Associate Professor Keith Ireton

2026

Journal - Research Other

Ireton, K. (2026). Role of the host membrane trafficking protein Dynamin 2 in cell-to-cell spread of bacterial pathogens. Cells, 15, 994. doi: 10.3390/cells15110994

2024

Journal - Research Article

Tijoriwalla, S., Liyanage, T., Herath, T. U. B., Lee, N., Rehman, A., Gianfelice, A., & Ireton, K. (2024). The host GTPase Dynamin 2 modulates apical junction structure to control cell-to-cell spread of Listeria monocytogenes. Infection & Immunity, 92(10), e00136-24. doi: 10.1128/iai.00136-24

2023

Journal - Research Other

Ireton, K., Gyanwali, G. C., Herath, T. U. B., & Lee, N. (2023). Exploitation of the host exocyst complex by bacterial pathogens. Molecular Microbiology, 120, 32-44. doi: 10.1111/mmi.15034

2022

Journal - Research Article

Gyanwali, G. C., Herath, T. U. B., Gianfelice, A., & Ireton, K. (2022). Listeria monocytogenes co-opts the host exocyst complex to promote internalin A-mediated entry. Infection & Immunity, 90(12), e00326-22. doi: 10.1128/iai.00326-22

Conference Contribution - Verbal presentation and other Conference outputs

Ireton, K., Dowd, G. C., Mortuza, R., Herath, T. U. B., Roy, A., & Gianfelice, A. (2022, August). The bacterial pathogens Listeria monocytogenes and Shigella flexneri exploit host polarized exocytosis to enhance cell-to-cell spread. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Herath, T. U. B., Roy, A., Gianfelice, A., & Ireton, K. (2022, August). Role of host exocytosis in cell-to-cell spread of Shigella flexneri. Verbal presentation at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Herath, T. U. B., Roy, A., Gianfelice, A., & Ireton, K. (2021). Shigella flexneri subverts host polarized exocytosis to enhance cell-to-cell spread. Molecular Microbiology, 116, 1328-1346. doi: 10.1111/mmi.14827

Journal - Research Other

Ireton, K., Mortuza, R., Gyanwali, G. C., Gianfelice, A., & Hussain, M. (2021). Role of internalin proteins in pathogenesis of Listeria monocytogenes. Molecular Microbiology, 116, 1407-1419. doi: 10.1111/mmi.14836

Dowd, G. C., Mortuza, R., & Ireton, K. (2021). Molecular mechanisms of intercellular dissemination of bacterial pathogens. Trends in Microbiology, 29(2), 127-141. doi: 10.1016/j.tim.2020.06.008

Conference Contribution - Published proceedings: Abstract

Roy, A., & Ireton, K. (2021). Role of host membrane remodeling proteins in cell-to-cell spread of the bacterium Shigella flexneri. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 144). Retrieved from https://www.faobmb2021.org

Herath, T. U. B., Roy, A., Gianfelice, A., & Ireton, K. (2021). Role of host exocytosis in cell-to-cell spread of Shigella flexneri. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 138). Retrieved from https://www.faobmb2021.org

2020

Journal - Research Article

Dowd, G. C., Mortuza, R., Bhalla, M., Ngo, H. V., Li, Y., Rigano, L. A., & Ireton, K. (2020). Listeria monocytogenes exploits host exocytosis to promote cell-to-cell spread. PNAS, 117(7), 3789-3796. doi: 10.1073/pnas.1916676117

Nakatani, Y., Shimaki, Y., Dutta, D., Muench, S. P., Ireton, K., Cook, G. M., & Jeuken, L. J. C. (2020). Unprecedented properties of phenothiazines unraveled by a NDH-2 bioelectrochemical assay platform. Journal of the American Chemical Society, 142(3), 1311-1320. doi: 10.1021/jacs.9b10254

