D. J., Pitcher, T. L., MacAskill, M. R., Pearson, J. F., Lacey, C., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Epidemiology of Parkinson’s in New Zealand: Sex, age, and future burden. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 70). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Horne, K., Myall, D. J., Livingston, L., Grenfell, S. F., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2016). Risk of dementia in Parkinson’s disease: Towards optimal short cognitive testing. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 61). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Pitcher, T. L., Myall, D. J., MacAskill, M. R., Pearson, J. F., Lacey, C., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Ethnic and regional differences in Parkinson’s disease in New Zealand. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 31). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Pitcher, T. L., Wood, K., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Tracking Parkinson's disease over 2-6 years with MRI. Movement Disorders, 31(Suppl. 2), (pp. S427). doi: 10.1002/mds.26688
Almuqbel, M. M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Wood, K., Pitcher, T. L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Corticol atrophy in cognitively impaired Parkinson's disease patients. Movement Disorders, 31(Suppl. 2), (pp. S397). doi: 10.1002/mds.26688
Pitcher, T. L., Myall, D. J., MacAskill, M. R., Pearson, J. F., Lacey, C. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Ethnic differences in rates of Parkinson's in New Zealand: A nation-wide prevalence and incidence study. Movement Disorders, 31(Suppl. 2), (pp. S147-S148). doi: 10.1002/mds.26688
Myall, D. J., Pitcher, T. L., MacAskill, M. R., Pearson, J. F., Lacey, C. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Parkinson's in an aging population: Implications from a nation-wide prevalence and incidence study in New Zealand. Movement Disorders, 31(Suppl. 2), (pp. S145). doi: 10.1002/mds.26688
Conference Contribution - Poster Presentation (not in published proceedings)
Almuqbel, M., Melzer, T., Myall, D., MacAskill, M., Livingston, L., Wood, K., Pitcher, T., Keenan, R., Dalrymple-Alford, J., & Anderson, T. (2016, June). Regional cortical thinning is associated with cognitive decline in Parkinson's disease. Poster session presented at the 22nd Annual Meeting of the Organization for Human Brain Mapping (OHBM), Geneva, Switzerland.
Conference Contribution - Verbal presentation and other Conference outputs
Pitcher, T. (2016, November). Parkinson's disease in New Zealand: Ethnic and regional analyses. Verbal presentation at the 2nd Pharmacoepidemiology Research Network Symposium, Dunedin, New Zealand.
2015
Journal - Research Article
Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Watts, R., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLoS ONE, 10(12), e0143923. doi: 10.1371/journal.pone.0143923
Conference Contribution - Published proceedings: Abstract
Wood, K., Livingston, L., Myall, D. J., Grenfell, S., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., & Dalrymple-Alford, J. C. (2015). Neuropsychiatric status and different MCI criteria in Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 37). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Wood, K.-L., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., … Anderson, T. J., & Dalrymple-Alford, J. C. (2015). Progression to dementia in Parkinson's disease over four-years: Risk with alternative MCI criteria. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal
Almuqbel, M., Melzer, T., Myall, D., MacAskill, M., Livingston, L., Wood, K., Pitcher, T., Keenan, R., Dalrymple-Alford, J., & Anderson, T. (2015). Longitudinal magnetic resonance spectroscopy and cognitive impairment in Parkinson's disease. Proceedings of the Organization for Human Brain Mapping (OHBM) 21st Annual Meeting. 1902. Retrieved from http://www.humanbrainmapping.org
Melzer, T., Myall, D., Livingston, L., Wood, K., Pitcher, T., Watts, R., Keenan, R., MacAskill, M., Dalrymple-Alford, J., & Anderson, T. (2015). White matter lesions contribute to future dementia in Parkinson's disease. Proceedings of the Organization for Human Brain Mapping (OHBM) 21st Annual Meeting. 1167. Retrieved from http://www.humanbrainmapping.org
Myall, D. J., Wood, K.-L., Livingston, L., Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2015). Individualised medicine using an abbreviated cognitive screen for dementia prediction in Parkinson's disease. Movement Disorders, 30(Suppl. 1), (pp. S346). doi: 10.1002/mds.26295
Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Pitcher, T. L., Watts, R., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2015). Multimodal MRI changes in Parkinson's disease over one year. Movement Disorders, 30(Suppl. 1), (pp. S18-S19). doi: 10.1002/mds.26295
2014
Journal - Research Article
Pitcher, T. L., MacAskill, M. R., & Anderson, T. J. (2014). Trends in antiparkinsonian medication use in New Zealand: 1995-2011. Parkinson's Disease, 2014, 379431. doi: 10.1155/2014/379431
Conference Contribution - Published proceedings: Abstract
Wood, K.-L., Livingston, L., Myall, D. J., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2014). Alternative criteria for mild cognitive impairment in Parkinson's disease: Relevance to dementia onset. Movement Disorders, 29(Suppl. 1), (pp. S371). doi: 10.1002/mds.25914
Myall, D. J., Wood, K., Livingston, L., Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2014). Individualised medicine: Predicting dementia in Parkinson's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 73). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Almuqbel, M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Wood, K.-L., Pitcher, T. L., Dalrymple-Alford, J. C., & Anderson, T. J. (2014). Cognitive status in Parkinson's disease characterized by magnetic resonance spectroscopy. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 56). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Wood, K., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2014). Comparing mild cognitive impairment criteria in Parkinson's disease: Influence on dementia onset. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 41). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Melzer, T. R., Myall, D. J., Livingston, L., Wood, K.-L., Pitcher, T. L., Keenan, R. J., MacAskill, M. R., Dalrymple-Alford, J. C., & Anderson, T. J. (2014). White matter lesions: A factor in developing dementia in patients with Parkinson's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 34). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Almuqbel, M., Melzer, T. R., Myall, D., MacAskill, M., Livingston, L., Pitcher, T., Dalrymple-Alford, J., & Anderson, T. (2014). Magnetic Resonance Spectroscopy: A potential marker for cognitive impairment in Parkinson’s disease. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal
2013
Journal - Research Article
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80(8), 1841-1849. doi: 10.1212/WNL.0b013e3182929f62
Conference Contribution - Published proceedings: Abstract
Pitcher, T. L., MacAskill, M. R., & Anderson, T. J. (2013). Trends in anti-Parkinsonian medication use in New Zealand: 1995-2011. Movement Disorders, 28(Suppl. 1), (pp. S386). doi: 10.1002/mds.25605
Dalrymple-Alford, J. C., McCurrie, C. H., Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Keenan, R., Anderson, T. J., & Livingston, L. (2013). Domain specific cognitive dysfunction in Parkinson's and associated pattern of grey atrophy. Movement Disorders, 28(Suppl. 1), (pp. S202-S203). doi: 10.1002/mds.25605
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). Serial DTI and cognitive decline in Parkinson's disease. Movement Disorders, 28(Suppl. 1), (pp. S197-S198). doi: 10.1002/mds.25605
Wood, K., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2013). Criteria for Parkinson's disease with mild cognitive impairment associated with increased progression to dementia. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 58). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Dalrymple-Alford, J. C., Livingston, L., Melzer, T. R., Wood, K., Goh, T. J., Pitcher, T. L., Graham, C. F., Keenan, R. J., MacAskill, M. R., & Anderson, T. J. (2013). Current perspectives on Parkinson's disease: Cognition to the fore. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Feng, S. D. W., MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Graham, C. F., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). ASL derived perfusion network shows correlation with saccadic eye movement measures in Parkinson's disease. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Melzer, T., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R., Dalrymple-Alford, J., & Anderson, T. (2013, June). Longitudinal microstructural change is related to cognitive decline in Parkinson's disease. Poster session presented at the Organization for Human Brain Mapping (OHBM) 19th Annual Meeting, Seattle, WA.
