Contact Details
- Phone
- +64 3 470 3548
- pete.jones@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Physiology
- Qualifications
- BSc(Hons) PhD
- Research summary
- Molecular mechanisms underlying heart disease, arrhythmia and skeletal muscle disease
Research
My principal research interest is in how calcium cycling is controlled in cardiac myocytes. In particular, my focus is on the mechanisms by which calcium release from intra-cellular stores (sarcoplasmic reticulum, SR) is controlled by the cardiac ryanodine receptor (RyR2). The aim of my research is to characterize how the activity of RyR2 is altered both physiologically and in disease. This is achieved using a broad spectrum of assays from molecular biology and single channel recordings, through to isolated cardiac myocytes and ultimately whole animal models.
Publications
Clowsley, A. H., Meletiou, A., Janicek, R., Bokhobza, A. F. E., Lučinskaitė, E., Bleuer, G., … Jones, P. P., … Soeller, C. (2025). MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells. Nature Communications. Advance online publication. doi: 10.1038/s41467-025-67801-6 Journal - Research Article
McNamara, L., Pollack, S., Vyas, Y., Laouby, Z., Jung, Y., Jones, P., … Montgomery, J. M. (2025). Assessing the impact of miniscopes in an in vivo Alzheimer's disease model. In A. Banstola (Ed.), Proceedings of the 41st International Australasian Winter Conference on Brain Research (AWCBR). 3.3, (pp. 39). Retrieved from https://www.awcbr.org Conference Contribution - Published proceedings: Abstract
Gonano, L. A., Kinns, A. M., Bergan-Dahl, A., Louch, W. E., & Jones, P. P. (2025). Interplay between ryanodine receptor arrangement and function: Implications for (patho)physiological control of calcium release. Circulation Research, 137, 902-923. doi: 10.1161/circresaha.125.325387 Journal - Research Other
Hintz, M. O., Zellhuber-McMillan, U., & Jones, P. P. (2025). Simple method to isolate individual mouse cardiomyocytes using enzymatic digestion via retrograde perfusion. In D. N. K. Chandrasekera & R. Katare (Eds.), Cardiomyocytes: Methods and protocols: Methods in molecular biology (Vol. 2894). (pp. 7-20). New York, NY: Springer. doi: 10.1007/978-1-0716-4342-6_2 Chapter in Book - Research
Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2024, August). Dual site phosphorylation of calsequestrin II decreases store overload induced calcium release. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
2025
Chapter in Book - Research
Hintz, M. O., Zellhuber-McMillan, U., & Jones, P. P. (2025). Simple method to isolate individual mouse cardiomyocytes using enzymatic digestion via retrograde perfusion. In D. N. K. Chandrasekera & R. Katare (Eds.), Cardiomyocytes: Methods and protocols: Methods in molecular biology (Vol. 2894). (pp. 7-20). New York, NY: Springer. doi: 10.1007/978-1-0716-4342-6_2
Journal - Research Article
Clowsley, A. H., Meletiou, A., Janicek, R., Bokhobza, A. F. E., Lučinskaitė, E., Bleuer, G., … Jones, P. P., … Soeller, C. (2025). MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells. Nature Communications. Advance online publication. doi: 10.1038/s41467-025-67801-6
Journal - Research Other
Gonano, L. A., Kinns, A. M., Bergan-Dahl, A., Louch, W. E., & Jones, P. P. (2025). Interplay between ryanodine receptor arrangement and function: Implications for (patho)physiological control of calcium release. Circulation Research, 137, 902-923. doi: 10.1161/circresaha.125.325387
Conference Contribution - Published proceedings: Abstract
McNamara, L., Pollack, S., Vyas, Y., Laouby, Z., Jung, Y., Jones, P., … Montgomery, J. M. (2025). Assessing the impact of miniscopes in an in vivo Alzheimer's disease model. In A. Banstola (Ed.), Proceedings of the 41st International Australasian Winter Conference on Brain Research (AWCBR). 3.3, (pp. 39). Retrieved from https://www.awcbr.org
2024
Journal - Research Article
Ruud, M., Frisk, M., Melleby, A. O., Norseng, P. A., Mohamed, B. A., Li, J., … van Hout, I., Coffey, S., … Jones, P. P., … Louch, W. E. (2024). Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation. Journal of Physiology, 602(18), 4487-4510. doi: 10.1113/jp284566
Conference Contribution - Published proceedings: Abstract
Hames, M., Potapov, K., Ohline, S. M., & Jones, P. P. (2024). Investigating the effect of CK2 phosphorylation of RyR2 on neuronal excitability. In K.-L. Horne (Ed.), Proceedings of the 40th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 49). Retrieved from https://www.awcbr.org
