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Tups Laboratory

Research interests

The focus of our research at the Centre for Neuroendocrinology is on the neuroendocrine regulation of metabolism. In particular we are interested in the central interaction of the adiposity hormones leptin and insulin, which appears crucial for the maintenance of energy and glucose homeostasis. We established that a loss of central leptin action during obesity leads to impaired insulin action, which might explain the striking correlation of obesity and type 2 diabetes.

We investigate neuroendocrine mechanisms that link obesity, diabetes and Alzheimer's disease.

We focus on manipulating these crucial pathways via nutritive, genetherapeutic and pharmacological approaches to potentially avoid the manifestation of nutrition related diseases.

Clinical conditions

  • Obesity
  • Type 2 diabetes
  • Alzheimer’s disease
  • Bipolar disorder
  • Cancer

List of publications for Alexander Tups (Google Scholar)

Kaj Kamstra_webKaj Kamstra, PhD student
WNT signalling and diabetes
Email kajkamstra@hotmail.com

Mo Rizwan_webMohammed Rizwan, Postdoctoral Fellow
Neuroendocrine control of metabolism
Email mohammed.rizwan@otago.ac.nz

Nathan Skinner_webNathan Skinner, PhD student
Circadian desynchrony and its impact on obesity and diabetes
Email skina239@student.otago.ac.nz

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A. (2020). Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal. Advance online publication. doi: 10.1096/fj.202001147R

Loehfelm, A., Rizwan, M. Z., & Tups, A. (2020). A New Zealand green-lipped mussel oil-enriched high-fat diet exhibits beneficial effects on body weight and metabolism in mice. British Journal of Nutrition. Advance online publication. doi: 10.1017/s0007114520002342

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

Benzler, M., Benzler, J., Stoehr, S., Hempp, C., Rizwan, M. Z., Heyward, P., & Tups, A. (2019). "Insulin-like" effects of palmitate compromise insulin signalling in hypothalamic neurons. Journal of Comparative Physiology B, 189(3-4), 413-424. doi: 10.1007/s00360-019-01220-0

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB Journal, 33, 12175-12187. doi: 10.1096/fj.201901004R

Journal - Research Article

Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A. (2020). Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal. Advance online publication. doi: 10.1096/fj.202001147R

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

Loehfelm, A., Rizwan, M. Z., & Tups, A. (2020). A New Zealand green-lipped mussel oil-enriched high-fat diet exhibits beneficial effects on body weight and metabolism in mice. British Journal of Nutrition. Advance online publication. doi: 10.1017/s0007114520002342

Benzler, M., Benzler, J., Stoehr, S., Hempp, C., Rizwan, M. Z., Heyward, P., & Tups, A. (2019). "Insulin-like" effects of palmitate compromise insulin signalling in hypothalamic neurons. Journal of Comparative Physiology B, 189(3-4), 413-424. doi: 10.1007/s00360-019-01220-0

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB Journal, 33, 12175-12187. doi: 10.1096/fj.201901004R

Skinner, N. J., Rizwan, M. Z., Grattan, D. R., & Tups, A. (2019). Chronic light cycle disruption alters central insulin and leptin signaling as well as metabolic markers in male mice. Endocrinology, 160(10), 2257-2270. doi: 10.1210/en.2018-00935

Sergi, D., Campbell, F. M., Grant, C., Morris, A. C., Bachmair, E.-M., Koch, C., … Tups, A., & Williams, L. M. (2018). SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice 06 Biological Sciences 0604 Genetics. Genes & Nutrition, 13, 28. doi: 10.1186/s12263-018-0619-1

McEwen, H. J. L., Cognard, E., Ladyman, S. R., Khant-Aung, Z., Tups, A., Shepherd, P. R., & Grattan, D. R. (2018). Feeding and GLP-1 receptor activation stabilize beta-catenin in specific hypothalamic nuclei in male rats. Journal of Neuroendocrinology, 30(6), e12607, 1-10. doi: 10.1111/jne.12607

Tups, A., Benzler, J., Sergi, D., Ladyman, S. R., & Williams, L. M. (2017). Central regulation of glucose homeostasis. Comprehensive Physiology, 7(2), 741-764. doi: 10.1002/cphy.c160015