2012
Journal - Research Article
Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Reduced striatal volumes in Parkinson's disease: A magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. doi: 10.1186/2047-9158-1-17
MacAskill, M. R., Graham, C. F., Pitcher, T. L., Myall, D. J., Livingston, L., van Stockum, S., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). The influence of motor and cognitive impairment upon visually-guided saccades in Parkinson's disease. Neuropsychologia, 50(14), 3338-3347. doi: 10.1016/j.neuropsychologia.2012.09.025
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 83, 188-194. doi: 10.1136/jnnp-2011-300828
Conference Contribution - Published proceedings: Abstract
Melzer, T. R., Myall, D. J., Watts, R., MacAskill, M. R., Pitcher, T. L., Keenan, R., Livingston, L., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). MRI brain integrity and perfusion measures in Parkinson's disease: Prediction and progression. Movement Disorders, 27(Suppl. 1), (pp. S26-S27). doi: 10.1002/mds.25051
2011
Journal - Research Article
Schulz, J. M., Pitcher, T. L., Savanthrapadian, S., Wickens, J. R., Oswald, M. J., & Reynolds, J. N. J. (2011). Enhanced high-frequency membrane potential fluctuations control spike output in striatal fast-spiking interneurones in vivo. Journal of Physiology, 589(17), 4365-4381. doi: 10.1113/jphysiol.2011.212944
Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., … Dalrymple-Alford, J. C., & Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease. Brain, 134(3), 845-855. doi: 10.1093/brain/awq377
Conference Contribution - Published proceedings: Abstract
Feng, S. D. W., MacAskill, M. R., Pitcher, T. L., Melzer, T. R., & Anderson, T. J. (2011). Correlations between ASL blood flow MRI and eye movement abnormalities in Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 7.5. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Borlase, N. M., Melzer, T., Watts, R., Livingston, L., Graham, C., Pitcher, T., MacAskill, M., Keenan, R., Anderson, T. J., & Dalrymple-Alford, J. C. (2011). Diffusion tensor imaging in the thalamus: An advanced method used to investigate cognitive decline in Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 2.2. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Keenan, R., Livingston, L., Dalrymple-Alford, J. C., & Anderson, T. J. (2011). Decreasing structural integrity with cognitive impairment in Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 2.1. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
2010
Conference Contribution - Published proceedings: Abstract
Borlase, N., Melzer, T., Watts, R., Livingston, L., Graham, C., Pitcher, T., … Keenan, R., Anderson, T., & Dalrymple-Alford, J. (2010). Diffusion tensor imaging and fibre tracking applied to the thalamus: A new approach to understanding Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 54). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Feng, S. D. W., MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Pearson, J. F., Graham, C., & Anderson, T. J. (2010). Correlations between ASL blood flow MRI and eye movement abnormalities in Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 52). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Graham, C., MacAskill, M. R., Dalrymple-Alford, J., Livingston, L., Pitcher, T., & Anderson, T. J. (2010). Memory-guided saccades, cognitive status, and dementia in Parkinson's disease. Movement Disorders. 25(Suppl. 3), (pp. S691). doi: 10.1002/mds.23386
2009
Conference Contribution - Published proceedings: Abstract
Pitcher, T. L., Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Melzer, T. R., Watts, R., & Anderson, T. J. (2009). MRI volumetric analysis of the putamen and caudate nucleus in Parkinson's disease. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 45). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
2007
Journal - Research Article
Pitcher, T. L., Wickens, J. R., & Reynolds, J. N. J. (2007). Differences in striatal spiny neuron action potentials between the spontaneously hypertensive and Wistar-Kyoto rat strains. Neuroscience, 146, 135-142.
2006
Awarded Doctoral Degree
Pitcher, T. L. (2006). In vivo electrophysiology of striatal spiny projection neurons in the spontaneously hypertensive rate (SHR) (PhD). University of Otago, Dunedin, New Zealand. 186p.
2005
Conference Contribution - Verbal presentation and other Conference outputs
Reynolds, J. N. J., Pitcher, T. L., & Wickens, J. R. (2005, November). Characterising the cellular effects of dopamine in the striatum: A problem in four dimensions. Verbal presentation at the First Dunedin Workshop on the Neurobiology of ADHD, Dunedin, New Zealand.
2004
Conference Contribution - Published proceedings: Abstract
Pitcher, T. L., Reynolds, J. N. J., & Wickens, J. R. (2004). Cellular properties of striatal neurons in the spontaneously hypertensive rat. Proceedings of the 8th Triennial Meeting of the International Basal Ganglia Society. (P126), (pp. 110). [Abstract]
2003
Conference Contribution - Published proceedings: Abstract
Pitcher, T., Reynolds, J. N. J., & Wickens, J. (2003). Cellular properties of neostriatal spiny projection neurons in the spontaneously hypertensive rat. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003
Pitcher, T. L., Reynolds, J. N. J., & Wickens, J. R. (2003). Striatal neuron action potential threshold in an animal model of ADHD. New Zealand Medical Journal, 116(1186). Retrieved from http://journal.nzma.org.nz/journal/116-1186/689/content.pdf