Meletiou, A., Clowsley, A. H., Lucinskaite, E., Jansen, I., Jones, P. P., Louch, W. E., & Soeller, C. (2024). Analysis of RYR2 distribution in HEK293 cells and mouse cardiac myocytes using 3D minflux microscopy achieves all optical subunit resolution. Biophysical Journal, 123(Suppl. 1), (pp. 130a). doi: 10.1016/j.bpj.2023.11.743
Conference Contribution - Poster Presentation (not in published proceedings)
Tausi, T. F., Zellhuber-McMillan, U., Mishra-Vakaoti, V., Munro, M. L., & Jones, P. P. (2024, August-September). Investigating CK2 phosphorylation and RyR2 clusters. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chan, J. A., Vergara-Silva, R., Zellhuber-McMillan, U., Khaing, E. P., Ohline, S. M., Munro, M. L., & Jones, P. P. (2024, August-September). Ryanodine receptor type II ultrastructural remodelling in an Alzheimer’s disease-like mouse model. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Anscombe, M. J., Jones, P. P., & Erickson, J. R. (2024, August-September). HEK293-RyR2 cells as a model for cardiac arrhythmia in high throughput screening. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2024, August). Dual site phosphorylation of calsequestrin II decreases store overload induced calcium release. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.
Langdon, A. J., Jones, P., Zellhuber-McMillan, U., Augustine, R. A., & Coffey, S. (2024, August). Role of CK2 phosphorylation of RyR2 on post-myocardial infarct complications. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.
Langdon, A. J., Zellhuber-McMillan, U., Augustine, R. A., Coffey, S., & Jones, P. P. (2024, August-September). Role of CK2 phosphorylation of RyR2 on post-myocardial infarct complications. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sibbles, E., Jones, P., & Munro, M. (2024, August-September). Calsequestrin-2 glycosylation does not affect Ca2+ leak in a non-cardiac cell line. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2024, August-September). Dual site phophorylation of calsequestrin II decreases store overload induced calcium release. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Other Research Output
Jones, P. (2024, August). Dr Jones and the calcium of doom. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2023
Journal - Research Article
Okolo, C. A., Khaing, E.-P., Mereacre, V., Wallace, R. S., Munro, M. L., Erickson, J. R., & Jones, P. P. (2023). Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation. Cardiovascular Diabetology, 22, 276. doi: 10.1186/s12933-023-02010-3
Parveen, S., Cheah, P. H. S., Worthington, L. P. I., Smither, R. A., Munro, M. L., Bussey, C. T., Lamberts, R. R., & Jones, P. P. (2023). Depressed HCN4 function in the type 2 diabetic sinoatrial node. Molecular & Cellular Biochemistry, 478, 1825-1833. doi: 10.1007/s11010-022-04635-6
Journal - Research Other
Aitken-Buck, H. M., Khaing, E. P., Lamberts, R. R., & Jones, P. P. (2023). Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling. Journal of Cellular & Molecular Medicine, 27, 3641-3645. doi: 10.1111/jcmm.17949
Conference Contribution - Verbal presentation and other Conference outputs
Chan, J. A., Ohline, S. M., Munro, M. L., & Jones, P. P. (2023, August). Ryanodine type II receptor clustering in Alzheimer's disease. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sibbles, E., Jones, P., & Munro, M. (2023, August). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2023, August). Determining the functional effect of phosphorylated calsequestrin II in heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kinns, A. M., Zellhuber-McMillan, U., & Jones, P. P. (2023, August). The anti-arrhymthmic effects of maintaining CK2 constitutive phosphorylation of RyR2. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2022
Journal - Research Article
Ng, Y. H., Lamberts, R. R., Jones, P. P., Sammut, I. A., Diffee, G. M., Wilkins, G. T., & Baldi, J. C. (2022). Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Scientific Reports, 12(1), 16904. doi: 10.1038/s41598-022-20520-0
Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876
Satthenapalli, R., Lee, S., Bellae Papannarao, J., Hore, T. A., Chakraborty, A., Jones, P. P., Lamberts, R. R., & Katare, R. (2022). Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage. Stem Cell Research & Therapy, 13(1), 185. doi: 10.1186/s13287-022-02845-9