Saila, S., Gyanwali, G. C., Hussain, M., Gianfelice, A., & Ireton, K. (2020). The host GTPase Arf1 and its effectors AP1 and PICK1 stimulate actin polymerization and exocytosis to promote entry of Listeria monocytogenes. Infection & Immunity, 88(2), e00578-19. doi: 10.1128/iai.00578-19

2019

Journal - Research Article

Bhalla, M., Van Ngo, H., Gyanwali, G. C., & Ireton, K. (2019). The host scaffolding protein Filamin A and the exocyst complex control exocytosis during InlB-mediated entry of Listeria monocytogenes. Infection & Immunity, 87(1), e00689-18. doi: 10.1128/iai.00689-18

2018

Journal - Research Other

Ireton, K. (2018). A helpful PEST for Listeriolysin O? [Preview]. Cell Host & Microbe, 23(6). doi: 10.1016/j.chom.2018.05.010

Ireton, K., Van Ngo, H., & Bhalla, M. (2018). Interaction of microbial pathogens with host exocytic pathways. Cellular Microbiology, 20(8), e12861. doi: 10.1111/cmi.12861

Conference Contribution - Published proceedings: Abstract

Russell, E. R., Shimaki, Y., Ireton, K., Nakatani, Y., & Cook, G. M. (2018). Elucidating the role of ndh2 in metabolism and virulence in Listeria monocytogenes. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 83). Retrieved from https://www.nzmsconference.org.nz

2017

Journal - Research Article

Ngo, H. V., Bhalla, M., Chen, D.-Y., & Ireton, K. (2017). A role for host cell exocytosis in InlB-mediated internalization of Listeria monocytogenes. Cellular Microbiology, 19(11), e12768. doi: 10.1111/cmi.12768

Bhalla, M., Law, D., Dowd, G. C., & Ireton, K. (2017). Host serine/threonine kinases mTOR and protein kinase C-α promote InlB-mediated entry of Listeria monocytogenes. Infection & Immunity, 85(7), e00087-17. doi: 10.1128/iai.00087-17

2016

Journal - Research Article

Dowd, G. C., Bhalla, M., Kean, B., Thomas, R., & Ireton, K. (2016). Role of host type IA Phosphoinositide 3-Kinase pathway components in invasin-mediated internalization of Yersinia enterocolitica. Infection & Immunity, 84(6), 1826-1841. doi: 10.1128/iai.00142-16

Journal - Research Other

Ireton, K. (2016). Rickettsia evades a tense situation [Preview]. Cell Host & Microbe, 20(5), 549-550. doi: 10.1016/j.chom.2016.10.017

2015

Journal - Research Article

Gianfelice, A., Le, P. H. B., Rigano, L. A., Saila, S., Dowd, G. C., McDivitt, T., … Ireton, K. (2015). Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes. Cellular Microbiology, 17(6), 876-892. doi: 10.1111/cmi.12409

2014

Journal - Research Article

Rigano, L. A., Dowd, G. C., Wang, Y., & Ireton, K. (2014). Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread. Cellular Microbiology, 16(7), 1068-1079. doi: 10.1111/cmi.12260

Polle, L., Rigano, L. A., Julian, R., Ireton, K., & Schubert, W.-D. (2014). Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading. Structure, 22(2), 304-314. doi: 10.1016/j.str.2013.10.017

Journal - Research Other

Ireton, K., Rigano, L. A., & Dowd, G. C. (2014). Role of host GTPases in infection by Listeria monocytogenes. Cellular Microbiology, 16(9), 1311-1320. doi: 10.1111/cmi.12324

Ireton, K., Rigano, L. A., Polle, L., & Schubert, W.-D. (2014). Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria. Frontiers in Cellular & Infection Microbiology, 4, 21. doi: 10.3389/fcimb.2014.00021