Rizwan, M. Z., Mehlitz, S., Grattan, D. R., & Tups, A. (2017). Temporal and regional onset of leptin resistance in diet-induced obese mice. Journal of Neuroendocrinology, 29(10), e12481. doi: 10.1111/jne.12481

Helfer, G., & Tups, A. (2016). Hypothalamic Wnt signalling and its role in energy balance regulation. Journal of Neuroendocrinology, 28. doi: 10.1111/jne.12368

Boucsein, A., Benzler, J., Hempp, C., Stöhr, S., Helfer, G., & Tups, A. (2016). Photoperiodic and diurnal regulation of WNT signaling in the arcuate nucleus of the female Djungarian hamster, Phodopus sungorus. Endocrinology, 157(2), 799-809. doi: 10.1210/en.2015-1708

Stark, R., Reichenbach, A., Lockie, S. H., Pracht, C., Wu, Q., Tups, A., & Andrews, Z. B. (2015). Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice. Endocrinology, 156(3), 858-868. doi: 10.1210/en.2014-1733

Benzler, J., Ganjam, G. K., Pretz, D., Oelkrug, R., Koch, C. E., Legler, K., … Tups, A. (2015). Central inhibition of IKKβ/NF-κB signalling attenuates high-fat diet–induced obesity and glucose intolerance. Diabetes, 64, 2015-2027. doi: 10.2337/db14-0093

Koch, C. E., Lowe, C., Pretz, D., Steger, J., Williams, L. M., & Tups, A. (2014). High-fat diet induces leptin resistance in leptin-deficient mice. Journal of Neuroendocrinology, 26(2), 58-67. doi: 10.1111/jne.12131

Briggs, D. I., Lockie, S. H., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., … Tups, A., & Andrews, Z. B. (2014). Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology, 155(7), 2411-2422. doi: 10.1210/en.2013-1861

Williams, L. M., Campbell, F. M., Drew, J. E., Koch, C., Hoggard, N., Rees, W. D., … Tups, A. (2014). The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. PLoS ONE, 9(8), e106159. doi: 10.1371/journal.pone.0106159

Koch, C. E., Lowe, C., Legler, K., Benzler, J., Boucsein, A., Böttiger, G., Grattan, D. R., … Tups, A. (2014). Central adiponectin acutely improves glucose tolerance in male mice. Endocrinology, 155(5), 1806-1816. doi: 10.1210/en.2013-1734

Penzkofer, D., Bonauer, A., Fischer, A., Tups, A., Brandes, R. P., Zeiher, A. M., & Dimmeler, S. (2014). Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development. PLoS ONE, 9(6), e101153. doi: 10.1371/journal.pone.0101153

Koch, C. E., Göddeke, S., Krüger, M., & Tups, A. (2013). Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus). Journal of Comparative Physiology B, 183(2), 261-268. doi: 10.1007/s00360-012-0699-y

Koch, C. E., Ganjam, G. K., Steger, J., Legler, K., Stöhr, S., Schumacher, D., … Tups, A. (2013). The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling. British Journal of Nutrition, 109(6), 1040-1051. doi: 10.1017/s0007114512003005

Ganjam, G. K., Benzler, J., Pinkenburg, O., Boucsein, A., Stöhr, S., Steger, J., … Tups, A. (2013). Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes. Journal of Comparative Physiology B, 183(8), 1101-1111. doi: 10.1007/s00360-013-0772-1

Benzler, J., Ganjam, G. K., Legler, K., Stöhr, S., Krüger, M., Steger, J., & Tups, A. (2013). Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice. Journal of Neuroendocrinology, 25(5), 446-454. doi: 10.1111/jne.12018

Benzler, J., Andrews, Z. B., Pracht, C., Stöhr, S., Shepherd, P. R., Grattan, D. R., & Tups, A. (2013). Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology, 154(12), 4737-4745. doi: 10.1210/en.2013-1746

Tups, A., Stöhr, S., Helwig, M., Barrett, P., Krol, E., Schachtner, J., … Klingenspor, M. (2012). Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. Journal of Comparative Physiology B, 182(4), 553-567. doi: 10.1007/s00360-011-0637-4

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