Gonano, L. A., Aitken-Buck, H. M., Chakraborty, A. D., Worthington, L. P. I., Cully, T. R., Lamberts, R. R., … Jones, P. P. (2022). Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G. Current Research in Physiology, 5, 171-178. doi: 10.1016/j.crphys.2022.03.004
Journal - Research Other
Sibbles, E. T., Waddell, H. M. M., Mereacre, V., Jones, P. P., & Munro, M. L. (2022). The function and regulation of calsequestrin-2: Implications in calcium-mediated arrhythmias. Biophysical Reviews, 14, 329-352. doi: 10.1007/s12551-021-00914-6
Conference Contribution - Published proceedings: Abstract
Chan, J. A., & Jones, P. P. (2022). The effect of benzothiazepine S107, a preventative Ca2+ leak drug, on ryanodine type II receptor (RyR2) calcium leak. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 58). Retrieved from https://www.queenstownresearchweek.org
Silva, R., Ohline, S., Munro, M., & Jones, P. (2022). Role of ryanodine receptor clustering in Alzheimer's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.queenstownresearchweek.org
Aitken-Buck, H., Krause, J., Coffey, S., Zeller, T., Jones, P., & Lamberts, R. (2022). Identification of acylcarnitine dysregulation in atrial fibrillation and the role of circulating acylcarnitines in arrhythmogenesis. Heart, Lung & Circulation, 31(Suppl. 3), (pp. S312). doi: 10.1016/j.hlc.2022.06.541
Conference Contribution - Poster Presentation (not in published proceedings)
de Jonge, W., Van Hout, I., Leleai, M., Gosling, A., Parry, D., Coffey, S., Jones, P. P., Schwenke, D. O., Matisoo-Smith, L., Coppell, K., & Lamberts, R. R. (2022, August-September). Representation of Māori and Pacific Island patients in cardiac research requiring tissue collection in the Southern District Health Board region in Aotearoa. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Khaing, E. P., Okolo, C. A., Erickson, J. R., & Jones, P. P. (2022, August-September). Regulation of RyR2 by O-GlcNAcylation. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Watanabe, E., Deb, A., & Jones, P. P. (2022, August-September). The development of a super-resolution fluorescence microscope for investigating protein distribution in human tissue. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Pirker, T., & Jones, P. P. (2022, August-September). CK2 phosphorylation of RyR2 in heart failure patients. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Jones, P. (2022, August). Role of calcium in arrhythmias. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Aitken-Buck, H. M., Waddell, H. M. M., Babakr, A. A., Moore, M. K., Berkahn, E. F., van Hout, I., Fomison-Nurse, I. C., Moharram, M., … Coffey, S., Jones, P. P., & Lamberts, R. R. (2022, August). Linking epicardial fat to cardio-metabolic disease: Evidence from basic research. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022, August-September). Altered membrance properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer's disease. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Hintz, M., Mereacre, V., & Jones, P. (2022, August-September). CK2-mediated hyperphosphorylation of RyR2: Can it protect against cardiac arrhythmia? Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sibbles, E., Jones, P., & Munro, M. (2022, August-September). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Mereacre, V., & Jones, P. (2022, August-September). Phosphorylation of RyR2 by CK2 is anti-arrhythmic. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2021
Journal - Research Article
Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021
Ng, Y. H., Okolo, C. A., Erickson, J. R., Baldi, J. C., & Jones, P. P. (2021). Protein O-GlcNAcylation in the heart. Acta Physiologica, 233, e13696. doi: 10.1111/apha.13696
Zhong, X., Guo, W., Wei, J., Tang, Y., Liu, Y., Zhang, J. Z., … Jones, P. P., … Wayne Chen, S. R. (2021). Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Bioscience Reports, 41, BSR20210209. doi: 10.1042/bsr20210209
Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704
Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044
Conference Contribution - Published proceedings: Abstract
Mereacre, V., & Jones, P. (2021). Phosphorylation of RyR2 by CK2 is anti-arrhythmic. New Zealand Medical Journal, 134(1547), (pp. 138-139). Retrieved from https://www.nzma.org.nz/journal