Conference Contribution - Published proceedings: Abstract

Ireton, K., Dowd, G. C., & Thomas, R. (2014). Comparison of the role of human PI 3-kinase pathway in internalization of the bacterial pathogens Yersinia enterocolitica and Listeria monocytogenes. Proceedings of the American Society for Cell Biology and International Federation for Cell Biology (ASCB/IFCB) Annual Meeting. P741. ASCB. Retrieved from http://ascb.org/past-annual-meetings-2/

2013

Journal - Research Article

Ireton, K. (2013). Molecular mechanisms of cell – cell spread of intracellular bacterial pathogens. Open Biology, 3, 130079. doi: 10.1098/rsob.130079

Leung, N., Gianfelice, A., Gray-Owen, S. D., & Ireton, K. (2013). Impact of the Listeria monocytogenes protein inlC on infection in mice. Infection & Immunity, 81(4), 1334-1340. doi: 10.1128/IAI.01377-12

2012

Journal - Research Article

Jiwani, S., Wang, Y., Dowd, G. C., Gianfelice, A., Pichestapong, P., Gavicherla, B., … Ireton, K. (2012). Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes. Infection & Immunity, 80(3), 1252-1266. doi: 10.1128/IAI.06082-11

2010

Journal - Research Article

Ireton, K. (2010). Anthrax toxins: Roadblocks for exocytic trafficking. Developmental Cell, 19(5), 643-644. doi: 10.1016/j.devcel.2010.10.019

Taylor, M., Navarro-Garcia, F., Huerta, J., Burress, H., Massey, S., Ireton, K., & Teter, K. (2010). Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol. Journal of Biological Chemistry, 285(41), 31261-31267. doi: 10.1074/jbc.M110.148981

Gavicherla, B., Ritchey, L., Gianfelice, A., Kolokoltsov, A. A., Davey, R. A., & Ireton, K. (2010). Critical role for the host GTPase-activating protein ARAP2 in InIB-mediated entry of Listeria monocytogenes. Infection & Immunity, 78(11), 4532-4541. doi: 10.1128/IAI.00802-10

2009

Journal - Research Article

Goldoni, S., Humphries, A., Nyström, A., Sattar, S., Owens, R. T., McQuillan, D. J., Ireton, K., & Iozzo, R. V. (2009). Decorin is a novel antagonistic ligand of the Met receptor. Journal of Cell Biology, 185(4), 743-754. doi: 10.1083/jcb.200901129

Rajabian, T., Gavicherla, B., Heisig, M., Müller-Altrock, S., Goebel, W., Gray-Owen, S. D., & Ireton, K. (2009). The bacterial virulence factor InIC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nature Cell Biology, 11(10), 1212-1218. doi: 10.1038/ncb1964

Gao, X., Lorinczi, M., Hill, K. S., Brooks, N. C., Dokainish, H., Ireton, K., & Elferink, L. A. (2009). Met receptor tyrosine kinase degradation is altered in response to the leucine-rich repeat of the Listeria invasion protein Internalin B. Journal of Biological Chemistry, 284(2), 774-783. doi: 10.1074/jbc.M805989200

2007

Journal - Research Article

Li, N., Lorinczi, M., Ireton, K., & Elferink, L. A. (2007). Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase. Journal of Biological Chemistry, 282(23), 16764-16775. doi: 10.1074/jbc.M610835200

Ireton, K. (2007). Entry of the bacterial pathogen Listeria monocytogenes into mammalian cells. Cellular Microbiology, 9(6), 1365-1375. doi: 10.1111/j.1462-5822.2007.00933.x

Dokainish, H., Gavicherla, B., Shen, Y., & Ireton, K. (2007). The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase. Cellular Microbiology, 9(10), 2497-2516. doi: 10.1111/j.1462-5822.2007.00976.x

Lee, W. L., Cosio, G., Ireton, K., & Grinstein, S. (2007). Role of CrkII in Fcγ receptor-mediated phagocytosis. Journal of Biological Chemistry, 282(15), 11135-11143. doi: 10.1074/jbc.M700823200