Aitken-Buck, H. M., van Hout, I., Krause, J., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Arrhythmogenic and inotropic effects of long-chain acylcarnitines in the human heart. New Zealand Medical Journal, 134(1537), (pp. 111-112). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, E540-E547. doi: 10.1152/ajpendo.00202.2020
Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal
McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd2 (hextrz)4]4+ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061
Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R
Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019
Journal - Research Other
Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856
Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569
Conference Contribution - Published proceedings: Abstract
Moharram, M., van Hout, I., Jones, P., Lamberts, R., Whalley, G., Williams, M., & Coffey, S. (2020). Speckle tracking strain analysis for the detection of changes in left ventricular function in patients with hypertension. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2020.05.048
Frisk, M., Le, C., Hou, Y., Røe, Å., Dahl, C., Shen, X., … Jones, P., & Louch, W. (2020). T-tubule disruption is a prominent feature of HFrEF but not HFpEF. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 26). doi: 10.1016/j.yjmcc.2019.11.060
Gonano, L. A., Chakraborty, A. D., Aitken-Buck, H., Vila Petroff, M., & Jones, P. P. (2020). Phosphorylation of cardiac ryanodine receptors by protein kinase G: Evaluation of its impact on store overload-induced calcium release. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 49). doi: 10.1016/j.yjmcc.2019.11.117
Hou, Y., Laasmaa, M., Li, J., Manfra, O., Shen, X., Jones, P. P., … Louch, W. E. (2020). Correlating calcium sparks and ryanodine receptor localization in live cardiomyocytes. Biophysical Journal, 118(3, Suppl. 1), (pp. 567a). doi: 10.1016/j.bpj.2019.11.3088
2019
Journal - Research Article
Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387
Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003
Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562
Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476
Conference Contribution - Published proceedings: Abstract
Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101
Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276
Parveen, S., Lamberts, R., & Jones, P. (2019). Clock changes in the type 2 diabetic sinoatrial node. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S206). doi: 10.1016/j.hlc.2019.06.169
Conference Contribution - Poster Presentation (not in published proceedings)
Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Aitken-Buck, H. M., van Hout, I., Davis, P. J., Coffey, S., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2019, September). Long-chain acylcarnitines as acute modulators of human atrial muscle function. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2018
Journal - Research Article
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070
Journal - Research Other
Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773
Conference Contribution - Published proceedings: Abstract
Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β1-but not β3-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283
Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093
Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018
Conference Contribution - Verbal presentation and other Conference outputs
Munro, M. L., Jayasinghe, I. D., Crossman, D. J., Baddeley, D., Soeller, C., & Jones, P. P. (2018, August). Super resolved calcium channel organisation in the heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Okolo, C. A., McLay, J. C., McLachlan, J. J., Munro, M., Tanner, C., Chakraborty, A. D., Erickson, J. R., & Jones, P. P. (2018, August). Regulation of RyR2 by O-linked glycosylation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Journal - Research Article
Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799
Journal - Research Other
Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805
Conference Contribution - Published proceedings: Abstract
Chakraborty, A., Gonano, L., McLay, J., Dulhunty, A., & Jones, P. (2017). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 11). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Jones, P., Chakraborty, A., Gonano, L. A., & Dulhunty, A. (2017). Arrhythmogenic ATP-based kinase inhibitors directly increase the activity of RyR2. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S158). doi: 10.1016/j.hlc.2017.06.262
Conference Contribution - Poster Presentation (not in published proceedings)
Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chakraborty, A. D., Gonano, L. A., Mclay, J. C., Dulhunty, A., & Jones, P. P. (2017, September). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2016
Journal - Research Article
Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca2+ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528
Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036
Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389
Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33
Conference Contribution - Poster Presentation (not in published proceedings)
Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca2+ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Okolo, C. A., McLachlan, J. J., McLay, J. C., Erickson, J. R., & Jones, P. P. (2016, August-September). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Okolo, C. A., McLachlan, J. J., McLay, J., Erickson, J. R., & Jones, P. P. (2016, August). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Chakraborty, A., McLay, J., & Jones, P. (2016, August). Regulation of RyR2 by protein kinase CK2. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August). Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca++ waves in cardiac myocytes. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Chakraborty, A. D., McLay, J., & Jones, P. (2016, August-September). Regulation of RyR2 by protein kinase CK2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Jones, P. (2016, August-September). FKBPs facilitate the termination of spontaneous Ca2+ release in wild type RyR2 but not CPVT mutant RyR2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August-September). RyR2 dysfunction and digitalis toxicity. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
McLachlan, J., & Jones, P. (2016, August). Development of RyR2-based redox sensor for H2O2 quantification in cardiac dyad microdomain. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053
Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021
Mi, T., Xiao, Z., Guo, W., Tang, Y., Hiess, F., Xiao, J., … Zhang, J. Z., … Jones, P. P., & Chen, S. R. W. (2015). Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor. Biochemical Journal, 467(1), 177-190. doi: 10.1042/BJ20141263
Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955
Liu, Y., Sun, B., Xiao, Z., Wang, R., Guo, W., Zhang, J. Z., … Jones, P. P., … Chen, S. R. W. (2015). Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination. Journal of Biological Chemistry, 290(12), 7736-7746. doi: 10.1074/jbc.M114.618827
Conference Contribution - Published proceedings: Full paper
Zhang, J. Z., Waddell, H. M. M., & Jones, P. P. (2015). Regulation of RyR2 by sarcoplasmic reticulum Ca2+. Clinical & Experimental Pharmacology & Physiology, 42(6), (pp. 720-726). doi: 10.1111/1440-1681.12364
Conference Contribution - Published proceedings: Abstract
Lamberts, R. R., Hughes, G., Bussey, C. T., Saxena, P., Galvin, I. F., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., on behalf of HeartOtago. (2015). Left ventricular calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 312-313). doi: 10.1093/eurheartj/ehv399
2014
Journal - Research Article
Zhang, J. Z., McLay, J. C., & Jones, P. P. (2014). The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+. Journal of Molecular & Cellular Cardiology, 74, 22-31. doi: 10.1016/j.yjmcc.2014.04.019
Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72
Chen, W., Wang, R., Chen, B., Zhong, X., Kong, H., Bai, Y., … Jones, P. P., … Chen, S. R. W. (2014). The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nature Medicine, 20(2), 184-192. doi: 10.1038/nm.3440
Conference Contribution - Published proceedings: Abstract
Zhang, J. Z., McLay, J., & Jones, P. P. (2014). Regulation of cardiac ryanodine receptor by histidine rich Ca2+ binding protein. Proceedings of the Medical Sciences Congress (MedSci). (pp. 17). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Jones, P. P., Bai, Y., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. (2014). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Proceedings of the Medical Sciences Congress (MedSci). (pp. 7). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Conference Contribution - Verbal presentation and other Conference outputs
Jones, P. (2014, November). Role of RyR2 in arrhythmia. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.
2013
Journal - Research Article
Liu, Y., Kimlicka, L., Heiss, F., Tian, X., Wang, R., Zhang, L., Jones, P. P., … Chen, S. R. W. (2013). The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+ release and destabilizes the N-terminal domains. Biochemical Journal, 454(1), 123-131. doi: 10.1042/BJ20130594
Bai, Y., Jones, P. P., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. W. (2013). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research, 113, 517-526. doi: 10.1161/circresaha.113.301678
Conference Contribution - Published proceedings: Abstract
Diong, C., Gray, E., Jones, P., & Schwenke, D. (2013). Increased sympathetic activity in obesity may protect against pulmonary hypertension. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal
Lamberts, R., Lingam, S., Wang, S., Saxena, P., Galvin, I., Bunton, R., Williams, M., Coffey, S., Baldi, J., & Jones, P. (2013). Impaired functional relaxation despite upregulated calcium handling proteins in human diabetic myocardium. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S57). doi: 10.1016/j.hlc.2013.05.137
Zhang, J., McLay, J., & Jones, P. (2013). Histidine-rich Ca2+ binding protein inhibits the propensity for store overload-induced Ca2+ release (SOICR). Heart, Lung & Circulation, 22(Suuppl. 1), (pp. S78). doi: 10.1016/j.hlc.2013.05.186
Conference Contribution - Poster Presentation (not in published proceedings)
Waddell, H. M. M., McLay, J. C., & Jones, P. P. (2013, August). Oxidation of the cardiac ryanodine receptor reduces the threshold for spontaneous calcium release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Hoeksema, K. J., McLay, J. C., & Jones, P. P. (2013, August). Assessing the efficacy of a new class of anti-arrhythmics in human atrial samples. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Lingam, S. J., Wang, S. H. Y., Saxena, P., Galvin, I. F., Bunton, R. W., Williams, M. J. A., Coffey, S., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2013, August). Relaxation in human diabetic myocardium. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Diong, C. T., Gray, E. A., Jones, P., & Schwenke, D. O. (2013, August). Can sympathetic hyperexcitation in obesity protect against pulmonary hypertension? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2012
Conference Contribution - Published proceedings: Abstract
Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Protein expression of SERCA2a and PLB in diabetes. Proceedings of the Oxygen Theme Meeting. (pp. 34). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca2+ release. Proceedings of the Oxygen Theme Meeting. (pp. 30). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Lingam, S., Saxena, P., Coffey, S., Williams, M., Baldi, J., Lamberts, R., & Jones, P. (2012). Improved atrial relaxation in human type 2 diabetes mellitus. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Deo, M., McLay, J., & Jones, P. (2012). Triadin decreases the propensity for Store Overload Induced Calcium Release (SOICR). New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Deo, M., Wu, E., McLay, J., & Jones, P. P. (2012). Proteins associated with the cardiac ryanodine receptor alter the threshold for store overload-induced calcium release. Heart, Lung & Circulation, 21(12), (pp. 860). doi: 10.1016/j.hlc.2012.08.023
Jones, P. P. (2012). From dyes to proteins, imaging subcellular calcium events. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Lingam, S. J., Saxena, P., Coffey, S., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Hastened relaxation in a non-failing diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 67). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca2+ release. Proceedings of the Medical Sciences Congress (MedSci). (pp. 66). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Jones, P., Bai, Y., Vallmitjana, A., Wang, R., Clark, R., Zhou, Q., … Chen, S. (2012). Disrupting Ca2+ waves, but not Ca2+ leak, protects against cardiac arrhythmia. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S78). doi: 10.1016/j.hlc.2012.05.198
Conference Contribution - Poster Presentation (not in published proceedings)
Deo, M., McLay, J., & Jones, P. P. (2012, September). Luminal regulation of the RYR2 by triadin reduces the propensity for store overload induced calcium release. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Zhang, J., McLay, J., & Jones, P. P. (2012, September). Histidine-rich CA2+ binding protein (HRC) attenuates the propensity for store overload-induced CA2+ release (SOICR). Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012, September). Improved atrial relaxation in human type 2 diabetes mellitus. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Jones, P. P. (2012, August). From dyes to proteins: Imaging subcellular calcium events. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Beca, S., Helliwell, P. B., Simpson, J. A., Zhao, D., Farman, G. P., Jones, P. P., … Backx, P. H. (2011). Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-Type Ca2+ current. Circulation Research, 109(9), 1024-1030. doi: 10.1161/CIRCRESAHA.111.250464
Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011). Carvedilol and its new analogs suppress arrhythmogenic store overload—induced Ca2+ release. Nature Medicine, 17, 1003-1009. doi: 10.1038/nm.2406
Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P. P., … Chen, S. R. W. (2011). Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14), 12202-12212. doi: 10.1074/jbc.M110.194316
Conference Contribution - Poster Presentation (not in published proceedings)
Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011, August). Unique action of carvedilol and its novel analogues: Suppression of store-overload-induced Ca2+ release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Jones, P. (2011, September). Regulation of RyR2 and its implications in arrhythmia. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2010
Journal - Research Article
Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. A., Anfinogenova, Y., El-Yazbi, A., … Jones, P. P., … Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300
Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., … Gollob, M. H. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666
Conference Contribution - Published proceedings: Abstract
Mufti, R., Welsh, S. B., El-Rahman, R. A., Jones, P., Chen, W., & Welsh, D. (2010). The role of IP3 receptors in generating calcium waves and cerebral myogenic tone. FASEB Journal, 24(Meeting Abstracts), 1033.3. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Chen, S. R. W., Wang, R., Clark, R. B., Zhou, Q., & Jones, P. P. (2010, November-December). Increased calcium leak alone is not sufficient to cause arrhythmia. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Other
Jones, P. P., & Braun, A. P. (2009). Store operated Ca2+ entry (SOCE) [Commentary]. Channels, 3(1), 1-2. doi: 10.4161/chan.3.1.7983
Conference Contribution - Published proceedings: Abstract
Chen, S. R. W., Chen, W., Tian, X., Wang, R., Kong, H., O'Mara, M. L., Jones, P. P., … Tieleman, D. P. (2009). Molecular basis of luminal Ca2+ gating of the cardiac ryanodine receptor. Biophysical Journal. 96(3, Suppl. 1), (pp. 551a). doi: 10.1016/j.bpj.2008.12.2984
2008
Journal - Research Article
Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008). Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochemical Journal, 414, 441-452. doi: 10.1042/BJ20080489
Jones, P. P., Meng, X., Xiao, B., Cai, S., Bolstad, J., Wagenknecht, T., … Chen, S. R. W. (2008). Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor. Biochemical Journal, 410, 261-270. doi: 10.1042/BJ20071257
Jiang, D., Chen, W., Xiao, J., Wang, R., Kong, H., & Jones, P. P. (2008). Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. Journal of Biological Chemistry, 283(30), 20813-20820. doi: 10.1074/jbc.M801944200
Jones, P. P., Jiang, D., Bolstad, J., Hunt, D. J., Zhang, L., Demaurex, N., & Chen, S. R. W. (2008). Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. Biochemical Journal, 412, 171-178. doi: 10.1042/BJ20071287
2007
Journal - Research Article
Xiao, B., Tian, X., Xie, W., Jones, P. P., Cai, S., Wang, X., … Chen, S. R. W. (2007). Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store overload-induced Ca2+ release. Journal of Biological Chemistry, 282(41), 30256-30264. doi: 10.1074/jbc.M703510200
Xiao, J., Tian, X., Jones, P. P., Bolstad, J., Kong, H., Wang, R., … Chen, S. R. W. (2007). Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Journal of Biological Chemistry, 282(48), 34828-34838. doi: 10.1074/jbc.M707423200
Hunt, D. J., Jones, P. P., Wang, R., Chen, W., Bolstad, J., Chen, K., … Chen, S. R. W. (2007). K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochemical Journal, 404, 431-438. doi: 10.1042/BJ20070135
2006
Journal - Research Article
Jones, P. P., Bazzazi, H., Kargacin, G. J., & Colyer, J. (2006). Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient. Biophysical Journal, 91, 433-443. doi: 10.1529/biophysj.106.083931